Jianyuan Chai

picture of Jianyuan  Chai

Associate Adjunct Professor II, Medicine
School of Medicine

Principal Investigator, Medicine
School of Medicine

Ph.D., The City University of New York, 1998, Biology
M.S., Academia Sinica, Wuhan, 1985, Cell Biology
B.S., Inner Mongolia University, 1982, Zoology

Phone: (562) 826-5676
Fax: (562) 826-5675
Email: jianyuan.chai@gmail.com

University of California, Irvine
Research, VA Medical Center
5901 E. 7th St
Long Beach, CA 90822
Research Interests
molecular and cellular biology of wound healing, angiogenesis, apoptosis, and cancer development
Academic Distinctions
Principal Investigator of VA Merit Review Grant
Principal Investigator of AHA Grant-in-Aid.
Principal Investigator of VA Career Development Award.
Principal Investigator of UCI Pilot Project Grant.
Recipient of NIH Ruth L. Kirschstein National Research Service Award
Postdoctoral Fellow, Harvard University 1998—2001
1. Chai J. 2013. Validity of markers for epithelial cells and mesenchymal cells. In: Hayat MA. (Ed), Stem Cells and Cancer Stem cells (Vol. 10): Therapeutic Applications in Disease and Injury. Springer, Dordrecht. pp. 23-33.
2. Chai J. 2013. Roles of SRF in endothelial cells during hypoxia. In: Chai, J. (Ed), Research Directions in Tumor Angiogenesis. ISBN 980-953-307-875-0. Intech Publisher, Rijeka. pp. 29-45.
3. Chai J. 2013. Research Directions in Tumor Angiogenesis. ISBN 978-953-51-0963-1. InTech, Croatia.
4. Chai J, Jamal MM. 2012. Esophageal malignancy – A growing concern. World Journal of Gastroenterology. 18(45): 6521-6526.
5. Chai J, Jamal MM. 2012. S100A4 in esophageal cancer: Is this the one to blame? World Journal of Gastroenterology. 18(30): 3931-3935.
6. Chai J, Modak C, Ouyang Y, Wu SY, Jamal MM. 2012. CCN1 induces ß-catenin translocation in esophageal squamous cell carcinoma through integrin a11. ISRN Gastroenterology. 2012: 207235.
7. Chai J. 2011. Peptic Ulcer Disease. ISBN 978-953-307-976-9. InTech, Croatia.
8. Chai J. 2011. Gastric ulcer healing – Role of serum response factor. In: Chai, J. (Ed), Peptic Ulcer Disease. ISBN 978-953-307-976-9. Intech Publisher, Rijeka. pp. 143-64.
9. Chai J, Modak C, Mouazzen W, Narvaez R, Pham J. 2010. Epithelial or mesenchymal: Where to draw the line? BioScience Trends. 4(3): 130-142.
10. Chai J, Norng M, Modak C, Reavis K, Mouazzen W, Pham J. 2010. CCN1 Induces a Reversible Epithelial-Mesenchymal Transition in Gastric Epithelial Cells. Laboratory Investigation. 90(8): 1140-1151.
11. Modak C, Chai J. 2010. Serum response factor: Look into the gut. World Journal of Gastroenterology. 16(18): 2195-2201.
12. Modak C, Mouazzen W, Narvaez R, Reavis KM, Chai J. 2010. CCN1 is critical for acid-induced esophageal epithelial cell transformation. Biochemical and Biophysical Research Communication. 392 (4): 533-537.
13. Modak C, Chai J. 2009. Potential of casein kinase I in digestive cancer screening. World Journal of Gastrointestinal Oncology. 1(1): 26-33.
14. Modak C, Chai J. 2009. Roles of Casein Kinase I e and d in Gastrointestinal Cancers: potential new screening markers and drug targets. Current Cancer Therapy Reviews. 5(3): 151-157.
15. Chu EC, Chai J, Tarnawski AS. 2007. Mesalamine downregulates c-Myc and genes promoting survival and proliferation of human colon cancer cells. A key to its chemopreventive action? Alimentary Pharmacology & Therapeutics. 25(12): 1443-9.
16. Nguyen T, Chai J, Li A, Akahoshi T, Tanigawa T, Tarnawski AS. 2007. Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces Cyclooxygenase-2 in a phosphatidylinositol-3 kinase dependent manner. American Journal of Pathology. 170(4): 1219-28.
17. Chow J, Norng M, Zhang J, Chai J. 2007. TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells – Mechanisms behind a possible new “hot” cancer treatment. Biochimica et Biophysica Acta – Molecular Cell Research. 1773(4): 565-76.
18. Chai J, Norng M, Tarnawski AS, Chow J. 2007. A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rat. Gut. 56(5): 621-30.
19. Huang RH, Chai J, Tarnawski AS. 2006. Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells. World Journal of Gastroenterology. 12(40): 6446-52.
20. Tarnawski AS, Chai J, Jones MK. 2005. Esophageal and Gastrointestinal Microcirculation: Essential for Mucosal Protection, a Target for Injury, and a Critical Component of Injury and Ulcer Healing. In: Ishii H, et al (Eds.), Organ Microcirculation: A Gateway to Diagnostic and Therapeutic Interventions, Springer, Tokyo. pp 49-61.
21. Tarnawski A, Pai R, Chiou SK, Chai J, Chu EC. 2005. Rebamipide inhibits gastric cancer growth by targeting survivin and Aurora-B. Biochemical and Biophysical Research Communication, 334: 207-12.
22. Moon WS, Tarnawski AS, Chai J, Yang JT, Majumdar AP. 2005. Reduced expression of epidermal growth factor receptor related protein in gastric cancer. Gut. 54: 201-6.
23. Chu EC, Chai J, Tarnawski AS. 2004. NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs. Biochemical and Biophysical Research Communication, 320: 875-9.
24. Chai J, Baatar D, Tarnawski AS. 2004. Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing. Gastroenterology. 126: 1809-18.
25. Chai J, Jones MK, Tarnawski AS. 2004. Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis: Insight into the mechanisms. FASEB Journal, 18: 1264-6.
26. Tarnawski AS, Chai J, Pai R, Chiou SK. 2004. Rebamipide activates genes encoding angiogenic growth factors, Cox2 and stimulates angiogenesis. A key to its ulcer healing action? Digestive Diseases & Sciences, 49: 202-9.
27. Chai J, Baatar D, Moon W, Tarnawski A. 2002. Expression of serum response factor in normal gastric mucosa. Journal of Physiology and Pharmacology, 53: 289-94.
28. Chai J, Tarnawski A. 2002. Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing. Journal of Physiology and Pharmacology, 53: 147-57. (has been cited 107 times)
29. Zhang X, Chai J, Azhar G, Sheridan P, Nagano K, Brown T, Yang J, Khrapko K, Borras A, Lawitts J, Misra R, Wei JY. 2001. Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor. Journal of Biological Chemistry, 276: 40033-40. (has been cited 42 times)
30. Zhang X, Azhar G, Chai J, Sheridan P, Nagano K, Brown T, Yang J, Khrapko K, Borras A, Lawitts J, Misra R, Wei JY. 2000. Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor. American Journal of Physiology, 280: H1782-92. (has been cited 66 times)
31. Chai J, Lee JJ. 2000. Recognition, establishment and maintenance of diatom endosymbiosis in larger foraminifera. Micropaleontology, 46: 182-95.
32. Chai J, Lee JJ. 1999. Initial recognition of endosymbiotic diatom surface antigens by the larger foraminifer, Amphistegina lobifera. Symbiosis, 26: 39-53.
33. Chai J, Lee JJ. 1999. Establishment and maintenance of diatom endosymbiosis in larger foraminifer, Amphistegina lobifera. In: Wagner, E., Norman, J., Greppin, H., Hackstein, J. H. P., Herrmann, R. G., Kowallik, K. V., Schenck, H. E. A., & Seckbach, J., Eds., Endocytobiology VII. Universities of Freiburg and Geneva, 137-52.
34. Lee JJ, Morales J, Chai J, et al. 1995. Progress in identification of endosymbionts of larger foraminifera. In: Schenk, H. E. A. et al, (Eds.), Eukaryotism and Symbiosis, Springer, Berlin. pp. 329-44.
35. Song D, Chai J. 1992. On new species of jumping spiders (Araneae: Salticidae) from Wuling mountains area, Southwestern China. J. Xingjiang University, 9(3): 76-86.
36. Song D, Chai J. 1991. New species and new records of the Family Salticidae (Arachnida: Araneae) from Hainan, China. Zoologica Research, 3: 13-30.
37. Chai J, Xie X, Chen C. 1991. Observations on the sporogenesis of Myxosoma bibullatum in the heart of allogynogenetic crucian carp. Acta Zoologica Sinica, 37(4): 397-401.
38. Song D, Chai J. 1990. Notes of some species of the Family Thomisidae (Arachnida: Araneae) from Wuling mountain area. In: From Water to Land, pp. 364-74.
39. Chai J, Chen C. 1990. Studies on the life cycle of Haemogregarina sinensis Chai et Chen, 1990. I. Observations on H. sinensis in a leech, Mooreotorix cotylifer. Acta Hydrobiolgica Sinica, 14(3): 260-64.
40. Chai J, Chen C. 1990. Studies on the life cycle of Haemogregarina sinensis Chai et Chen, 1990. II. Observations on the development of H. sinensis in a Chinese turtle, Trionyx sinensis. Acta Hydrobiologica Sinica, 14(4): 321-27.
41. Chai J, Chen C. 1990. Notes on two species of Trypanosoma from Chinese turtles. Acta Zootaxonomica Sinica, 15(1): 1-5.
42. Chai J, Chen C. 1990. Six new species of Haemogregarina from Chinese turtles. Acta Hydrobiologica Sinica, 14(2): 129-37.
Merit Review: Role of Cyr61 in gastric ulcer healing from the Department of Veteran Affairs.
Career Development Award: Gastrointestinal ucler healing-Role of serum response factor from the Department of Veteran Affairs.
Grant-in-Aid: Critical roles of serum response factor in hypoxia-induced angiogenesis and apoptosis from the American Heart Association
Ruth L. Kirschstein National Research Service Award: SRF in cardiac development and function from National Institute of Health
Professional Societies
American Gastroenterological Association
International Symbiotic Society
Sigma Xi
American Heart Association
Society for Experimental Biology and Medicine
American Society for Biochemistry and Molecular Biology
Other Experience
Associate Investigator
VA Medical Center, Long Beach 2001—2004

Editorial Board Memeber
Journal of Oncology and Biomarker Research; Journal of Biomarkers; Gastroenterology and Hepatology; WebMedCentral; World Journal of Gastroenterology; World Journal of Gastrointestinal Oncology; World Journal of Gastrointestinal Endoscopy; World Journal of Biological Chemistry

Graduate Programs
Cellular and Molecular Biosciences

Research Center
Research, VA Medical Center
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