Associate Professor of Clinical Medicine, Medicine
School of Medicine

Chief, Pediatric Allergy and Immunology Clinic

Interim Chief, Adult Allergy and Asthma Clinic

Faculty, Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies
School of Medicine

Member, Institute for Immunology

Associate Medical Director,, Tu & Yuen Center for Functional Onco-Imaging

Disease Mechanisms, Genetic Basis and Diagnosis, and Treatment Approaches in Primary Immunodeficiency and Immunological Disorders

UCI Faculty Member with an Exceptional Impact, UCI Undergraduate Honors Convocation, 2003
America's Top Pediatricians-Allergy/Immunology, 2002-2003, Consumer's Research Council of America
America's Top Physicians, Allergy / Immunology, 2005-2010, Consumer's Research Council of America

Post-Doctoral Research Associate / Fellowship in Allergy / Immunology (Pediatric and Adult): St. Jude Children's Research Hospital / Departments of Pediatrics / Medicine, University of Tennessee, Memphis, TN (1995-1997)

Residency in General Pediatrics: Department of Pediatrics, Le Bonheur Children’s Medical Center, University of Tennessee, Memphis, TN (1997-1998)

Fellowship in Clinical and Laboratory Immunology (Added Qualification in Allergy and Immunology): Immunology / Department of Medicine, University of California, Irvine (1998-1999)

Yel L, Minegishi Y, Coustan-Smith E, Buckley RH, Trübel H, Pachman LM, Kitchingman GR, Campana D, Rohrer J, Conley ME. Mutations in the mu heavy chain gene in patients with agammaglobulinemia (see comments). N Engl J Med 335:1486-1493, 1996.

Sanal O, Smeets D, Aksoy Y, Berkel AI, Ersoy F, Gariboglu S, Metin A, Ogus H, Ozer N, Tezcan I, Weemaes C, Yel L. Heterogeneity in ataxia-telangiectasia: Various laboratory features of 56 cases. Disease Markers 38:63-65, 1998.

Yel L, Aggarwal S, Gupta S. Cartilage-hair hypoplasia syndrome: Increased apoptosis of T lymphocytes is associated with altered expression of Fas (CD95), FasL (CD95L), IAP, Bax, and Bcl-2. J Clin Immunol 19:428-434, 1999.

Yel L, Blaiss MS. “Allergic reactions to drugs” in Rakel RE, Kersey R, eds. Conn’s Current Therapy, 51st edition Philadelphia: WB Saunders 781-786, 1999.

Sanal O, Morgan G, Gocmen A, Novelli V, Klein N, Tezcan F, Ersoy F, Berkel AI, Yel L. Isolated cutaneous response to granulocyte-monocyte colony stimulating factor in fatal idiopathic disseminated Bacillus- Calmette-Guerin infection. E J Pediatr 159:149-152, 2000.

Yel L, Liao O, Lin F, Gupta S. Severe T-and B-Cell immune deficiency associated with malignant thymoma. Ann Allergy Asthma Immunol 91:501-505, 2003.

Imai K, Slupphaung G, Lee WI, REvy P, Nonoyama S, Catalan N, Yel L, Forveille M, Kavli B, Krokan H, Ochs HD, Fischer A, Durandy A. Uracil-DNA glycosylase Deficiency associated with profoundly impaired immunoglobulin class switch recombination, leading to a hyper-IgM syndrome. Nat Immunol 4:1023-1028, 2003.

Sanal O, Ersoy F, Tezcan I, Metin A, Turul T, Gariboglu S, Yel L. Antibody response to a seven-valent pneumococcal conjugated vaccine in patients with ataxia-telangiectasia. J Clin Immunol 24:411-417, 2004.

Yel L, Chen W, Gupta S. Cellular immune dificiency and autoimmunity in chronic mineral oil administration. Ann Allergy Asthma Immunol 92: 1-000, 2004

Yel L, Brown LE, Su K, Gollapudi S, Gupta S. Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria. Int J Mol Med 16:971-977, 2005.

Nicolay U, Kiessling P, Berger M, Gupta S, Yel L, Roifman CM, Gardulf A, Eichmann F, Haag S, Massion C, Ochs HD. Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home. J Clin Immunol 26:65-72, 2006.

Baysan A, Yel L, Gollapudi G, Su H, Gupta S. Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells. Int J Oncol 30:313-318, 2007.

Yel L. Approach to Primary Immunodeficiency Diseases. Journal of Pediatric Sciences 3:5-8, 2007 (review).

Yel L, Ramanuja S, Gupta S. Clinical and Immunological Features in IgM deficiency. Int Arch Allergy Immunol 150:291-298, 2009.

Gupta S, Yel L. “Chapter 3: Molecular Biology and Genetic Engineering” in Adkinson NF, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons FE, eds. Middleton’s Allergy Principles & Practice, 7th edition, London: Elsevier 37-58, 2009.

Yel L. IgA Deficiency. J Clin Immunol 30(1):10-6, 2010. (review).

“Effect of mercury on apoptosis of neuronal cells" Cure Autism Now (CAN)

"The role of ATM (Ataxia-Telangiectasia Mutated) in the mitochondrial pathway of apoptosis" Ataxia Telangiectasia Children's Project (ATCP)

Fellow, American Academy of Allergy, Asthma and Immunology (AAAAI)

Fellow, American Academy of Pediatrics (AAP)

Fellow, American College of Allergy, Asthma & Immunology (ACAAI)

American Association of Immunologists (AAI)

British Society for Immunology (BSI)

Clinical Immunology Society (CIS)

European Academy of Allergology&Clinical Immunology (EAACI)

Orange County Society of Allergy & Clinical Immunology, CA

Member; Advisory Panel
The Primary Immunodeficiency Research Consortium, United States Immunodeficiency Network (USIDNET) 2005—Pres

Member; American Academy of Allergy, Asthma & Immunology (AAAAI) Training Program Directors In-Training Exam Committee
2005—Pres

Member; Committee on Practice, Diagnostics, and Therapeutics (PDT), American Academy of Allergy, Asthma & Immunology (AAAAI)
2005—Pres

President; Orange County Society of Allergy & Clinical Immunology, California (OCSACI)
2004—2005

Vice-Chair; Basic and Clinical Immunology Committee, American College of Allergy, Asthma and Immunology (ACAAI)
2009—Pres

Link to this profile
https://faculty.uci.edu/profile/?facultyId=5227

Last updated
07/12/2010