ion channels, cellular physiology, neural circuits and behavior; circadian and visual circuits
Whitehead Faculty Fellowship (1999), NSF CAREER Award (2001), Outstanding Investigator/MIRA R35 Award (2018)
My laboratory has developed pioneering approaches for understanding neural circuits and whole animal behavior. We focus on unraveling the functional operations of neurons in vivo with the goal of understanding integrative neural function from molecules to behavior. Recently, we have discovered novel phototransduction mechanisms that occur directly in neurons that rapidly modulate electrical excitability. Other recent projects include modeling human neurodegenerative diseases using Drosophila as a model system.
Ni, J.D., Baik, L.S., Holmes. T.C. and Montell, C. (2017) A rhodopsin in central pacemaker neurons functions in circadian photoentrainment in Drosophila. Nature 545(7654):340-344.
Baik, L.S., Fogle, K.J., Roberts, L., Galschiodt, A.M., Chevez, J.A., Recinos, Y., Nguy, V., and Holmes, T.C. (2017) CRYPTOCHROME mediates behavioral executive choice in response to UV light. Proc Natl Acad Sci U S A. 114:776-781.
Sun, Y., Ikrar, T., Davis, M.F., Gong, N., Zheng, X., Luo, Z.D., Lai, C., Mei, L., Holmes, T.C., Gandhi, S.P., and Xu, X. (2016) Neuregulin-1/ErbB4 signalling regulates visual cortical plasticity. Neuron, 92(1):160-173.
Roberts, L., Leise, T.L., Noguchi, T., Galschiot, A.M., Houl, J.H., Welsh, D.K. and Holmes, T.C. (2015) Light Evokes Rapid Circadian Network Oscillator Desynchrony Followed by Gradual Phase Retuning of Synchrony. Current Biology, 25: 858-867.
Fogle, K.J., Baik, L.S., Houl, J.H., Tran, T.T., Dahm, N.A, Cao, Y., Zhou, M. and Holmes. T.C., (2015) CRYPTOCHROME mediates membrane phototransduction by modulation of the potassium ion channel beta subunit redox sensor. Proc. Natl. Acad. Sci. USA 112:2245-2250.
Fogle, K.J., Parson, K.G., Dahm, N.A, and Holmes. T.C., (2011) Cryptochrome is a blue light sensor that rapidly regulates neuronal firing rate. Science. 331:1409-1413 (see also Perspective, Im, S.H. and Taghert, P.H., Science, 331:1394-1395.)
Sheeba, V., Gu, H., Sharma, V.K., O’Dowd, D.K., and Holmes, T.C. (2007) Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila melanogaster large ventral lateral circadian pacemaker neurons. J. Neurophysiology, 99:976-988, published Online, December 12, 2007, PMC2692874
Nitabach, M.N., Blau, J. and Holmes, T.C. (2002) Electrical silencing of central pacemaker neurons stops the central molecular clock. Cell 109:485-495 (see also van den Pol and Obrietan, Nature Neuroscience, 5: 616-618, News and Views), PMID: 12086605
Holmes, T.C., de Lacalle, S., Su, X., Liu, G., Rich, A. and Zhang, S. (2000) Extensive neurite outgrowth and active synapse formation on transportable self-complimentary oligopeptide matrices. Proc. Natl. Acad. Sci. USA 97:6728-6733 (see also Schachner, M. 2000, Nature, 405: 747-748, News and Views). PMID:10841570
Holmes, T.C., Fadool, D.A., Ren, R. and Levitan, I.B. (1996) Direct association of Src tyrosine kinase with the human Kv1.5 potassium channel mediated by src homology 3 domain. Science 274:2089-2091.
Grants from the NIH and NSF
Society for Neuroscience
Cellular and Molecular Biosciences
Interdepartmental Neuroscience Program