MariaCristina Kenney MD,PhD

picture of MariaCristina  Kenney

Professor in Dept. of Ophthalmology Research, The Gavin Herbert Eye Institute
School of Medicine

Director of Mitochondrial Research, The Gavin Herbert Eye Institute
School of Medicine


M.D., University of California, Los Angeles, CA, 1987, Medicine
Ph.D., University of Arizona, College of Medicine, Tucson, Arizona, 1978, Anatomy
Post-doctoral fellowship, University of Southern California, Los Angeles, CA
Internship, Cedars-Sinai Medical Center, Los Angeles, CA
Residency, White Memorial Hospital/Loma Linda University affiliate, Los Angeles, CA

Phone: (949) 824-7603
Fax: (949) 824-9626
Email: mkenney@uci.edu

University of California, Irvine
Gavin Herbert Eye Institute
843 Health Sciences Rd.
Rm. 2028
Mail Code: 4390
Irvine, CA 92697
Research Interests
Age-related macular degeneration, AMD, mitochondrial genetics, Keratoconus, KC
Academic Distinctions
AS A GRADUATE STUDENT:
University of Arizona, Society of Sigma Xi, 1973.
University of Arizona, Society of Sigma Xi, 1974.
University of Arizona, Society of Sigma Xi, 1976.
University of Arizona Foundation Award for Meritorious Performance in Teaching, 1976.

AS A MEDICAL STUDENT:
Emil Bogan Research Prize for Outstanding Research as a Medical Student, 1987, University of California, Los Angeles.
Solomon Scholar Award for Medical Research, 1988, Cedars-Sinai Medical Center and University of California, Los Angeles.
Solomon Scholar Award for Medical Research, 1989, Cedars-Sinai Medical Center and University of California, Los Angeles.
Paul Rubenstein Award for Research, 1989, Cedars-Sinai Medical Center, Los Angeles.

AS A FACULTY MEMBER:
Kaiser Permanente Award for Excellence in Teaching, 1980, Univ of California, Davis.
Invited speaker at the ARVO Protease Symposium, 1993, Sarasota .FL.
Everett Kinsey Lecture presented at 1999 CLAO Annual Meeting, Las Vegas NV.
Whitney Sampson Invited Speaker 2006, CLAO Annual Meeting, Las Vegas, NV.
Global Keratoconus International Meeting 2007, Invited Speaker, Las Vegas, NV
Research Abstract
Mitochondrial Genetics in Age-related Macular Degeneration – We have used molecular and biochemical studies to identify the role of mitochondria in the development and progression of age-related macular degeneration (AMD). We discovered that retinas from AMD patients had several genetic mitochondrial DNA (mtDNA) defects and that their mitochondria were highly damaged compared to normal retinas. When mitochondria are damaged then energy production is decreased and the cell can undergo apoptosis or programmed cell death. My laboratory uses the transmitochondrial cybrid (cytoplasmic hybrid) model, where all cells have identical nuclei, but differ in their mtDNA content to compare mitochondria from AMD versus age-matched normal subjects. We find that the cybrids containing AMD mitochondria have higher levels of apoptosis, autophagy and inflammation compared to the normal cybrids. These degenerative pathways can be blocked by treatment with humanin-G, a mitochondrial derived peptide. Our cybrid model allows us to identify important mitochondria-targeting drugs and peptides to treat age-related retinal diseases.

Role of Mitochondria in Ethnic/Racial Susceptibility Differences to Diseases and Responses to Medications – African-origin populations are more susceptible to diabetes and other age-related diseases compared to European-origin populations, but mechanisms for the differential susceptibility remain unknown. Human mitochondrial (mt) DNA haplogroups, as defined by accumulations of single nucleotide polymorphisms (SNPs), are maternally inherited ancient polymorphisms representing geographic origins of populations. Several studies have shown that Type 2 diabetes and its complications can be linked to mtDNA haplogroup subsets. In the past, it has been difficult to assign functional consequences to the different mtDNA haplogroups. However, my laboratory can now be addresses this question using the transmitochondrial cybrid (cytoplasmic hybrid) model, where all cells have identical nuclei, but differ in their mtDNA content. Our studies provide evidence that cybrids containing African-origin (L) haplogroup mtDNA have significantly different bioenergetic profiles, production levels of reactive oxygen species, and expression levels for complement, inflammation, apoptosis, WNT pathway and diabetes-related genes compared to the European-origin H cybrids. Our findings support the hypothesis that an individual’s mtDNA haplogroup background acts as a “modifier” for the expression of diabetes-related genes, thereby contributing to the ethnic/racial disparities associated with Type 2 diabetes and its complications.

Keratoconus Research – We have also applied the mitochondrial medicine approach to the corneal disease called keratoconus (KC). My laboratory has demonstrated that KC corneas and cultured cells have signs of oxidative damage including damage to the mitochondrial DNA (mtDNA), altered levels of antioxidant enzymes, and accumulations of cytotoxic reactive oxygen/nitrogen species (ROS/RNS). In addition the isolated, cultured KC cells show an increased sensitivity to oxidative stress and cannot eliminate the cytotoxic elements as efficiently as age-matched normal corneal cells. These data support Dr. Kenney’s overall hypothesis that oxidative stress, including mitochondrial damage and ROS/RNS production, are factors that may contribute to development and progression of keratoconus.
Available Technologies
Publications
176. 2021 Singh L, Atilano SR, Jager MJ, and Kenney MC. Mitochondrial DNA polymorphisms and biogenesis genes in primary and metastatic uveal melanoma cell lines. Cancer Genetics. In Press. (Impact factor 3.1)
 
175. 2021 Hamid MA, Moustafa MT, Nashine S, Donato-Costa R, Schneider K, Atilano SR, Kuppermann BD, and Kenney MC. Anti-VEGF drugs influence epigenetic regulation and AMD-specific molecular markers in ARPE-19 cells. Cells MDPI. Apr; 10(4): 878. Published online 2021 Apr 12. doi: 10.3390/cells10040878. PMCID: PMC8069662. (Impact factor 4.366)
 
174. 2021 Yu JJ, Azzam D, Chwa M, Schneider K, Cho JH, Hsiang C, Klassen H, Kenney MC and Yang J. Age-related macular degeneration (AMD) transmitochondrial cybrids protected from cellular damage and death by human retinal progenitor cells (hPRCs). Stem Cells International. 6655372. Doi:10. 1155/2021/6655372. PMCID: PMC7886532. (Impact factor 3.873)
 
173. 2021 Atilano SR, Udar N, Satalich T, Chwa M, Kenney MC. Low frequency mitochondrial DNA heteroplasmy SNPs in blood, retina and choroid of age-related macular degeneration subjects. PLoS One. 16(1): e0246114. doi: 10.1371/
journal.pone.0246114. PMCID: PMC7846006 (Impact factor 3.5)
 
172. 2020 Nashine S and MC Kenney. Effects of Mitochondrial-Derived peptides (MDPs) on mitochondrial and cellular health in AMD. Cells. 9, 1102; doi:10.3390/cells9051102 (impact factor 4.366)
 
171. 2020 Nicholson C, Ishii M, Annamalai B, Chandler K, Chwa M, Kenney MC, Shah N, Rohrer B. J or H mtDNA haplogroups in retinal pigment epithelial cells: Effects on cell physiology, cargo in extracellular vesicles, and differential uptake of such vesicles by naïve recipient cells. BBA General Subjects. 8:129798. doi: 10.1016/j.bbagen.2020.129798. Online ahead of print. PMID: 33217521. (Impact factor 3.42)
 
170. 2020 Schneider K, Chwa M, Atilano SR, Shao Z, Park J, Karageozian H, Karageozian V, Kenney MC. Differential effects of Risuteganib and Bevacizumab on AMD cybrid cells. Experimental Eye Research. Oct 16:108287. doi: 10.1016/ j.exer.2020.108287. Online ahead of print. PMID: 33075294 (Impact factor 3.3)
 
169. 2020 Singh L, Singh MK, Kenney MC, Jager MJ, Rizvi MA, Meel R, Neiwete L, Bakhshi S, Sen S, Kashyap S. Prognostic significance of PD-1/PD-L1 expression in Uveal Melanoma: Correlation with tumor-infiltrating lymphocytes and clinicopathological parameters. Cancer Immunology, Immunotherapy. doi: 10.1007/s00262-020-02773-8. (Impact factor 5.44)
 
168. 2020 Mehta U, Diep A, Nguyen K, Le B, Yuh C, Frambach C, Doan J, Wei A, Palma A, Farid M, Garg S, Kedhar S, Wade M, Jameson KA, Kenney MC, Browne AW. Quantifying Color Vision Changes Associated with Cataracts Using Cone Contrast Thresholds. Transl Vis Sci Technol. 2020 Nov; 9(12): 11. Published online 2020 Nov 3. doi: 10.1167/tvst.9.12.11. PMCID: PMC7645251. (Impact factor 2.5)
 
167. 2020 Neekhra A, Tran J, Riazi P, Pham K, Chwa M, Luthra S, Gramajo AL, Seigel GM, Kuppermann BD, Kenney MC. Inhibition of 7-Ketocholesterol-induced apoptosis in retinal pigment epithelial cells and neurosensory retinal cells. Journal of Vision Research. 25;15(4):470-480. doi: 10.18502/jovr.v15i4.7781. eCollection 2020 Oct-Dec. PMID: 33133437 (Impact factor 2.178)
 
166. 2020 Abedi S, Yung G, Atilano SR, Thaker K, Chang S, Chwa M, Udar N, Bota D, Kenney MC. The anti-cancer drug, cisplatin, has differential effects on cybrid cells with varying mitochondrial DNA haplogroups. PeerJ. Oct 1;8:e9908. doi: 10.7717/peerj.9908. eCollection 2020. PMID: 33062421. (Impact factor 2.353)
 
165. 2020 Ali Pour P, Kenney MC, Kheradvar A Bioenergetic consequences of mitochondrial transplantation in cardiomyocytes. Journal American Heart Association. Apr 7;9(7):e014501. PMID: 32200731. doi: 10.1161/JAHA.119.014501. (Impact factor 4.5)
 
164. 2020 Salimiaghdam N, Singh L, Schneider K, Nalbandian A, Chwa M, Atilano SR, Bao A, Kenney MC. Potential adverse effects of ciprofloxacin and tetracycline on ARPE-19 cell lines. British Journal Ophthalmology. Open Ophthalmol. 2020 Jul 21;5(1):e000458. doi: 10.1136/bmjophth-2020-000458. eCollection 2020. PMID: 32724857. (Impact factor 3.8)
 
163. 2020 Nashine S, Kenney MC. Further understanding of epigenetic dysfunction of the retinal pigment epithelium in AMD. Expert Review of Ophthalmology. doi: 10.1080/17469899.2020.1767597. (Impact factor 0.76)
 
162. 2020 Jameson KA, Satalich TA, Joe KC, Bochko VA, Atilano SR, Kenney MC. Human color vision and tetrachromacy. Cambridge Elements HSS1. In Press.
 
161. 2020 Nashine S, Kenney MC. Role of Citicoline in an in vitro AMD model. Aging (Albany NY). May 29;12(10):9031-9040. doi: 10.18632/aging.103164. Epub 2020 May 29. PMID: 32470946. (Impact factor 5.15)
 
160. 2020 Atilano SR, Kenney MC, Briscoe AD, Jameson KA. Two-step method for identifying photopigment opsin and rhodopsin gene sequences underlying human color vision phenotypes. Molecular Vision Mar 5;26:158-172 eCollection 2020. PMID:32180681. PMCID: 7058431 (Impact factor 2.2)
 
159. 2020 Nashine S, Nesburn AB, Kuppermann BD, Kenney MC. Role of Resveratrol in transmitochondrial AMD RPE cells. Nutrients Jan 6;(12(1). Pii: E159. Doi: 10.3390/nu 12010259. PMID: 31935891. (Impact factor 4.17)
 
158. 2020 Caceres-del-Carpio J, Moustafa MT, Toledo-Corral J, Hamid MA, Atilano SR, Schneider K, Fukuhara P, Rodrigo Donato-Costa R, Norman L, Malik D, Chwa M, Boyer D, Limb AG, Kenney MC, Kuppermann BD. In vitro response and gene expression of human retinal Müller cells treated with different anti-VEGF drugs. Experimental Eye Research Feb;191:107903. doi: 10.1016/j.exer.2019.107903. Epub 2020 Jan 3. PMID:31904361. (Impact factor 3.3)
 
157. 2020 Dolinko AH, Chwa M, Atilano SR, Kenney MC. African and Asian mitochondrial DNA haplogroups confer resistance against diabetic stresses on retinal pigment epithelial cybrid cells in vitro. Molecular Neurobiology Mar;57(3):1636-1655. doi: 10.1007/s12035-019-01834-z. Epub 2019 Dec 6. . (Impact factor 4.2)
 
156. 2019 Salimiaghdam N, Riazi-Esfahani M, Fukuhara PS, Schneider K, Kenney MC. Age-related macular degeneration (AMD): A review on its epidemiology and risk factors. The Open Ophthalmology Journal. Nov. 13:90-99. TOOPHTHJ-13-90. doi: 10.2174/1874364101913010090. (Impact factor 0.57)
 
155. 2019 Gabriel R, Toledo J, Kenney MC, Mehta M. A Prospective Study on Hereditary Bias of Age-Related Macular Degeneration". Journal of VitreoRetinal Diseases. SAGE (jvrd.sagepub.com). vol 3(2) 90-93. doi: 10:1177/2474126418822890. (Impact factor – not ranked-open access)
 
154. 2019 Nashine S, Sudhakar RS, Chwa M, Nesburn AB, Kuppermann BD, Federoff H, Kenney MC., PU-91 drug rescues human age-related macular degeneration RPE cells; Implications for AMD therapeutics. Aging (Albany NY). Sep 2;11(17):6691-6713. doi: 10.18632/aging.102179. Epub 2019 Sep 2. PMID: 31477635. (Impact factor 5.51)
 
153. 2019 Patel TH, Norman L, Chang S, Abedi S, Liu C, Chwa M, Atilano SR, Thaker K, Lu S, Jazwinski SM, Miceli MV, Udar N, Bota D, Kenney MC. European mtDNA variants are associated with differential responses to cisplatin, an anticancer drug: Implications for drug resistance and side effects. Frontiers of Oncology 9 Jul 19;9:640. doi: 10.3389/fonc.2019.00640. eCollection 2019. PMID:31380278 (Impact factor 4.6)
 
152. 2019 Nashine S, Nesburn AB, Kuppermann BD, Kenney MC. Age-related Macular Degeneration (AMD) mitochondria modulate epigenetic mechanisms in retinal pigment epithelial cells. Experimental Eye Research Jun 18:107701. doi: 10.1016/j.exer.2019.107701. [Epub ahead of print] PMID:31226340 (Impact factor 3.15)
 
151. 2019 Nashine S, Kanodia R, Nesburn AB, Soman G, Kuppermann BD, Kenney MC. Nutraceutical effects of Emblica officinalis in age-related macular degeneration.. Aging (Albany NY) Feb 21;11(4):1177-1188. doi: 10.18632/aging.101820. PMID: 30792375. (Impact factor 5.1)
 
150. 2019 Atilano SR, Lee DH, Fukuhara PS, Chwa M, Nesburn AB, Udar N, Kenney MC. Corneal oxidative damage in keratoconus cells due to decreased oxidant elimination from modified expression levels of SOD enzymes, PRDX6, SCARA3, CPSF3, and FOXM1. Journal Ophthalmic Vision Research Jan-Mar;14(1):62-70. doi: 10.4103/jovr.jovr_80_18. PMID: 30820289. (Impact factor 0.77)
 
149. 2018 Tsao SW, Gabriel R, Thaker K, Kuppermann BD, Kenney MC. Effects of Brimonidine on retinal pigment epithelial cells and Müller cells exposed to amyloid-Beta 1-42 peptide in vitro. Ophthalmic Surg Lasers Imaging Retina Oct 15;49(10):S23-S28. doi: 10.3928/23258160-20180814-04. PMID: 30339264. (Impact factor 1.27)
 
148. 2018 Hamid MA, Moustafa MT, Càceres-Del-Carpio J, Kuppermann BD, Kenney MC. Effects of antiangiogenic drugs on expression patterns of epigenetic pathway genes. Ophthalmic Surg Lasers Imaging Retina Oct 15;49(10):S29-S33. doi: 10.3928/23258160-20180814-05. PMID: 30339265. (Impact factor 1.27)
 
147. 2018 Sapkal AU, Nashine S, Mansoor S, Sharma VR, Ramirez CA, Migon RZ, Gupta NK, Chwa M, Kuppermann BD, Kenney MC. Protective effects of 17?-estradiol on Benzo(E)pyrene [B(e)P]-induced toxicity in ARPE-19 cells. Journal Ophthalmic Vision Research Oct-Dec;13(4):419-425. doi: 10.4103/jovr/jovr_16_18. PMID: 30479711. (Impact factor 0.77).
 
146. 2018 Nashine S, Cohen P, Nesburn AB, Kuppermann BD, Kenney MC. Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration. Scientific Reports Oct 11;8(1):15175. doi: 10.1038/s41598-018-33290-5. PMID:30310092 (Impact factor 4.6)
 
145. 2018 Vo AT, Abedi S, Schneider K, Chwa M, Kenney MC. Effects of bevacizumab, ranibizumab, and aflibercept on phagocytic properties in human RPE cybrids with AMD versus normal mitochondria. Experimental Eye Research Jul 30;177:112-116. doi: 10.1016/j.exer.2018.07.025. PMID: 30071215. (Impact factor 3.15)
 
144. 2018 Yu JJ, Lee Daniel H, Gallagher SP, Kenney MC, Boisvert CJ. Mitochondrial impairment in antibiotic-induced toxic optic neuropathies. Current Eye Research Jul 24:1-6. doi: 10.1080/02713683.2018.1504086. PMID: 30040491. (Impact factor 1.87)
 
143. 2017 Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nature Medicine Nov 27. doi: 10.1038/nm.4450. PMID:29176737. (Impact factor 13.03)
 
142. 2017 Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nature Medicine. 2017 Nov 27. doi: 10.1038/nm.4450. PMID:29176737
 
141. 2017 Udar N, Atilano SR, Boyer DS, Chwa M, Memarzadeh M, Langberg J, Nesburn AB, Hertzog D, Kenney MC. CKMT2 mutation in a patient with fatigue, age-related macular degeneration, deafness and atrial fibrillation. Biomed Genet Genomics, 2017 doi: 10.15761/BGG.1000133
 
140. 2017 Moustafa MT, Ramirez C, Schneider K, Atilano SR, Limb GA, Kuppermann BD, Kenney MC. Protective Effects of Memantine on Hydroquinone-Treated Human Retinal Pigment Epithelium Cells and Human Retinal Müller Cells. J Ocul Pharmacol Ther. 2017 Oct:33(8):610-619. doi: 10.1089/jop.2016.0129. PMID: 28961056. (Impact factor 1.42)
 
139. 2017 Riazi-Esfahani M, Kuppermann BD, Kenney MC. The Role of Mitochondria in AMD: Current Knowledge and Future Applications. J Ophthalmic Vis Res. 12(4):424-428. doi: 10.4103/jovr.jovr_182_17. PMID: 29090054. (Impact factor 0.77)
 
138. 2017 Nashine S, Cohen P, Chwa M, Lu S, Nesburn AB, Kuppermann BD, Kenney MC. Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis. 20;8(7):e2951. doi: 10.1038/cddis.2017.348. PMID:28726777
 
137. 2016 Nashine S, Chwa M, Kazemian M, Thaker K, Lu S, Nesburn AB, Kuppermann BD, Kenney MC. Differential expression of complement markers in Normal and AMD transmitochondrial cybrids. PLoS ONE. 2016 Aug 3;11 8:e0159828. doi: 10.1371. PMID: 27486856
 
136. 2016 Thaker K, ChwA M, Atilano SR, Coskun P, Cáceres-del-Carpio J, Udar N, Boyer DS, Jazwinski SM, Miceli MV, Nesburn AB, Kuppermann BD and Kenney MC. Increased expression of ApoE and protection from Amyloid-beta toxicity in transmitochondrial cybrids with haplogroup K mtDNA. Neurobiol Dis. 2016 Apr 21. pii: S0969-9961(16)30078-X. doi: PMID: 27109188
 
135. 2016 Gupta NK, Mansoor S, Sapkal AU, A Limb A, Kuppermann BD and Kenney MC. Effects of Benzo(e)Pyrene, a toxic component of cigarette smoke, on Muller Cells (MIO-M1) in vitro. New Front Ophthalmol, 2016 doi: 10.15761/NFO.1000124.
 
134. 2016 Kenney MC, Falatoonzadeh P, Atilano SR, Chwa M, Caceres-del-Carpio J, Malik D, Boyer DS, Nesburn AB and Kuppermann BD. African-origin mitochondrial DNA variants as a contributing factor to susceptibilities for diabetes and age-related diseases. Int J Diabetes Clin Res. 3:053. ISSN: 2377-3634
 
133. 2016 Ferrington DA, Kapphahn RJ, Leary MM, Atilano SR, Terluk MR, Karunadharma P, Chen GK, Ratnapriya R, Swaroop A, Montezuma SR, Kenney MC. Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration. Exp Eye Res. 145:269-277. doi: 10.1016 PMID: 26854823
 
132. 2016 Ramírez C, Cáceres-Del-Carpio J, Chu J, Chu J, Moustafa MT, Chwa M, Limb GA, Kuppermann BD, Kenney MC. Brimonidine can prevent in vitro Hydroquinone damage on retinal pigment epithelium cells and retinal Müller cells (MIO-M1). J Ocul Pharmacol Ther. 32(2):102-8. doi: 10.1089/jop.2015.0083. Epub 2015 Dec 1. PMID: 26624556
 
131. 2015 Mansoor S, Sharma A, Cáceres-del-Carpio J, Zacharias LC, Patil AP, Gupta N, Limb GA, Kenney MC, Kuppermann BD. Effects of light on retinal pigment epithelial cells, neurosensory retinal cells, and Müller cells treated with Brilliant Blue G. Clinical and Experimental Ophthalmology. Dec;43(9):820-9. doi: 10.1111. PMID: 26126999.
 
130. 2015 Atilano SR, Malik D, Chwa M, Cáceres-del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC. Mitochondrial DNA variants can mediate methylation status of inflammation, angiogenesis and signaling genes. Human Molecular Genetics. Aug 15;24(16):4491-503. doi: 10.1093/hmg/ddv173. Epub 2015 May 10. PMID: 25964427.
 
129. 2015 Nalbandian A, Llewellyn K, Gomez A, Walker N, Su H, Dunnigan A, Vesa J, Chwa M, Kenney MC, Kimonis VE. In vitro studies in VCP-associated multisystem proteinopathy suggest altered mitochondrial bioenergetics. Mitochondrion. 22:1-8. PMID: 25724235
 
128. 2014 Kuppermann BD, Zacharias LC, Kenney MC. Steroid differentiation: the safety profile of various steroids on retinal cells in vitro and their implications for clinical use (an American Ophthalmological Society thesis). Trans American Ophthalmology Society. Jul;112:116-41. PMID:25646032.
 
127. 2014 Malik D, Tarek M, Cáceres-del-Carpio J, Ramirez C, Boyer D, Kenney MC, Kuppermann BD. Safety profiles of anti-VEGF drugs: bevacizumab, ranibizumab, aflibercept and ziv-aflibercept on human retinal pigment epithelium cells in culture. British Journal Ophthalmology. Jun;98 Suppl 1:i11-16. PMID:24836865.
 
126. 2014 Malik D, Cáceres-del-Carpio J, Tarek M, Falatoonzadeh P, Hsu Y, Chwa M, Atilano SR, Ramirez C, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC. Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: Implications for retinal diseases. PLoS ONE. 11:9(2):e99003. PMID:24919117.
 
125. 2014 Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Cáceres-del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Vawter M, Jazwinski SM, Miceli M, Wallace DC, Udar N. Inherited mitochondrial DNA variants can affect complement, inflammation, and apoptosis pathways: Insights into mitochondrial-nuclear interactions. Human Molecular Genetics. 23(13):3537-51.PMID:24584571.
 
124. 2014 Mansoor S, Gupta N, Falatoonzadeh P, Kuppermann BD, Kenney MC. 2-Ethylpyridine, a cigarette smoke component, causes mitochondrial damage in human retinal pigment epithelial cells in vitro. Indian J Ophthalmol. 62(1):16-22. PMID:24492497
 
123. 2014 Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Cáceres-del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Micelli M, Wallace DC, Udar N. Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases. Biochim Biophys Acta. Molecular Basis for Disease. 1842(2):208-219. PMID:24200652
 
122. 2014 Sharma A, Patil JA, Estrago-Franco F, Mansoor S, Raymond V, Kenney MC, Kuppermann BD. Effects of triamcinolone acetonide on human trabecular meshwork cells in vitro. Indian J Ophthalmology 62(4):429-36. PMID:24817746
 
121. 2013 Kenney MC, Deborah A. Ferrington, Nitin Udar, Mitochondrial Genetics of Retinal Diseases. Retina 5th Edition. Editors: Stephen J. Ryan MD, Andrew P. Schachat MD, Charles P. Wilkinson MD, David R Hinton MD, Srinivas Sadda MD, Peter Wiedemann.
 
120. 2013 Zacharias LC, Damico FM, Kenney MC, Gasparin F, Acquesta FB, Ventura DF, Takahashi WY, Kuppermann BD. In vitro evidence for mycophenolic acid dose-related cytotoxicity in human retinal cells. Retina 33(10):2155-61. PMID:23615344
 
119. 2013 Chang M, Bany-Mohammed F, Kenney MC, Beharry KD. Effects of a superoxide dismutase mimetic on biomarkers of lung angiogenesis and alveolarization during hyperoxia with intermittent hypoxia. Am J Transl Res. 5(6):594-607.PMID:24093057
 
118. 2013 Ramírez C, Pham K, Estragó Franco MF, Chwa M, Limb A, Kuppermann BD, Kenney MC. Hydroquinone induces oxidative and mitochondrial damage to human retinal Müller cells (MIO-M1). Neurotoxicology. 39:102-108. . PMID:23994029
 
117. 2013 Luthra S, Sharma A, Dong J, Neekhra A, Gramajo AL, Seigel GM, Brown DJ, Kenney MC, Kuppermann BD. Effect of bevacizumab (AvastinTM) on mitochondrial function of in vitro retinal pigment epithelial, neurosensory retinal and microvascular endothelial cells. Indian J Ophthalmol. 61(12):705-10. PMID:24413824
 
116. 2013 Sharma A, Patil JA, Estrago-Franco F, Mansoor S, Raymond V, Kenney MC, Kuppermann BD. Effects of triamcinolone acetonide on human trabecular meshwork cells in vitro. Indian J Ophthalmol. In Press. PMID:24212220
 
115. 2013 Gupta N, Mansoor S, Sharma A, Sapkal A, Sheth J, Falatoonzadeh P, Kuppermann BD, Kenney MC. Diabetic Retinopathy and VEGF. Open Ophthalmol J. 7:4-10. PMID:23459241
Grants
2007-2008 Discovery Eye Foundation/ Lincy Foundation, “Genetics of Age-Related Macular Degeneration,” $250,000.
2008 Ko Family Foundation “Studies on Diabetic Retinopathy,” $10,000.
2008-2009 Discovery Eye Foundation/Isabel Horn Estate, Genetics of Age-Related Macular Degeneration,” $144,000.
2002-2006 Discovery Eye Foundation and Iris and B. Gerald Cantor Foundation, Aquaporins in Diabetic Retinopathy, $150,000 per year
2006-2007 Discovery Eye Foundation/Lincy Foundation, Genetics of Age-Related Macular Degeneration, $200,000
2006-2007 Discovery Eye Foundation/Pearle Vision Foundation, The Molecular Regulation of Aquaporins to Eliminate Diabetic Macular Edema, $16,000
2007-2008 Discovery Eye Foundation/ Lincy Foundation, Genetics of Age-Related Macular Degeneration, $250,000
2008 Ko Family Foundation, Studies on Diabetic Retinopathy, $10,000.
2008-2009 Discovery Eye Foundation/Isabel Horn Estate, Genetics of Age-Related Macular Degeneration, $144,000
2008-2010 Discovery Eye Foundation/Lincy Foundation, Advanced Genetic Analyses of Age-Related Macular Degeneration (AMD)—Focusing on Mitochondrial Genetic Defects, $356,000
2009-2010 Polly and Michael Smith Foundation, Studies on Age-Related Macular Degeneration (AMD), Co-PI’s - Kuppermann, Klassen and Kenney, $100,000
2010-2011 Beckman Initiative for Macular Research, Association of Mitochondrial Haplogroups with Age-related Macular Degeneration, $75,000
2010-2011 Discovery Eye Foundation/Sussman Foundation, Genetics of Age-Related Macular Degeneration (AMD), $50,000
2010-2011 Discovery Eye Foundation/ Argyros Foundation, Genetic Studies of Age-related Macular Degeneration, $5,000
2010-2011 Polly and Michael Smith Foundation, Studies on Age-Related Macular Degeneration (AMD), Kenney, $30,000
2010-2011 Beckman Initiative for Macular Research, Examining the Interaction between mtDNA Damage, Genetic Risk Factors, and Development of AMD, Kenney-collaborator, Deborah Ferrington - Principal investigator, $15,000
2010-2011 Research to Prevent Blindness, Medical Student Award for Janelle Marshall, $30,000
2011-2012 Polly and Michael Smith, Studies on Age-Related Macular Degeneration (AMD), $30,000
2012-2013 Discovery Eye Foundation, Genetics of Age-Related Macular Degeneration (AMD), $200,000
2013-2014 Discovery Eye Foundation, Genetics of Age-Related Macular Degeneration (AMD), $140,000
2013-2014 Beckman Initiative for Macular Research, Role of Mitochondria in Dry AMD. Kenney - Co-investigator. Kuppermann –Principal investigator, $100,000
2014-2018 Discovery Eye Foundation, private bequest, Genetics of Age-Related Macular Degeneration (AMD). $505,000
2013-2018 Polly and Michael Smith, Mitochondrial Dysfunction in Dry AMD. $120,000
2016-2018 Edith and Roy Carver Foundation, Screening Novel Therapies for the Dry Form of Age-related Macular Degeneration Using ‘Personalized’ Transmitochondrial Cybrids, $125,000
2016-2017 Research to Prevent Blindness, Medical Student Award for Thomas Vo, MS-III, Role of Mitochondrial-derived Peptide Humanin in Patients with Age-related Macular Degeneration, $30,000
2017 Ayala School of Medicine Pilot Award, Investigations of Human Photopigment Opsin Gene Variations and Age-related Macular Degeneration (AMD), $48,724
2019-2022 National Eye Institute, Protective Effects of Humanin on AMD Mitochondria, $1,180,250
2019-2023, National Eye Institute, Adaptation and Visual Coding, $1,772,928
2019-2021, Department of Defense, Mitochondrial Variance in Systemic Lupus Erythematosus (SLE): Understanding Mitochondrial Regulation via Cytoplasmic Hybrid Cell Lines, $150,000
2020-2025, National Institute of Neurological Disorders & Stroke, Targeting of Mitochondrial Lon Protease as a Novel Therapy for Glioblastoma, $2,072,690
Professional Societies
Association for Research in Vision and Ophthalmology
American Academy of Ophthalmology,
Los Angeles County Women’s Medical Association –
Women in Ophthalmology
LA Research Study Club
Contact Lens Association of Ophthalmologists (CLAO)
Orange County Society of Ophthalmology
Other Experience
Adjunct Associate Professor
Dept. of Anatomy and Cell Biology, UCLA Medical School, Los Angeles, CA 1993—1997

Board Member - Research Director
Discovery Eye Foundation 1985—Pres

Research Scientist II – IV (equivalent to full professor)
Cedars-Sinai Medical Center, Los Angeles, CA 1985—2002

Half-time Research Associate
Department of Anatomy, School of Medicine, University of California, Davis 1983—1985

Assistant Professor
Department of Anatomy, School of Medicine, University of California, Davis 1978—1983

Lecturer II, Department of Anatomy,
School of Medicine, University of California, Davis, CA 1977—1978

Professor, Department of Ophthalmology,
School of Medicine, UC Irvine, CA 2002—pres

Research Center
Gavin Herbert Eye Institute
Last updated
10/04/2021