David Christian Lyon

picture of David Christian Lyon

Associate Professor, Director of Graduate Studies, Anatomy & Neurobiology
School of Medicine

Ph.D., Vanderbilt University, 2001, Psychology (Neuroscience)

Phone: (949) 824-0447
Fax: (949) 824-9788
Email: dclyon@uci.edu

University of California, Irvine
317B/318 Med Surge II
Mail Code: 1275
Irvine, CA 92697
Research Interests
Visual Cortex, Pulvinar Nucleus, Orientation Selectivity, Optical Imaging, Single Cell Electroporation, Neurophysiology, Neuroanatomy, Rabies Virus, Inhibitory Neurons
Academic Distinctions
Krieg Cortical Scholar Award, Cajal Club, 2003
Krieg Cortical Explorer Award, Cajal Club, 2007
Postdoctoral Fellow, MIT
Postdoctoral Fellow, Salk Institute
Research Abstract
The lab relates structure to function in the mammalian visual cortex and thalamus using a variety of techniques - from intrinsic signal imaging to genetically targeted viral tracing. We are interested in the number and organization of cortical areas in different animal models, how modules within each area derive their functional characteristics, and the detailed circuitry underlying sensory capabilities of particular neuron subtypes, such as inhibitory neurons.
Liu Y, Arreola M, Coleman C, Lyon DC (2014) Very long-range disynaptic V1 connections through layer 6 pyramidal neurons revealed by transneuronal tracing with rabies virus. Eye and Brain. 6:45-56.
Liu YJ, Ehrengruber MU, Negwer M, Shao HJ, Cetin AH, Lyon DC (2013) Tracing inputs to inhibitory or excitatory neurons of mouse and cat visual cortex with a targeted rabies virus. Curr Biol. 23(18):1746-55.
Liu YJ, Hashemi-Nezhad M, Lyon DC (2013) Sharper orientation tuning of the extraclassical suppressive-surround due to a neuron's location in the V1 orientation map emerges late in time. Neuroscience. 229:100-17.
Lyon DC (2012) Morphological approaches to the anatomical dissection of neuronal circuits. In: Neuromethods (Vol. 67), Neuronal Network Analysis: Concepts and Experimental Approaches, T Fellin and MM Halassa, eds. Springer, New York, pp. 375-389.
Hashemi-Nezhad M, Lyon DC (2012) Orientation tuning of the suppressive extraclassical surround depends on intrinsic organization of V1. Cerebral Cortex.22(2):308-26.
Lyon DC, Connolly JD (2012) The case for primate V3. Proc Biol Sci. 279(1729):625-33.Review.
Lyon DC, Rabideau C (2012) Lack of robust LGN label following transneuronal rabies virus injections into macaque area V4. J Comp Neurol. 520(11):2500-11.
Liu YJ, Hashemi-Nezhad M, Lyon DC (2011) Dynamics of extraclassical surround modulation in three types of V1 neurons.J Neurophysiol. 105(3):1306-17.
Lyon DC, Nassi JJ, Callaway EM (2010) A disynaptic relay from superior colliculus to dorsal stream visual cortex in macaque monkey. Neuron.65(2):270-9.
Stimberg M, Wimmer K, Martin R, Schwabe L, Mariño J, Schummers J, Lyon DC, Sur M, Obermayer K (2009) The operating regime of local computations in primary visual cortex.Cereb Cortex. 19(9):2166-80.
Wickersham IR, Lyon DC, Barnard RJ, Mori T, Finke S, Conzelmann KK, Young JA, Callaway EM (2007) Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons. Neuron. 53:639-647.
Kaas JH and Lyon DC (2007) Pulvinar contributions to the dorsal and ventral streams of visual processing
in primates. Brain Research Reviews, Special Issue on Golgi and Cajal. 55:285-296.
Nassi JJ*, Lyon DC* and Callaway EM (2006) The parvocellular LGN provides a robust disynaptic input to the visual motion area MT. Neuron. 50:319-327. *Co-First Authors
Mariño J, Schummers J, Lyon DC, Schwabe L, Beck O, Wiesing P, Obermayer K and Sur M (2005) Invariant computations in local cortical networks with balanced excitation and inhibition. Nature Neuroscience. 8:194-201.
Professional Societies
Society for Neuroscience
Vision Sciences Society
Graduate Programs
Interdepartmental Neuroscience Program

Research Center
Center for Cognitive Neuroscience and Engineering
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