neuroscience, intellectual disability, autism, stress, synaptic plasticity, learning and memory
Lauterborn JC, Schultz MN, Le AA, Amani M, Friedman AE, Leach PT, Gall CM, Lynch GS, Crawley JN. Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities. Transl Psychiatry 2019 Jun 10;9(1):166
Lauterborn JC, Cox CD, Chan SW, Vanderklish PW, Lynch G, Gall CM. Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease. Brain Pathol 2020 Mar;30(2):319-331
Morè L, Lauterborn JC, Papaleo F, Brambilla R. Enhancing cognition through pharmacological and environmental interventions: Examples from preclinical models of neurodevelopmental disorders. Neurosci Biobehav Rev 2020 Mar;110:28-45
Wang W, Le AA, Hou B, Lauterborn JC, Cox CD, Levin ER, Lynch G, Gall CM, Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus. J Neurosci 2018 Sep 12;38(37):7935-7951
Lauterborn JC, Kramár EA, Rice JD, Babayan AH, Cox, CD, Karsten CA, Gall CM, and Lynch G. (2017) Cofilin activation is temporally associated with the cessation of growth in the developing hippocampus. Cerebral Cortex. 27: 2640-2651
Lauterborn J.C. and C.M. Gall. Defects in Rho GTPase signaling to the spine actin cytoskeleton in FMR1 knockout mice. In: R. Williamsen and F. Kooy (Eds), Fragile X Syndrome: From Genetics to Targeted Treatment, Elsevier. (2017).
Chen Y, Molet J, Lauterborn JC, Trieu BT, Bolton JL, Patterson KP, Gall CM, Lynch G, and Baram TZ. (2016) Converging, synergistic actions of multiple stress hormones mediate enduring impairments after acute simultaneous stresses. J. Neurosci. 36: 11295-11307. *Featured on Cover.
Lauterborn JC, Palmer LC, Jia Y, Pham DT, Hou B, Wang W, Trieu BH, Cox CD, Kantorovich S, Gall CM, and Lynch G. (2016) Chronic ampakine treatments stimulate dendritic growth and promote learning in middle-aged rats. J. Neurosci. 36: 201-219. *Featured in Nature highlights (Vol 530, 2016)
Lauterborn JC, Jafari M, Babayan AH, and Gall CM. (2015) Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of fragile X syndrome. Cerebral Cortex 25:516-527
Hjelm B, Galke B, Mamdani F, Lauterborn J, Kirov G, Lynch G, Gall C, Sequeira PA, Vawter M. (2015) Evidence of mitochondrial dysfunction within the complex genetic etiology of schizophrenia. Molecular Neuropsychiatry 1: 201-219
Gall, C.M., G. Lynch and J.C. Lauterborn, (2009) Activity –regulated BDNF expression: Contributions to synaptic plasticity and neuroprotection. In: P. Schwartzkroin (Ed.) Encyclopedia of Basic Epilepsy Research, Elsevier
Babayan AH, Kramár EA, Barrett RM, Jafari M, Häettig J, Chen LY, Rex CS, Lauterborn JC, Wood MA, Gall CM, Lynch G (2012) Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J. Neurosci. 32: 12854-12861. *Featured on Cover and This Week in the Journal.
Lauterborn, J.C. (2007), Fragile X and Stress: Insights from studies on the Fragile X mutant. In: J.J. Upner (Ed.), New Research in Fragile X, Nova Science Publishers, Hauppauge, New York, pp. 77-95.
Jafari M, Seese RR, Babayan AH, Gall CM, Lauterborn JC (2012) Glucocorticoid receptors are localized to dendritic spines and influence local actin signaling. Mol Neurobiol. 46: 304-315. * Featured on Cover
Gall, C.M., and J.C. Lauterborn (2000) Regulation of BDNF Expression: Multifaceted, Region-Specific Control of a Neuronal Survival Factor in the Adult CNS. In: I. Mocchetti (Ed.) Professional Book Series in Pharmacology, Neuroscience, and Biomedical Sciences, “Neurobiology of the Neurotrophins” FP Graham Publishing Co., Johnson City, TN, pp. 541-579
Seese RR, Babayan AH, Katz AM, Cox CD, Lauterborn JC, Lynch G, Gall CM (2012) LTP induction translocates cortactin at distant synapses in wild-type, but not Fmr1-KO, mice. J. Neurosci., 32: 7403-7413
Conner, J.M., J.C. Lauterborn, and C.M. Gall (1998) Anterograde transport of neurotrophin proteins in the CNS- A reassessment of the neurotrophic hypothesis. Reviews in the Neurosciences, 9:91-103
Kramár EA, Chen LY, Lauterborn JC, Simmons DA, Gall CM, Lynch G. (2012) BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiol Aging. Jul 29; 33:708-719
Simmons DA, Mehta RA, Lauterborn JC, Gall CM, Lynch G (2011) Brief Ampakine treatments slow the progression of Huntington's Disease phenotypes in R6/2 mice. Neurobiol Disease. 41: 436-444
Hagerman, R, J. Lauterborn, J. Au, and E. Berry-Kravis (2011) Fragile X Syndrome and Targeted Treatment Trials. In: R. Denman (Ed.) Modeling the Fragile X Syndrome, Springer-Verlag.
Lynch G, JC Lauterborn, and CM Gall (2010) Positive modulation of AMPA receptors as a broad-spectrum strategy for treating neuropsychiatric disorders. In: Glutamate based therapies for psychiatric disorders. P. Skolnick, Volume Ed.; Milestones in Drug Therapy, M. J. Parnham and J. Bruinvels, Series Eds. Birkhauser Verlag AG, Basel.
Chen LY, Rex CS, Babayan AH, Kramár EA, Lynch G, Gall CM, Lauterborn JC. (2010) Physiological activation of synaptic Rac>PAK (p-21 Activated Kinase) signaling is defective in a mouse model of Fragile X Syndrome. J Neurosci. Aug 18; 30 (33): 10977-84.
Lauterborn, J.C., E. Pineda, E.A. Ramirez, G. Lynch, and C.M. Gall. (2009) Ampakines cause sustained increases in BDNF signaling at excitatory synapses without changes in AMPA receptor subunit expression. Neuroscience 159: 283-295
Lauterborn, J.C. , C.S. Rex, E. Kramar, L.Y. Chen. V. Pandyarajan, G. Lynch, and C.M. Gall (2007) Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome J. Neurosci. 27: 10685-10694. *Featured in This Week in The Journal
Rex C., J.C. Lauterborn, E. Kramar, G. Rogers, C.M. Gall, G. Lynch, (2006) Restoration of LTP in middle-aged hippocampus following induction of brain-derived neurotrophic factor. J Neurophysiology, 96: 677-685. Corresponding Author: Dr. Lauterborn
Solbrig M.V., R. Adrian, J. Baratta, J. C. Lauterborn, and G. F. Koob, (2006) Kappa opioid sensitive viral epilepsy. Brain, 129: 642-54
Jourdi H, X. Lu, T. Yanagihara, J.C. Lauterborn, X. Bi, C.M. Gall, and M. Baudry (2005) Prolonged positive modulation of AMPA receptors induces calpain-mediated PDZ protein degradation and AMPA receptor down-regulation in cultured hippocampal slices. J Pharmacol Exp Ther. 314: 16-26
Poulsen FR, J.C. Lauterborn, J. Zimmer, and CM Gall. (2004) Differential expression of brain-derived neurotrophic factor transcripts after pilocarpine-induced seizure-like activity is related to mode of Ca2+ entry. Neuroscience, 126(3):665-76
Lauterborn J.C. (2004) Stress induced changes in cortical and hypothalamic c-fos expression are altered in fragile X mutant mice. Mol Brain Res., 131:101-9
Lauterborn, J.C., G. Troung, M. Baudry, X Bi, G. Lynch, and C.M. Gall, (2003) Chronic elevation of brain-derived neurotrophic factor by ampakines J. Pharmacol. Exp. Ther 307: 297-305; Corresponding and Primary Author: Dr. Lauterborn
Gall, C., J.K. Pinkstaff, J.C.Lauterborn, Y. Xie, and G. Lynch, (2003) Integrins regulate neuronal neurotrophin gene expression through effects on voltage –sensitive calcium channels, Neuroscience, 118: 925-40
Makuch, R.,J. Baratta, L.D. Karaelias, J.C. Lauterborn, C.M. Gall, J. Yu, R.T. Robertson, (2001) Arrival of afferents and the differentiation of target neurons: studies of developing cholinergic projections to the dentate gyrus. Neurosci., 104: 81-91
Bender, R.A., J.C. Lauterborn, C.M. Gall, W. Cariaga, and T.Z. Baram, (2001) Enhanced CREB phosphorylation in immature dentate gyrus granule cells precedes neurotrophin expression and indicates a specific role of CREB in granule cell differentiation. Eur. J. Neurosci., 13: 679-686
Gall, C.M., J.C. Lauterborn, K.M. Guthrie, and C.T. Stinis (1997) Seizures and the regulation of neurotrophic factor expression: associations with structural plasticity in epilepsy. In F.J. Seil (Ed.) Neuronal Regeneration, Reorganization, and Repair, Advances in Neurology Vol. 72, Lipincott-Raven Press, Philadelphia, pp. 9-24
Gall, C., J. Lauterborn, and K. Guthrie (1996) Stimulation of neurotrophic factor expression: links to different forms of brain plasticity. In C.F. Ibáñez, T. Hökfelt, L. Olson, K. Fuxe, H. Jörnvall, and D. Ottoson (Eds.) Life and Death in the Nervous System: Role of neurotrophic factors and their receptors, Wenner-Gren International Series Vol. 67, Pergamon, Elsevier, New York, pp.275-296
Gall, C., J. Lauterborn, and K. Guthrie (1995) In situ hybridization as a sensitive measure of activity dependent neuronal gene expression. In W.E. Strumpf and H.F. Solomon (Eds.) Autoradiography and Correlative Imaging, Academic Press, San Diego, pp. 379-399
Gall, C., and J. Lauterborn (1992) The dentate gyrus: a model system for studies of neurotrophin regulation. In C.E Ribak, C.M. Gall, and I. Moody (Eds.) The Dentate Gyrus and its Role in Seizures, Epilepsy Research Supplement No. 7, Elsevier, Amsterdam, pp. 171-185
Gall, C., J. Lauterborn, M. Bundman, K. Murray, and P. Isackson (1991) Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain. In V.E. Anderson, W.A. Hauser, T.E. Leppik, J.L. Noebels and S.S. Rich (Eds.), Genetic Strategies in Epilepsy Research (Epilepsy Res Suppl. 4), pp. 219-239
Gall, C., and J. Lauterborn (1991) Activity-dependent gene expression in hippocampus and cortex: implications for memory storage mechanisms. In J. McGaugh, N. Weinberger and G. Lynch (Eds.) The Neurobiology of Learning and Memory, Oxford Press, New York, pp. 301-329
Gall, C., J. Lauterborn, P. Isackson, and J. White (1990) Seizures, Neuropeptide Regulation and mRNA Expression in the Hippocampus. In. J. Storm-Mathisen, J. Zimmer, and O.P. Ottersen (Eds.), Understanding the Brain Through the Hippocampus, Progress in Brain Research, Vol. 83, pp. 371-390
Lauterborn, J.L., G. Lynch, P.W. Vanderklish, A. Arai and C.M. Gall, (2000) Modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J. Neurosci., 20: 8-21; Corresponding Author: Dr. Lauterborn
Bizon, J.L., J.C. Lauterborn, and C.M. Gall, (1999) Subpopulations of striatal interneurons can be distinguished on the basis of neurotrophic factor expression. J. Comp. Neurol., 408: 283-298
Lauterborn, J.C., F.R. Poulsen, C.T. Stinis, P.J. Isackson, and C.M. Gall (1998) Transcript-specific effects of adrenalectomy on seizure-induced BDNF expression in rat hippocampus. Mol. Brain Res., 55: 81-91
Bednarski, E., J.C. Lauterborn, C.M. Gall, and G. Lynch (1998) Lysosomal dysfunction reduces brain-derived neurotrophic factor expression. Exp. Neurology, 150: 128-135.
Robertson, R.T., K.A. Gallardo, K.J. Claytor, D.H. Ha, K. Ko-Hsiu, B.P. Yu, J.C. Lauterborn, R.G. Wiley, J. Yu, C.M. Gall, and F.M. Leslie (1998) Neonatal treatment with 192 IgG-saporin produces long term forebrain cholinergic deficits and reduces dendritic branching and spine density of neocortical pyramidal neurons. Cerebral Cortex, 8: 142-155
Conner, J.M., J.C. Lauteborn, Q. Yan, C.M. Gall, and S. Varon (1997) Distribution of brain-derived neurotrophic factor (BDNF) protein and messenger RNA in the normal adult rat CNS: evidence for anterograde axonal transport. J. Neurosci., 17: 2295-2313
Lauterborn, J., S. Rivera, C. Stinis, V. Hayes, P. Isackson, and C. Gall (1996) Differential effects of protein synthesis inhibition on the activity-dependent expression of BDNF mRNA transcripts: evidence for immediate-early gene responses from specific promoters. J. Neurosci. 16: 7428-7436
Bizon, J.L., J.C. Lauterborn, P.J. Isackson, and C.M. Gall (1996) Acidic fibroblast growth factor mRNA is expressed by basal forebrain and striatal cholinergic neurons, J. Comp. Neurol., 366: 379
Kornblum, H.K., C.M. Gall, K.B. Seroogy, and J.C. Lauterborn, (1995) A subpopulation of striatal GABAergic neurons expresses the epidermal growth factor receptor, Neurosci., 69: 1025-1029
O’Connor, L.T., J.C. Lauterborn, M.A. Smith, and C.M. Gall (1995) Agrin mRNA expression is altered following seizures in the adult rat brain. Mol. Brain .Res., 33: 277-287
Lauterborn, J.C., J.L. Bizon, T.M.D. Tran, and C.M. Gall (1995) NGF mRNA is expressed by GABAergic but not cholinergic neurons in rat basal forebrain. J. Comp. Neurol., 360: 454-462
Lauterborn, J.C., R. Berschauer, and C.M. Gall (1995) Cell-specific modulation of basal and seizure-induced neurotrophin expression by adrenalectomy. Neuroscience, 68: 363-378.
Lauterborn, J.C., P.J. Isackson, and C.M. Gall (1994) Cellular localization of NGF and NT-3 mRNAs in the postnatal rat forebrain. Mol. and Cell. Neurosci., 5: 46-62.
Lauterborn, J.C., P.J. Isackson, and C.M. Gall (1994) Seizure-induced increases in NGF mRNA exhibit different time courses across forebrain regions and are biphasic in hippocampus. Exp. Neurology, 125: 22-40.
O’Connor, L.T., J.C. Lauterborn, C.M. Gall, and M.A. Smith (1994) Localization and alternative splicing of agrin mRNA in adult rat brain: transcripts encoding isoforms that aggregate acetylcholine receptors are not restricted to cholinergic regions. J. Neuroscience, 14: 1141-1152.
Lauterborn, J.C., T.M.D. Tran, P.J. Isackson, and C.M. Gall (1993) Nerve growth factor mRNA is expressed by GABAergic neurons in rat hippocampus. NeuroReport, 5: 273-276
Ribak, C.E., J.C. Lauterborn, M.S. Navetta, and C.M. Gall (1993) The inferior colliculus of GEPR contains elevated numbers of cells that express mRNA for glutamate decarboxylase. Epilepsy Brain Res., 14: 105-113.
Lauterborn, J.C., P.J. Isackson, R. Montalvo, and C.M. Gall, (1993) In situ hybridization localization of choline acetyl transferase mRNA expression in adult rat brain. Mol. Brain Res., 17: 59-69.
White, J.D., G.L. Yount, J.C. Lauterborn, J.E. Krause, and C.M. Gall (1992) Bi-phasic response of hippocampal dynorphin expression following recurrent limbic seizure. Mol. and Cell. Neurosci., 3: 79-87.
Lauterborn, J.C., P.J. Isackson, and C.M. Gall (1991) Nerve growth factor mRNA-containing cells are distributed within regions of cholinergic neurons in the rat basal forebrain. J. Comp. Neurol., 306: 439-446.
Lauterborn, J.C. and C.E. Ribak (1989) Differences in dopamine ß-hydroxylase immunoreactivity between the brains of genetically epilepsy prone and Sprague-Dawley rats. Epilepsy Res., 4: 161-176.
Gall, C., R. Pico, and J. Lauterborn (1988) Focal hippocampal lesions induce seizures and long-lasting changes in mossy fiber enkephalin and CCK immunoreactivity. Peptides, 9: 79-84.
Lauterborn, J.C. (1992) Localization and Regulation of Nerve Growth Factor mRNA Expression in the Rat Brain. Doctoral Dissertation. University of California, Irvine.
Gall, C., J. Lauterborn, D. Burke, and K. Seroogy (1987) Co-localization of enkephalin and cholecystokinin in discrete areas of rat brain. Brain Res., 403: 403-408
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