Daniela Bota

Associate Professor, Neurology
School of Medicine

Medical Director, Neuro-Oncology Program

M.D., Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 1997

Ph.D., University of Southern California, 2003, Molecular Biology

United Council for Neurologic Subspecialties, 2011, Neuro-Oncology

Phone: 877-824-9111
Email: dbota@uci.edu

University of California, Irvine
200 S. Manchester Ave.
Ste. 206
Mail Code: 4280
Irvine, CA 92868

picture of Daniela  Bota

URL Brain Tumor Program
Publications Daniela A Bota, Henry S. Friedman Interstitial Chemotherapy with Biodegradable BCNU (Gliadel) Wafers in the Treatment of Malignant Gliomas Therapeutics and Clinical Risk Management, 3(5): 707-715. 2007

D. A. Bota, MD, PhD; G. Gronseth, MD; M. Glantz, MD. Practice Parameter: Radiation therapy and Chemotherapy for Low-Grade Glioma (An Evidence-Based Review). Report of the Quality Standards Subcommittee of the American Academy of Neurology (accepted for publication)

Dafer, R.M., Bota, D.A., Perez, M., Smith, SM. Acute Methotrexate Neurotoxicity with Choreiform Movements and Focal Deficits: A Case Report. South Med J. 102 (10):1071-4, October 2009

Bota RG, M.D., Munro JS, M.D., Ricci WF, M.D., Bota DA, M.D., Ph.D. “Dynamics of insight in the prodrome of schizophrenia” CNS Spectrum 11(5):355-62. 2006

Bota RG, M.D., Munro JS, M.D., Ricci WF, M.D., Bota DA, M.D., Ph.D. “Dynamics of insight in the prodrome of schizophrenia” CNS Spectrum 11(5):355-62. 2006

Bota, D.A., Ngo, J.K., and Davies, K.J.A., 2005. Downregulation of the Human Lon Protease Impairs Mitochondrial Structure, Function and Replication, and Causes Cell Death. Free Radic. Biol. Med. 38, 665-77

Bota, D.A., and Davies, K.J.A., 2002. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nature Cell Biology 4, 674-680.

Bota, D.A., Van Remmen, H. and Davies, K.J.A., 2002. Modulation of Lon Protease Activity and Aconitase Turnover during Aging and Oxidative Stress. FEBS Letters 532, 103-106.

Bota, D.A., 2002. Importance of the Lon protease in Mitochondrial Protein Turnover and Cellular Bioenergetics during Oxidative Stress and Aging. PhD Dissertation Defense, University of Southern California, Department of Molecular and Computational Biology

Bota, D. A., and Davies, K.J.A., 2001. Protein Degradation in Mitochondria: Implications for Oxidative Stress, Aging and Disease. A novel etiological classification of mitochondrial proteolysis disorders. Mitochondrion 1, 33-49.
Grants ASC Seed Award
National Institutes of Health (NIH), "The Mechanisms of Chemotherapy Induced Cognitive Defects" 2011-2012
Society of Neuro-Oncology
American Society of Clinical Oncology
American Academy of Neurology
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5555
Last updated 03/20/2014