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Vi K. Chiu

Assistant Professor, Division of Hematology/Oncology
School of Medicine

Fellowship — Hematology/Oncology, Memorial Sloan-Kettering Cancer Center, 2009

Residency — Internal Medicine, UT Southwestern, Dallas, 2005

M.D., Ph.D. — Internal Medicine & Cell Biology, New York University, 2002

B.S. — Biochemistry; Chemistry and Material Sciences, UCLA, 1994

Phone: (949) 824-9432
Fax: (949) 824-2557

University of California, Irvine
839 Health Sciences Road
Sprague Hall, Room 116
Irvine, CA 92697

picture of Vi K. Chiu

Stem Cell Aberrancy in Cancer, Colorectal Cancer, Pancreatic Cancer, Small Cell Lung Cancer and Tumor Microenvironment
ASCO Young Investigator Award (2008)
Pasteur Foundation Fellowship (2005)
UCLA President’s Undergraduate Fellowship (1994)
UT Southwestern (Dallas) SURFellowship (1994)
UCLA Ramsey Award in Physical Chemistry (1993)
As a physician scientist, I prioritize translational research to develop effective oncologic therapies for human colon, pancreatic and small cell lung cancers. My laboratory focuses on oncogenic Ras, Wnt and chemokine signaling pathways in the human tumor microenvironment. These pathways drive the development and progression of human tumors from aberrant adult stem cells and their activated stromal microenvironment. Therapeutic targeting of stem cell aberrancies and chemokine signaling may lead to improvement in patient survival.
Publications Peer review:

Le Rolle, AF, Chiu, TK, Zeng, Z, Shia, J, Weiser, MR, Paty, PB, Chiu, VK. Oncogenic KRAS activates the embryonic stem cell-like program in human colon cancer initiation. Oncotarget. 2016 Jan 19; 7(3):2159-74. PMID 26744320

Le Rolle, A., Chiu, T.K., Fara, M., Zeng, Z., Shia, J., Weiser, M.R., Paty, P.B., Chiu, V.K. The prognostic significance of CXCL1 hypersecretion by human colorectal epithelia and myofibroblasts. Journal of Translational Medicine. 2015 June 24. PMID 26104296

Le Rolle, A., Klempner, S.J., Christopher, G.R., Serry, T., Sanford, E.M., Balasubramanian, S., Ross, J.S., Stephens, P.J., Miller, V.A., Ali, S.M., and Chiu, V.K. Identification and characterization of RET fusions in advanced colorectal cancer. Oncotarget. 2015 May 30. PMID 26078337

Mirpuri, R.G., Brammeier, J., Chen, H., Hsu, F., Chiu, V.K., and Chang, E.Y. Spinal Cord Stimulation for Treatment of the Pain Associated with Hereditary Multiple Osteochondromas. Journal Of Pain Research. 2015 Aug 8; 8: 557-560.

Kobayashi, H., Butler, J.M., O’Donnell, R., Kobayashi, M., Ding, BS, Bonner, B., Chiu, V.K., Nolan, D.J., Shido, K., Benjamin, L., and Rafii, S. Angiocrine factors derived from Akt-activated endothelium balance self-renewal and differentiation of hematopoietic stem cells. Nature Cell Biology. 2010 Nov 4; 12 (11): 1046-56. PMID 20972423

Michaelson, D., Ali W., Chiu, V.K., Bergo, M., Silletti, J., Wright, L., Young, S.G., and Philips, M.R. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Mol Biol Cell. 2005 Apr; 16(4): 1606-16. PMID 15659645

Chiu, V.K., Silletti, J., Dinsell, V., Wiener, H., Loukeris, K., Ou, G., Philips, M.R., and Pillinger, M.H. Carboxyl methlylation of Ras regulates membrane targeting and effector engagement. J Biol Chem. 2004 Feb 20;279(8): 7346-52. PMID 14660603

Bivona, T.G., Weiner, H., Silletti, J., Chiu, V.K., and Philips, M.R. Rap1 upregulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol. 2004 Feb 2;164(3): 461-70. PMID 11988737

Bivona, T.G., de Castro, I.P., Ahearn, I.M., Grana, T.M Chiu, V.K., Lockyer, P.J., Cullen, P.J., Pellicer, A., Cox, A.D., and Philips, M.R. Phospholipase C activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 2003 Aug 7;424: 694-698. PMID 14757755

Chiu, V.K., Bivona, T., Hach, A., Sajous, B.J., Silletti, J., Weiner, H., Johnson-II, R.L., Cox, A.D., and Philips, M.R. Ras signalling on the endoplasmic reticulum and the Golgi. Nature Cell Biology. 2002 May;4(5): 343-50. PMID 12845332

Choy, E., Chiu, V.K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I.E., and Philips, M.R. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 1999 Jul 9;98(1): 69-80. PMID 10412982

Dai, Q., Choy, E., Chiu, V., Romano, J., Slivka, S.R., Steitz, S.A., Michaelis, S., and Philips, M.R. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem. 1998 Jun 12;273(24): 15030-4. PMID 9614111

Chiu, V.K., Walsh, C.M., Liu, C.C., Reed, J.C., and Clark, W.R. Bcl-2 blocks degranulation but not fas based cell-mediated cytotoxicity. J Immunol. 1995 Mar 1;154(5): 2023-32. PMID 7532659

Walsh, C.M., Glass, A.A., Chiu, V., and Clark, W.R. The role of the Fas lytic pathway in a perforin-less CTL hybridoma. J Immunol. 1994 Sep 15;153(6): 2506-14. PMID 7521365

Editorials, Chapters
Chiu, VK and Le Rolle, AF. Cancer comes of age embryonically. Aging. 2016. May 12. PMID 27191151

Chiu, VK. “Myelodysplastic and Myeloproliferative Disorders.” Parkland Manual of in-patient medicine: an evidence based approach. Philadelphia: F.A. Davis Company, 2006.
American Society for Clinical Oncology
American Association for Cancer Research
Research Centers Chao Family Comprehensive Cancer Center
Cancer Research Institute
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Last updated 08/02/2016