Lbachir BenMohamed

picture of Lbachir  BenMohamed

Professor and Director, Cellular and Molecular Immunology, Ophthalmology
School of Medicine


Ph.D., Pasteur Institute, Paris, France, 1997, Immunology and Vaccine Development

Phone: 949-824- 8937
Fax: 949-824-9626
Email: lbenmoha@uci.edu

University of California, Irvine
843 Health Sciences Road
Hewitt Hall , Building 843, 2nd Floor, Room 2032
Mail Code: 4390
Irvine, CA 92697
Research Interests
Two major topics: (1) Infection and Immunity/immunopathology; (2) Cancer and immunity/immunopathology
URLs
Academic Distinctions
• 1992-1996 Assistant Researcher. Immuno-Parasitology, Department of Immunology, Pasteur Institute, France.

• 1997-1998 Research Fellow. Immuno-virology, Department of Hematology/BMT, City of Hope National Medical Center, Duarte, CA, USA

• 1998-1999 Research Fellow. Immuno-virology, Division of Immunology, Beckman Research Institute, City of Hope, Duarte, CA, USA
Appointments
• 1999-2001 Research Scientist Step I. Immuno-virology, Ophthalmology Research. Cedars-Sinai Medical Center, Los Angeles, CA, USA

• 2002-2004 Assistant Researcher Step IV. Immuno-virology, Department of Ophthalmology & Center for Immunology. University of California Irvine, Orange, CA, USA

• 2004-2007 Assistant Professor of Immunology. Department of Ophthalmology, University of California Irvine, Orange, CA, USA

• 2007-2014 Associate Professor of Immunology, Step I. Department of Ophthalmology, University of California Irvine, Orange, CA, USA

• 2014 -present Professor of Immunology, Step I. Department of Ophthalmology, University of California Irvine, Orange, CA, USA
Research Abstract
Dr. Benmohamed is a Professor of Immunology, the founder and the head of the Laboratory of Cellular and Molecular Immunology in the Department of Ophthalmology at the University of California. He also holds a joint appointment with the Center of Immunology at UC Irvine and with Chao Family Comprehensive Cancer Center UCI Medical center. Dr. BenMohamed received his Ph.D. in Immunology from the Pasteur Institute, Paris, France in 1997 where he worked as the key developer and co-inventor of a new promising vaccine strategy that uses mucosal delivery of clinically approved lipopeptide molecules. Dr. BenMohamed has been involved in clinical immunology, humoral and cellular immune responses, epitope mapping, epitope improvement, and the development and optimization of sub-unit vaccines against several infectious diseases including malaria Plasmodium falciparum, human immunodeficiency virus (HIV), human cytomegalovirus (HCMV) and herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2). Dr. BenMohamed is an independent immunologist, with a national and international reputation in vaccine development against both infectious diseases and cancer. Dr. BenMohamed is well integrated into the scientific community within the United States as well as Europe and is actively involved in a number of professional societies including American Association of Immunologists (AAI), American Society for Microbiology (ASM), American Society for Hematology (ASH), Association for Research in Vision and Ophthalmology (ARVO).
Available Technologies
Publications
1. Fidock DA, Gras-Masse H, Lepers JP, Brahimi K, Benmohamed L, Mellouk S, Guerin-Marchand C, Londono A, Raharimalala L & Meis JF. Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants. The Journal of Immunology. 1994.153(1): 190-204.

2. Bottius E, BenMohamed L, Brahimi K, Gras H, Lepers JP, Raharimalala L, Aikawa M, Meis J, Slierendregt B, Tartar A, Thomas A & Druilhe P. A novel Plasmodium falciparum sporozoite and liver stage antigen (SALSA) defines major B, T helper, and CTL epitopes. The Journal of Immunology. 1996. 156(8): 2874-84.

3. BenMohamed L, Gras-Masse H, Tartar A, Daubersies P, Brahimi K, Bossus M, Thomas A & Druilhe P. Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees. European Journal of Immunology. 1997. 27(5): 1242-53.

4. Bossus M, BenMohamed L, Londono A, Barbier B, Tartar A, Druilhe P & Gras-Masse H. Improved detection of human antibodies to a Plasmodium antigen using a peptide modified with Aib residues. Journal of Peptide Science. 1997. 3(1): 47-53.

5. Daubersies P, Thomas AW, Millet P, Brahimi K, Langermans JA, Ollomo B, BenMohamed L, Slierendregt B, Eling W, Van Belkum A, Dubreuil G, Meis JF, Guérin-Marchand C, Cayphas S, Cohen J, Gras-Masse H, Druilhe P. Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3. Nature Medicine. 2000. 6(11): 1258-63.

6. BenMohamed L, Krishnan R, Longmate J, Auge C, Low L, Primus J, Diamond DJ. Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted T(H) response. Human Immunology. 2000. 61(8): 764-79.

7. BenMohamed L, Thomas A, Bossus M, Brahimi K, Wubben J, Gras-Masse H, Druilhe P. High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules. Vaccine. 2000. 18(25): 2843-55.

8. Brahimi K, Badell E, Sauzet JP, BenMohamed L, Daubersies P, Guérin-Marchand C, Snounou G, Druilhe P. Human antibodies against Plasmodium falciparum liver-stage antigen 3 cross-react with Plasmodium yoelii preerythrocytic-stage epitopes and inhibit sporozoite invasion in vitro and in vivo. Infection and Immunity. 2001. 69(6): 3845-52.

9. Perng GC, Maguen B, Jin L, Mott KR, Kurylo J, BenMohamed L, Yukht A, Osorio N, Nesburn AB, Henderson G, Inman M, Jones C, Wechsler SL. A novel herpes simplex virus type 1 transcript (AL- RNA) antisense to the 5? end of the latency-associated transcript produces a protein in infected rabbits. Journal of Virology. 2002. 76(16): 8003-10.

10. BenMohamed L, Wechsler SL, Nesburn AB. Lipopeptide vaccines–yesterday, today, and tomorrow. Lancet Infectious Diseases. 2002. 2(7): 425-31.

11. BenMohamed L, Belkaid Y, Loing E, Brahimi K, Gras-Masse H, Druilhe P. Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant. European Journal of Immunology. 2002. 32(8): 2274-81.

12. BenMohamed L, Krishnan R, Auge C, Primus JF, Diamond DJ. Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses. Immunology. 2002. 106(1): 113-21.

13. Vichier-Guerre S, Lo-Man R, BenMohamed L, Dériaud E, Kovats S, Leclerc C, Bay S. Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use. Journal of Peptide Research. 2003. 62(3): 117-24.

14. BenMohamed L, Bertrand G, McNamara CD, Gras-Masse H, Hammer J, Wechsler SL & Nesburn AB. Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity. Journal of Virology. 2003. 77(17): 9463- 73.

15. Zhu X, Ramos TV, Gras-Masse H, Kaplan BE & BenMohamed L. Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll- like receptor-2 pathway and trigger a Th1-dependent protective immunity. European Journal of Immunology. 2004. 4(11): 3102-14.

16. Lo-Man R, Vichier-Guerre S, Perraut R, Dériaud E, Huteau V, BenMohamed L, Diop OM, Livingston PO, Bay S & Leclerc C. A fully synthetic therapeutic vaccine candidate targeting carcinoma- associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates. Cancer Research. 2004. 64(14): 4987-94.

17. BenMohamed L, Thomas A & Druilhe P. Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides. Infection and Immunity. 2004. 72(8): 4376-84.

18. Peng W, Henderson G, Inman M, BenMohamed L, Perng GC, Wechsler SL & Jones C. The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice. Journal of Virology. 2005. 79(10): 6162-71.

19. Nesburn AB, Ramos TV, Zhu X, Asgarzadeh H, Nguyen V & BenMohamed L. Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant. Vaccine. 2005. 23(7): 873-83.

20. Zhang X, Issagholian A, Berg EA, Fishman JB, Nesburn AB & BenMohamed L. Th-cytotoxic T- lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection. Journal of Virology. 2005. 79(24): 15289-301.

21. Bettahi I, Zhang X, Afifi RE & BenMohamed L. Protective immunity to genital herpes simplex virus type 1 and type 2 provided by self-adjuvanting lipopeptides that drive dendritic cell maturation and elicit a polarized Th1 immune response. Viral Immunology. 2006. 19(2): 220-36.

22. Nesburn AB, Bettahi I, Zhang X, Zhu X, Chamberlain W, Afifi RE, Wechsler SL & BenMohamed L. Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system. Ocular Surface. 2006. 4(4): 178-87.

23. Nesburn AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL & BenMohamed L. Functional Foxp3+ CD4+ CD25(Bright+) “natural” regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection. Journal of Virology. 2007. 81(14): 7647-61.

24. Carpenter D, Hsiang C, Brown DJ, Jin L, Osorio N, BenMohamed L, Jones C & Wechsler SL. Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis. Virology. 2007. 369(1): 12-8.

25. Bettahi I, Nesburn AB, Yoon S, Zhang X, Mohebbi A, Sue V, Vanderberg A, Wechsler SL & BenMohamed L. Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines. Investigative Ophthalmology and Visual Science. 2007. 48(10): 4643-53.

26. Carpenter D, Henderson G, Hsiang C, Osorio N, BenMohamed L, Jones C & Wechsler SL. Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity. Microbes and Pathogens. 2008. 44(2):98-102.

27. Chentoufi AA, Zhang X, Lamberth K, Dasgupta G, Bettahi I, Nguyen A, Wu M, Zhu X, Mohebbi A, Buus S, Wechsler SL, Nesburn AB, BenMohamed L. HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D. The Journal of Immunology. 2008. 180(1): 426-37.

28. Renaudet O, BenMohamed L, Dasgupta G, Bettahi I & Dumy P. Towards a self-adjuvanting multivalent B and T cell epitope containing synthetic glyco-lipopeptide cancer vaccine. Chemistry Enabling Drug Discovery (ChemMedChem). 2008. 3(5): 737-41.

29. Zhang X, Castelli FA, Zhu X, Wu M, Maillère B & BenMohamed L. Gender-Dependent HLA-DR Restricted Epitopes Identified from the Herpes Simplex Virus Type 1 Glycoprotein D. Clinical Vaccine Immunology. 2008. (9): 1436-49.

30. Chentoufi AA, Binder NR; Berka N, Durrand G, Nguyen A, Bettahi I, Maillere B & BenMohamed L. Asymptomatic Human CD4+ Cytotoxic T-Cell Epitopes Identified from Herpes Simplex Virus Glycoprotein B. Journal of Virology. 2008. (23): 11792-802.

31. Bettahi I; Dasgupta G; Renaudet O; Chentoufi AA; Zhang X; Carpenter D; Yoon S; Dumy P & BenMohamed L. Antitumor Activity of a Self-Adjuvanting Glyco-Lipopeptide Vaccine Bearing B-Cell, CD4+ and CD8+ T-Cell Epitopes. Cancer Immunology and Immunotherapy. 2009. 58(2): 187-200.

32. Mott KR, Bresee CJ, Allen SJ, BenMohamed L, Wechsler SL & Ghiasi H. Level of Herpes Simplex Virus Type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice. Journal of Virology. 2009. 83(5): 2246-54.

33. Mott KR, Chentoufi AA, Carpenter D, BenMohamed L, Wechsler SL & Ghiasi H. The role of a glycoprotein K (gK) CD8+ T-cell epitope of herpes simplex virus on virus replication and pathogenicity. Investigative in Ophthalmology and Visual Science. 2009. 50(6): 2903-12.

34. Zhang X, Chentoufi AA, Dasgupta G, Nesburn AB, Wu M, Zhu X, Carpenter D, Wechsler SL, You S, & BenMohamed L. A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8(+) T cells and protects against herpes simplex virus type 2 challenge. Mucosal Immunology (Nature Publishing Group). 2009. 2(2): 129-43.

35. Dasgupta G., Chentoufi AA., Wechsler SL., Nesburn AB & BenMohamed L. Herpes Simplex Virus Vaccine Development: Notes and Challenges from a Battlefield. Expert Review Vaccine. 2009. 8(8): 1023-35.

36. Chentoufi AA., Nesburn AB & BenMohamed L. Recent Advances in Multivalent Self-Adjuvanting Glyco-lipopeptide Vaccine Strategies against Breast Cancer. Archivum Immunologiae et Therapiae Experimentalis. 2009. 57(6): 409-23.

37. Chentoufi A.A., Dasgupta G., Azeem A. Choudhury Z., Christensen N, Wechsler SL., Nesburn AB & BenMohamed L. A Novel Human Leukocyte Antigen (HLA-A*0201) Transgenic Rabbit Model to Evaluate the Protective Efficacy of Human CD8+ T-Cell Epitopes against Ocular Herpes Infection and Disease. Journal of Immunology. 2010. 184(5): 2561-71.

38. Dasgupta G, Nesburn AB, Wechsler SL. & BenMohamed L. Developing an asymptomatic mucosal herpes vaccine: the present and the future. Future Microbiology. 2010. 5:1-4.

39. Chentoufi AA, Dasgupta G, Nesburn AB, Bettahi I, Binder NR, Choudhury ZS, Chamberlain WD, Wechsler SL, & BenMohamed L. Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunization. Clinical Vaccine Immunology. 2010. 17(3): 342-53.

40. Renaudet O, Dasgupta G, Bettahi I, Shi A, Nesburn AB, Dumy P & BenMohamed L. Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity. PLoS One. 2010. 5(6): 11216.

41. Chentoufi AA, & BenMohamed L. Future Viral Vectors for the Delivery of Asymptomatic Herpes Epitopes-Based Immunotherapeutic Vaccines. Future Virology. 2010. 5(5): 525-528.

42. Dasgupta G, Chentoufi AA, You S, Falatoonzadeh P, Urbano LA, Akhtarmalik A, Nguyen K, Ablabutyan L, Nesburn AB & BenMohamed L. Engagement of TLR2 Reverses the Suppressor Function of Conjunctiva CD4+CD25+ Regulatory T Cells, and Promotes Herpes Simplex Virus Epitope-Specific CD4+CD25- Effector T Cell Responses. Investigative in Ophthalmology and Visual Sciences. 2011. 52(6): 3321-33.

43. Jiang, X. Chentoufi AA., Hsiang, C., Carpenter, D., Osorio, N., BenMohamed L. Fraser, NW., Jones, C., & Wechsler SL. The herpes simplex virus type 1 latency associated transcript (LAT) can protect neuronal derived C1300 and Neuro2A cells from Granzyme B induced apoptosis and CD8+ T-cell killing. Journal of Virology. 2011. 85(5): 2325-32.

44. Perlaza BL., Sauzet JP. Brahimi K. BenMohamed L & Druilhe P. Interferon-?, a valuable surrogate marker of protective immunity against P. falciparum pre-erythrocytic stages. Malaria Journal. 10(1): 27. 2011.

45. Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL & Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. Journal of Virology. 2011. 85(9): 4184-97.

46. Dasgupta G. & BenMohamed L. Of Mice and Not Humans: Reliable Pre-clinical Animal Models for Evaluation of Human Herpes Immunotherapeutic Vaccine Candidates? Vaccine. 2011. 29(35): 5824- 36.

47. Rubbo PA, Tuaillon E, Nagot N, Chentoufi AA, Bollore K, Reynes J, Vendrell JP, BenMohamed L & DE Perre PV. HIV-1 Infection Impairs HSV-Specific CD4+ and CD8+ T Cell Response by Reducing Th1 Cytokines and CCR5 Ligand Secretion. Journal of Acquired Immune Deficiency Syndrome. 2011. 58(1):9-17.

48. Allen SJ, Mott KR, Chentoufi AA, BenMohamed L, Wechsler SL, Ballantyne CM & Ghiasi H. CD11c controls the capacity of HSV-1 responses to limit virus replication during primary infection. Journal of Virology. 2011. 85(19):9945-55.

49. Chentoufi, A.A., E. Kritzer, M. Tran, G. Dasgupta, R. EA., J. Xianzhi, D. Carpenter, O. Osorio, A. B. Nesburn, S. L. Wechsler & L. BenMohamed. The Herpes Simplex Virus-1 Encoded Latency- Associated Transcript Promotes Dysfunctional Virus-Specific CD8+ T Cells in Latently Infected Trigeminal Ganglia: A Novel Immune Evasion Mechanism. Journal of Virology. 2011. 85(17): 9127- 38.

50. Chentoufi AA., Dasgupta G., Huw D., Falatoonzadeh P., Lim CH., Kalantari-Dehaghi M., Felgner LP. & BenMohamed L. Identification of Asymptomatic Antigens by Probing Whole Herpes Simplex Virus Type 1 and Type 2 Open Reading Frame Proteome Microarrays By Sera From Seropositive Asymptomatic Versus Symptomatic Individuals. Journal of Virology. 2012. In press.

51. Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individuals. Chentoufi AA., Dasgupta G., Huw D., Falatoonzadeh P., Lim CH., Kalantari-Dehaghi M., Felgner LP. & BenMohamed L. Journal of Virology. 2012. (8): 4358-69.

52. Discovery of potential diagnostic and vaccine antigens in herpes simplex virus 1 and 2 by proteome-wide antibody profiling. Kalantari-Dehaghi, M., Chun S., Chentoufi AA., Molina, DM., Liang L., Dasgupta G., Ms. Pablo G., Jasinskas A., Nakajima-Sasaki R., BenMohamed L., Felgner, LP. & Huw DM.,. Journal of Virology. 2012. (8): 4328-39.

53. Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown. Chentoufi, AA., Kritzer, E. & BenMohamed L. Clinical & Developmental Immunology. 2012. 187585.

54. Future of an “Asymptomatic” T-cell Epitope-Based Therapeutic Herpes Simplex Vaccine. Dervillez, X., Gottimukkala, C., Kabbara, KW. Nguyen, C., Kim, SM., Nesburn, A.B., Wechsler S.L. & BenMohamed L. Future Virology. 2012. 7(4): 371-378.

55. The Herpes Simplex Virus Type 1 Latency Associated Transcript Inhibits Phenotypic and Functional Maturation of Dendritic Cells. Chentoufi, AA.,Dervillez, X., Dasgupta G., Nguyen C., Kabbara, KW., Jiang X., Nesburn, A.B., Wechsler S.L. & BenMohamed L. Viral Immunology. 2012. (3):204-15.

56. Targeting the Genital Tract Mucosa with a Lipopeptide/Recombinant Adenovirus Prime/Boost Vaccine Induces Potent and Long-Lasting CD8+ T Cell Immunity Against Herpes: Importance of Myeloid Differentiation Factor 88. Xiuli Zhang; Xavier Dervillez; Aziz Alami Chentoufi; Tina Badakhshan; Ilham Bettahi & BenMohamed L. The Journal of Immunology. 2012. 89(9): 4496-509.

57. Mucosal Herpes Immunity and Immuno-pathology to Ocular, Oro-Facial and Genital Herpes Simplex Virus Infections. Chentoufi, A. A. & BenMohamed L. Clinical and Developmental Immunology. 2012. In press.

58. Immunity to Ocular and Genital Herpes Simplex Viruses Infections. Chentoufi, A. A.; BenMohamed L., Philippe Van De Perre, and Ali A. Ashkar. Clinical and Developmental Immunology. 2012. In press.

59. Current Trends in Negative Immuno-Synergy between Two Sexually Transmitted Infectious Viruses: HIV-1 and HSV-1/2. Aziz Alami Chentoufi; Xiuli Zhang; Pierre Alan Rubbo; Xavier Dervillez; Nicolas Nagot, Edouard Tuaillon; Philippe Van De Perre & BenMohamed L. Current Trends in Immunology. 2012. 13:51-68.

60. Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Q? Capsids. Yin Z, Comellas-Aragones M, Chowdhury S, Bentley P, Kaczanowska K, BenMohamed L, Gildersleeve JC, Finn MG, Huang X. ACS Chem Biol. 2013 Mar 29. In Press.

61. Valosin Containing Protein Disease is Associated with Cytokine Imbalances E. Dec, P. Rana, V. Katheria, R. Dec, M. Khare, A. Nalbandian, S-Y Leu, S. Radom-Aizik, F. Zaldivar, BenMohamed L., V. Kimonis. 2013. Clinical and Translational Science. In Press.

62. HLA-A*01:03, -A*24:02, -B*08:01, -B*27:05, -B*35:01, -B*44:02 and C*07:01 Monochain Transgenic / H-2 Class I Null Mice: Novel Versatile Pre-Clinical Models of Human T Cell Responses. R. Boucherma, H. Kridane-Miledi, R. Bouziat, M. Rasmussen†, T. Gatard, F. Langa-Vives, B. Lemercier, A. Lim, M. Bérard, BenMohamed L., S. Buus, R. Rooke, and F. A. Lemonnier. 2013. The Journal of Immunology. In Press.

63. Khan AA; Ruchi Srivastava; Patricia Pardo Lopes; Christine Wang; Thanh T. Pham, Justin Cochrane,
Nhi Thi Uyen Thai, Lucas Gutierrez, & BenMohamed L. Asymptomatic Memory CD8+ T cells: From
Development and Regulation to Considerations for Human Vaccines and Immunotherapeutics.
Human Vaccines & Immunotherapeutics. 2014. 10(4): 945-63

64. Planes R. BenMohamed, L. & Bahraoui E. HIV-1 Tat protein induces PD-L1 (B7-H1) expression on
dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated
mechanisms. The Journal of Virology. 2014. 88(12): 6672-89.

65. Samandary S, Kridane-Miledi H, Choudhury ZS, Langa-Vives F, Spenser D, Chentoufi AA,
Lemonnier FA, & BenMohamed, L. Associations of HLA-A, HLA-B and HLA-C Alleles Frequency
with Prevalence and Distribution of Herpes Simplex Infections and Diseases Across Global
Populations: Implication for the Development of an Universal CD8+ T-Cell Epitope-Based
Vaccine. Human Immunology. 2014. 75(8): 715-29.

66. Prakash, S., Agrawal, S.’ Siraj, H., Ngyuen, M., BenMohamed, L. Gupta, S. & Agrawal., A Dendritic
Cells from Aged Subjects Contribute to Chronic Airway Inflammation by Activating Bronchial
Epithelial Cells under Steady State. Mucosal Immunology. 2014. 7(6): 1386-94.

67. Richichi B, Thomas B, Fiore M, Bosco R, Qureshi H, Nativi C, Renaudet O, & BenMohamed L.
Clustered Tn-Antigen Mimetics-Based Cancer Vaccine Induce Strong and Long-Lasting Antibody-
Mediated Protective Immunity. Angew Chem Int Ed Engl. 2014. 53(44): 11917-20.

68. Kuo T, & BenMohamed L. The challenges and opportunities for the development of a T-cell
epitope-based herpes simplex vaccine. Vaccine. 2014. 32(50): 6733-6745.

69. Ben Haij N, Planès R, Leghmari K, Serrero M, Delobel P, Izopet J, BenMohamed L, Bahraoui E.
HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells
and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation
of NF-?B Pathway. PLoS One. 2015. 19; 10(6).

70. Llewellyn KJ, Walker N, Nguyen C, Tan B, BenMohamed L, Kimonis VE, Nalbandian A. A Fine
Balance of Dietary Lipids Improves Pathology of a Murine Model of VCP-Associated Multisystem
Proteinopathy. PLoS One. 2015. 10(7).

71. Srivastava; R. Khan A.A., Nesburn, A.B.; Steven L. Wechsler S.L. & BenMohamed L. HLA-A02:01-
Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12
Preferentially Recall Polyfunctional Effector Memory CD8+ T Cells from Seropositive
Asymptomatic Individuals and Protect “Humanized” HLA-A*02:01 Transgenic Mice Against
Ocular Herpes. Journal of Immunology. 2015. 194(5): 2232-48.

72. Khan AA, Srivastava R, Spencer D, Garg S, Fremgen D, Vahed H, Lopes PP, Pham TT, Hewett C,
Kuang J, Ong N, Huang L, Scarfone VM, Nesburn AB, Wechsler SL, & BenMohamed L. Phenotypic and functional characterization of herpes simplex virus glycoprotein B epitope-specific effector
and memory CD8+ T cells from symptomatic and asymptomatic individuals with ocular herpes.
The Journal of Virology. 2015. 89(7): 3776-92.

73. Jiang X, Brown D, Osorio N, Hsiang C, Li L, Chan L, BenMohamed L, Wechsler SL. A herpes simplex
virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of
reactivation. Journal of NeuroVirology. 2015. 21(2): 199-209.

74. Srivastava R, Khan AA, Huang J, Nesburn AB, Wechsler SL & BenMohamed L. A Herpes Simplex
Virus Type 1 Human Asymptomatic CD8+ T-Cell Epitopes-Based Vaccine Protects Against Ocular
Herpes in a "Humanized" HLA Transgenic Rabbit Model. Invest Ophthalmol Vis Sci. 2015. 56(6):
4013-28.

75. Khan AA, Srivastava R, Chentoufi AA, Geertsema R, Thai NT, Dasgupta G, Osorio N, Kalantari M,
Nesburn AB, Wechsler SL & BenMohamed L. Therapeutic immunization with a mixture of herpes
simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases
spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low
frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells. The Journal of Virology. 2015. 89(13):
6619-32.

76. Farid M, Agrawal A, Fremgen D, Tao J, Chuyi H, Nesburn AB, & BenMohamed L. Age-related
Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye
Disease. Ocular Immunology and Inflammation. 2015. 24:1-21.

77. BenMohamed L, Osorio N, Khan AA, Srivastava R, Huang L, Krochmal JJ, Garcia JM, Simpson JL,
Wechsler SL. Prior Corneal Scarification and Injection of Immune Serum are Not Required Before
Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal
Disease in Latently Infected Mice. Current Eye Research. 2015. 23:1-10.

78. BenMohamed L, Osorio N, Srivastava R, Khan AA, Simpson JL, Wechsler SL. Decreased reactivation
of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in
vivo mouse UV-B model of induced reactivation. Journal of NeuroVirology. 2015. 21(5): 508-17.

79. Carpenter D, Hsiang C, Jiang X, Osorio N, BenMohamed L, Jones C, Wechsler SL. The herpes
simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shockinduced
apoptosis by maintaining phosphorylation of protein kinase B (AKT). Journal of
NeuroVirology. 2015. 21(5): 568-75.

80. Yin Z, Chowdhury S, McKay C, Baniel C, Wright WS, Bentley P, Kaczanowska K, Gildersleeve JC,
Finn MG, BenMohamed L, Huang X. Significant Impact of Immunogen Design on the Diversity of
Antibodies Generated by Carbohydrate-Based Anticancer Vaccine. ACS Chem Biol. 2015. 16:
10(10): 2364-72.

81. Jester JV, Morishige N, BenMohamed L, Brown DJ, Osorio N, Hsiang C, Perng GC, Jones C,
Wechsler SL. Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent
Herpes Stromal Keratitis. Cornea. 2016. 35(1): 81-8.

82. Jiang X, Brown D, Osorio N, Hsiang C, BenMohamed L, Wechsler SL. Increased neuro-virulence
and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative
mutant dLAT2903 with a disrupted LAT miR-H2. Journal of NeuroVirology. 2016. 22(1): 38-49.

83. Perng GC, Osorio N, Jiang X, Geertsema R, Hsiang C, Brown D, BenMohamed L, Wechsler SL.
Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in
Stressed Rabbits Latently Infected with Herpes Simplex Virus. Current Eye Research. 2016. 41(3):
284-91.

84. Srivastava R, Dervillez X, Khan AA, Chentoufi AA, Chilukuri S, Shukr N, Fazli Y, Ong NN, Afifi RE,
Osorio N, Geertsema R, Nesburn AB, Wechsler SL, & BenMohamed L. The Herpes Simplex Virus
LAT Gene is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells
Retained Within The Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits. The Journal
of Virology. 2016. 90(8): 3913-28.

85. Planès R, Ben Haij N, Leghmari K, Serrero M, BenMohamed L, Bahraoui E. HIV-1 Tat Protein
Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and
Interleukin-10 in Human Monocytes. The Journal of Virology. 2017. 90 (13): 5886-98.

86. Srivastava, R; Khan, AA.; Garg, S.; Syed, S.A.; Vahed, H.; Pham, T.; Yu, H.T; Nesburn, A.B., &
BenMohamed, L. Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus
Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory
CD44highCD62LlowCD8+ TEM Cells and Protect “Humanized” HLA-A*02:01 Transgenic Mice Against
Ocular Herpes. The Journal of Virology. 2017. 3; 91 (2).

87. Nalbandian, A., Khan, AA. Srivastava, R., Llewellyn, KJ., Tan, B., Shukr, N., Fazli Y., Kimonis, V.E.,
& BenMohamed L. Activation of the NLRP3 Inflammasome is Associated with Valosin Containing
Protein Myopathy. Inflammation. 2017. 40(1): 21-41.

88. Agrawal S, Srivastava R, Rahmatpanah F, Madiraju C, BenMohamed L, Agrawal A. Airway
epithelial cells enhance the immunogenicity of human myeloid dendritic cells under steady
state. Clin Exp Immunol. 2017 Sep;189(3):279-289. doi: 10.1111/cei.12983. Epub 2017 May 22.
PMID: 28470729

89. Nesburn AB, BenMohamed L. A Tribute to Professor Steven L. Wechsler (1948-2016): The Man
and the Scientist. Curr Eye Res. 2017. 42(1):161-162.

90. Srivastava; R., Khan A.A., Sravya Chilukuri; Sumit Garg; David C. Yu; Hawa Vahed; Lei Huang;
Sabrina A. Syed; Julie N. Furness; Tien T Tran; Nesburn B. Anthony; John Sidney; Alessandro
Sette; Randolph J. Noelle; & BenMohamed L. CXCL10/CXCR3-Dependent Mobilization of HSVSpecific
CD8+ TEM and CD8+ TRM Cells within Latently Infected Trigeminal Ganglia Tissue Allows
Efficient Protection Against Virus Shedding and Recurrent Ocular Herpetic Disease. The Journal
of Virology. 2017. 26; 91(14).

91. Khan A.A., Srivastava; R., Aziz A. Chentoufi; Elizabeth Kritzer; Sravya Chilukuri; Sumit Garg; David
C. Yu; Hawa Vahed; Lei Huang; Sabrina A. Syed; Julie N. Furness; Tien T Tran; Nesburn B. Anthony;
John Sidney; Alessandro Sette; Randolph J. Noelle; & BenMohamed L. Bolstering the Number of
Functional HSV-Specific Asymptomatic CD8+ TEM and TRM cells in Latently Infected Trigeminal
Ganglia Through Genome Wide-Derived HSV-1 Human Epitopes/CXCL10-Based Prime/Pull
Therapeutic Vaccine Reduces Recurrent Ocular Herpes Infection and Disease. Journal of
Immunology. 2017. 199(1):186-203.

92. Lopes PP, Todorov G, Pham TT, Nesburn AB, Bahraoui E & BenMohamed, L. Laser Adjuvant
Assisted Peptide Vaccine Promotes Skin Mobilization of Dendritic Cells and Enhances Protective
CD8+ TEM and TRM Cell Responses Against Herpes Infection and Disease. The Journal of
Virology. 2018 Mar 28;92(8). pii: e02156-17. doi: 10.1128/JVI.02156-17. Print 2018 Apr 15.
PMID: 29437976

93. Esteves, PJ.; Abrantes J.; Baldauf HM.; BenMohamed L.; Chen, Y.; Christensen, N.; González-
Gallego, J.; Giacani, L.; Hu, J.; Kaplan, G.; Keppler, OT.; Knight, KL.; Kong, XP.: Lanning, DK.; Le
Pendu, J.; Lemos de Matos, A.; Liu J.; Liu S.; Lopes, AM.; Lu, S.; Lukehart, S.; Manabe, YC.; Neves,
F.; McFadden, G.; Pan, R.; Peng, X.; Tuñón, PM.; van der Loo , W.; Vaine, M.; Via, LE.; Wang S.; & Mage., R. The wide utility of rabbits as models of human diseases. Experimental & Molecular
Medicine. 2018, July. 22;50(5):66.

94. Khan A.A., Srivastava; R.; Vahed H; Roy S; Walia SS; Kim GJ; Fouladi MA; Yamada T; Ly V; Lam C;
Lou A; Nguyen V; Boldbaatar U; Geertsema R; Fraser NW & BenMohamed L. Human
Asymptomatic Epitope Peptides/CXCL10-Based Prime/Pull Vaccine Induces HSV-Specific IFN-
+CD107+CD8+ T Cells that Infiltrate the Cornea and Trigeminal Ganglia of Humanized HLA
Transgenic Rabbits and Protect Against Ocular Herpes Challenge. The Journal of Virology.

95. Srivastava R, Hernández-Ruiz M, Khan AA, Fouladi MA, Kim GJ, Ly VT, Yamada T, Lam C, Sarain
SAB, Boldbaatar U, Zlotnik A, Bahraoui E, BenMohamed L. CXCL17 Chemokine-Dependent
Mobilization of CXCR8+CD8+ Effector Memory and Tissue-Resident Memory T Cells in the Vaginal
Mucosa Is Associated with Protection against Genital Herpes. J Immunol. 2018 Apr
15;200(8):2915-2926. doi: 10.4049/jimmunol.1701474. Epub 2018 Mar 16. PMID: 29549178.

96. Planès R, Serrero M, Leghmari K, BenMohamed L, Bahraoui E. HIV-1 Envelope Glycoproteins
Induce the Production of TNF-a and IL-10 in Human Monocytes by Activating Calcium Pathway.
Scientific Report. 2018 Nov 21;8(1):17215. doi: 10.1038/s41598-018-35478-1. PMID: 30464243.

97. Srivastava R, Coulon PG, Roy S, Chilukuri S, Garg S, BenMohamed L. Phenotypic and Functional
Signatures of Herpes Simplex Virus-Specific Effector Memory CD73+CD45RAhighCCR7lowCD8+ TEMRA
and CD73+CD45RAlowCCR7lowCD8+ TEM Cells Are Associated with Asymptomatic Ocular Herpes.
Journal of Immunology. 2018. 199(1):186-203. PMID: 30201808.

98. Vahed H, Agrawal A, Srivastava R, Prakash S, Coulon PA, Roy S, BenMohamed L. Unique Type I
Interferon, Expansion/Survival Cytokines, and JAK/STAT Gene Signatures of Multifunctional
Herpes Simplex Virus-Specific Effector Memory CD8+ TEM Cells Are Associated with Asymptomatic
Herpes in Humans. The Journal of Virology. 2018 Feb 5; 93(4). pii: e01882-18. doi:
10.1128/JVI.01882-18.. PMID: 30487281.

99. Roy S, Coulon PG, Srivastava R, Vahed H, Kim GJ, Walia SS, Yamada T, Fouladi MA, Ly VT,
BenMohamed L. Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic
Vaccination Restore the Function of Tissue-Resident Anti-viral CD8+ T Cells and Protect Against
Recurrent Ocular Herpes Simplex Infection and Disease. Frontiers Immunology. 2018 Dec 17.
PMID: 30619285.

100. Srivastava R, Roy S, Coulon PG, Vahed H, Prakash S, Dhanushkodi N, Kim GJ, Fouladi MA, Campo
J, Teng AA, Liang X, Schaefer H, BenMohamed L. Therapeutic Mucosal Vaccination of Herpes
Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts
Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated
with Protection against Recurrent Genital Herpes. The Journal of Virology. 2019 Apr 17 ;93(9).
PMID: 30787156.

101. Roy S, Coulon PG, Prakash S, Srivastava R, Geertsema R, Dhanushkodi N, Lam C, Nguyen V,
Gorospe E, Nguyen AM, Salazar S, Alomari NI, Warsi WR, BenMohamed L. Blockade of PD-1 and
LAG-3 Immune Checkpoints Combined with Vaccination Restores the Function of Antiviral Tissue-
Resident CD8+ TRM Cells and Reduces Ocular Herpes Simplex Infection and Disease in HLA
Transgenic Rabbits. The Journal of Virology. 2019 Feb 5; In Press. PMID: 31217250

102. Coulon PG, Dhanushkodi N, Prakash S, Srivastava R, Roy S, Alomari NI, Nguyen AM, Warsi WR, Ye
C, Carlos-Cruz EA, Mai UT, Cruel AC, Ekmekciyan KM, Pearlman E, BenMohamed L. NLRP3,
NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-
1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease. Frontiers

103. Unique Type I Interferon, Expansion/Survival Cytokines, and JAK/STAT Gene Signatures of
Multifunctional Herpes Simplex Virus-Specific Effector Memory CD8+ T EM Cells Are Associated
with Asymptomatic Herpes in Humans. Hawa Vahed, Anshu Agrawal, Ruchi Srivastava, Swayam
Prakash, Pierre-Gregoire A Coulon, Soumyabrata Roy,& BenMohamed L. The Journal of Virology.
2020. In press PMID: 31477581.

104. Mzoughi O, Teixido M, Planès R, Serrero M, Hamimed I, Zurita E, Moreno M, Granados G, Lakhdar-
Ghazal F, BenMohamed L., Giralt E, Bahraoui E. Trimeric Heptad Repeat Synthetic Peptides HR1
and HR2 Efficiently Inhibit HIV-1. Entry. Biosci Rep. 2019 Sep 2; In press PMID: 31477581.

105. Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall
Multifunctional Effector Memory CD4 + T EM Cells in Asymptomatic Individuals and Protect from
Ocular Herpes Infection and Disease in "Humanized" HLA-DR Transgenic Mice. Ruchi Srivastava
1, Pierre-Gregoire A Coulon, Swayam Prakash, Nisha R Dhanushkodi, Soumyabrata Roy, Angela
M Nguyen, Nuha I Alomari, Uyen T Mai, Cassendra Amezquita, Caitlin Ye, Bernard Maillère,&
BenMohamed L. The Journal of Virology. 2020. In press PMID: 31477581.

106. High Frequency of Gamma Interferon-Producing PLZF lo ROR?t lo Invariant Natural Killer 1 Cells
Infiltrating Herpes Simplex Virus 1-Infected Corneas Is Associated with Asymptomatic Ocular
Herpesvirus Infection. Nisha R Dhanushkodi, Ruchi Srivastava, Swayam Prakash, Soumyabrata
Roy, Pierre-Gregoire A Coulon, Hawa Vahed, Angela M Nguyen, Stephanie Salazar, Lan Nguyen,
Cassandra Amezquita, Caitlin Ye, Vivianna Nguyen, & BenMohamed L. The Journal of
Immunology. 2020. In press PMID: 31477581.

107. Up-Regulation of Multiple CD8+ T Cell Exhaustion Pathways is Associated to Recurrent Herpes
Simplex Virus Type 1 Infection. Pierre-Grégoire Coulon; Soumyabrata Roy; Swayam Prakash;
Ruchi Srivastava; Nisha Dhanushkodi; Stephanie Salazar; Cassandra Amezquita; Lan Nguyen;
Hawa Vahed; Angela M. Nguyen; Wasay R. Warsi; Caitlin Ye; Edgar A. Carlos-Cruz; Uyen T. Mai &
BenMohamed L. The Journal of Immunology. 2020. In press PMID: 31477581.

108. Genome-Wide B Cell, CD4 +, and CD8 + T Cell Epitopes That Are Highly Conserved between
Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Preemptive
Pan-Coronavirus Vaccines. Swayam Prakash, Ruchi Srivastava, Pierre-Gregoire Coulon, Nisha R
Dhanushkodi, Aziz A Chentoufi , Delia F Tifrea, Robert A Edwards, Cesar J Figueroa, Sebastian D
Schubl, Lanny Hsieh, Michael J Buchmeier, Mohammed Bouziane, Anthony B Nesburn, Baruch D
Kuppermann & BenMohamed L. BioRvix. 2020. In press

109. Unique molecular signatures of antiviral memory CD8+ T cells associated with asymptomatic
recurrent ocular herpes. Swayam Prakash, Soumyabrata Roy, Ruchi Srivastava, Pierre-Gregoire
Coulon, Nisha R Dhanushkodi, Hawa Vahed, Allen Jankeel, Roger Geertsema, Cassandra
Amezquita, Lan Nguyen, Ilhem Messaoudi, Amanda M Burkhardt & BenMohamed L. Scientific
Report. 2020. In press

110. Healing of Ocular Herpetic Disease Following Treatment with an Engineered FGF-1 is Associated
with Increased Corneal Anti-Inflammatory M2 Macrophages. Nisha R Dhanushkodi, Ruchi
Srivastava, Pierre-Gregoire A. Coulon, Swayam Prakash, Soumyabrata Roy, Didier Bagnol, Eveleth,
D. David, & BenMohamed L. Frontiers in Immunology. 2021. In press

111. Genome-Wide B Cell, CD4 +, and CD8 + T Cell Epitopes That Are Highly Conserved between
Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Targets for Preemptive Pan-
Coronavirus Vaccines. Swayam Prakash, Ruchi Srivastava, Pierre-Gregoire Coulon, Nisha R
Dhanushkodi, Aziz A Chentoufi , Delia F Tifrea, Robert A Edwards, Cesar J Figueroa, Sebastian D
Schubl, Lanny Hsieh, Michael J Buchmeier, Mohammed Bouziane, Anthony B Nesburn, Baruch D
Grant
Current Grant Funding 1. RO1 Grant from National Institute of Health (NIH). Development of a Pan-Coronavirus Vaccine. R01 AI158060-01. August 1, 2020 to July 31, 2025. (Principal Investigator, Lbachir BenMohamed): $3,700,000,00. 2. RO1 Grant from National Institute of Health (NIH). Mucosal Chemokines and CD8+ T Cell Immunity to Genital Herpes. R01 AI143348. August 1, 2019 to July 31, 2024. (Principal Investigator, Lbachir BenMohamed): $2,440,000,00. 3. RO1 Grant from National Institute of Health (NIH). A Novel Prime/Pull Therapeutic Vaccine Strategy to Prevent Recurrent Genital Herpes. R01150091-01. August 1, 2018 to July 31, 2024. (Principal Investigator, Lbachir BenMohamed): $2,549,500,00. 4. RO1 Grant from National Institute of Health (NIH). Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits. R01EY019896-01. August 1, 2010 to July 31, 2021. (Principal Investigator, Lbachir BenMohamed): $2,052,500,00. 5. RO1 Grant from National Institute of Health (NIH). Mechanisms of CD8+ T Cell Dynamics in Recurrent Ocular Herpetic Disease. R01EY026103-01A1. August 1, 2016 to July 31, 2021. (Principal Investigator, Lbachir BenMohamed): $1,947,000,00. 6. RO1 Grant from National Institute of Health (NIH). Blockade of T-Cell Co-Inhibitory Pathways & Immunotherapy to Prevent Ocular Herpes. R01EY024618-01. September 30, 2014 to July 31, 2018. (Principal Investigator, Lbachir BenMohamed): $1,950,500,00. 7. R21 Grant from National Institute of Health (NIH). LAT-HVEM Interactions Effect Hsv-1 Latency/Reactivation. R21AI110902-02. May 31, 2013 to June 31, 2017. (Principal Investigator, Lbachir BenMohamed): $450,000,00. 8. Business Pharmaceutical Grant (Redbiotec AG, Switzerland). Pre-clinical Vaccine Efficacy study of 12 Novel HSV-2 Tegument and Capsid Proteins in Guinea Pig Genital Herpes Model. August 1, 2016 to July 31, 2017. (Principal Investigator, Lbachir BenMohamed): $152,128,00. 9. SBIR Grant from National Institute of Health (NIH). LAT-HVEM Interactions Effect Hsv-1 Latency/Reactivation. R43AI124911-01. July 15, 2016 to June 31, 2018. (Principal Investigator, Xiaowu Liang and Co-Principal Investigator, Lbachir BenMohamed): $450,000,00. 10. T32 Grant from National Institute of Health (NIH). Immunology Research Training Program. Institute for Immunology. T32AI060573. June 1, 2010 to August 31, 2016. (Principal Investigator, Eric Pearlman): $837,000,00. 11. SBIR Grant from National Institute of Health (NIH). A NOVEL SELF-ASSEMBLING PROTEIN NANOPARTICLES-BASED GENITAL HERPES VACCINE. R41AI138764-01. Feb 1, 2018 to January 31, 2019. (Principal Investigator, Lbachir BenMohamed): $450,000,00. 12. Business Pharmaceutical Grant (Trefoil Therapeutics, Inc., San Diego). Pre-clinical Efficacy of TTHX1114 on Herpetic Keratopathy Using Mouse Models of Primary and Recurrent Ocular Herpetic Disease. Feb 1, 2018 to June 30, 2019. (Principal Investigator, Lbachir BenMohamed): $262,885,00. Pending Grant Funding 1. R01 Grant. Nat
Professional Societies
American Association of Immunologists (AAI)
Association for Research in Vision and Ophthalmology (ARVO)
American Society for Microbiology (ASM)
American Association for Cancer Research (AACR)
Other Experience
Founder
Micro Antigens Technologies, LLC 2007—Pres

Graduate Programs
Immunology and Pathogenesis

Last updated
10/04/2021