Jack J Lin

picture of Jack J Lin

Professor of Clinical Neurology, Director UC Irvine Comprehensive Epilepsy Program, Neurology
School of Medicine
Professor of Biomedical Engineering
The Henry Samueli School of Engineering

M.D., Rush Medical College, 1998

Phone: 714-456-6203
Email: linjj@uci.edu

University of California, Irvine
100 Irvine Hall
Mail Code: 4275
Irvine, CA 92697
Academic Distinctions
1995 Selected for NIH Summer Research Fellowship Program (SRFP)
2001, 2002 Golden Neuron Award for Resident of the Year, UCSD
2003-2004 Fritz E. Dreifuss Award; National EpiFellows Foundation
2003-2004 William Gowers Fellowship, Epilepsy Foundation
2009 van den Noort Award for junior faculty research, Department of Neurology, UC Irvine
2010-2015 Selected as Steward for NIH/NINDS Epilepsy Research Benchmarks
2013 Selected as a “rising star” in epilepsy by the Editorial Board of Epilepsy & Behavior
2013 Butler Family Endowed Lectureship in Epilepsy, University of Alberta, Edmonton
2014 Member of the Editorial Board of Epilepsy & Behavior
2017 Fellow, Center of Neurobiology of Learning and Memory
2017 Fellow, American Epilepsy Society
2018 Orange County Physician of Excellence Award
Research Abstract
Jack Lin is a clinician scientist who directs the UC Irvine Comprehensive Epilepsy Program, a highly productive human intracranial electrophysiology research program. He has expertise in studying human cognitive and emotional processing using intracranial electrophysiology with high spatial and temporal dynamics. In patients with implanted depth electrodes in the mesial temporal lobe, he has demonstrated that during contextual fear processing, the amygdala unidirectional influences the hippocampus. In addition, he has shown that such modulation is mediated through coherent theta and alpha frequency oscillations between these two core brain structures. More recently, his laboratory has developed the ability to record single-unit neuron activity from the human hippocampus and medial prefrontal cortex. Such technical advancement to explore human neurophysiology at the level of single neuron resolution is rare and only a few laboratory in the United States and worldwide currently process this ability.
1. Lin JJ, Salamon N, Dutton RA, Lee AD, Geaga JA, Hayashi KM, Toga AW, Engel J, Jr., Thompson PM. Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy. Neurology, (2005) 65: 1094–1097. (54 citations)

2. *Lin JJ, Salamon N, Dutton RA, Lee AD, Geaga JA, Hayashi KM, Luders E, Toga AW, Engel J, Jr., Thompson PM. Reduced cortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cerebral Cortex, (2007) 17: 2007- 2018. (148 citations)

3. *Lin JJ, Riley JD, Juranek J, Cramer SC. Vulnerability of the frontal-temporal connections in temporal lobe epilepsy. Epilepsy Research, (2008) 82: 162-170. (66 citations)

4. Ogren, JA, Wilson, CL, Bragin A, Lin JJ, Salamon N, Dutton, RA, Luders, E, Fields, FA, Fried I, Toga AW, Thompson PM, Engel, J, Jr., Statba, RJ. Three-Dimensional Surface Maps Link Local Atrophy and Fast Ripples in Human Epileptic Hippocampus. Annals of Neurology, (2009) 66: 783-791. (48 citations)

5. Ogren JA, Bragin A, Wilson CL, Hoftman, GD, Lin JJ, Dutton RA, Fields TA, Toga AW, Thompson PM, Engel J, Jr., Staba, RJ. Three-Dimensional Hippocampal Atrophy Maps Distinguish Two Common Temporal Lobe Seizure Onset Patterns. Epilepsia (2009) 50: 1361-1367. (45 citations)

6. Hermann BP, Lin JJ, Jones, JE, Seidenberg, M. The emerging architecture of neuropsychological impairment in epilepsy. Neurologic Clinic, (2009) 27: 881-907. (Review) (48 citations)

7. Riley JD, Franklin DL, Choi V, Kim RC, Binder DK, Cramer SC, *Lin JJ. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles. Epilepsia (2010), 51(4): 536-45. (66 citations)

8. Riley JD, Moore S, Cramer SC, *Lin JJ. Caudate atrophy and impaired frontostriatal network is linked to executive dysfunction in temporal lobe epilepsy. Epilepsy and Behavior (2011), 21(1): 80-7. (36 citations)

9. Jackson DC, Irwin W, Dabbs K, Lin JJ, Jones JE, Hsu DA, Stafstrom CE, Seidenberg, M, Hermann, BP. Ventricular Enlargement in New Onset Pediatric Epilepsies. Epilepsia, (2011), 52(12): 2225-32. PMC3347640

10. Kemmotsu N, Girard HM, Bernhardt BC, Bonilha L, Lin JJ, Tecoma ES, Iragui VJ, Halgren E, Dale AM, McDonald CR. MRI Analysis in Temporal Lobe Epilepsy: Cortical Thinning and White Matter Disruptions Are Related to Side of Seizure Onset, Epilepsia, (2011), 52(12): 2257-2266. (58 citations)

11. Bell B, Lin JJ**, Seidenberg M, Hermann BP. The neurobiology of cognitive disorders in temporal lobe epilepsy, Nature Reviews Neurology, (2011) 7:154-164. PMC 21304484 **All authors have equal contribution (131 citations)

12. *Lin JJ, Riley JD, Hsu DA, Stafstrom CE, Dabb K, Becker T, Seidenberg M, Hermann BP. Striatal Hypertrophy and Its Cognitive Effects in New Onset Benign Epilepsy with Centrotemporal Spikes. Epilepsia, (2012), 53(4):677-85. PMC 3321058 (29 citations)

13. Lin JJ, Mula M, Hermann BP. Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan, The Lancet, (2012) 29:1180-92. PMC3838617 (Review), (142 citations)

14. *Lin JJ, Siddarth P, Riley J, Gurbani SG, Ly R, Yee, VW, Lewitt J, Toga AW. Caplan R. Neurobehavioral comorbidities of pediatric epilepsies are linked to thalamic abnormalities. Epilepsia (2013) 54(12):2116-24

15. Addis L, Lin JJ, Pal DK, Hermann B, Caplan R. Imaging genetics of language and cognition in pediatric epilepsy, Epilepsy and Behavior (2013) 26(3):303-312 (Review accompanied by “Rising Star” in epilepsy award in this special issue)

16. Bonilha L, Tabesh A, Dabbs K, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP, Lin JJ*. Neurodevelopmental alterations of large-scale structural networks in children with new-onset epilepsy. Human Brain Mapping, (2014) 35(8):3661-72. Featured Cover Article

17. Jackson DC, Lin JJ**, Chambers KL, Kessler-Jones A, Jones JE, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP. Birth weight and cognition in children with epilepsy. Epilepsia (2014).) 55(6):901-8. **Co-first author

18. Flint RD, Wang PT, Wright ZA, King CE, Krucoff MO, Schuele SU, Rosenow JM, Hsu FP, Liu CY, Lin JJ, Sazgar M, Millett DE, Shaw SJ, Nenadic Z, Do AH, Slutzky MW. Extracting kinetic information from human motor cortical signals. Neuroimage. 2014 Nov 1;101:695-703. PubMed PMID: 25094020.

19. Lin JJ*, Dabb K Riley JD, Jones JE, Jackson DC, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP. Neurodevelopment in new-onset juvenile myoclonic epilepsy over the first 2 years. Annals of Neurology (2014) 76(5):660-8

a. Accompanied commentary by Prof. Shlomo Shinnar, MD, PhD "Whatever happened to the primary generalized epilepsies of childhood and adolescence?"

20. Kellermann TS, Bonilha L, Lin JJ, Hermann, BP. Mapping the landscape of cognitive development in children with epilepsy. Cortex (2015) 66:1-8

21. Riley JD, Fling BW, Cramer SC, Lin JJ*. Altered organization of face-processing networks in temporal lobe epilepsy. Epilepsia (2015) 56(5):762-71.

22. Bonilha L, Jensen JH, Baker N, Breedlove J, Nesland T, Lin JJ, Drane DL, Saindane AM, Binder JR, Kuzniecky RI. The brain connectome as a personalized biomarker of seizure outcomes after temporal lobectomy. Neurology. (2015) 84(18):1846-53 PMID: 25854868.

23. Garcia-Romos C, Jackson DC, Lin JJ, Dabbs K, Jones JE, Hsu DA, Stafstrom CE, Zawadzki L, Seidenberg M, Prabhakaran V, Hermann BP. Cognition and brain development in children with benign epilepsy with centrotemporal spikes. Epilepsia (2015) 56(10):1615-22.

24. Garcia-Romos C, Lin JJ, Prabhakaran, V, Hermann BP. Developmental reorganization of the cognitive network in pediatric epilepsy. PLOS One (2015) 27;10(10):e0141186.

25. Veenstra A, Riley JD, Barrett LE, Muhonen MG, Zupanc ML, Romain JE, Lin JJ, Mucci G. The impact of bilingualism on working memory in pediatric epilepsy. Epilepsy and Behavior (2016) 55:6-10

26. Kellermann TS, Bonilha L, Eskandari R, Garcia-Ramos C, Lin JJ, Hermann BP. Mapping the neuropsychological profile of temporal lobe epilepsy using cognitive network topology and graph theory. Epilepsy and Behavior (2016) 63:9-16.

27. Caplan R, Mefford H, Berl M, Chang B, Lin J, Mazarati A, Fureman B, Dingledine R; American Epilepsy Society (AES)/National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Benchmark Stewards. 2014 Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions. Epilepsy Current. 2016 May-Jun;16(3):182-6.

28. Garcia-Ramos C, Lin JJ, Kellermann TS, Bonilha L, Prabhakaran V, Hermann BP. Graph theory and cognition: A complementary avenue for examining neuropsychological status in epilepsy. Epilepsy Behavior. 2016 Epub ahead print

29. Garcia-Ramos C, Lin JJ, Bonilha L, Jones JE, Jackson DC, Prabhakaran V, Hermann BP. Disruptions in cortico-subcortical covariance networks associate with anxiety in new-onset childhood epilepsy. Neuroimage Clinical 2016 Oct 23;12:815-824. PubMed PMID: 27830114

30. Chan AY, Kharrat S, Lundeen K, Mnatsakanyan L, Sazgar M, Sen-Gupta I, Lin JJ, Hsu FPK, Vadera S. Length of stay for patients undergoing invasive electrode monitoring with stereoelectroencephalography and subdural grids correlates positively with increased institutional profitability. Epilepsia. 2017 Jun;58(6):1023-1026. PubMed PMID:28426130.

31. Jackson DC, Jones JE, Hsu DA, Stafstrom CE, Lin JJ, Almane D, Koehn MA, Seidenberg M, Hermann BP. Language function in childhood idiopathic epilepsy syndromes. Brain Lang. 2018 Mar 30. pii: S0093-934X(16)30274-7.

32. Mnatsakanyan L, Vadera S, Ingalls CW, Zheng J, Sazgar M, Hsu FP, Lin JJ. Language recovery after epilepsy surgery of the Broca's area. Epilepsy Behav Case Rep. 2017 Jun 17;9:42-45. PubMed PMID: 29692970

33. Chan AY, Mnatsakanyan L, Sazgar M, Sen-Gupta I, Lin JJ, Hsu FPK, Vadera S. Accuracy and Efficacy for Robotic Assistance in Implanting Responsive Neurostimulation Device Electrodes in Bilateral Mesial Temporal Lobe Epilepsy. Oper Neurosurg (Hagerstown). 2018 Mar 1;14(3):267-272. PubMed PMID: 29462446.

34. Young MG, Vadera S, Lin JJ, Mnatsakanyan L. Using electrocorticogram baseline seizure frequency to assess the efficacy of responsive neurostimulation. Epilepsy Behav. 2018 Aug;85:7-9. Epub 2018 Jun 8. PubMed PMID: 29890343

35. Vadera S, Chan AY, Mnatsankanyan L, Sazgar M, Sen-Gupta I, Lin J, Hsu FPK.
Strategic hospital partnerships: improved access to care and increased epilepsy surgical volume. Neurosurg Focus. 2018 May;44(5):E9. PubMed PMID: 29712523.

36. Garcia-Ramos, C, Dabbs K, Lin JJ, Jones, JE, Stafstrom CE, Hsu, DA, Meyerand ME , Prabhakaran V, Hermann BP. Progressive Dissociation of Cortical and Subcortical Network Development in Children with New Onset Juvenile Myoclonic Epilepsy, Epilepsia, in press.

37. Do AH, Wang PT, King CE, Schombs A, Lin JJ, Sazgar M, Hsu FP, Shaw SJ, Millett DE, Liu CY, Szymanska AA, Chui LA, Nenadic Z. Sensitivity and specificity of upper extremity movements decoded from electrocorticogram. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:5618-21.

38. Wang PT, King CE, McCrimmon CM, Lin JJ, Sazgar M, Hsu FP, Shaw SJ, Millet DE, Chui LA, Liu CY, Do AH, Nenadic Z. Comparison of decoding resolution of standard and high-density electrocorticogram electrodes. J Neural Eng. (2016) 13:026016. Epub 2016 Feb 9.

39. Piai V, Anderson KL, Lin JJ, Dewar C, Parvizi J, Dronkers, NF, Knight RT. A key role for the hippocampus in language processing: evidence from intracranial neurophysiology. Proceedings of the National Academy of Science (2016) Oct 4;113(40):11366-11371.

40. Holdgraf, C.R., De Heer, W., Pasley, B., Rieger, J., Crone, N., Lin, JJ, Knight, RT, and Theunissen, F. Rapid tuning adaption in human auditory cortex enhances speech intelligibility. Nature Communications Dec 2017:13654. doi: 10.1038/ncomms13654

41. Perry A, Stiso J, Chang EF, Lin JJ, Parvizi J, Knight RT. Mirroring in the human brain: Deciphering the spatial-temporal patterns of the human mirror neuron system. Cerebral Cortex, Jan 30, 2017. doi: 10.1093/cercor/bhx013

42. Zheng J, Anderson KL, Leal, SL, Shestyuk, A, Gulsen G, Mnatsakanyan, L, Vadera S, Hsu FPK, Yassa MA, Knight RT, Lin JJ*. Amygdala-hippocampal dynamics during salient information processing. Nature Communications (2017) Feb 8;8:14413. doi: 10.1038/ncomms14413

43. Riès SK, Dhillon RK, Clarke A, King-Stephens D, Laxer KD, Weber PB, Kuperman RA, Auguste KI, Brunner P, Schalk G, Lin JJ, Parvizi J, Crone NE, Dronkers NF, Knight RT. Spatiotemporal dynamics of word retrieval in speech production revealed by cortical high-frequency band activity. Proceedings of the National Academy of Science. 2017 Jun 6;114(23):E4530-E4538. doi: 10.1073/pnas.1620669114. PubMed PMID: 28533406; PubMed Central PMCID: PMC5468648.

44. Jafarpour A, Piai V, Lin JJ, Knight RT. Human hippocampal pre-activation predicts behavior. Scientific Report, Jul 20;7(1):5959. doi: 10.1038/s41598-017-06477-5.

45. Kam JWY, Szczepanski SM, Canolty RT, Flinker A, Auguste KI, Crone NE, Kirsch HE, Kuperman RA, Lin JJ, Parvizi J, Knight RT. Differential Sources for 2 Neural Signatures of Target Detection: An Electrocorticography Study. Cereb Cortex. 2018 Jan 1;28(1):9-20. doi: 10.1093/cercor/bhw343. PubMed PMID: 29253249.

46. Zheng J, Lin JJ*. Modulating Amygdala-Hippocampal Network Communication: A Potential Therapy for Neuropsychiatric Disorders. Neuropsychopharmacology. 2018 Jan;43(1):218-219. doi: 10.1038/npp.2017.201. PubMed PMID: 29192669; PubMed Central PMCID: PMC5719108.

47. Johnson, EL, Adams, JN, Solbakk, A-K, Endestad T, Larsson PG, Lin JJ, Knight, RT. Dynamic frontotemporal systems for episodic working memory. PLOS Biology, 2018 Mar 30;16(3):e2004274.

48. Stolk A, Griffin SM, van der Meij R, Dewar C, Saez I, Lin JJ, Piantoni G, Schoffelen J, Knight RT, Oostenveld R Integrated analysis of anatomical and electrophysiological human intracranial data. Nature Protocols, Jul;13(7):1699-1723. PubMed PMID: 29988107.

49. Helfrich RF, Fiebelkorn IC, Szczepanski SM, Lin JJ, Parvizi J, Knight RT, Kastner S. Neural Mechanisms of Sustained Attention Are Rhythmic. Neuron. 2018 Aug 22;99(4):854-865.e5. PubMed PMID:30138591.

50. Saez I, Lin, J, Stolk A, Chang E, Parvizi, J, Schalk G, Knight RT, Encoding of multiple computations in transient and sustained high-frequency activity in human OFC. Current Biology in Sep 24;28(18):2889-2899, PubMed PMID: 30220499

51. Stevenson R, Zheng J, Mnatsakanyan, L, Vadera S, Knight RT, Lin JJ*, Yassa MA*, Hippocampal CA1 gamma power predicts the precision of spatial memory judgments, Proceedings of the National Academy of Science, in press *Co-senior author
9/1/2018 – 8/31/2023 NIH/NINDS $ 232,522 Computational and Circuit Mechanisms Underlying Rapid Learning In parallel studies in monkeys and humans, this grant proposes to take advantage of newly available large-scale recording techniques to examine hippocampal-neocortical interaction that may underlie both the development of a schema and the use of a schema for rapid learning. Role: Site-PI
1 U01 NS108916-01 Schalk G (PI) 0.24 calendar months 9/1/2018 – 8/31/2020 $64,732 NIH/NINDS Dynamics and Causal Functions of Large-Scale Cortical and Subcortical Networks The goal of this project is to create the first formal interdisciplinary human electrocorticography consortium, whose application is to answer new, fundamental and important questions about speech perception in humans. Role: Site-PI
R37NS021135-30 Knight RT (PI) 07/1/2017 – 06/30/2020 0.24 calendar months NIH/NINDS (SubK from UC Berkeley) $46,350 Attention, orientation and human prefrontal cortex This grant examines the contribution of human prefrontal cortex to executive control of goal-directed behavior using neuropsychological, EEG, and ECoG methods. Role: Co-investigator
Professional Societies
American Epilepsy Society, American Academy of Neurology
Society of Neurosciences
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