Jack J Lin

Professor of Clinical Neurology, Director UC Irvine Comprehensive Epilepsy Program, Neurology
School of Medicine

M.D., Rush Medical College, 1998

Phone: 714-456-6203
Email: linjj@uci.edu

University of California, Irvine
100 Irvine Hall
Mail Code: 4275
Irvine, CA 92697

picture of Jack J Lin

2009 – 2014 National Institutes of Health Career Development Research Award (K23; NINDS)

2010 - Current Steward for NIH/NINDS Epilepsy Research Benchmarks: The Comorbidities of Epilepsy (To provide progress report to NINDS in order to promote and track progress in epilepsy research; identify challenges and opportunities; Chair: John W. Swan, PhD)

2009 Stanley van den Noort, MD Award for excellence in research, Department of Neurology, UC Irvine

2006 - Current Member of the Epilepsy Foundation Working Group for Targeted Research Initiative for Mood Disorders (Develop yearly “Request for Proposal” and review grants)

2003 – 2004 William Gowers Fellowship, Epilepsy Foundation Research and Clinical Training Fellowship

2003 – 2004 Fritz E. Dreifuss Award, National Epifellows Foundation
The first focus of my laboratory is the study of cognitive and behavior comorbidities associated with epilepsy. We use advanced neuroimaging techniques to uncovered neurodevelopemental impacts of new-onset pediatric epilepsies and delineate relationships between brain structural changes and cognitive deficits in a wide range of epilepsy syndromes. A second focus of the laboratory is the neurophysiological analysis of cognitive and emotional processing in humans. This is achieved using direct intracranial EEG recordings (electrocorticography) in patients implanted with subdural and depth electrodes for neurosurgical reasons. As a postdoctoral epilepsy fellow at UCLA, I carried out structural neuroimaging studies in temporal lobe epilepsy patients with Professor Paul Thompson and gained expertise in intracranial electrophysiology from Professor Jerome Engel. At UC Irvine, I expanded the epilepsy clinical program and became the Director of the Comprehensive Epilepsy program; I specialize in the surgical treatment of patients with medically refractory epilepsy. An NIH career development award in 2009 provided me the opportunity to develop an independent programmatic line of research, focusing on cognitive complications of epilepsy. In the past four years, I have uncovered key relationships between aberrant brain connections and cognitive dysfunction in the epileptic human brain. I have formed research collaborations with Dr. Robert Knight, using electrocorticography to examine cortical and subcortical oscillations associated with emotional processing in neurosurgical patients. I also gained considerable knowledge in neuropsychology from Professor Bruce Hermann, a renowned neuropsychologist and an expert in the psychiatric and cognitive complications of epilepsy. In summary, I have demonstrated a commitment to understand neurobehavioral comorbidities in patients with epilepsy, the third most common neurological disorder. I have accumulated important technical knowledge, generated a track record of productive research, and cultivated a collaborative environment across disciplines, institutions, and laboratories to carry out the proposed project.
Publications 1. Lin JJ, Salamon N, Dutton RA, Lee AD, Geaga JA, Hayashi KM, Toga AW, Engel J, Jr., Thompson PM. Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy. Neurology, (2005) 65: 1094–1097.

2. Lin JJ, Salamon N, Dutton RA, Lee AD, Geaga JA, Hayashi KM, Luders E, Toga AW, Engel J, Jr., Thompson PM. Reduced cortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cerebral Cortex, (2007) 17: 2007- 2018.

3. Lin JJ, Riley DJ, Juranek J, Cramer SC. Vulnerability of the frontal-temporal connections in temporal lobe epilepsy. Epilepsy Research, (2008) 82: 162-170.

4. Lin JJ, Mazziotta JC. Computational Anatomy. In: Engel J. Jr. and Pedley TA, eds. Epilepsy: A Comprehensive Textbook Second Edition. Philadelphia: Lippincott Williams & Wilkins. 2008: 999-1009.

5. Ogren, JA, Wilson, CL, Bragin A, Lin JJ, Salamon N, Dutton, RA, Luders, E, Fields, FA, Fried I, Toga AW, Thompson PM, Engel, J, Jr., Statba, RJ. Three-Dimensional Surface Maps Link Local Atrophy and Fast Ripples in Human Epileptic Hippocampus. Annals of Neurology, (2009) 66: 783-791.

6. Ogren JA, Bragin A, Wilson CL, Hoftman, GD, Lin JJ, Dutton RA, Fields TA, Toga AW, Thompson PM, Engel J, Jr., Staba, RJ. Three-Dimensional Hippocampal Atrophy Maps Distinguish Two Common Temporal Lobe Seizure Onset Patterns. Epilepsia (2009) 50: 1361-1367.

7. Hermann BP, Lin JJ, Jones, JE, Seidenberg, M. The emerging architecture of neuropsychological impairment in epilepsy. Neurologic Clinic, (2009) 27: 881-907.

8. Riley DJ, Franklin DL, Choi V, Kim RC, Binder DK, Cramer SC, Lin JJ. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles. Epilepsia (2010), 51(4): 536-45.

9. Riley JD, Moore S, Cramer SC, Lin JJ. Caudate atrophy and impaired frontostriatal network is linked to executive dysfunction in temporal lobe epilepsy. Epilepsy and Behavior (2011), 21(1): 80-7.

10. Bell B*, Lin JJ*, Seidenberg M*, Hermann BP*. The neurobiology of cognitive disorders in temporal lobe epilepsy, Nature Reviews Neurology, (2011) 7:154-164. **All authors have equal contribution

11. Jackson DC, Irwin W, Dabbs K, Lin JJ, Jones JE, Hsu DA, Stafstrom CE, Seidenberg, M, Hermann, BP. Ventricular Enlargement in New Onset Pediatric Epilepsies. Epilepsia, (2011), 52(12): 2225-32.

12. Kemmotsu N, Girard HM, Bernhardt BC, Bonilha L, Lin JJ, Tecoma ES, Iragui VJ, Halgren E, Dale AM, McDonald CR. MRI Analysis in Temporal Lobe Epilepsy: Cortical Thinning and White Matter Disruptions Are Related to Side of Seizure Onset, Epilepsia, (2011), 52(12): 2257-2266.

13. Lin JJ, Riley JD, Hsu DA, Stafstrom CE, Dabb K, Becker T, Seidenberg M, Hermann BP. Striatal Hypertrophy and Its Cognitive Effects in New Onset Benign Epilepsy with Centrotemporal Spikes. Epilepsia, (2012), 53(4):677-85.

14. Lin JJ, Mula M, Hermann BP. Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan, The Lancet, (2012) 29:1180-92.

Invited Review for The Lancet (Impact factor: 39.027, ranked second out of 150 journals in the general medicine category).

15. Lin JJ, Siddarth P, Riley J, Gurbani SG, Ly R, Yee, VW, Lewitt J, Toga AW. Caplan R. Neurobehavioral comorbidities of pediatric epilepsies are linked to thalamic abnormalities Epilepsia (2013) 54(12):2116-24

16. Bonilha L, Tabesh A, Dabbs K, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP, Lin JJ. Neurodevelopmental alterations of large-scale structural networks in children with new-onset epilepsy. Human Brain Mapping, (2014) 35(8):3661-72.

Featured Cover Article

17. Jackson DC, Lin JJ**, Chambers KL, Kessler-Jones A, Jones JE, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP. Birth weight and cognition in children with epilepsy. Epilepsia (2014).) 55(6):901-8. **Co-first author

18. Lin JJ, Dabb K Riley JD, Jones JE, Jackson DC, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP. Neurodevelopment in new-onset juvenile myoclonic epilepsy over the first 2 years. Annals of Neurology 2014 Nov;76(5):660-8.

Accompanied Commentary by Prof. Shlomo Shinnar, MD, PhD "Whatever happened to the primary generalized epilepsies of childhood and adolescence?"
  19 Flint RD, Wang PT, Wright ZA, King CE, Krucoff MO, Schuele SU, Rosenow JM, Hsu FP, Liu CY, Lin JJ, Sazgar M, Millett DE, Shaw SJ, Nenadic Z, Do AH, Slutzky MW. Extracting kinetic information from human motor cortical signals. Neuroimage. 2014 Nov 1;101:695-703. PubMed PMID: 25094020.

20 Kellermann TS, Bonilha L, Lin JJ, Hermann, BP. Mapping the landscape of cognitive development in children with epilepsy. Cortex (2015) 66:1-8

21 Riley JD, Fling BW, Cramer SC, Lin JJ*. Altered organization of face-processing networks in temporal lobe epilepsy. Epilepsia (2015) 56(5):762-71.

22 Bonilha L, Jensen JH, Baker N, Breedlove J, Nesland T, Lin JJ, Drane DL, Saindane AM, Binder JR, Kuzniecky RI. The brain connectome as a personalized biomarker of seizure outcomes after temporal lobectomy. Neurology. (2015) 84(18):1846-53 PMID: 25854868.

23 Garcia-Romos C, Jackson DC, Lin JJ, Dabbs K, Jones JE, Hsu DA, Stafstrom CE, Zawadzki L, Seidenberg M, Prabhakaran V, Hermann BP. Cognition and brain development in children with benign epilepsy with centrotemporal spikes. Epilepsia (2015) 56(10):1615-22.

24 Garcia-Romos C, Lin JJ, Prabhakaran, V, Hermann BP. Developmental reorganization of the cognitive network in pediatric epilepsy. PLOS One (2015) 27;10(10):e0141186.

25 Veenstra A, Riley JD, Barrett LE, Muhonen MG, Zupanc ML, Romain JE, Lin JJ, Mucci G. The impact of bilingualism on working memory in pediatric epilepsy. Epilepsy and Behavior (2016) 55:6-10

26 Wang PT, King CE, McCrimmon CM, Lin JJ, Sazgar M, Hsu FP, Shaw SJ, Millet DE, Chui LA, Liu CY, Do AH, Nenadic Z. Comparison of decoding resolution of standard and high-density electrocorticogram electrodes. J Neural Eng. (2016) 13:026016. Epub 2016 Feb 9.

27 Kellermann TS, Bonilha L, Eskandari R, Garcia-Ramos C, Lin JJ, Hermann BP. Mapping the neuropsychological profile of temporal lobe epilepsy using cognitive network topology and graph theory. Epilepsy and Behavior (2016) 63:9-16.

28 Caplan R, Mefford H, Berl M, Chang B, Lin J, Mazarati A, Fureman B, Dingledine R; American Epilepsy Society (AES)/National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Benchmark Stewards. 2014 Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions. Epilepsy Current. 2016 May-Jun;16(3):182-6.

29 Garcia-Ramos C, Lin JJ, Kellermann TS, Bonilha L, Prabhakaran V, Hermann BP. Graph theory and cognition: A complementary avenue for examining neuropsychological status in epilepsy. Epilepsy Behavior. 2016 Epub ahead print

30 Garcia-Ramos C, Lin JJ, Bonilha L, Jones JE, Jackson DC, Prabhakaran V, Hermann BP. Disruptions in cortico-subcortical covariance networks associate with anxiety in new-onset childhood epilepsy. Neuroimage Clinical 2016 Oct 23;12:815-824. PubMed PMID: 27830114

31 Piai V, Anderson KL, Lin JJ, Dewar C, Parvizi J, Dronkers, NF, Knight RT. A key role for the hippocampus in language processing: evidence from intracranial neurophysiology. Proceedings of the National Academy of Science (2016) Oct 4;113(40):11366-11371.

32 Holdgraf, C.R., De Heer, W., Pasley, B., Rieger, J., Crone, N., Lin, JJ, Knight, RT, and Theunissen, F. Rapid tuning adaption in human auditory cortex enhances speech intelligibility. Nature Communications Dec 20;7:13654. doi: 10.1038/ncomms13654

33 Kam JWY, Szczepanski, SM, Canolty RT, Flinker A, Auguste KI, Crone NE, Kirsch HE, Kuperman RA, Lin JJ, Parvizi, J, Knight RT. Differential sources for two neural signatures of target detection: An electrocorticography study. Cerebral Cortex (in press).

34 Zheng J, Anderson KL, Leal, SL, Shestyuk, A, Gulsen G, Mnatsakanyan, L, Vadera S, Hsu FPK, Yassa MA, Knight RT, Lin JJ*. Basolateral amygdala and hippocampal dynamics during processing of salient information, Nature Communications (in press).
Grants 2009-2014 NIH NINDS NS060993 K23: Mentored Patient-Orientated Career Development Award Project Title: Early-onset epilepsy and genetics influence white matter tracts and cognition
Site-Principal Investigator, DARPA BTO Neural Engineering System Design (NESD) Project Title: Neural I/O Bus (NIOB) using Microwire Bundles: Speech Prosthesis Funding date: 1/1/2017 to 12/31/2020 Goal: This project focuses on defining and validating Sensory Data Transformation Algorithms in human single and multi-unit recordings prior to availability of the NIOB system. The specific application is a Speech Prosthetic device that supports READ and WRITE transformations. The goal of this Task is to identify the best performing predictive READ/WRITE algorithms in humans. TDC: $1,700,000 PI: Matthew R. Angles, PhD (Paradromics, Inc.)
American Epilepsy Society, American Academy of Neurology
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Last updated 01/14/2017