Jack J Lin

Professor of Clinical Neurology, Director UC Irvine Comprehensive Epilepsy Program, Neurology
School of Medicine

Professor of Biomedical Engineering
The Henry Samueli School of Engineering

M.D., Rush Medical College, 1998

Phone: 714-456-6203
Email: linjj@uci.edu

University of California, Irvine
100 Irvine Hall
Mail Code: 4275
Irvine, CA 92697

picture of Jack J Lin

1995 Selected for NIH Summer Research Fellowship Program (SRFP)
2001, 2002 Golden Neuron Award for Resident of the Year, UCSD
2003-2004 Fritz E. Dreifuss Award; National EpiFellows Foundation
2003-2004 William Gowers Fellowship, Epilepsy Foundation
2009 van den Noort Award for junior faculty research, Department of Neurology, UC Irvine
2010-2015 Selected as Steward for NIH/NINDS Epilepsy Research Benchmarks
2013 Selected as a “rising star” in epilepsy by the Editorial Board of Epilepsy & Behavior
2013 Butler Family Endowed Lectureship in Epilepsy, University of Alberta, Edmonton
2014 Member of the Editorial Board of Epilepsy & Behavior
2017 Fellow, Center of Neurobiology of Learning and Memory
2017 Fellow, American Epilepsy Society
2018 Orange County Physician of Excellence Award
Jack Lin is a clinician scientist who directs the UC Irvine Comprehensive Epilepsy Program, a highly productive human intracranial electrophysiology research program. He has expertise in studying human cognitive and emotional processing using intracranial electrophysiology with high spatial and temporal dynamics. In patients with implanted depth electrodes in the mesial temporal lobe, he has demonstrated that during contextual fear processing, the amygdala unidirectional influences the hippocampus. In addition, he has shown that such modulation is mediated through coherent theta and alpha frequency oscillations between these two core brain structures. More recently, his laboratory has developed the ability to record single-unit neuron activity from the human hippocampus and medial prefrontal cortex. Such technical advancement to explore human neurophysiology at the level of single neuron resolution is rare and only a few laboratory in the United States and worldwide currently process this ability.
Publications 1. Lin JJ, Salamon N, Dutton RA, Lee AD, Geaga JA, Hayashi KM, Toga AW, Engel J, Jr., Thompson PM. Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy. Neurology, (2005) 65: 1094–1097. (54 citations)

2. *Lin JJ, Salamon N, Dutton RA, Lee AD, Geaga JA, Hayashi KM, Luders E, Toga AW, Engel J, Jr., Thompson PM. Reduced cortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cerebral Cortex, (2007) 17: 2007- 2018. (160 citations)

3. *Lin JJ, Riley JD, Juranek J, Cramer SC. Vulnerability of the frontal-temporal connections in temporal lobe epilepsy. Epilepsy Research, (2008) 82: 162-170. (78 citations)

4. Ogren, JA, Wilson, CL, Bragin A, Lin JJ, Salamon N, Dutton, RA, Luders, E, Fields, FA, Fried I, Toga AW, Thompson PM, Engel, J, Jr., Statba, RJ. Three-Dimensional Surface Maps Link Local Atrophy and Fast Ripples in Human Epileptic Hippocampus. Annals of Neurology, (2009) 66: 783-791. (48 citations)

5. Ogren JA, Bragin A, Wilson CL, Hoftman, GD, Lin JJ, Dutton RA, Fields TA, Toga AW, Thompson PM, Engel J, Jr., Staba, RJ. Three-Dimensional Hippocampal Atrophy Maps Distinguish Two Common Temporal Lobe Seizure Onset Patterns. Epilepsia (2009) 50: 1361-1367. (45 citations)

6. Hermann BP, Lin JJ, Jones, JE, Seidenberg, M. The emerging architecture of neuropsychological impairment in epilepsy. Neurologic Clinic, (2009) 27: 881-907. (Review) (48 citations)

7. Riley JD, Franklin DL, Choi V, Kim RC, Binder DK, Cramer SC, *Lin JJ. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles. Epilepsia (2010), 51(4): 536-45. (116 citations)

8. Riley JD, Moore S, Cramer SC, *Lin JJ. Caudate atrophy and impaired frontostriatal network is linked to executive dysfunction in temporal lobe epilepsy. Epilepsy and Behavior (2011), 21(1): 80-7. (36 citations)

9. Jackson DC, Irwin W, Dabbs K, Lin JJ, Jones JE, Hsu DA, Stafstrom CE, Seidenberg, M, Hermann, BP. Ventricular Enlargement in New Onset Pediatric Epilepsies. Epilepsia, (2011), 52(12): 2225-32. PMC3347640

10. Kemmotsu N, Girard HM, Bernhardt BC, Bonilha L, Lin JJ, Tecoma ES, Iragui VJ, Halgren E, Dale AM, McDonald CR. MRI Analysis in Temporal Lobe Epilepsy: Cortical Thinning and White Matter Disruptions Are Related to Side of Seizure Onset, Epilepsia, (2011), 52(12): 2257-2266. (78 citations)

11. Bell B, Lin JJ**, Seidenberg M, Hermann BP. The neurobiology of cognitive disorders in temporal lobe epilepsy, Nature Reviews Neurology, (2011) 7:154-164. PMC 21304484 **All authors have equal contribution (160 citations)

12. *Lin JJ, Riley JD, Hsu DA, Stafstrom CE, Dabb K, Becker T, Seidenberg M, Hermann BP. Striatal Hypertrophy and Its Cognitive Effects in New Onset Benign Epilepsy with Centrotemporal Spikes. Epilepsia, (2012), 53(4):677-85. PMC 3321058 (29 citations)

13. Lin JJ, Mula M, Hermann BP. Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan, The Lancet, (2012) 29:1180-92. PMC3838617 (Review), (198 citations)

14. *Lin JJ, Siddarth P, Riley J, Gurbani SG, Ly R, Yee, VW, Lewitt J, Toga AW. Caplan R. Neurobehavioral comorbidities of pediatric epilepsies are linked to thalamic abnormalities. Epilepsia (2013) 54(12):2116-24

15. Addis L, Lin JJ, Pal DK, Hermann B, Caplan R. Imaging genetics of language and cognition in pediatric epilepsy, Epilepsy and Behavior (2013) 26(3):303-312 (Review accompanied by “Rising Star” in epilepsy award in this special issue)

16. Do AH, Wang PT, King CE, Schombs A, Lin JJ, Sazgar M, Hsu FP, Shaw SJ, Millett DE, Liu CY, Szymanska AA, Chui LA, Nenadic Z. Sensitivity and specificity of upper extremity movements decoded from electrocorticogram. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:5618-21.

17. Bonilha L, Tabesh A, Dabbs K, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP, Lin JJ*. Neurodevelopmental alterations of large-scale structural networks in children with new-onset epilepsy. Human Brain Mapping, (2014) 35(8):3661-72. Featured Cover Article

18. Jackson DC, Lin JJ**, Chambers KL, Kessler-Jones A, Jones JE, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP. Birth weight and cognition in children with epilepsy. Epilepsia (2014).) 55(6):901-8. **Co-first author

19. Flint RD, Wang PT, Wright ZA, King CE, Krucoff MO, Schuele SU, Rosenow JM, Hsu FP, Liu CY, Lin JJ, Sazgar M, Millett DE, Shaw SJ, Nenadic Z, Do AH, Slutzky MW. Extracting kinetic information from human motor cortical signals. Neuroimage. 2014 Nov 1;101:695-703. PubMed PMID: 25094020.

20. Lin JJ*, Dabb K Riley JD, Jones JE, Jackson DC, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP. Neurodevelopment in new-onset juvenile myoclonic epilepsy over the first 2 years. Annals of Neurology (2014) 76(5):660-8

a. Accompanied commentary by Prof. Shlomo Shinnar, MD, PhD "Whatever happened to the primary generalized epilepsies of childhood and adolescence?"

21. Kellermann TS, Bonilha L, Lin JJ, Hermann, BP. Mapping the landscape of cognitive development in children with epilepsy. Cortex (2015) 66:1-8

22. Riley JD, Fling BW, Cramer SC, Lin JJ*. Altered organization of face-processing networks in temporal lobe epilepsy. Epilepsia (2015) 56(5):762-71.

23. Bonilha L, Jensen JH, Baker N, Breedlove J, Nesland T, Lin JJ, Drane DL, Saindane AM, Binder JR, Kuzniecky RI. The brain connectome as a personalized biomarker of seizure outcomes after temporal lobectomy. Neurology. (2015) 84(18):1846-53 PMID: 25854868.

24. Garcia-Romos C, Jackson DC, Lin JJ, Dabbs K, Jones JE, Hsu DA, Stafstrom CE, Zawadzki L, Seidenberg M, Prabhakaran V, Hermann BP. Cognition and brain development in children with benign epilepsy with centrotemporal spikes. Epilepsia (2015) 56(10):1615-22.

25. Garcia-Romos C, Lin JJ, Prabhakaran, V, Hermann BP. Developmental reorganization of the cognitive network in pediatric epilepsy. PLOS One (2015) 27;10(10):e0141186.

26. Veenstra A, Riley JD, Barrett LE, Muhonen MG, Zupanc ML, Romain JE, Lin JJ, Mucci G. The impact of bilingualism on working memory in pediatric epilepsy. Epilepsy and Behavior (2016) 55:6-10

27. Wang PT, King CE, McCrimmon CM, Lin JJ, Sazgar M, Hsu FP, Shaw SJ, Millet DE, Chui LA, Liu CY, Do AH, Nenadic Z. Comparison of decoding resolution of standard and high-density electrocorticogram electrodes. J Neural Eng. (2016) 13:026016. Epub 2016 Feb 9.

28. Kellermann TS, Bonilha L, Eskandari R, Garcia-Ramos C, Lin JJ, Hermann BP. Mapping the neuropsychological profile of temporal lobe epilepsy using cognitive network topology and graph theory. Epilepsy and Behavior (2016) 63:9-16.

29. Caplan R, Mefford H, Berl M, Chang B, Lin J, Mazarati A, Fureman B, Dingledine R; American Epilepsy Society (AES)/National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Benchmark Stewards. 2014 Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions. Epilepsy Current. 2016 May-Jun;16(3):182-6.

30. Garcia-Ramos C, Lin JJ, Kellermann TS, Bonilha L, Prabhakaran V, Hermann BP. Graph theory and cognition: A complementary avenue for examining neuropsychological status in epilepsy. Epilepsy Behavior. 2016 Epub ahead print

31. Garcia-Ramos C, Lin JJ, Bonilha L, Jones JE, Jackson DC, Prabhakaran V, Hermann BP. Disruptions in cortico-subcortical covariance networks associate with anxiety in new-onset childhood epilepsy. Neuroimage Clinical 2016 Oct 23;12:815-824. PubMed PMID: 27830114

32. Piai V, Anderson KL, Lin JJ, Dewar C, Parvizi J, Dronkers, NF, Knight RT. A key role for the hippocampus in language processing: evidence from intracranial neurophysiology. Proceedings of the National Academy of Science (2016) Oct 4;113(40):11366-11371.

33. Holdgraf, C.R., De Heer, W., Pasley, B., Rieger, J., Crone, N., Lin, JJ, Knight, RT, and Theunissen, F. Rapid tuning adaption in human auditory cortex enhances speech intelligibility. Nature Communications Dec 20;7:13654. doi: 10.1038/ncomms13654

34. Kam JWY, Szczepanski, SM, Canolty RT, Flinker A, Auguste KI, Crone NE, Kirsch HE, Kuperman RA, Lin JJ, Parvizi, J, Knight RT. Differential sources for two neural signatures of target detection: An electrocorticography study. Cerebral Cortex, Nov 22, 2016. Doi:10.1093/cercor/bhw343

35. Perry A, Stiso J, Chang EF, Lin JJ, Parvizi J, Knight RT. Mirroring in the human brain: Deciphering the spatial-temporal patterns of the human mirror neuron system. Cerebral Cortex, Jan 30, 2017. doi: 10.1093/cercor/bhx013

36. Zheng J, Anderson KL, Leal, SL, Shestyuk, A, Gulsen G, Mnatsakanyan, L, Vadera S, Hsu FPK, Yassa MA, Knight RT, Lin JJ*. Amygdala-hippocampal dynamics during salient information processing. Nature Communications (2017) Feb 8;8:14413. doi: 10.1038/ncomms14413

37. Jafarpour A, Piai V, Lin JJ, Knight RT. Human hippocampal pre-activation predicts behavior. Scientific Report, Jul 20;7(1):5959. doi: 10.1038/s41598-017-06477-5.

38. Zheng J, Lin JJ. Modulating amygdala-hippocampal network communication: a potential therapy for neuropsychiatric disorders. Neuropsychopharmacology, in press
Grants 2009-2014 NIH NINDS NS060993 K23: Mentored Patient-Orientated Career Development Award Project Title: Early-onset epilepsy and genetics influence white matter tracts and cognition
Site-Principal Investigator, DARPA BTO Neural Engineering System Design (NESD) Project Title: Neural I/O Bus (NIOB) using Microwire Bundles: Speech Prosthesis Funding date: 1/1/2017 to 12/31/2020 Goal: This project focuses on defining and validating Sensory Data Transformation Algorithms in human single and multi-unit recordings prior to availability of the NIOB system. The specific application is a Speech Prosthetic device that supports READ and WRITE transformations. The goal of this Task is to identify the best performing predictive READ/WRITE algorithms in humans. TDC: $1,700,000 PI: Matthew R. Angles, PhD (Paradromics, Inc.)
American Epilepsy Society, American Academy of Neurology
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Last updated 02/12/2018