Anandk Ganesan

picture of Anandk  Ganesan

Professor, Dermatology
School of Medicine

Professor, Biological Chemistry

Vice Chair for Research, Dermatology
School of Medicine

Co-Director, BIDD Program, Chao Family

Equity Advisor,
School of Medicine

M.D., Medical College of Wisconsin, 2001
PhD, Medical College of Wisconsin, 1999, Microbiology and Molecular Genetics

Phone: (949) 824-2926

University of California, Irvine
Mail Code: 2400
Irvine, CA 92697
Research Interests
melanogenesis, melanoma, vitiligo
Core Co-Director, Imaging Core, UCI Skin

Co-Director, Molecular Diagnostics and Therapeutics Program, Chao Family Comprehensive Cancer Center

Advisor, Medical Scientist Training Program

Vice Chair for Research, Department of Dermatology

Standing Member, AMS Study Section, CSR

Equity Advisor, UCI School of Medicine
Research Abstract
Dr Ganesan’s research work focuses: 1) understanding how melanocytes respond to environmental cues (UV irradiation, inflammation) in order to maintain normal homeostasis; and 2) determining how this homeostasis is disrupted in disease (melanoma, vitiligo). His research utilizes a combination of advanced functional genomic technology (si/shRNA, CRISPR/Cas9 Genome Engineering, bulk and single cell RNA sequencing, DNA sequencing), cell biology methods, and rational drug design strategies to develop novel diagnostics and treatments for disease. Most work in his lab employs a combination of human derived cell lines/ strains, transgenic mouse models, and human tissues.
Awards and Honors
1994 Honors Graduate, University of California, Berkeley
2001 Armand J. Quick Award for Excellence in Biochemistry
2004-2006 Physician Scientist Training Program Fellow, UT Southwestern Medical Center, Dallas, TX
2007 ESDR/SID Collegiality Award
2008 IID Travel Fellowship
2009-present Best Doctors of America
2010 Dermatology Teaching Award
2011 American Cancer Society Research Scholar
2013 Research Associates Dean’s Junior Physician Scientist Award
1. Hall JA. Ganesan AK. Chen J. Nikaido H. Two modes of ligand binding in maltose-binding protein of Escherichia coli. Functional significance in active transport. Journal of Biological Chemistry. 272(28):17615-22. 1997 Jul 11.

2. Ganesan AK. Frank DW. Misra RP. Schmidt G. Barbieri JT. Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites. Journal of Biological Chemistry. 273(13):7332-7. 1998 Mar 27.

3. Ganesan AK. Mende-Mueller L. Selzer J. Barbieri JT. Pseudomonas aeruginosa exoenzyme S, a double ADP-ribosyltransferase, resembles vertebrate mono-ADP-ribosyltransferases. Journal of Biological Chemistry. 274(14):9503-9. 1999 Apr

4. Ganesan AK. Vincent TS. Olson JC. Barbieri JT. Pseudomonas aeruginosa exoenzyme S disrupts Ras-mediated signal transduction by inhibiting guanine nucleotide exchange factor-catalyzed nucleotide exchange. Journal of Biological Chemistry. 274(31):21823-9. 1999 Jul 30.

5. Ganesan AK. Kho, Y. Kim, SC. Chen Y. Zhao Y. White MA. Broad spectrum identification of SUMO substrates in melanoma cells. Proteomics. 2007 Jul 7(13):2216-21

6. Ganesan AK. Ho H, Bodemann B. Petersen S. Aruri J. Koshy S. Richardson Z. Le LQ. Krasieva T. Roth MG. Farmer P. White MA. Genome-Wide siRNA-Based Functional Genomics of Pigmentation Identifies Novel Genes and Pathways That Impact Melanogenesis in Human Cells. PLoS Genet. 2008 Dec;4(12):e1000298

7. Milenkovic T. Memisevic V. Ganesan AK. Przulj N. Systems-level Cancer Gene Identification from Protein Interaction Network Topology Applied to Melanogenesis-related Functional Genomics Data. J R Soc Interface, 2010 Mar 6; 7(44):423-37.

8. Ho H. Milenkovic T. Memisevic V. Aruri J. Przulj N. Ganesan AK. Protein Interaction Network Topology Uncovers Melanogenesis Regulatory Network Components Within Functional Genomics Datasets. BMC Syst. Biol. 2010 Jun 15; 4(1):84

9. Ho H. Kapadia R. Al-Tahan S. Ahmad S. Ganesan AK. WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition. J Biol Chem. 2011 Apr 8;286(14):12509-23.

10. Ho H. Ganesan AK. The Pleiotropic Roles of Autophagy Regulators in Melanogenesis. Pigment Cell Melanoma Res. 2011 Aug;24(4):595-604

11. Ghasri P. Gattu S. Saedi N. Ganesan A. Chemical leukoderma following application of transdermal methylphenidate patch. JAAD 2011 in press

12. Ho, H. Aruri, J. Kapadia, R. Mehr, H. White MA. Ganesan AK. RhoJ and Pak Kinases Regulate Melanoma Chemoresistance by Suppressing Pathways that Sense DNA Damage. Cancer Research, 2012 Nov 1;72(21):5516-28.

13. Ho H. Hopkin AS. Kapadia R. Vasudeva P. Schilling J. Ganesan AK. RhoJ Modulates Melanoma Invasion by Altering Actin Cytoskeletal Dynamics. Pigment Cell Melanoma Res. 2013 Mar;26(2):218-25.

14. Paterson E. Ho H. Kapadia R. Ganesan AK. 9-cis Retinoic Acid is the ALDH1A1 Product that Stimulates Melanogenesis. Exp. Dermatol. 2013 Mar;22(3):202-209.

15. Saedi N. Ganesan AK. Treating hyperpigmentation in darker-skinned patients. J Drugs Dermatol. 2013 May; 12(5): 563-7.

16. Paterson EK. Fielder TJ. MacGregor GR. Ito S. Wakamatsu K. Gillen DJ. Evy V. Boissy RE. Ganesan AK. Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle. PLoS One. 2015 Nov 30;10(11):e0143702

17. Realini N. Palese F. Pizzrani D. Pontis S. Basit A. Bach A. Ganesan A. Piomelli D. Acid Ceramidase in Melanoma: Expression, Localization, and effects of Pharmacologic Inhibition. J Biol Chem 2016 Jan 29;291(5):2422-34.

18. Hopkin AS, Paterson EK, Ruiz R, Ganesan AK. Pigment Production Analysis in Human Melanoma Cells. Methods Mol Biol. 2016 May 25.

19. Chen CF, Ruiz-Vega R, Vasudeva P, Espitia F, Krasieva TB, de Feraudy S, Tromberg BJ, Huang S, Garner CP, Wu J, Hoon DS, Ganesan AK. ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment. Cell Rep. 2017 Mar 7;18(10):2331-2342.

20. Ortega JA, Arencibia, JM, La Sala G, Brogogno M, Bauer I, Bono L, Braccia C, Amirotti A, Girotto S, Ganesan A, De Vivo M. Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells. J Med Chem 2017. 2017 Jul 13;60(13):5800-5815.

21. Ruiz-Vega R, Jahid S, Harris M, Marzese DM, Espitia F, Vasudeva P, Chen CF, de Feraudy S, Wu J, Gillen DL, Krasieva TB, Tromberg BJ, Pavan WJ, Hoon DS, Ganesan AK. The RhoJ BAD Singaling Network: An Achilles Heel for BRAF Mutant Melanoma. PLoS Genetics. 2017 Jul 28;13(7):e1006913.

22. Lai M, Realini N, LaFerla M, Passalacqua I, Matteoli G, Ganesan A, Pistello M, Mazanti CM, Piomell D. Complete Acid Ceramidase ablation prevents cancer initiating cell formation in melanoma cells. Sci Rep. 2017 Aug 7; 7(1);7411.

23. Thomas LW, Elsensohn A, Bergheim T, Shiu J, Ganesan A. Intramuscular Steroids in the Treatment of Dermatologic Disease: A Systematic Review. 2018 Mar 1;17(3):323-329.

24. Liggins MC, Flesher JL, Jahid S, Vasudeva P, Eby V, Takasuga S, Sasaki J, Sasaki T, Boissy RE, Ganesan AK. PIKfyve Regulates Melanosome Biogenesis. PLoS Genetics. 2018 Mar 27;14(3):e100729.

25. Lentsch G, Balu M, Williams J, Lee S, Harris RM, Konig K, Ganesan A, Tromberg BJ, Nair N, Santhanam U, Misra M. In vivo multiphoton microscopy of melasma. Pigment Cell Melanoma Res. 2019 May; 32(3) 403-411.

26. Wang C, Kraus CN, Patel KG, Ganesan AK, Grando SA. Real-world experience of dupilumab treatment for atopic dermatitis in adults: a retrospective analysis of patients’ records. Int J Dermatol 2019 Jul 8.

27. Mobasher P, Guerra R, Jiaying Li S, Frangos J, Ganesan AK, Huang V. Open Label Pilot Study of 2% Tofacitinib for the Treatment of Refractory Vitiligo. Br J Dermatol. 2019 Oct 12.

28. Flesher JL, Paterson-Coleman EK, Vasudeva P, Ruiz-Vega R, Marshall M, Pearlman E, MacGregor GR, Neumann J, Ganesan AK. Delineating the role of MITF isoforms in pigmentation and tissue homeostasis. Pigment Cell Melanoma Res. 2020 Mar;33(2):279-292.

29. Hoang T, Ganesan AK, Hiyama D, Dayyani F. Gene mutations distinguishing gastric from colorectal and esophageal adenocarcinoma. J Gastrointest Oncol. 2020 Feb;11(1):45-54.

30. Lentsch G, Valdebran M, Sakrite I, Smith J, Linden KG, Konig K, Barr RJ, Harris RM, Tromberg BJ, Ganesan AK, Zachary CB, Kelly KM, Balu M. Non-invasive optical biopy by multiphoton microscopy identifies the live morphology of common melanocytic nevi. Pigment Cell Melanoma Research. 2020 Jun 2.

31. Ruiz-Vega R, Chen CF, Razzak E, Vasudeva P, Kraseiva TB, Shiu J, Caldwell MG, Yan H, Lowengrub J, Ganesan AK, Lander AD. Dynamics of Nevus Development implicate cell cooperation in the growth arrest of melanocytic nevi. Elife. 2020 Oct 13;9:e61026.

32. Habowski AN. Flesher JL. Bates JM. Tsai CF. Martin K. Zhao R. Ganesan AK. Edwards RA, Shi T. Wiley HS. Shi Y. Hertel KJ. Waterman ML. Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. Commun Biol. 2020 Aug 19;3(1):453. doi: 10.1038/s42003-020-01181-z.

33. Fast A. Lai A. Durkin AF. Lentsch G. Harris RM. Zachary CB. Ganesan AK. Balu M. Fast, large area multiphoton exoscope (FLAME) for macroscopic imaging with microscopic resolution of human skin. Sci Rep. 2020 Oct 22; 10(1):18093. doi: 10.1038/s41598-020-75172-9.

34. Mobasher P. Shiu J. Lentsch G. Ganesan AK. Comparing the Efficacy of 2 Different Harvesting Techniques for Melanocyte Keratinocyte Transplantation in Vitiligo. Dermatologic Surgery: December 21, 2020 doi: 10.1097/DSS.0000000000002922
12/04/2019-11/30/2024 NCI Role: Principal Investigator Title: R01CA244571 Identifying Therapeutic Targets for Stage III Melanoma This grant seeks to develop new methods to treat melanoma tumors before they have had a chance to metastasize to distant organs. JIT information has been requested and it is now pending administrative approval by NCI.
07/01/2018-06/30/2023 NIBIB Role: MPI Title: R01EB026705 Development of a fast scanning, extended field of view, multiphoton microscope for clinical skin imaging. The major goal of this project is to develop a new MPM technology to visualize tissue homeostasis and transformation in the human epidermis
04/01/2018-03/31/2023 NCI Role: Co-Leader, Project 2 Title: U54CA217378-01 Complexity, Cooperativity, and Community in Cancer. The major goal of this project is to understand the premalignancy risk of melanocytic nevi and how they transform into melanoma.
09/18/2017-07/31/2022 NCI Role: Co-Investigator Title: R25-CA214654 A Short Course in Cancer Systens Biology This grant establishes an annual three weeks course at the University of California, Irvine for training biomedical researchers with interests in applying Systems biology approaches to the study of cancer.
08/15/2018-07/31/2023 NIAMS Role: co-director, Imaging Core Title: 1P3011935106 Skin Biology Resource-based Center at UCI. This grant supports my work as co-director of the imaging core of the P30 skin disease resource center.
Professional Societies
(2002-2015) Member, American Academy of Dermatology
(2002-present) Member, Society for Investigative Dermatology
(2011-present) Member, Pan American Society for Pigment Cell Research
(2012-2014) Member, American Association for Cancer Research
(2015-present) Member, Global Vitiligo Foundation
Graduate Programs
Cellular and Molecular Biosciences

Mathematical and Computational Biology

Research Centers
Chao Family Comprehensive Cancer Center
Cancer Research Institute
Center for Cancer Systems Biology
UCI Skin
Institute for Immunology
Stem Cell Research Center
Beckman Laser Institute
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