Pietro Renato Galassetti

picture of Pietro Renato Galassetti

Associate Professor, Pediatrics
School of Medicine

Joint Appointment, Pharmacology
School of Medicine

M.D., University of Rome "La Sapienza", 1986
Ph.D., Vanderbilt University, 1998, Molecular Physiologyand Biophysics

Phone: (949) 824-3353
Fax: (949) 824-3360
Email: pgalasse@uci.edu

University of California, Irvine
UC Irvine Campus
1111 Hewit Hall
Mail Code: 4094
Irvine, CA 92697
Research Interests
stress in children with dysmetabolic states, obesity, type 1 and 2 diabetes
Academic Distinctions
Travel awards
06/1996 American Diabetes Association, 56th Sicientific Sessions,
San Francisco, CA
06/1998 American Diabetes Association 58th Sicientific Sessions, Chicago, IL
05/2000 American Society of Clinical Investigation, Baltimore, MD
06/2000 American Diabetes Association’s 60th Sicientific Sessions,
San Antonio, TX
03/2001 Association for Patient Oriented Research, Vienna, VA
03/2003 Association for Patient Oriented Research, Baltimore, MD
06/2003 American Diabetes Association’s 63rd Sicientific Sessions,
San Francisco, CA
04/2007 American Society of Clinical Investigation, Chicago, IL
04/2008 American Society of Clinical Investigation, Chicago, IL

Training and fellowship grants
1991-1992 CNR (Italian National Research Council), one year research fellowship
1995-1998 NIH (DRTC), three year training grant
1999-2001 Juvenile Diabetes Foundation, two year post-doctoral fellowship grant

Research awards and honors
1992-May Trainee Investigator Award, American Federation of Clinical Research
1997-April Honorable Mention Award, Endocrinology and Metabolism, FASEB
2000-August Member of the T.R. Harrison Society for Physician-Scientists
2001-March First Place Winner, Southern Society for Clinical Investigation Young Investigator Award.
2001-March Outstanding Young Investigator Award, Association for Patient Oriented Research (Clinical Research 2001).
2001- April Tum-Suden/Hellebrandt Award, Experimental Biology 2001.
2001- April American Physiological Society (Endocrinology & Metabolism Section) Young Investigator Research Award.
2002 - March Distinguished Faculty Medical Licensure, State of Tennessee
2003 – May Early Career Patient-Oriented Diabetes Research Award, Juvenile Diabetes Research Foundation
2003 – Sept NIH K23 Mentored Patient Oriented Research Career Development Award
2005 – March UC Irvine College of Medicine Committee on Research Award
2007 – May JDRF Mary Jane Kugel Award
2007 – June Dean’s Junior Physician-Scientist Research Award - UC Irvine
2010 - March Medical Research Fellowship Mentoring Award - UC Davis
Research Abstract
Dr. Pietro R. Galassetti, MD, PhD, is internationally recognized as a leader in breath analysis, and in-vivo metabolism, Director of the Bionutrition/Metabolism Research Unit of the UCI Institute for Clinical Translational Science. He holds 2 extramural grants, and has 20 years experience in in-vivo metabolism research focusing on diabetes, obesity and metabolic syndrome in children. He is the editor-in-chief of “Clinical Medicine: Pediatrics”, member of the editorial board of three more journals, and acts as reviewer for approximately 20 periodicals and several funding agencies, including the NIH. His laboratory’s work has addressed multiple key issues in the prevention, diagnosis and management of cardiovascular complications of pediatric obesity. He was in fact one of the UC Irvine Co-investigators (and national chair for the physical measures committee) for the HEALTHY project, a large multi-center NIH-funded study aimed at reducing obesity and diabetes risk factors in middle school children through a school-based intervention including nutritional, physical activity, educational and advertising interventions.

His laboratory is also actively conducting projects aimed at: a) detecting, in children with type 1 diabetes, biomarkers of inflammation and oxidative stress, both at the systemic and immune cell level, during hyperglycemic fluctuation and their interaction with physical exercise; b) the development of non-invasive, breath-based testing methodologies as alternatives for current glucose, insulin and lipid plasma testing in healthy, obese and diabetic subjects; c) the quantification of inflammatory, growth factor and oxidative stress responses in children with varying severity of obesity, during exercise and after ingestion of lipid-rich meals. Dr. Galassetti has published > 84 peer-reviewed papers, has been an invited speaker for 100+ talks, and his latest research focuses on alterations in stress responses, and development of non-invasive metabolic markers in obesity and diabetes.
Available Technologies
PEER REVIEWED PAPERS (from a total of 84)

Jago R, Drews KL, McMurray RG, Baranowski T, Galassetti P, Foster GD, Moe E, Buse JB. BMI change, fitness change and cardiometabolic risk factors among 8th grade youth. Pediatr Exerc Sci 25(1):52-68, 2013. PMID: 23406707.

Galassetti, P. Inflammation and Oxidative Stress in Obesity, Metabolic Syndrome and Diabetes. Exp Diabetes Res. 2012;2012:943706. doi: 10.1155/2012/943706. PMID: 23319940.

HEALTHY Study Group. Effect of nutrition changes on foods selected by students in a middle school-based diabetes prevention intervention program: the HEALTHY experience. J Sch Health 82(2): 82-90, 2012. PMID: 22239133.

HEALTHY Study Group. Student public commitment in a school-based diabetes prevention project: impact of physical health and health behavior. BMC public Health 11:711, 2011. PMID: 21933431

Oliver, SR, SR Hingorani, JS Rosa, FP Zaldivar, PR Galassetti . Synergistic Effect of Obesity and Lipid Ingestion in Suppressing the Growth Hormone Response to Exercise in Children. J Appl Physiol, 113(2):192-8, 2012 PMID 22401327

Choi, B, , P Schnall, M Dobson, L Israel, , P Landsbergis, P Galassetti, A Pontello, S Kojaku , and D Baker. Exploring Occupational and Behavioral Risk Factors for Obesity in Firefighters: A Theoretical Framework and Study Design. Saf Health Work 2:301-12, 2011.

HEALTHY Study Group. The effects of HEALTHY study intervention on middle school student dietary intakes. Int J Behav Nutr Phys Act Feb 4;8:7, 2011. PMID 21294869.

Rosa, JS, S Heydari, SR Oliver, RL Flores, AM Pontello M Ibardolaza, PR Galassetti. Inflammatory cytokine profiles during exercise in obese, diabetic, and healthy children. J Clin Res Pediatr Endocrinol. 3(3): 115-21, 2011. PMID 21911323

Minh,TDC, SR. Oliver, J Ngo, R Flores, J Midyett, S Meinardi, MK Carlson, FS Rowland, DR Blake, and PR Galassetti. Non-invasive Measurement of Plasma Glucose from Exhaled Breath in Healthy and Type 1 Diabetic Mellitus Subjects. Am J Physiol Endocrinol Metab 300 (6): E1166-75, 2011. PMID: 21467303.

Minh, TDC, SR Oliver, R Flores, J N, S Meinardi, MK Carlson, J Midyett, FS Rowland, DR Blake, and PR Galassetti. Non-Invasive Measurement of Plasma Triglycerides and Free Fatty Acids from Exhaled Breath. J Diabetes Sci Technol, 6(1):86-101, 2012. PMID: 22401327

HEALTHY study Group. A School-based Intervention for Diabetes Risk Reduction. N Engl J Med 363(5):443-53, 2010. PMID: 20581420

Rosa, JS, SR Oliver, RL Flores, J Ngo, GL Milne, FP Zaldivar, and PR Galassetti. Altered Inflammatory, Oxidative, and Metabolic Responses to Exercise in Pediatric Obesity and Type 1 Diabetes. Pediatric Diabetes 12 (5): 464-72, 2011. PMID: 21443585

Radom-Aizik,S, FP Zaldivar, Jr., SR Oliver, P Galassetti, and DM Cooper. Evidence for microRNA Involvement in Exercise-Associated Neutrophil Gene Expression Changes. J Appl Physiol 109 (1): 252-61, 2010. PMID: 20110541

Tran, B, S Oliver, J Rosa, and P Galassetti. Aspects of inflammation and oxidative stress in pediatric obesity and type 1 diabetes: an overview of ten years of studies. Exp Diabetes Res 2012:683680. doi: 10.1155/2012/683680. Epub 2012 Oct 11. 2012. PMID23093053

Minh,TDC, PR Galassetti. The Clinical Potential of Exhaled Breath Analysis For Diabetes Mellitus. Diabetes Res Clin Pract 97(2):195-205, 2012. doi: 10.1152/japplphysiol.01184.2011. PMID:22410396.

Galassetti, P. Pathogenetic Mechanisms of Exercise-Associated Hypoglycemia: Permanent and Reversible Counterregulatory Failure. In: “Hypoglycemia: Causes and Occurrences” (Chapter 4), EC Rigobelo Editor, InTech Publisher, 2011(invited review). http://www.intechopen.com/articles/show/title/pathogenetic-mechanisms-of-exercise-associated-hypoglycemia-permanent-and-reversible-counterregulato
Graduate Programs
Pharmacological Sciences

Research Center
UCI Institute for Clinical and Translational Science
Last updated