YoungJik Kwon

picture of YoungJik  Kwon

Professor, Pharmaceutical Sciences

Professor (Joint), Chemical Engineering & Materials Science

Professor (Joint), Biomedical Engineering

Professor (Joint), Molecular Biology and Biochemistry

Ph.D., University of Southern California, 2003, Chemical Engineering
M.S., University of Southern California, 2000, Chemical Engineering
B.S., Inha University, South Korea, 1998, Biological Engineering

Phone: (949) 824-8714

University of California, Irvine
132 Sprague Hall
Mail Code: 3905
Irvine, CA 92697
Research Interests
Gene therapy, drug delivery, multi-modal therapeutics for cancer, vaccines, extracellular blebs
Academic Distinctions
Brain Pool scholar and visiting professor, Chemical and Biomolecular Engineering, Korea University, Korea (2015 – 2016)

Special visiting research fellow (Science without Borders Scholar), College of Pharmacy, Federal University of Minas Gerais, Brazil (2015 – 2017)

Top downloaded article award in 2014, Journal of Materials Chemistry, Royal Society of Chemistry Publishing (2015)

Top-cited article award, FEBS Journal, Wiley (2013)

Medical Research Award, Gabrielle's Angel Foundation for Cancer Research (2011)

Faculty Early Career Development (CAREER) Award, National Science Foundation (2010)

Faculty Career Development Award, UC Irvine (2008)

M. Frank and Margaret Domiter Rudy Assistant Professor of Biomedical Engineering in Cancer Research, Case Western Reserve University (2006-2007)
Postdoc, Chemistry, UC Berkeley (2003-2005)
Available Technologies
Shirley Wong, Young Jik Kwon. Facile synthesis of high-molecular-weight acid-labile polypeptides using urethane derivatives. Journal of Polymer Science A: Polymer Chemistry 53, 280-286 (2015)

Soo Kyung Cho, Chris Dang, Xi Wang, Regina Ragan, Young Jik Kwon. Mixing-sequence-dependent nucleic acid complexation and gene transfer efficiency by polyethylenimine. Biomaterials Science 3, 1124-1133 (2015)

Minjeong Jang, Young Jik Kwon, Nae Yoon Lee. Non-photolithographic plastic-mold-based fabrication of cylindrical and multi-tiered poly(dimethylsiloxane) microchannels for biomimetic Lab-on-a-Chip applications. RSC Advances 5, 100905-100911 (2015)

Mohammad M. Al-Sanea, Ahmed Z. Abdelazem, Byung Sun Park, Kyung Ho Yoo, Taebo Sim, Young Jik Kwon, So Ha Lee*. ROS1 kinase inhibitors for molecular-targeted therapies. Current Medicinal Chemistry 23, 142-160 (2016)

Jessica A. Kemp, Min Suk Shim, Chan Yeong Heo, Young Jik Kwon. “Combo” Nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe therapy for cancer. Advanced Drug Delivery Reviews 98, 3-18 (2016)

Yi Xi Wu, Young Jik Kwon*. Aptamers: The “evolution” of SELEX. Methods 106, 21-28 (2016)

Xingyi Ma, June Huh, Wounjhang Park, Luke P. Lee, Young Jik Kwon, Sang Jun Sim*. Gold nanocrystals with DNA-directed morphologies. Nature Communications 7, 12873 (2016)

Cheol Am Hong, Soo Kyung Cho, Julius A. Edson, Jane Kim, Dominique Ingato, Bryan Pham, Anthony Chuang, David A. Fruman, Young Jik Kwon. Viral/nonviral chimeric nanoparticles to synergistically suppress leukemia proliferation via simultaneous gene transduction and silencing. ACS Nano 10, 8705-8714 (2016)

Dominique Ingato, Jong Uk Lee, Sang Jun Sim, and Young Jik Kwon*. Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery. Journal of Controlled Release 241, 174-185 (2016)

Julius A. Edson, Young Jik Kwon*. Design, challenge, and promise of stimuli-responsive nanoantibiotics. Nano Convergence 3, 26 (2016)

Chang Soo Kim, Dominique Ingato, Petra Wilder-Smith, Zhongping Chen*, Young Jik Kwon. Simtuli-disassembling gold nanoclusters for diagnosis of early state oral cancer by optical coherence tomography. Nano Convergence 5, 3 (2018)

Marina França Dias, Kwangsic Joo, Jessica A. Kemp, Silvia Ligório Fialho, Armandoda Silva Cunha Jr.*, Se Joon Woo*, Young Jik Kwon. Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives. Progress in Retinal and Eye Research 63, 107-132 (2018)

Julius A. Edson, Dominique Ingato, Shirley Wu, Bianca Lee, Young Jik Kwon. Aqueous-soluble, acid-transforming chitosan for efficient and stimuli-responsive gene silencing. Biomacromolecules 19, 1508-1516 (2018)

Dominique Ingato, Julius A. Edson, Michael Zakharian, Young Jik Kwon. Cancer cell-derived, drug-loaded nanovesicles induced by sulfhydryl-blocking for effective and safe cancer therapy. ACS Nano 12, 9568-9577 (2018)

Kyuri Lee, Soo Young Kim, Yunmi Seo, Hyokyung Kwon, Young Jik Kwon, Hyukjin Lee. Multicistronic IVT mRNA for simultaneous expression of multiple fluorescent proteins. Journal of Industrial and Engineering Chemistry 80, 770–777 (2019)

Jessica Kemp, Andrew Keebaugh, Julius Edson, David Chow, Michael Kleinman, Yap Ching Chew, Alison McCracken, Aimee Edinger, Young Jik Kwon. Biocompatible chemotherapy for leukemia by acid-cleavable, PEGylated FTY720. Bioconjugate Chemistry 31, 673-684 (2020)

Hyejin Kim, Dajeong Kim, Hyangsu Nam, Sunghyun Moon, Young Jik Kwon, Jong Bum Lee. 2020. Engineered extracellular vesicles and their mimetics for clinical translation.Methods 177, 80–94 (2020)

Melissa N. Thonea, Young Jik Kwon. Extracellular blebs: Artificially-induced extracellular vesicles for facile production and clinical translation. Methods 177, 135–145 (2020)

For a complete list check the lab webpage listed above.
Professional Societies
American Chemical Society
Amecian Institute of Chemical Engineers
American Society for Gene and Cell Therapy
Controlled Release Society
Graduate Programs
Chemical Engineering

Biomedical Engineering

Cellular and Molecular Biosciences

Pharmacological Sciences

Research Centers
Biotechnology, Imaging & Drug Development (BIDD) program, The Chao Family Comprehensive Cancer Center
Center for Virus Research
Institute for Immunology
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