Anand k Ganesan

picture of Anand k  Ganesan

MD, Dermatology
School of Medicine
Joint Appointee, Biological Chemistry
School of Medicine

M.D., Medical College of Wisconsin, 2001
PhD, Medical College of Wisconsin, 1999, Microbiology and Molecular Genetics

Phone: (949) 824-2926

University of California, Irvine
Mail Code: 2400
Irvine, CA 92697
Research Interests
functional genomics, melanogenesis, melanoma
Academic Distinctions
1994 Honors Graduate, University of California, Berkeley
2001 Armand J. Quick Award for Excellence in Biochemistry
2007 ESDR/SID Collegiality Award
2010-present America's Best Doctors
2004-2006 Physician Scientist Training Program Fellow, UT Southwestern Medical Center, Dallas, TX
Research Abstract
Dr. Ganesan’s work has focused on utilizing systems-level approaches to define novel pathways that regulate melanin production and melanoma chemoresistance. Currently, his work is focusing on the role of autophagy regulators in melanosome biogenesis and the role of RhoJ/PAK1 in melanoma chemoresistance. In addition to managing an active research laboratory, Dr. Ganesan maintains an active clinical practice focusing on patients with pigmentary disorders and skin cancer, although he also sees general dermatology patients. The ultimate goal of his research/clinical work is to develop new therapies to treat melanoma and pigmentary disorders.
Available Technologies
1. Hall JA. Ganesan AK. Chen J. Nikaido H. Two modes of ligand binding in maltose-binding protein of Escherichia coli. Functional significance in active transport. Journal of Biological Chemistry 272(28):17615 -22. 1997 Jul 11.
2. Ganesan AK. Frank DW. Misra RP. Schmidt G. Barbieri JT. Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites. Journal of Biological Chemistry. 273(13):7332-7. 1998 Mar 27.
3. Ganesan AK. Mende-Mueller L. Selzer J. Barbieri JT. Pseudomonas aeruginosa exoenzyme S, a double ADP-ribosyltransferase, resembles vertebrate mono-ADP-ribosyltransferases. Journal of Biological Chemistry. 274(14):9503-9. 1999 Apr
4. Ganesan AK. Vincent TS. Olson JC. Barbieri JT. Pseudomonas aeruginosa exoenzyme S disrupts Ras-mediated signal transduction by inhibiting guanine nucleotide exchange factor-catalyzed nucleotide exchange. Journal of Biological Chemistry. 274(31):21823-9. 1999 Jul 30.
5. Ganesan AK. Kho Y. Kim SC. Chen Y. Zhao Y. White MA. Broad spectrum identification of SUMO substrates in melanoma cells. Proteomics. 2007 Jul 7(13):2216-21
6. Ganesan AK. Ho H, Bodemann B. Petersen S. Aruri J. Koshy S. Richardson Z. Le LQ. Krasieva T. Roth MG. Farmer P. White MA. Genome-Wide siRNA-Based Functional Genomics of Pigmentation Identifies Novel Genes and Pathways That Impact Melanogenesis in Human Cells. PLoS Genet. 2008 Dec;4(12):e1000298
7. Milenkovic T. Memisevic V. Ganesan AK. Przulj N. Systems-level Cancer Gene Identification from Protein Interaction Network Topology Applied to Melanogenesis-related Functional Genomics Data. J R Soc Interface, 2009 Jul 22
8. Ho H. Milenkovic T. Memisevic V. Aruri J. Przulj N. Ganesan AK. Protein Interaction Network Topology Uncovers Melanogenesis Regulatory Network Components Within Functional Genomics Datasets. BMC Syst Biol. 2010;4:84. PMCID: 2904735
9. Ho H. Kapadia R. Al-Tahan S. Ahmad S. Ganesan AK. WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition. J Biol Chem. 2011; 8;286(14):12509-23.
10. Ho H. Ganesan AK. The Pleiotropic Roles of Autophagy Regulators in Melanogenesis. Pigment Cell Melanoma Res. 2011 Aug;24(4):595-60.
11. Ghasri P. Gattu S. Saedi N. Ganesan A. Chemical leukoderma following application of transdermal methylphenidate patch. J Am Acad Dermatol. 2012 Jun;66(6):e237-8.
12. Ho, H. Aruri, J. Kapadia, R. Mehr, H. White MA. Ganesan AK. RhoJ and Pak Kinases Regulate Melanoma Chemoresistance by Suppressing Pathways that Sense DNA Damage. Cancer Res. 2012 Sep 12.
13. Ho H. Hopkin AS. Kapadia R. Vasudeva P. Schilling J. Ganesan AK. RhoJ Modulates Melanoma Invasion by Altering Actin Cytoskeletal Dynamics. Pigment Cell Melanoma Res. 2012 Dec 18
Professional Societies
American Academy of Dermatology
American Association for Cancer Research
Society for Investigative Dermatology
Pan American Society for Pigment Cell Research
Graduate Programs
Cellular and Molecular Biosciences

Research Centers
Chao Family Comprehensive Cancer Center
Cancer Research Institute
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