Dongbao Chen

Professor, Obstetrics & Gynecology
School of Medicine

Professor, Pathology
School of Medicine

Ph.D., China (Beijing) Agricultural University, 1991, Reproductive Physiology

Phone: (949) 824-2739
Fax: 949-824-2403

University of California, Irvine
Med Surge 1
Bldg. 810, Room 140
Mail Code: 3230
Irvine, CA 92697

picture of Dongbao  Chen

Reactive nitrogen and oxygen species, Nitrosylation, Estrogens, Hormones, Growth factors, Angiogenesis, Placenta, Corpus luteum, Ovary, Uterus, Menopause, Pregnancy, Maternal adaptation, Preeclampsia, Perinatal vascular biology, Obstetrics and Gynecology.
URL Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology
• Pfizer Award, SGI, 2013
• External Expert Panel, NMRC, Singapore, 2012-2014
• Pfizer Award, SGI, 2012
• Regular Member, NIH/NICHD CHHDB Study Section, 07/2011-06/2014
• Pfizer Award, SGI, 2011
• USDA NRI Merit Award (Mentor), SSR 2011
• Elected to Council, Perinatal Research Society, 2010-2012.
• Member, Vascular Wall Biology Basic Science 3 Committee,, AHA, 2010-
• Pfizer Award, SGI, 2010
• Member, NIH Pregnancy & Neonatology Study Section, 02/2007, 01/2008
• President’s Presenter Award (Mentor), SGI 2005
• NIH Young Investigator Award, Perinatal Research Society, 1999
• Lalor Postdoctoral Fellowship, Lalor Foundation, 1998
• Lalor Postdoctoral Fellowship, Lalor Foundation, 1997
Appointments 07/2013 – Present: Professor, Dept of Ob/Gyn, UC Irvine
04/2010 – Present: Associate Professor Jointly Appointed, Dept of Experimental Pathology, UC Irvine
06/2008 – 07/2013: Associate Professor and Director, Perinatal Research Laboratories, Dept of Ob/Gyn, UC Irvine
07/2007 - 05/2008: Associate Professor with Tenure, Dept of Reproductive Medicine, UC San Diego
07/2005 - 06/2007: Assistant Professor on Tenure-Track, Dept of Reproductive Medicine, UC San Diego
07/2003 - 06/2005: Assistant Adjunct Professor, Dept of Reproductive Medicine, UC San Diego
10/2001 - 07/2003: Specialist/Assistant Scientist, Dept of Reproductive Medicine, UC San Diego
06/2000 - 10/2000: Consultant, Genetics Computer Group (GCG)
01/1999 - 10/2001: Research Assistant Professor/Assistant Scientist, Perinatal Research Laboratories, Dept of Ob/Gyn, University of Wisconsin - Madison, WI
05/1995 - 05/1999: Postdoctoral Fellow/Research Associate, The Women’s Research Institute, Dept of Ob/Gyn, University of Kansas School of Medicine - Wichita, KS
07/1993 - 05/1995; Postdoctoral Fellow, Dept of Ob/Gyn, Baylor College of Medicine, Houston, TX
We are currently investigating the cellular and molecular mechanisms underlying hormone and growth factor regulation of vasodilatation and angiogenesis at the maternal, fetal and placental interface with focus on reactive nitrogen and oxygen species as well as reactive sulfides.
Publications 1. Lechuga TJ, Zhang HH, Sheibani L, Karim M, Jia J, Magness RR, Rosenfeld CR, Chen DB. Estrogen Replacement Therapy in Ovariectomized Nonpregnant Ewes Stimulates Uterine Artery Hydrogen Sulfide Biosynthesis by Selectively Up-Regulating Cystathionine ß-Synthase Expression. Endocrinology. 2015 Jun;156(6):2288-98. doi: 10.1210/en.2015-1086. Epub 2015 Mar 31. PubMed PMID: 25825818; PubMed Central PMCID: PMC4430606.
2. Zhang HH, Lechuga TJ, Tith T, Wang W, Wing DA, Chen DB. S-nitrosylation of cofilin-1 mediates estradiol-17ß-stimulated endothelial cytoskeleton remodeling. Mol Endocrinol. 2015 Mar;29(3):434-44. doi: 10.1210/me.2014-1297. Epub 2015 Jan 30. PubMed PMID: 25635941; PubMed Central PMCID: PMC4347286.
3. Satohisa S, Zhang HH, Feng L, Yang YY, Huang L, Chen DB. Endogenous NO upon estradiol-17ß stimulation and NO donor differentially regulate mitochondrial S-nitrosylation in endothelial cells. Endocrinology. 2014 Aug;155(8):3005-16. doi: 10.1210/en.2013-2174. Epub 2014 May 30. PubMed PMID: 24877627; PubMed Central PMCID: PMC4098011.
4. Zhang HH, Wang W, Feng L, Yang Y, Zheng J, Huang L, Chen DB. S-nitrosylation of Cofilin-1 Serves as a Novel Pathway for VEGF-stimulated Endothelial Cell Migration. J Cell Physiol. 2014 Jul 24. doi: 10.1002/jcp.24724. [Epub ahead of print] PubMed PMID: 25056928.
5. Jiang YZ, Li Y, Wang K, Dai CF, Huang SA, Chen DB, Zheng J. Distinct roles of HIF1A in endothelial adaptations to physiological and ambient oxygen. Mol Cell Endocrinol. 2014 Jun 25;391(1-2):60-7. doi: 10.1016/j.mce.2014.04.008. Epub 2014 May 2. PubMed PMID: 24796659; PubMed Central PMCID: PMC4079002.
6. Chen DB, Zheng J. Regulation of placental angiogenesis. Microcirculation. 2014 Jan;21(1):15-25. doi: 10.1111/micc.12093. Review. PubMed PMID: 23981199.
7. Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. Enhanced cellular responses and distinct gene profiles in human fetoplacental artery endothelial cells under chronic low oxygen. Biol Reprod. 2013 Dec 5;89(6):133. doi: 10.1095/biolreprod.113.110551. Print 2013 Dec. PubMed PMID: 24152727; PubMed Central PMCID: PMC4076354.
8. Ehsanipoor RM, Fortson W, Fitzmaurice LE, Liao WX, Wing DA, Chen DB, Chan K. Nitric oxide and carbon monoxide production and metabolism in preeclampsia. Reprod Sci. 2013 May;20(5):542-8. doi: 10.1177/1933719112459231. Epub 2012 Sep 25. PubMed PMID: 23012314; PubMed Central PMCID: PMC3713541.
9. Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. Transcriptional and functional adaptations of human endothelial cells to physiological chronic low oxygen. Biol Reprod. 2013 May 9;88(5):114. doi: 10.1095/biolreprod.113.108225. Print 2013 May. PubMed PMID: 23536375; PubMed Central PMCID: PMC4013893.
10. Chen DB, Wang W. Human placental microRNAs and preeclampsia. Biol Reprod. 2013 May 23;88(5):130. doi: 10.1095/biolreprod.113.107805. Print 2013 May. Review. PubMed PMID: 23575145; PubMed Central PMCID: PMC4013914.
11. Feng L, Zhang HH, Wang W, Zheng J, Chen DB. Compartmentalizing proximal FGFR1 signaling in ovine placental artery endothelial cell caveolae. Biol Reprod. 2012 Aug 23;87(2):40. doi: 10.1095/biolreprod.112.100750. Print 2012 Aug. PubMed PMID: 22674390; PubMed Central PMCID: PMC3431425. Cover page story
12. Feng L, Liao WX, Luo Q, Zhang HH, Wang W, Zheng J, Chen DB. Caveolin-1 orchestrates fibroblast growth factor 2 signaling control of angiogenesis in placental artery endothelial cell caveolae. J Cell Physiol. 2012 Jun;227(6):2480-91. doi: 10.1002/jcp.22984. PubMed PMID: 21830216; PubMed Central PMCID: PMC3248968.
13. Wang W, Feng L, Zhang H, Hachy S, Satohisa S, Laurent LC, Parast M, Zheng J, Chen DB. Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta. J Clin Endocrinol Metab. 2012 Jun;97(6):E1051-9. doi: 10.1210/jc.2011-3131. Epub 2012 Mar 21. PubMed PMID: 22438230; PubMed Central PMCID: PMC3387422.
Highlighted in Faculty of 1000, 18 Apr 2012. "This is an intriguing report indicating a potential role of microRNA (miRNA) in the (dys..." Evaluation of: [Wang W et al. Preeclampsia Up-Regulates Angiogenesis-Associated MicroRNA (i.e., miR-17, -20a, and -20b) That Target Ephrin-B2 and EPHB4 in Human Placenta.
14. Ramadoss J, Liao WX, Morschauser TJ, Lopez GE, Patankar MS, Chen DB, Magness RR. Endothelial caveolar hub regulation of adenosine triphosphate-induced endothelial nitric oxide synthase subcellular partitioning and domain-specific phosphorylation. Hypertension. 2012 May;59(5):1052-9. doi: 10.1161/HYPERTENSIONAHA.111.189498. Epub 2012 Mar 26. PubMed PMID: 22454479; PubMed Central PMCID: PMC3337759.
15. Liao WX, Laurent LC, Agent S, Hodges J, Chen DB. Human placental expression of SLIT/ROBO signaling cues: effects of preeclampsia and hypoxia. Biol Reprod. 2012 Apr 12;86(4):111. doi: 10.1095/biolreprod.110.088138. Print 2012 Apr. PubMed PMID: 22262697; PubMed Central PMCID: PMC3338657.
16. Zhang HH, Feng L, Wang W, Magness RR, Chen DB. Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-ß. J Cell Physiol. 2012 Jan;227(1):146-59. doi: 10.1002/jcp.22712. PubMed PMID: 21374595; PubMed Central PMCID: PMC3125455.
17. Zhang HH, Wang YP, Chen DB. Analysis of nitroso-proteomes in normotensive and severe preeclamptic human placentas. Biol Reprod. 2011 May;84(5):966-75. doi: 10.1095/biolreprod.110.090688. Epub 2011 Jan 12. PubMed PMID: 21228217; PubMed Central PMCID: PMC3080422.
18. Cheung CY, Li S, Chen D, Brace RA. Regulation of caveolin-1 expression and phosphorylation by VEGF in ovine amnion cells. Reprod Sci. 2010 Dec;17(12):1112-9. doi: 10.1177/1933719110378175. Epub 2010 Aug 18. PubMed PMID: 20720263; PubMed Central PMCID: PMC3965204.
19. Ramadoss J, Liao WX, Chen DB, Magness RR. High-throughput caveolar proteomic signature profile for maternal binge alcohol consumption. Alcohol. 2010 Nov-Dec;44(7-8):691-7. doi: 10.1016/j.alcohol.2009.10.010. Epub 2010 Jan 6. PubMed PMID: 20053519; PubMed Central PMCID: PMC2889021.
20. Li SM, Zeng LW, Feng L, Chen DB. Rac1-dependent intracellular superoxide formation mediates vascular endothelial growth factor-induced placental angiogenesis in vitro. Endocrinology. 2010 Nov;151(11):5315-25. doi: 10.1210/en.2010-0178. Epub 2010 Sep 15. PubMed PMID: 20844008; PubMed Central PMCID: PMC2954717.
21. Liao WX, Wing DA, Geng JG, Chen DB. Perspectives of SLIT/ROBO signaling in placental angiogenesis. Histol Histopathol. 2010 Sep;25(9):1181-90. Review. PubMed PMID: 20607660.
22. Zhang HH, Feng L, Livnat I, Hoh JK, Shim JY, Liao WX, Chen DB. Estradiol-17beta stimulates specific receptor and endogenous nitric oxide-dependent dynamic endothelial protein S-nitrosylation: analysis of endothelial nitrosyl-proteome. Endocrinology. 2010 Aug;151(8):3874-87. doi: 10.1210/en.2009-1356. Epub 2010 Jun 2. PubMed PMID: 20519370; PubMed Central PMCID: PMC2940521.
23. Liao WX, Feng L, Zheng J, Chen DB. Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor. Endocrinology. 2010 Jul;151(7):3432-44. doi: 10.1210/en.2009-1305. Epub 2010 May 12. PubMed PMID: 20463056; PubMed Central PMCID: PMC2903938. Cover page story
24. Mata-Greenwood E, Liao WX, Wang W, Zheng J, Chen DB. Activation of AP-1 transcription factors differentiates FGF2 and vascular endothelial growth factor regulation of endothelial nitric-oxide synthase expression in placental artery endothelial cells. J Biol Chem. 2010 Jun 4;285(23):17348-58. doi: 10.1074/jbc.M109.092791. Epub 2010 Apr 6. PubMed PMID: 20371606; PubMed Central PMCID: PMC2878498.
25. Wang K, Jiang YZ, Chen DB, Zheng J. Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways. Placenta. 2009 Dec;30(12):1045-51. doi: 10.1016/j.placenta.2009.10.007. Epub 2009 Nov 5. PubMed PMID: 19892399; PubMed Central PMCID: PMC2788063.
26. Song Y, Wang K, Chen DB, Magness RR, Zheng J. Suppression of protein phosphatase 2 differentially modulates VEGF- and FGF2-induced signaling in ovine fetoplacental artery endothelial cells. Placenta. 2009 Oct;30(10):907-13. doi: 10.1016/j.placenta.2009.07.003. Epub 2009 Aug 18. PubMed PMID: 19692121; PubMed Central PMCID: PMC2748137.
27. Liao WX, Feng L, Zhang H, Zheng J, Moore TR, Chen DB. Compartmentalizing VEGF-induced ERK2/1 signaling in placental artery endothelial cell caveolae: a paradoxical role of caveolin-1 in placental angiogenesis in vitro. Mol Endocrinol. 2009 Sep;23(9):1428-44. doi: 10.1210/me.2008-0475. Epub 2009 May 28. PubMed PMID: 19477952; PubMed Central PMCID: PMC2737550.
28. Cheng WM, An L, Wu ZH, Zhu YB, Liu JH, Gao HM, Li XH, Zheng SJ, Chen DB, Tian JH. Effects of disulfide bond reducing agents on sperm chromatin structural integrity and developmental competence of in vitro matured oocytes after intracytoplasmic sperm injection in pigs. Reproduction. 2009 Apr;137(4):633-43. doi: 10.1530/REP-08-0143. Epub 2009 Jan 20. PubMed PMID: 19155332.
29. Wang K, Song Y, Chen DB, Zheng J. Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells. Biol Reprod. 2008 Oct;79(4):704-10. doi: 10.1095/biolreprod.108.068957. Epub 2008 May 28. PubMed PMID: 18509162; PubMed Central PMCID: PMC2574765.
30. Smith A, Contreras C, Ko KH, Chow J, Dong X, Tuo B, Zhang HH, Chen DB, Dong H. Gender-specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion. Endocrinology. 2008 Sep;149(9):4554-66. doi: 10.1210/en.2007-1597. Epub 2008 May 22. PubMed PMID: 18499763; PubMed Central PMCID: PMC2553385.
31. Mata-Greenwood E, Liao WX, Zheng J, Chen DB. Differential activation of multiple signalling pathways dictates eNOS upregulation by FGF2 but not VEGF in placental artery endothelial cells. Placenta. 2008 Aug;29(8):708-17. doi: 10.1016/j.placenta.2008.05.005. Epub 2008 Jun 20. PubMed PMID: 18571718; PubMed Central PMCID: PMC2596925.
32. Hou X, Arvisais EW, Jiang C, Chen DB, Roy SK, Pate JL, Hansen TR, Rueda BR, Davis JS. Prostaglandin F2alpha stimulates the expression and secretion of transforming growth factor B1 via induction of the early growth response 1 gene (EGR1) in the bovine corpus luteum. Mol Endocrinol. 2008 Feb;22(2):403-14. Epub 2007 Oct 4. PubMed PMID: 17916653; PubMed Central PMCID: PMC2234593.
33. Zheng J, Wen Y, Song Y, Wang K, Chen DB, Magness RR. Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation. Biol Reprod. 2008 Jan;78(1):143-50. Epub 2007 Sep 26. PubMed PMID: 17901071; PubMed Central PMCID: PMC2441762.
34. Mata-Greenwood E, Chen DB. Racial differences in nitric oxide-dependent vasorelaxation. Reprod Sci. 2008 Jan;15(1):9-25. doi: 10.1177/1933719107312160. Review. PubMed PMID: 18212350; PubMed Central PMCID: PMC2459254.
35. Qian XX, Mata-Greenwood E, Liao WX, Zhang H, Zheng J, Chen DB. Transcriptional regulation of endothelial nitric oxide synthase expression in uterine artery endothelial cells by c-Jun/AP-1. Mol Cell Endocrinol. 2007 Dec 15;279(1-2):39-51. Epub 2007 Sep 8. PubMed PMID: 17933457; PubMed Central PMCID: PMC2131711.
36. Chen DB, Jia S, King AG, Barker A, Li SM, Mata-Greenwood E, Zheng J, Magness RR. Global protein expression profiling underlines reciprocal regulation of caveolin 1 and endothelial nitric oxide synthase expression in ovariectomized sheep uterine artery by estrogen/progesterone replacement therapy. Biol Reprod. 2006 May;74(5):832-8. Epub 2006 Jan 25. PubMed PMID: 16436525.
37. Zheng J, Wen Y, Austin JL, Chen DB. Exogenous nitric oxide stimulates cell proliferation via activation of a mitogen-activated protein kinase pathway in ovine fetoplacental artery endothelial cells. Biol Reprod. 2006 Feb;74(2):375-82. Epub 2005 Oct 26. PubMed PMID: 16251502.
38. Chen DB, Li SM, Qian XX, Moon C, Zheng J. Tyrosine phosphorylation of caveolin 1 by oxidative stress is reversible and dependent on the c-src tyrosine kinase but not mitogen-activated protein kinase pathways in placental artery endothelial cells. Biol Reprod. 2005 Oct;73(4):761-72. Epub 2005 Jun 15. PubMed PMID: 15958730.
39. Zheng J, Wen Y, Chen DB, Bird IM, Magness RR. Angiotensin II elevates nitric oxide synthase 3 expression and nitric oxide production via a mitogen-activated protein kinase cascade in ovine fetoplacental artery endothelial cells. Biol Reprod. 2005 Jun;72(6):1421-8. Epub 2005 Feb 23. PubMed PMID: 15728793.
40. Magness RR, Phernetton TM, Gibson TC, Chen DB. Uterine blood flow responses to ICI 182 780 in ovariectomized oestradiol-17beta-treated, intact follicular and pregnant sheep. J Physiol. 2005 May 15;565(Pt 1):71-83. Epub 2005 Mar 17. PubMed PMID: 15774510; PubMed Central PMCID: PMC1464500.
41. Byers MJ, Zangl A, Phernetton TM, Lopez G, Chen DB, Magness RR. Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levels. J Physiol. 2005 May 15;565(Pt 1):85-99. Epub 2005 Mar 17. PubMed PMID: 15774511; PubMed Central PMCID: PMC1464491.
42. Zheng J, Bird IM, Chen DB, Magness RR. Angiotensin II regulation of ovine fetoplacental artery endothelial functions: interactions with nitric oxide. J Physiol. 2005 May 15;565(Pt 1):59-69. Epub 2005 Mar 24. Review. PubMed PMID: 15790666; PubMed Central PMCID: PMC1464493.
43. Liao WX, Magness RR, Chen DB. Expression of estrogen receptors-alpha and -beta in the pregnant ovine uterine artery endothelial cells in vivo and in vitro. Biol Reprod. 2005 Mar;72(3):530-7. Epub 2004 Nov 24. PubMed PMID: 15564597.
44. Chen DB, Bird IM, Zheng J, Magness RR. Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells. Endocrinology. 2004 Jan;145(1):113-25. Epub 2003 Sep 25. PubMed PMID: 14512434.
45. Chen DB, Davis JS. Epidermal growth factor induces c-fos and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independent pathways in bovine luteal cells. Mol Cell Endocrinol. 2003 Feb 28;200(1-2):141-54. PubMed PMID: 12644307.
46. Tsoi SC, Wen Y, Chung JY, Chen D, Magness RR, Zheng J. Co-expression of vascular endothelial growth factor and neuropilin-1 in ovine feto-placental artery endothelial cells. Mol Cell Endocrinol. 2002 Oct 31;196(1-2):95-106. PubMed PMID: 12385828.
47. Chen D, Fong HW, Davis JS. Induction of c-fos and c-jun messenger ribonucleic acid expression by prostaglandin F2alpha is mediated by a protein kinase C-dependent extracellular signal-regulated kinase mitogen-activated protein kinase pathway in bovine luteal cells. Endocrinology. 2001 Feb;142(2):887-95. PubMed PMID: 11159862.
48. Chen DB, Wang L, Wang PH. Insulin-like growth factor I retards apoptotic signaling induced by ethanol in cardiomyocytes. Life Sci. 2000 Aug 25;67(14):1683-93. PubMed PMID: 11021353.
49. Chen DB, Westfall SD, Fong HW, Roberson MS, Davis JS. Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells. Endocrinology. 1998 Sep;139(9):3876-85. PubMed PMID: 9724043.
50. Mamluk R, Chen D, Greber Y, Davis JS, Meidan R. Characterization of messenger ribonucleic acid expression for prostaglandin F2 alpha and luteinizing hormone receptors in various bovine luteal cell types. Biol Reprod. 1998 Mar;58(3):849-56. PubMed PMID: 9510976.
51. Yang ZM, Chen DB, Le SP, Harper MJ. Differential hormonal regulation of leukemia inhibitory factor (LIF) in rabbit and mouse uterus. Mol Reprod Dev. 1996 Apr;43(4):470-6. PubMed PMID: 9052938.
52. Yang ZM, Chen DB, Le SP, Brown RW, Chuong CJ, Harper MJ. Localization of leukemia inhibitory factor in human endometrium during the menstrual cycle. Early Pregnancy. 1996 Mar;2(1):18-22. PubMed PMID: 9363198.
53. Yang ZM, Le SP, Chen DB, Cota J, Siero V, Yasukawa K, Harper MJ. Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancy. Mol Reprod Dev. 1995 Dec;42(4):407-14. PubMed PMID: 8607969.
54. Kudolo GB, Yang YQ, Chen DB, Jones MA, Harper MJ. Differential metabolism of exogenous platelet-activating factor by glandular epithelial and stromal cells of rabbit endometrium. J Reprod Fertil. 1995 Nov;105(2):315-24. PubMed PMID: 8568777.
55. Chen DB, Yang ZM, Hilsenrath R, Le SP, Harper MJ. Stimulation of prostaglandin (PG) F2 alpha and PGE2 release by tumour necrosis factor-alpha and interleukin-1 alpha in cultured human luteal phase endometrial cells. Hum Reprod. 1995 Oct;10(10):2773-80. PubMed PMID: 8567812.
56. Yang ZM, Chen DB, Le SP, Harper MJ. Interleukin-1 alpha in the rabbit uterus during early pregnancy. Early Pregnancy. 1995 Sep;1(3):201-5. PubMed PMID: 9363252.
57. Chen DB, Hilsenrath R, Yang ZM, Le SP, Kim SR, Chuong CJ, Poindexter AN 3rd, Harper MJ. Leukaemia inhibitory factor in human endometrium during the menstrual cycle: cellular origin and action on production of glandular epithelial cell prostaglandin in vitro. Hum Reprod. 1995 Apr;10(4):911-8. PubMed PMID: 7650142.
58. Yang ZM, Le SP, Chen DB, Yasukawa K, Harper MJ. Expression patterns of leukaemia inhibitory factor receptor (LIFR) and the gp130 receptor component in rabbit uterus during early pregnancy. J Reprod Fertil. 1995 Mar;103(2):249-55. PubMed PMID: 7616497.
59. Yang ZM, Le SP, Chen DB, Harper MJ. Temporal and spatial expression of leukemia inhibitory factor in rabbit uterus during early pregnancy. Mol Reprod Dev. 1994 Jun;38(2):148-52. Erratum in: Mol Reprod Dev 1994 Nov;39(3):344. PubMed PMID: 8080643.
60. Wei QX, Fan JH, and Chen DB (1994) Pregnancy outcomes of transferring porcine fertilized eggs microinjected with exogenous genes into the same sows superovulated as the egg donors. Advances in Biotechnology 14: 49-50.
61. Wei QX, Fan JH, and Chen DB (1993) Integration, expression and genetics of exogenous OMT/pGH fusion gene introduced into Hubei white pigs. Journal of Huazhong Agricultural University 12: 606-611.
62. Chen DB, Zhang-Y (1992) Caprine early pregnancy factor: determination and characteristics. ACTA Agriculturate Bioreali-Occidentalis Sinica 1 (4) 75-79
Grant • NIH RO1 HL70562 - Estrogen actions in uterine artery endothelium (Chen-PI), 09/25/2001- 06/30/2020

• NIH R03 HD084972: Quantitative Analysis of VEGF-responsive Endothelial nitroso-Proteome using SILAC (Chen-PI), 07/01/2015 to 06/30/2017

• NIH R21 HL098746-01 - Estrogen and endothelial protein nitrosylation (Chen-PI), 04/01/2010 to 03/30/2012

• NIH RO1 HL74947-05A Caveolin-1, caveolae, and placental angiogenesis (Chen-PI), 04/01/2004-03/30/2010

• NIH R01 HD061541-01A1 - Cellular mechanisms of amniotic fluid volume regulation (PI-Cheung Cecilia, Chen-Consultant), 07/01/2010 to 06/30/2015

• NIH RO3 HD 58242-01 - Slit/Robo signaling and placental angiogenesis(Liao-PI, Chen-CoI), 04/2008 – 03/2010

• NIH RO1 HD 35890 Hypoxia effects on amniotic fluid volume (PI - Brace, Chen-CoI), 06/01/2004-05/30/2009

• NIH RO1 HL74947-02S1 - Caveolin-1 phosphorylation and placental angiogenesis (Chen-PI), 09/01/2005- 08/30/2007

• NIH R01 HL70562-01S1 Estrogen actions in uterine artery endothelial cells (Chen-PI), 2001-2002

• NIH RO1 R01 HL64703 - Effects of nitric oxide on fetoplacental angiogenesis (PI-Zheng, Chen-CoI), 04/01/2000-03/30/2004

• NIH RO1 HL64601-01A1 - Pregnancy dependent signaling pathways in UAEC (PI-Bird, Chen-CoI), 04/01/2000-03/30/2004

• NIH PO1 HD38843-01 - Placental angiogenic factors and uterine and placental artery endothelial NO production (PI–Magness) - Project I (PI-Bird, Chen-CoI), 04/2000-03/2005

• Chinese National Natural Science Foundation - Embryonic nuclear transplantation in pigs (Chen-PI), 1992-1995

• Society for the Study of Reproduction, 1995 -
• Society for Gynecological Investigation, 1999 -
• Perinatal Research Society, 2003 -
• Endocrine Society, 2007 -
• Society for Free Radical Biology and Medicine, 2006 -
• Sigma X, 2009 -
• North American Vascular Biology Organization, 2010-
• American Physiological Society, 2011-
• American Heart Association, 2011-
Other Experience
Graduate Programs Cellular and Molecular Biosciences

Obstetrics and Gynecology

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Last updated 07/20/2015