Daniela A Bota

picture of Daniela A Bota

Vice Dean for Clinical Research
School of Medicine

Medical Director, Center for Clinical Research

Director, UCI Alpha Stem Cell Clinic, Sue and Bill Gross Stem Cell Research Center

Medical Director, Neuro-Oncology Program

M.D., Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 1997
Ph.D., University of Southern California, 2003, Molecular Biology
United Council for Neurologic Subspecialties, 2011, Neuro-Oncology

Email: dbota@uci.edu

University of California, Irvine
1001 Health Science Road, Ste. 222
Irvine, CA 92697
Research Interests
Daniela A Bota, Henry S. Friedman Interstitial Chemotherapy with Biodegradable BCNU (Gliadel) Wafers in the Treatment of Malignant Gliomas Therapeutics and Clinical Risk Management, 3(5): 707-715. 2007

D. A. Bota, MD, PhD; G. Gronseth, MD; M. Glantz, MD. Practice Parameter: Radiation therapy and Chemotherapy for Low-Grade Glioma (An Evidence-Based Review). Report of the Quality Standards Subcommittee of the American Academy of Neurology (accepted for publication)

Dafer, R.M., Bota, D.A., Perez, M., Smith, SM. Acute Methotrexate Neurotoxicity with Choreiform Movements and Focal Deficits: A Case Report. South Med J. 102 (10):1071-4, October 2009

Bota RG, M.D., Munro JS, M.D., Ricci WF, M.D., Bota DA, M.D., Ph.D. “Dynamics of insight in the prodrome of schizophrenia” CNS Spectrum 11(5):355-62. 2006

Bota RG, M.D., Munro JS, M.D., Ricci WF, M.D., Bota DA, M.D., Ph.D. “Dynamics of insight in the prodrome of schizophrenia” CNS Spectrum 11(5):355-62. 2006

Bota, D.A., Ngo, J.K., and Davies, K.J.A., 2005. Downregulation of the Human Lon Protease Impairs Mitochondrial Structure, Function and Replication, and Causes Cell Death. Free Radic. Biol. Med. 38, 665-77

Bota, D.A., and Davies, K.J.A., 2002. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nature Cell Biology 4, 674-680.

Bota, D.A., Van Remmen, H. and Davies, K.J.A., 2002. Modulation of Lon Protease Activity and Aconitase Turnover during Aging and Oxidative Stress. FEBS Letters 532, 103-106.

Bota, D.A., 2002. Importance of the Lon protease in Mitochondrial Protein Turnover and Cellular Bioenergetics during Oxidative Stress and Aging. PhD Dissertation Defense, University of Southern California, Department of Molecular and Computational Biology

Bota, D. A., and Davies, K.J.A., 2001. Protein Degradation in Mitochondria: Implications for Oxidative Stress, Aging and Disease. A novel etiological classification of mitochondrial proteolysis disorders. Mitochondrion 1, 33-49.
ASC Seed Award
National Institutes of Health (NIH), "The Mechanisms of Chemotherapy Induced Cognitive Defects" 2011-2012
Professional Societies
Society of Neuro-Oncology
American Society of Clinical Oncology
American Academy of Neurology
American Medical Association
American Association of Cancer Research
American Association of Neurological Surgeons and the Congre
Medical Oncology Association of Southern California
Romanian Society of Oncology
National Federation of Aging Research – Glenn/AFAR Fellow
Society for Immunotherapy of Cancer
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