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Chad P. Garner

picture of Chad P. Garner

Associate Professor, Epidemiology
School of Medicine
Director, Bioinformatics Core, Chao Family Comprehensive Cancer Center, Genomics High-Throughput Facility

Ph.D., University of Oxford, 1999, Biological Sciences

Phone: (949) 824-2036
Fax: (949) 824-4773

University of California, Irvine
Sprague Hall
Mail Code: 3905
Irvine, CA 92697
Research Interests
Statistical and Population Genetics, Genomics, Bioinformatics, Computational Biology
Assoc. Professor, UC Irvine (2008 - present)
Asst. Professor, UC Irvine (2002 - 2008)
Postdoctoral Fellow, Department of Integrative Biology, UC Berkeley (1999-2002)
Research Abstract
The general goal of my research is to solve problems related to health and disease with statistical and computational tools that take advantage of large genomic and genetic data. My dry lab at UCI utilizes publicly available data and data generated for my funded disease research projects to discover causes of disease, understand the biology of disease, and to search for new therapeutics. We work on methodology that is applicable to all diseases and have disease-focused efforts in cancer, alcoholic hepatitis and cirrhosis, celiac disease, and the persistence of fetal hemoglobin.
Menzel S, Garner C, Rooks H, Spector TD and SL Thein (2013) HbA2 levels in adults are influenced by two distinct genetic mechanisms. British Journal of Haematology. 160:101-105
Ahn R, Ding YC, Murray J, Fasano A, Green PHR, Neuhausen SL, and C Garner (2012) Association analysis of the extended MHC region in celiac disease implicates multiple independent susceptibility loci. PLoS ONE. 7:e36926
McLaren CE, McLachlan S, Garner CP, Vulpe CD, Gordeuk VR, Eckfeldt JH, Adams PC, Acton RT, Murray JA, Leiendecker-Foster C, Snively BM, Barcellos LF, Cook JD, and GD McLaren (2012) Multiethnic Associations Between Single Nucleotide Polymorphisms in Iron-related Genes and Iron Status. PLoS ONE. e38339
McLaren CE, Garner CP, Constantine CC, McLachlan S, Vulpe CD, Snively BM, Gordeuk VR, Nickerson DA, Cook JD, Leiendecker-Foster C, Beckman KB, Eckfeldt JH, Barcellos LF, Murray JA, Adams PC, Acton RT, Killeen AA and GD McLaren (2011) Genome-wide association study identifies genetic loci associated with iron deficiency. PLoS One. Epub DOI:10.1371/journal.pone.0017390
Garner C (2011) Confounded by sequencing depth in association studies of rare alleles. Genetic Epidemiology. Epub DOI: 10.1002/gepi.20574
Lai MI, Garner C, Jiang J, Silver N, Best S, Menzel, and Thein SL (2010) A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability. Twin Research and Human Genetics. 13:567-572
Garner C (2010) A statistical method for scanning the genome for regions with rare disease alleles. Genetic Epidemiology. 34:386-395
Thein SL, Menzel S, Lathrop M and Garner C (2009) Control of fetal hemoglobin – new insights emerging from genomics and clinical implications. Human Molecular Genetics. 18:R216-R223
Garner CP, Murray JA, Ding YC, Tien Z, van Heel DA and Neuhausen SL (2009) Replication of celiac disease UK genome-wide association study results in a US population. Human Molecular Genetics. 18:4219-4225
Yu Z, Garner C, Ziogas A, Anton-Culver H, Schaid DJ. (2009) Genotype determination for polymorphisms in linkage disequilibrium. BMC Bioinformatics 10:63-69
Garner C, Ding YC, John EM, Ingles SA, Olopade OF, Huo D, Adebamowo C and Neuhausen SL (2008) Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. Human Genetics 123: 247-255
Ding YC, Weizman Z, Yerushalmi B, Elbedour K, Garner CP and Neuhausen SL (2008) An autosomal genome-wide screen for celiac disease in Bedouin families. Genes and Immunity 9:81-86
Menzel S, Garner C, Gut I, Matsuda F, Yamaguchi M, Heath S, Foglio M, Zelenika D, Boland A, Rooks H,Spector TD, Farrall M, Lathrop M and Thein SL (2007) Genome-wide association maps a QTL influencing F cell production to a Zn-finger protein on chromosome 2p15. Nature Genetics. 39:1197-1199
Garner C, Ding YC, Steele L, Book L, Carmi R, Leiferman K, Zone JJ and S Neuhausen (2007) Genome-wide linkage analysis of 160 families with celiac disease. Genes and Immunity 8:108-114
Garner C (2007) Upward bias in odds ratio estimates from genome-wide association studies. Genetic Epidemiology 31:288-295
Thein SL, Menzel S, Peng X, Best S, Jiang J, Close J, Silver N, Gerovasilli A, Ping C, Yamaguchi M, Wahlberg K, Ulug P, Spector TD, Garner C, Matsuda F, Farrall M and Lathrop M (2007) Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing HbF levels in adults. Proceedings of the National Academy of Sciences 104:11346-11351
Garner C, Best S, Menzel S, Rooks H, Spector TD and SL Thein (2006) Two candidate genes for low platelet count identified by genome-wide linkage analysis in an Asian-Indian kindred: glycoprotein IX and thrombopoietin. European Journal of Human Genetics 14:101-108
Garner C (2006) The use of random controls in genetic association studies. Human Heredity 61:22-26
Lai MI, Jiang J, Silver N, Best S, Menzel S, Mijovic A, Garner C, Weiss MJ and SL Thein (2006) ASHP is a quantitative trait gene that modifies the phenotype of ? thalassemia. British Journal of Haematology 133:675-682
Professional Societies
American Society of Human Genetics
American Association for the Advancement of Science
Graduate Programs

Research Centers
Genetic Epidemiology Research Institute
Institute for Genomics and Bioinformatics
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