Jin Kyung Kim

Associate Professor of Medicine
School of Medicine

Medical Director, Cardiac Diagnostic Center

M.D., University of Rochester, 2000

Ph.D., University of Rochester, 2000, Biochemistry

Phone: (714) 456-3380
Email: jkim13@uci.edu

University of California, Irvine
Division of Cardiology, UC Irvine Medical Center
101 The City Drive
City Tower, Suite 400
Mail Code: 4080
Orange, CA 92868

picture of Jin Kyung Kim

cardiomyocyte apoptosis, estrogen signaling, ischemia reperfusion injury
1989-1993 Dean’s List, Brandeis University
1991-1992 Korean Scientist and Engineers Association Scholarship
1992-1993 Undergraduate Research Fellowship Award
1992 Top Ten Pre-Med Award
1993 Department Honors in Biochemistry
1993 Magna Cum Laude
1996-1997 Luis S. & Molly B. Wolk Foundation Fellowship Award
2000 Dean’s Award, University of Rochester School of Medicine and Dentistry
2005 Vascular Biology Working Group Cardiovascular Fellowship Grant Award (relinquished in lieu of the American Heart Association Western Affiliate Postdoctoral Fellowship Award)
2005 American College of Cardiology ’06 Early Career Travel Award
2005-2007 American Heart Association Western Affiliate Postdoctoral
Fellowship Award
2007-2012 Mentored Clinical Scientist Research Career Development Award
(K08), National Heart Lung Blood Institute, NIH
2008 Fellow, American College of Cardiology
2012 Winner of UC Irvine School of Medicine Faculty Research Grant
2015 Faculty of the Year, Cardiology UCIMC
2017 Physician of Excellence, Orange Coast Magazine
2017 Fellow, American Society of Echocardiography
My research focus is on studying the mechanisms of cardiomyocyte apoptosis and how estrogen protects the heart from ischemia-related injury.

Ischemic heart disease (IHD) is the leading cause of morbidity and mortality in the United States. It has been known that women have a significantly lower incidence of IHD until menopause, after which point the incidence accelerates to equal that in men. Furthermore, a better prognosis is observed in women than men following acute coronary syndrome.

Although the ability of hormone replacement therapy to reduce cardiovascular mortality is currently controversial, it is clear that premenopausal women are better protected from IHD. While the mechanism behind this observation is poorly understood, overwhelming data from studies of various molecular, cellular, and animal models collectively implicate estrogen to have beneficial cardiovascular effects.

After a period of prolonged ischemia or sudden reperfusion, the function of the heart can be compromised by loss of cardiomyocytes through a death process of apoptosis. Estrogen is anti-apoptotic in many cell types, including cardiomyocytes. However, details behind the estrogen-driven protection from apoptosis are not clear.

In our previous work, we have shown that cytoprotective effects of estrogen involve inhibition of a stress-induced kinase, p38alpha, and activation of the pro-survival isoform, p38beta. This, in turn, reduces mitochondrial generation of the reactive oxygen species (ROS), a known trigger of apoptosis. However, it remains unclear how the p38 kinases affect the death process initiated by ROS. An attractive downstream target of the kinase is p53, a well-known mediator of apoptosis.

We propose that the cytoprotective actions of estrogen involve regulation of p53 via p38. Our goal is to investigate the specific interaction between the two p38 isoforms and p53 in the estrogen-mediated protection of cardiomyocytes following ischemia-related injury, using a comprehensive approach of molecular, cellular and whole-animal models.
Publications Kim JK. Ferri’s Clinical Advisor 2015, Abdominal Aortic Aneurysms. Sahni G [ed], Mosby, Elsevier, St. Louis, MO.
  Kim JK. A Perspective on Cardiovascular Research: A Practitioner’s Responsibility to the Disseminated Outcomes, J Cardiol Clin Res 1:2, 2013.
  Luo T, Kim JK, Chen B, Abdel-Latif A, Kitakaze M, and Yan L. Attenuation of ER Stress Prevents Post-infarction Induced Cardiac Rupture and Remodeling by Modulating Both Cardiac Apoptosis and Fibrosis. Manuscript in press doi:10.1016/j.cbi.2014.10.032
  Liu H, Yamandala M, Lee TC, Kim JK. Mitochondrial p38ß and Manganese Superoxide Dismutase Interaction Mediated by Estrogen in Cardiomyocytes. PLoS One. 2014 Jan 22;9(1):e85272
  Groves EM, Kim JK. Biventricular Failure due to Stress Cardiomyopathy after Pericardiectomy for Constrictive Pericarditis. Case Rep Med., 2013;2013:106757. doi: 10.1155/2013/106757. Epub 2013 Nov 28.
  Mohabar D, Kim JK, and Patel P. Unique Morphological Variations of Transient Mid-Ventricular Syndrome. Echocardiography Jul 2. [Epub ahead of print].2012
  Hong GR, Park JS, Lee SH, Shin DG, Kim U, Choi JH, Abdelmalik R, Vera JA, Kim JK, Narula J, Vannan MA. Prognostic Value of Real Time Dobutamine Stress Myocardial Contrast Echocardiography in Patients with Chest Pain Syndrome. Int J Cardiovasc Imaging. Suppl 1:103-12, Dec 27, 2011
  Liu H, Pedram A, Kim JK. Estrogen Prevents Cardiomyocyte Apoptosis by Suppressing p38alpha-mediated p53 and by Downregulating p53 Inhibition on p38beta. Cardiovascular Research 2011 Jan 1;89(1):119-28. Epub 2010 Aug 19.
  Pedram A, Razandi M, Kim JK, O’Mahony F, Lee EY, Luderer U, Levin ER. Developmental Phenotype of a Membrane Only Estrogen Receptor-alpha (MOER) Mouse. J Biol Chem 284(6): 3488-3495, 2009.
  Hong G-T, Pedrizzetti G, Tonti G, Li P, Wei Z, Kim JK, Baweja A, Liu S, Chung N, Houle H, Narula N, Vannan MA. Characterization and Quantification of Vortex Flow in the Human Left Ventricle by Contrast Echocardiography Using Vector Particle Image Velocimetry. J Am Coll Cardiol Img 1:705-717, 2008.
  Kim JK, Palaniappan C, Wu W, Fay PJ, and Bambara RA. Evidence for a unique mechanism of strand transfer from the TAR region of HIV-1. J Biol Chem 272:16769-77, 1997.

Palaniappan C., Kim JK, Wisniewski M, Fay PJ, and Bambara RA. Control of initiation of viral plus strand DNA synthesis by HIV reverse transcriptase. J Biol Chem 273:3808-16, 1998.

Kim JK, Palaniappan C, Chow S, Fay PJ, and Bambara RA. Human Immunodeficiency Virus Type 1 (HIV-1) viral protein R (Vpr) stimulates reverse transcription. Manuscript submitted.

Roda RH, Balakrishnan M, Kim JK, Roques BP, Fay PJ, Bambara RA. Strand transfer occurs in retroviruses by a pause-initiated two-step mechanism. J Biol Chem 277:46900-11, 2002.

Kim JK, Pedram A, Razandi M, and Levin ER. Estrogen protects cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J Biol Chem 281:6760-7, 2006.

Kim JK and Levin, E.R. Estrogen signaling in the cardiovascular system. Nuclear Receptor Signaling, 2006;4:e013. Epub 2006 Jul 7

Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CC, Levin ER A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem. 2007 Aug 3;282(31):22278-88
Grants 2007-2012 K08 #HL089066-01 NHLBI/NIH; Principal Investigator; Direct Cost $112750/year
2012- 2013 UCI SOM Faculty Research Grant, UCI; Role – PI
2013-2018 R01 #HL111180 NHLBI/NIH; Principal Investigator; Direct cost $250,000 per yr
American Heart Association
American Society of Nuclear Cardiology
American College of Cardiology
American Society of Echocardiography
Research Center The Edwards Lifesciences Center for Advanced Cardiovascular Technology
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Last updated 04/15/2017