Associate Project Scientist V, Medicine
School of Medicine
Ph.D., Tongji Medical University, 1993, Cardiovascular Pathophysiology
M.S., Inner Mongolia Medical College, 1987, Cardiovascular Pharmacology
M.D., Jiangxi Medical College, 1982
Phone: (949) 824-8161
University of California, Irvine
C240 - Medical Sciences 1
Mail Code: 4075
Irvine, CA 92697
Mechanisms of activation of sensory neural systems concerned with cardiovascular regulation.
UCI Faculty Career Development Award
First Award in Scientific Research, Hubei Province, China
Graduated in cardiology program with honors
MD degree with honors
My research interests are to investigate the mechanisms of cardiac sympathetic afferents activation and the associated central nervous system (CNS) reflex processing as well as modulation of electroacupuncture (EA) on CNS regulation of cardiovascular function. Studies of cardiac afferents activation are funded by a NIH grant (serve as CO-PI ). In these studies, I am investigating the mechanisms of activation and sensitization of cardiac afferents induced by multiple ischemic mediators including endothelins, thromboxane A2, 5-hydroxytryptamine (5-HT), histamine, lactic acid (protons), reactive oxygen species and bradykinin (BK), which stimulate and/or sensitize cardiac spinal afferents during ischaemia and reperfusion in an interactive and multifactorial fashion. I am also studying the mechanisms underlying CNS reflex processing evoked by ischemic metabolites during myocardial ischemia.
With respect to studies of the mechanisms of EA-modulated CNS regulation of cardiovascular function, funded by another NIH grant (as CO-investigator), I am studying the neurotransmitters dynamic mechanisms in the cardiovascular regulating centers of the brain including hypothalamus, midbrain and medulla, underlying modulation of EA on visceral sympathoexcitatory reflexes induced by chemical and mechanic stimuli. Currently, I am defining the mechanism of EA modulates sympathoexcitatory reflex responses through inhibition of the midbrain ventrolateral periaqueductal gray (vlPAG) release of ?-aminobutyric acid (GABA), but not glutamate, through presynaptic cannabinoid CB1 receptor mechanism.
Fu, L-W and JC Longhhurst: Interactions between histamine and bradykinin in stimulation of ischaemically sensitive cardiac afferents. Journal of Physiology. 2005, In Press.
Fu, L-W , W Schunack and JC Longhurst: Histamine contributes to ischemia-related activation of cardiac spinal afferents: role of H1 receptors and PKC. Journal of Neurophysiology. 93:713-722, 2005.
Fu, L-W and JC Longhurst: Role of activated platelets in excitation of cardiac afferents during ischmia in cats. American Journal of Physiology. 282:H100-H109, 2002.
Fu L-W, and JC Longhurst: Interleukin 1ß sensitized abdominal visceral afferents of cat to ischemia and histamine. Journal of Physiology 521:249-260,1999.
Fu, L-W, CA O'Neill and JC Longhurst: Increased histamine and 5-HT in portal vein plasma and mesenteric lymph during brief ischemia and reperfusion. American Journal of Physiology, 273: H1135-H1141, 1997.
Longhurst JC, SC Tjen-A-Looi, and L-W Fu: Cardiac sympathetic afferent activation provoked by myocardial ischemia and reperfusion. Mechanisms and reflexes.
Ann N Y Acad Sci. 940:74-95, 2001. Review.
"Mechanisms of Cardiac Afferents Activation and CNS reflex processing," National Institute of Health.
Role of Platelets in Activation of Cardiac Afferents: Potential Mechanisms," AHA, Western States Affiliate.
American Heart Association
Society for Neuroscience
American Physiological Society
Susan Samueli Center for Integrative Medicine