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Craig Vernon Smith

picture of Craig Vernon Smith

Division of Transplantation, Surgery
School of Medicine
Associate Clinical Professor, Surgery
School of Medicine

M.D., UCLA School of Medicine, 1986


B.S., U.C.R., 1983, Biomedical Sciences, Honors

Phone: (714) 456-8441
Fax: (714) 456-8796
Email: cvsmith@uci.edu

University of California, Irvine
333 City Blvd. West
City Tower, Suite 1205
Mail Code: 5375
Irvine, CA 92697
Research Interests
kidney transplantation islet cells
Academic Distinctions
AWARDS/HONORS:

1993 Outstanding Young Alumnus, University of Calif. Riverside.
July 1991-1992 Individual National Research Service Award
July 1989-1991 Biotechnology Fellowship, National Cancer Institute
1983 Honors, University of California, Riverside
1982 Student Research Commendation, American Heart Association
Publications
RESEARCH PAPERS (PEER REVIEWED)

1. Gardin JM, Tobis JM, Dabestani A, Smith C, Elkayam U, Castleman E, White D, Allfie A, Henry WL. Superiority of two dimensional measurement of aortic vessel diameter in Doppler echocardiographic estimates of left ventricular stroke volume. Journal of the American College of Cardiology 1985;6:66 74.

2. Smith C, Butler J, Cobb C, State D. Fine needle aspiration cytology in the diagnosis of primary breast cancer. Surgery 1988;103:178 183.

3. Smith C, Butler J. Efficacy of directed fine needle aspiration cytology in the diagnosis of intra abdominal masses. Archives of Surgery 1988;123:820 824.

4. Butler JA, Smith C. Fine needle aspiration biopsy in the diagnosis of recurrent and metastatic intraabdominal malignancies. American Journal of Surgery 1989;158:589 592.

5. Smith C, Butler JA. Colorectal cancer in patients younger than forty years of age. Diseases of the Colon and Rectum 1989;32:843 846.

6. Auchincloss H Jr, Moses R, Conti D, Sundt TM III, Smith C, Sachs DH, Winn HJ. Xenograft rejection of class I-expressing transgenic skin is CD4-dependent and CD8-independent. Transplantation Proceedings 1990;22:2335-6.

7. Baumgartner F, White GH, White RA, Bongard F, Smith C, Hiatt J, Chenevert M, Robertson JR. Delayed exsanguinating pelvic hemorrhage after blunt trauma without bony fracture: case report. Journal of Trauma 1990;30:1603.

8. Auchincloss H Jr, Moses R, Conti D, Sundt TM III, Smith C, Sachs DH, Winn HJ. Rejection of transgenic skin expressing xeno-class I antigen is CD4-dependent and CD8-independent. Transplantation Proceedings 1990;22:1059-60.

9. Rosengard BR, Ojikutu CA, Guzzetta PC, Smith CV, Sundt TM, Nakajima K, Boorstein SM, Hill GS, Sachs DH. Renal transplantation in miniature swine: preliminary evidence that graft infiltrating leukocytes suppress donor specific cell mediated lymphocytotoxicity in culture. Transplantation Proceedings 1991; 23:189 191.

10. Najima K, Smith CV, Rosengard BR, Mixon A, Eckhaus MA, Spitzer TR, Sachs DH. The effects of recombinant human IL 2 in miniature swine. Transplantation Proceedings 1991;23:248 250.

11. Smith CV, Rosengard BR, Guzzetta, PC, Nakajima K, Sachs DH. New approaches to transplantation tolerance. Transplantation Proceedings 1991; 23:2157-2161.

12. Sundt TM III, LeGuern C, Smith C, Sachs DH. Identification of a CD4 polymorphism in miniature swine. Transplantation Proceedings 1991;23:419:20.

13. Sundt TM III, LeGuern C, Germana S, Smith CV, Nakajima K, Lunney JL, and Sachs DH. Characterization of a polymorphism of CD4 in miniature swine. Journal of Immunology 1992; 148:3195-201.

14. Rosengard BR, Ojikutu CA, Guzzetta PC, Smith CV, Sundt TM, Nakajima K, Boorstein SM, Hill GS, Fishbein JM, Sachs DH. Induction of specific tolerance to class I disparate renal allografts in miniature swine with cyclosporine. Transplantation 1992; 54:490-7.

15. Nakajima K, Smith CV, Mixon A, Rosengard BR, Guzzetta PC, Spitzer TR, Eckhause MA and Sachs DH. In vitro and in vivo effects of recombinant human IL 2 in naive miniature swine. Journal of Immunotherapy 1992; 11:169-175.

16. Smith CV, Nakajima K, Mixon A, Guzzetta PC, Rosengard BR, Fishbein JM and Sachs DH. Successful induction of long term specific tolerance to fully allogeneic renal allografts in miniature swine. Transplantation 1992; 53:438-44.

17. Rosengard BR, Kortz EO, Ojikutu CA, Guzzetta PC, Sundt TM, Smith CV, Nakajima KN, Boorstein SM, Hill GS, Sachs DH. The failure of skin grafting to break tolerance to class I-disparate renal allografts in miniature swine despite inducing marked antidonor cellular immunity. Transplantation 1992; 52:1044-1052.

18. Smith CV, Suzuki T, Guzzetta PC, Nakajima K, Sundt TM III, Mixon A, Spitzer TR, Eckhaus MA and Sachs DH. Bone marrow transplantation in miniature swine: IV. Development of myeloablative regimens that allow engraftment across major histocompatibility barriers. Transplantation 1993; 56:541-549.

19. Latinne D, Gianello P, Smith CV, Nickeleit V, Kawai T, Beadle M, Haug C, Sykes M, Lebowitz E, Bazin H, Colvin R, Cosimi AB and Sachs D. Xenotransplantation from pig to cynomogulus monkey: an approach toward tolerance induction. Transplantation Proceedings 1993; 25:336-338.

20. Sachs DH, Smith CV, Emery DW, LeGuern C, Bodine D, Nienhuis A, and Sykes, M. Induction of specific tolerance to MHC-disparate allografts through genetic engineering; Experimental Nephrology 1993, 1:128-133.

21. Smith CV, Fishbein J, Nakajima K, Rosengard B, Guzzetta PC and Sachs DH. Effect of tolerance to allogeneic MHC antigens on rejection across minor antigen differences. Transplantation Proceedings 1993; 25:364-365.

22. Emery DW, Smith CV, Shafer GE, Karson EM, Sachs DH and LeGeurn C. Expression of allogeneic class II cDNA in swine PBL following retroviral-mediated gene transfer into bone marrow. Transplantation Proceedings 1993; 25:140-41.

23. Smith CV, Tabklinski T, Arn JS, Myers DE, Rosengard BR, Uckun FM and Sachs DH. In vivo treatment with monoclonal antibodies directed against CD4+ and CD8+ cells in miniature swine. Journal of Immunotherapy 1994; 16:105-14.

24. Fishbein JM, Rosengard BR, Gianello P, NIckeleit V, Guzzetta PC, Smith CV, Nakajima K, Vitiello D, Hill GM and Sachs DH. Development of tolerance to class II mismatched renal transplants following a short course of cyclosporine therapy in miniature swine.Transplantation 1994; 57:1303-1308.

25. Gritsch HA, Glaser RM, Emery DE, Lee LA, Smith CV, Sablinski T, Arn JS, Sachs DH and Sykes M. The importance of nonimmune factors in reconstitution by discordant xenogeneic hematopoietic cells. Transplantation 1994; 57:906-917.

26. Rosengard BR, Fishbein JM Gianello P, Ojikutu CA, Guzzetta PC, Smith CV, Sundt TM III, Nakajima K, Hill GS, and Sachs DH. Retransplantation in miniature swine: lack of a requirement for graft adaptation for maintenance of specific renal allograft tolerance. Transplantation 1994; 57:794-7999.

27. Oudiz R, Mahaisavariya P, Peng SK, Shane-Yospur L, Smith C, Baumgartner F, Shapiro S. Disseminated coccidiomycosis with rapid progression to effusive-constrictive pericarditis. Jornal of the American Society of Echocardiography 1995; 8:947-52.

28. Baumgartner F, White GH, White RA, Bongard F, Smith C, Klein SR. Controversies in the management of retroperitoneal hemorrhage associated with pelvic fractures. Journal of the National Medical Association 1995; 87:33-8.

29. Pinna AD, Smith CV, Furukawa H, Fung JJ and Starzl TE. Urgent revascularization of liver allografts after early hepatic artery thrombosis. Transplantation, 1996; 62 (11):1584-587.

30. Pinna AD, Dodson FS, Smith CV, Furukawa H, Sugitani A, Fung JJ and Corry RJ. Rapid en bloc technique for liver and pancreas procurement. Transplantation Proceedings, 1997, 29, 647-648.

31. Mullen Y, Arita S, Kenmochi T, Une S, Smith CV. A two-step digestion process and LAP-I cold preservation solution for human islet isolation. Ann Transplant. 1997;2(3):40-5.

32. Smith CV, Imagawa DK, Stock PG, Arita S, Une S, Kawahara T, Sakamoto Y, Ochiai M, Nagai T, Shevlin L, Mullen Y. Simultaneous islet-liver transplantation: preliminary results from the UC Islet Transplantation Consortium. Transplant Proc. 1998 Mar;30(2):295-6.

33. Arita S, Nagai T, Ochiai M, Sakamoto Y, Smith CV, Shevlin L, Mullen Y. Pravastatin prevents primary nonfunction of canine islet autografts. Transplant Proc. 1998 Mar;30(2):411.

34. Ochiai M, Arita S, Nagai T, Sakamoto Y, Smith CV, Shevlin L, Mullen Y. Islet toxicity of FK506 measured in canine autografts. Transplant Proc. 1998 Mar;30(2):663.

35. Arita S, Kasraie A, Une S, Ohtsuka S, Kawahara T, Smith CV, Mullen Y. Improved recovery of cryopreserved canine islets by use of beraprost sodium. Pancreas. 1999 Oct;19(3):289-96.

36. Arita S, Smith CV, Nagai T, Sakamoto Y, Ochiai M, Maruyama M, Tanabe Y, Shelvin L, Mullen Y. Improved human islet isolation by a tube method for collagenase infusion. Transplantation. 1999 Sep 15;68(5):705-7.

37. Mullen Y, Maruyama M, Smith CV. Current progress and perspectives in immunoisolated islet transplantation. J Hepatobiliary Pancreat Surg. 2000;7(4):347-57.

38. Arita S, Smith CV, Nagai T, Sakamoto Y, Maruyama M, Mullen Y. Islet graft primary nonfunction and its prevention. Transplant Proc. 2000 Nov;32(7):1667

39. Arita S, Kasraie A, Une S, Ohtsuka S, Smith CV and Mullen Y. Prolongation of islet allograft survival in mice by combined treatment with pravastatin and low-dose cyclosporine. Cell Transplant. 2001; 10(7):639-44.

40. Arita S, Une S, Ohtsuka S, Kawahara T, Kasraie A, Smith CV and Mullen Y. Increased islet viability by addition of beraprost sodium to collagenase solution. Pancreas. 2001; 23(1):62-7.

41. Arita S, Nagai T, Ochiai M, Sakamoto Y, Shevlin LA, Smith CV, Mullen Y. Prevention of primary nonfunction of canine islet autografts by treatment with pravastatin. Transplantation. 2002 Jan 15;73(1):7-12.

42. Kandeel F, Smith CV, Todorov I, Mullen Y. Advances in islet cell biology: from stem cell differentiation to clinical transplantation: conference report. Pancreas. 2003 Oct;27(3):e63-78.

43. Matsuda T, Omori K, Vuong T, Pascual M, Valiente L, Ferreri K, Todorov I, Kuroda Y, Smith CV, Kandeel F, Mullen Y. Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function. Am J Transplant. 2005 Mar;5(3):484-93.

44. Matsuda T, Ferreri K, Todorov I, Kuroda Y, Smith CV, Kandeel F, Mullen Y. Silymarin protects pancreatic beta-cells against cytokine-mediated toxicity: implication of c-Jun NH2-terminal kinase and janus kinase/signal transducer and activator of transcription pathways. Endocrinology. 2005 Jan;146(1):175-85.

45. Todorov I, Omori K, Pascual M, Rawson J, Nair I, Valiente L, Vuong T, Matsuda T, Orr C, Ferreri K, Smith CV, Kandeel F, Mullen Y. Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation. Pancreas. 2006 Mar;32(2):130-8.


BOOK CHAPTER
Guzzetta PC, Smith CV, Nakajima K, Mixon A, Sachs DH. Bone marrow transplantation in the pig. In: Cramer DV, Podesta L, Makowka L, eds. Handbook of animal models in transplantation research. CRC Press, 1992.
Grants
Sept 2001-2006 U42 RR016607 Islet-Cell Resources Ctr of Southern California Role: Co- Investigator
Sept 2000-2006 R01 DK056952 Islet-Kidney Transplantation for Type I Diabetes Role: Principal Investigator
July 1999-2002 R01 DK055185 Mechanisms of Adult Human Islet Proliferation Role: Principal Investigator
Other Experience
Associate Director
Southern California Islet Cell Resource Center 2002—2006

Associate Clinical Professor, Departments of Surgery and Urology
David Geffen School of Medicine at UCLA, Los Angeles, CA 1996—2006

Surgical Director, Pancreas Transplant Program
The Dumont-UCLA Transplant Center Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 1997—2004

Staff Surgeon
Veterans Affairs Greater Los Angeles Health Care System, West Los Angeles, CA 1996—2002

Graduate Programs
Surgery-General

Last updated
07/09/2009