Vincent F Procaccio
Associate Professor, Pediatrics
School of Medicine
School of Medicine
Joint Appointment, Pharmacology
School of Medicine
School of Medicine
M.D., University of Grenoble, France, 1989
Ph.D., University of Grenoble, France, 1998
Ph.D., University of Grenoble, France, 1998
University of California, Irvine
Room 2034, Hewitt Hall
Mail Code: 3940
Irvine, CA 92697
Room 2034, Hewitt Hall
Mail Code: 3940
Irvine, CA 92697
Research Interests
Mitochondrial diseases, human mitochondrial genetics, cellular and molecular biology, human embryonic stem cell mitochondrial biology, mouse and rat models
Websites
Research Abstract
Procaccio’s lab major research focus is investigation of mitochondrial function and implications for human disease. While mitochondria produce most of the energy, they also produce oxygen radicals as by-products causing mutations of mitochondrial DNA and irreparable damage to proteins and ultimately lead through mitochondrial apoptosis to cell destruction.
A major goal of our current studies is focused on the roles and functions of mitochondria in neurodegenerative disorders, with special emphasis on pharmacological and therapeutic aspects such as mechanisms of regulation of mitochondria by hormones. We have recently demonstrated that estrogen increases mitochondrial efficiency while decreasing ROS production providing insight into the role of mitochondria in preventing cerebrovascular dysfunction, and increasing our knowledge of how estrogen-related therapies impact vascular function and aged-related disorders.
In addition, a recent area of investigation of our lab has focused on the role of mitochondria dysfunction in human embryonic stem cell biology to evaluate the role of damaged mitochondria in controlling proliferation and differentiation of embryonic stem cells.
A major goal of our current studies is focused on the roles and functions of mitochondria in neurodegenerative disorders, with special emphasis on pharmacological and therapeutic aspects such as mechanisms of regulation of mitochondria by hormones. We have recently demonstrated that estrogen increases mitochondrial efficiency while decreasing ROS production providing insight into the role of mitochondria in preventing cerebrovascular dysfunction, and increasing our knowledge of how estrogen-related therapies impact vascular function and aged-related disorders.
In addition, a recent area of investigation of our lab has focused on the role of mitochondria dysfunction in human embryonic stem cell biology to evaluate the role of damaged mitochondria in controlling proliferation and differentiation of embryonic stem cells.
Publications
Recent Publications:
Volodko NV, L’vova MA, E. B. Starikovskaya, Derbeneva OA, Bychkov IY, Mikhailovskaya IE, Pogozheva IV, Fedotov FF, Soyan GV, Procaccio V, Wallace DC, Sukernik R. Spectrum of Pathogenic mtDNA Mutations in Leber’s Hereditary Optic Neuropathy Families from Siberia Genetika (2006) 42: 76-83.
Duckles S, Krause D, Stirone C, Procaccio V. Estrogen and Mitochondria: A New Paradigm for Vascular Protection? Molecular Interventions (2006) 6: 26-35.
Naïmi M, Bannwarth S , Procaccio V, Pouget J, Desnuelle C, Pellissier JF, Rötig A, Munnich A, Richelme C, Jonveaux P, Castelnovo G, Calvas P, Simon M, Wallace DC, Paquis-Flucklinger V. Molecular analysis of SLC25A4, TWINKLE and POLG in Patients With Multiple Deletions or Depletion of Mitochondrial DNA by a DHPLC-based assay. European Journal of Human Genetics (2006) 14 : 917-922.
Mishmar D, Ruiz-Pesini E, Mondragon-Palomino M, Procaccio V, Gaut B, Wallace DC. Phases of adaptive evolution in primate OXPHOS complex I shed light on the complex structure. Gene (2006) 378:11-8.
Procaccio V, Salazar G, Ono S, Styers M, Gearing M, Davila A, Jimenez R, Juncos J, Gutekunst CA, Meroni G, Fontanella B, Sontag E, J Sontag JM, Faundez V, Wainer BH. A mutation of ?-actin which alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness and dystonia. (2006) American Journal of Human Genetics (2006) 78:947-960.
Kleim J, Chan S, Pringle E, Schallert K, Procaccio V, Jimenez R, Cramer S. BDNF val66/met polymorphism is associated with impaired experience-dependent plasticity in human motor cortex. Nature Neuroscience (2006) 6: 735-737
Bannwarth S, Procaccio V, Paquis-Flucklinger V. Rapid identification of unknown heteroplasmic mtDNA mutations across the entire human mitochondrial genome with mismatch-specific Surveyor Nuclease. Nature Protocols (2006) 1:2037-2047.
Procaccio V, Neckelmann N, Paquis-Flucklinger V, Bannwarth S, Jimenez R, Davila A, Poole J and Wallace DC. Detection of Low Levels of the tRNAleu(UUR) 3243A>G Mutation in Mitochondrial DNA in Blood Derived from Patients with Diabetes. Molecular Diagnosis and Therapy (2006) 6: 381-389.
Sarzi E, Brown M, Lebon S, Chretien D, Munnich A, Rotig A, Procaccio V. A novel recurrent mtDNA mutation in ND3 gene causing Leigh syndrome and dystonia. American Journal of Medical Genetics (2007) 143: 33-41.
Ruiz-Pesini E, Lott MT, Procaccio V, Poole J, Brandon MC, Mishmar D, Yi C, Kreuziger J, Baldi P, Wallace DC. An Enhanced MITOMAP with a Global mtDNA Mutational Phylogeny. Nucleic Acid Research (2007) 35: D823-D828.
Volodko NV, L’vova MA, E. B. Starikovskaya, Derbeneva OA, Bychkov IY, Mikhailovskaya IE, Pogozheva IV, Fedotov FF, Soyan GV, Procaccio V, Wallace DC, Sukernik R. Spectrum of Pathogenic mtDNA Mutations in Leber’s Hereditary Optic Neuropathy Families from Siberia Genetika (2006) 42: 76-83.
Duckles S, Krause D, Stirone C, Procaccio V. Estrogen and Mitochondria: A New Paradigm for Vascular Protection? Molecular Interventions (2006) 6: 26-35.
Naïmi M, Bannwarth S , Procaccio V, Pouget J, Desnuelle C, Pellissier JF, Rötig A, Munnich A, Richelme C, Jonveaux P, Castelnovo G, Calvas P, Simon M, Wallace DC, Paquis-Flucklinger V. Molecular analysis of SLC25A4, TWINKLE and POLG in Patients With Multiple Deletions or Depletion of Mitochondrial DNA by a DHPLC-based assay. European Journal of Human Genetics (2006) 14 : 917-922.
Mishmar D, Ruiz-Pesini E, Mondragon-Palomino M, Procaccio V, Gaut B, Wallace DC. Phases of adaptive evolution in primate OXPHOS complex I shed light on the complex structure. Gene (2006) 378:11-8.
Procaccio V, Salazar G, Ono S, Styers M, Gearing M, Davila A, Jimenez R, Juncos J, Gutekunst CA, Meroni G, Fontanella B, Sontag E, J Sontag JM, Faundez V, Wainer BH. A mutation of ?-actin which alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness and dystonia. (2006) American Journal of Human Genetics (2006) 78:947-960.
Kleim J, Chan S, Pringle E, Schallert K, Procaccio V, Jimenez R, Cramer S. BDNF val66/met polymorphism is associated with impaired experience-dependent plasticity in human motor cortex. Nature Neuroscience (2006) 6: 735-737
Bannwarth S, Procaccio V, Paquis-Flucklinger V. Rapid identification of unknown heteroplasmic mtDNA mutations across the entire human mitochondrial genome with mismatch-specific Surveyor Nuclease. Nature Protocols (2006) 1:2037-2047.
Procaccio V, Neckelmann N, Paquis-Flucklinger V, Bannwarth S, Jimenez R, Davila A, Poole J and Wallace DC. Detection of Low Levels of the tRNAleu(UUR) 3243A>G Mutation in Mitochondrial DNA in Blood Derived from Patients with Diabetes. Molecular Diagnosis and Therapy (2006) 6: 381-389.
Sarzi E, Brown M, Lebon S, Chretien D, Munnich A, Rotig A, Procaccio V. A novel recurrent mtDNA mutation in ND3 gene causing Leigh syndrome and dystonia. American Journal of Medical Genetics (2007) 143: 33-41.
Ruiz-Pesini E, Lott MT, Procaccio V, Poole J, Brandon MC, Mishmar D, Yi C, Kreuziger J, Baldi P, Wallace DC. An Enhanced MITOMAP with a Global mtDNA Mutational Phylogeny. Nucleic Acid Research (2007) 35: D823-D828.
Grants
Anna Geissler-Stiftung Foundation
Seed Grant RS1-00432-1
Multi-Investigator Faculty Research Grants UCI
Professional Societies
American Society for Pharmacology and Experimental Therapeutics
American Society of Human Genetics
Mitochondrial Research Society
Graduate Programs
Interdepartmental Neuroscience Program
Pharmacological Sciences
Link to this profile
https://faculty.uci.edu/profile/?facultyId=5073
https://faculty.uci.edu/profile/?facultyId=5073
Last updated
10/11/2007
10/11/2007