Irene Munk Pedersen

picture of Irene Munk Pedersen

Assistant Professor, Molecular Biology and Biochemistry
School of Biological Sciences
Adjunct Professor, Department of Cellular and Molecular Medicine, Panum Instituttet, Copenhagen, Denmark

Ph.D., University of Copenhagen, Copenhagen, Denmark, Molecular Biology

Phone: 949-824-2587

University of California, Irvine

Department of Molecular Biology and Biochemistry
3244 McGaugh Hall
Mail Code: 3900
Irvine, CA 92697
Research Interests
Regulation of microRNAs (miRs) and their role in human disease (Cancer), Induced Pluripotent Stem Cells (iPSCs) development and viral defense.
Research Abstract
The recent discovery of microRNAs (miRs) has revolutionized our understanding of gene control. miRs are encoded by endogenous genes and regulate over half of all genes in mammalian cells. They regulate gene expression at the stages of translation and mRNA stability. Already there is evidence that specific miRs play key roles in controlling development, stem cell fates and differentiation, and mutations in human miR genes have been linked to oncogenic and other disease states. An important task is to unveil the functions of individual miRs, determine how the miRs themselves are regulated and elucidate their role in normal cell homeostasis and human diseases.

The main focus of my laboratory is to investigate the role of specific miRs (identified from miR/amiR screens) in normal cells including during induces pluripotent stem cell (iPSC)-development, and explore how to regulate/counteract such dysregulation in a diseased state (cancer, neurological disorders). A second area of research interest of my laboratory is to elucidate miRs function as a novel restriction mechanism against retroviral elements (LINE-1, hERVs and HIV-1) in human cells.

Research Interest of the Irene Munk Pedersen Lab
Hamdorf M, Idica A, Zisoulis DG, Gamelin L, Martin C, Sanders K, and Pedersen IM, 2015, miR-128 represses retrotransposition by directly binding to L1 RNA, Nat. Struct. Mol. Biol, 22:824-31, PMID:26367248

Spitale RC, Plikus MV and Pedersen IM., 2015, The emerging functions of regulatory RNA species in skin stem cells and regeneration, Exp Dermatol, 24:827-8. PMID:26309056

Pedersen IM and Zisoulis DG, Transposable elements and miRNA: Regulation of Genomic Stability and Plasticity, Mobile Genetic Elements, 2016, 6(3):e1175537. PMID:27511122

Rieß M, Hein-Fuchs N, Idica A, Hamdorf M, Flory E, Pedersen IM and König R, Interferons Induce Expression of SAMHD1 in Monocytes through Downregulation of miR-181a and miR-30a, J. Biol. Chem, 2017, 292:264-277. PMID:27909056
Miletic AV*, Anzelon-Mills A*, Omori S, Pedersen IM, Shin D, Ravetch JV, Bolland S, Morse S and Rickert R: Coordinate Suppression of B Cell Lymphoma by PTEN and SHIP Phosphatases, J. Exp. Med., 2010, 207:2407-20

Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, Ciarlariello D, Neviani P, Harb J, Kauffman LR, Shidham A, Croce CM., Ship and C/ebp{beta} are targeted by miR-155 in B cells of E{micro}-miR-155 transgenic mice., Blood, 2009, 114:1374-82

Pedersen IM, Otero D., Kao, E., Miletec A, Hother S. Ralfkiaer E, Rickert RC, Gronbeck K, David M, Onco-miR-155 targets SHIP to promote TNFa-dependent growth of B cell lymphomas, EMBO Mol. Med., 2009, 1:288-295.

Pedersen IM & David M., microRNAs in the immune response, Cytokine, 2008, 43:391-4.

Pedersen IM. and Reed JC., Microenvironmental interactions and survival of CLL B-cells., Leuk Lymphoma, 2004, 45:2365-72.
Pedersen IM, Wieland S, Cheng G, Violinia S, Croce CM, Chisari FV & David M., Interferon modulation of cellular miRs as a novel anti-viral mechanism, Nature, 2007, 449:919-22.

Schimmer AD., Walsh K., Pinilla C., Bonneau M., Wang Z., Krajewska M., Bonneau M.,
Pedersen IM., Kitada S., Scott FL., Bailly-Maitre B., Glinsky G., Scudiero D., Sausville E., Salvesen G., Nefzi A., Ostresh JM., Houghten RA., and Reed JC., Small-molecule antagonists of apoptosis-suppressor XIAP exhibit broad anti-tumor activity, Cancer Cell, 2004, 5:25-35.

Schimmer AD., Pedersen IM., Minden MD., Reed JC., Bcl-2 and Apoptosis in Chronic Lymphocytic Leukemia, Curr. Treat. Options Oncol, 2003, 4:211-8.

Schimmer A, Pedersen IM , Kitada S, Eksioglu-Demiralp E, Minden MD, Pinto R, Mah K, Andreeff M, Youngsoo K., Suh WS and Reed JC. Functional blocks in Caspase activation pathways are common in leukemia and predict patient-response to induction chemotherapy, Cancer Research, 2003, 63:1242-8.

Boatright KM., Renatus M., Scott FL., Sperandio S., Shin H., Pedersen IM., Ricci JE., Idris WA., Sutherlin DP., Green DR. and Salvesen GS., A Unified Model for Apical Caspase Activation”, Mol. Cell., 2003, 11:529-41.

Reed JC., Kitada S., Pedersen IM., Shimmer A., Dysregulation of apoptosis genes in hematopoietic malignancies. Oncogene, 2002, 21:3459-74
Pedersen IM, Kitada S, Schimmer, A, Kim Y, Zapata JM, Charboneau L, Andreeff M, Bennet,F, Sporn M, Liotta LA, Kipps TJ and Reed JC. The triterpenoid CDDO induces apoptosis in refractory CLL B-cells, Blood, 2002, 100:2965-2972.

Chu P, Deforce D., Pedersen IM, Kitada S., Reed JC., Kipps JC., Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia., Proc Natl Acad Sci U S A. 2002,99:3854-9.
Pedersen IM, Kitada S, Leoni LM, Zapata JM, Karres J, Tsukada N, Kipps TJ, Choi YS, Bennet F, Reed JC. Protection of CLL B-cells by a follicular dendritic cell line is dependent on induction of Mcl-1. Blood, 2002, 100:1795-801.

Pedersen IM, Buhl AM, Klausen P, Geisler CH and Jurlander J., The chimeric anti-CD20 antibody Rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells though a p38 mitogen activated protein-kinase-dependent mechanism. Blood 2002; 99: 1314-1319.
Research Centers
Sue and Bill Gross Stem Cell Research Center
Center for Immunology
Institute for Memory Impairments & Neurological Disorders
Chao Family Comprehensive Cancer Center
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