Human Immunology, Aging, Dendritic cells, respiratory mucosal immunity, Inflammation, vaccine adjuvants, Infectious diseases
2009 Honored as the Faculty mentor of the Month of Septembre ’09 by the undergraduate research program (UROP) of UCI
2009 Invited to Gordon Research Conferences on Aging.
2007 AAI Junior Faculty travel award
2006 New Scholar award in aging from the Ellison Medical Foundation.
Postdoctoral Fellowship from La Ligue Nationale Contre le Cancer, Paris, France.
Fellowship from Centre International de Etudiants et Stagiaires for Poster Presentation.
Research Fellowship from Council for Scientific and Industrial Research, New Delhi.
Guest editor for special issue on Novel Vaccine Adjuvants for Biomedical Research Journal
2015 Guest editor special Issue Cancer Immunology and Immunotherapy- Biomedical Research International.
2015 Travel Award FOCIS.
2016 Press release about the abstract submitted to society of mucosal immunology meeting 2016.
2016 Travel Award International Congress of Immunology 2016.
Research Scientist, ICGEB, India.
Post doctoral Fellow,France.
Postdoctoral Fellow, Emory Vaccine Center, Emory University
Assistant Clinical Professor, Department of Medicine UCI
Decline in immune function is a hallmark of aging, leading to increased susceptibility to infections and reduced response to vaccination in the elderly population. Paradoxically this decline in immune function is associated with low grade chronic inflammation. The molecular mechanisms underlying this chronic inflammatory condition and reduced immunity during cellular senescence are at present not well understood. The primary focus of my research is to understand the contribution of innate immune cells such as dendritic cells towards age-associated inflammation and reduced immunity in humans. The major research interests are –
1)Mechanisms leading to age-associated decline in the capacity of dendritic cells to maintain peripheral self tolerance and its contribution to chronic inflammation and autoimmune disorders.
2)Age-associated alterations in the functions of dendritic cells (Myeloid and plasmacytoid) that are responsible for reduced immunity and increased susceptibility to infections particularly, pneumonia and influenza.
3) Role dendritic cell-bronchial epithelial interactions in mucosal tolerance and immunity.
Another major interest of my laboratory is on the manipulation of the immune response by dendritic cells. We have recently published that activation of DCs by the Dectin-1 receptor ligand, curdlan induces Th17 cells as well highly cytolytic CD8 T lymphocytes against tumor cells. In addition, we have identified another novel C-type lectin receptor that induces a tolerogenic response in dendritic cells that can be used for treatment of inflammatory and autoimmune diseases.
Agrawal S, Agrawal A (co-corresponding author), Said HM. Biotin Deficiency Enhances the Inflammatory Response of Human Dendritic Cells. Am J Physiol Cell Physiol. 2016 Jul 13:ajpcell.00141.2016. doi: 10.1152/ajpcell.00141.2016. (paper is part of APSselect, a collection from the APS that showcases some of the best recently published articles in physiological research)
Agrawal, S., Ganguly, S., Tran, A., Sundaram, P., Agrawal, A. Retinoic Acid Treated Human Dendritic Cells Induce T Regulatory Cells via the Expression of CD141 and GARP which is impaired with age. Aging. 2016;8(6):1223-35. doi: 10.18632/aging.100973.
Agrawal, S., Ganguly, S., Hajian, P., Cao, J., & Agrawal, A. PDGF upregulates CLEC-2 to Induce T regulatory cells. Oncotarget. 2015; 5.
Prakash S, Agrawal S, Gupta S, Peterson E, Agrawal A. Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae. Mediators of Inflammation. 2014. 2014; 2014:436438.
Prakash S, Agrawal S, Vahed H, Ngyuen M, Benmohamad L, Gupta S, Agrawal A. Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. Mucosal Immunol. 2014. Apr 23. doi: 10.1038/mi.2014.28.
Comment on the paper in Human Immunology News-2.16.April 29,2014
Agrawal A, Mohammad O, Singh UP. Novel Vaccine Adjuvants (Editorial). BioMed Research International. 2013. Vol. 2013. dx.doi.org/10.1155/2013/835105.
Sridharan A, Esposo M, Kaushal K, Tay J, Osann K , Agrawal S, Gupta S, Agrawal A. Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity. AGE. 2010.DOI: 10.1007/s11357-010-9191-3.
Agrawal A and Gupta S. Impact of aging on dendritic cell functions in humans. Ageing Research Reviews. 2010. 10(3):336-45.
Agrawal A, Tay J, Yang GE, Agrawal S, Gupta S. Age-associated epigenetic modifications in human DNA increases its immunogenicity. Aging.2010. 2(2):93-100.
Agrawal A, Dillon S, Denning TL, and Pulendran B. ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to Experimental Autoimmune Encephalomyelitis. J Immunol. 2006. 176: 5788 - 5796.
Agrawal A, Tay J, Ton S, Agrawal S, Gupta S. Increased Reactivity of Dendritic Cells from Aged Subjects to Self Antigen, the Human DNA. J Immunol. 2009. 182: 1138-1145.
Agrawal A, Agrawal S, Jianing Cao, Houfen Su, Kathryn Osann, Gupta S. Altered innate immune functioning of dendritic cells in aging humans : Role of PI3Kinase signaling pathway. J Immunol. 2007.178:6912-6922.
Agrawal A, Lingappa J, Leppa SH, Agrawal S, Jabbar A, Quinn C, Pulendran B. Impairment of dendritic cells and adaptive immunity by Anthrax lethal factor Nature. 2003 Jul 17;424(6946): 329-34.
Agrawal S, Gupta S and Agrawal A. Human dendritic cells activated via Dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses. PLoS One. 2010 Oct 18;5(10):e13418.
Agarwal A, Nayak BP & Rao KVS .B cell responses to a peptide epitope. VII Antigen-dependent modulation of the germinal center reaction. J Immunol.1998. 161: 5832-5842.
Agarwal A & Rao KVS. B cell responses to a peptide epitope. III. Differential T helper cell thresholds in recruitment of B cell fine specifities. J Immunol. 1997. 159: 1077-1085.
Agarwal A, Kandpal H, Gupta HP, Singh NB & Gupta CM. Tuftsin bearing liposomes as rifampicin vehicles in treatment of tuberculosis in mice. Antimicrobial Agents & Chemotherapy. 1994. 38: 588-593.
American Associaion of Immunologists
Indian Immunologists Association
American Age Association
Society of mucosal immunology
Emory Vaccine Center, Emory University 2002—2005
Post Doctoral Fellow
Inserm Unite 255, Institut Curie, Paris, France 1999—2001
International center for Genetic Engineering and Biotechnology (UNIDO), New Delhi, India 1994—1999
Institute For Immunology
Division of Basic and Clinical Immunology