Xiaohui Sheila Zhao

picture of Xiaohui Sheila Zhao

Clinical Professor, Pathology
School of Medicine

Director - Residency Program, Pathology
School of Medicine

Director - Hematopathology, Pathology
School of Medicine


M.D., Nanjing Medical University
Ph.D., University of Illinois Urbana-Champaign

Phone: (714) 456-8914, 6141
Fax: (714) 456-3117
Email: zhaox@uci.edu

University of California, Irvine
UCIMC, Bldg. 1, Rm. 3426
Mail Code: 4805
Orange, CA 92868
Research Interests
AIDS-related lymphoma, diagnostic challenge of MDS & recurrence of acute leukemia and EBV related lymphoma.
Research Abstract
1. Monaco, MH, Zhao, X & Donovan, SM. Effect of food restriction during pregnancy on serum IGF and IGF-binding proteins. FASEB J 1992

2. Donovan, SM, Monaco, MH & Zhao, X. Hormonal treatment during recovery from malnutrition. The Endocrine Society Annual Meeting, 1992

3. Zhao, X & Donovan, SM. GH and IGF-I treatment during recovery from malnutrition. FASEB J 1993

4. Zhao, X & Donovan, SM. Combined GH and IGF-I treatment normalizes growth recovery following neonatal malnutrition. The Endocrine Society Annual Meeting, 1994

5. Zhao, X & Donovan, SM. GH and IGF-I enhance recovery from neonatal malnutrition. FASEB J 1994, Abstract A 424 (Presented in Experimental Biology, Anaheim, CA, 1994)

6. Zhao, X & Donovan, SM. Differential effects of GH and IGF-I on protein metabolism during recovery from malnutrition. FASEB J 1995, Abstract A 756

7. Zhao, X, Nijland, MJM, Ervin, G & Ross, M. Effect of fetal maturation on pituitary arginine vasopressin. 1998, SGI (Society of Gynecology Investigation) Conference

8. Zhao, X, Nijland, MJM, Ervin, G & Ross, M. Effects of acute maternal dehydration or hyponatremia on fetal arginine vasopressin (AVP) pituitary content and hypothalamic AVP mRNA expression. 1998, SMFM (Society of Maternal-fetal Medicine) Conference

9. Zhao, SX, & Sun, N. Changing Pattern of AIDS: A bone marrow study. 2002, ASCP & CAP Annual Meeting, Washington, DC

10. Sing-Tsung, Jerry Palma, Sheila X. Zhao et al. Correlation of cytoplasmic and surface immunoglobulin light chain results by flow cytometry. 2003, Blood, 102;11 #522. (American Society of Hematology Annual Meeting, San Diego)

11. X. Zhao, Q. Huang & L. Weiss. Comparison of ancillary studies in residual disease of plasma cell myeloma on bone marrow. 2004, United States and Canadian Academy of Pathology Annual Meeting, Vancouver, BC, Canada.

12. Zhao, X. & Samoszuk, M. A Case Report of Peripheral T-cell Lymphoma with Aberrant CD20 Expression in “Progress in T-cell and NK cell Malignancies”. Society for Hematology/EAHP 2005 Workshop, Houston, Oct. 2005

13. Wang, MX , Shi, HD, Zhao, XH, Taylor, KH , Duff, D and Caldwell, CW. Molecular Detection of Residual Leukemic Cells by a Novel DNA Methylation Biomarker. United States and Canadian Academy of Pathology Annual Meeting, San Diego, CA, March, 2007

14. Nelson, EL, Imagawa, DK, Zhao, X, Bhela, S, Nishimoto, KP, Laust, A, Lee, JG, Chang, K, Holcombe, RF. A Phase 1 Clinical Trial of Single Dose GM-CSF as an Immunomodulatory Biological Adjuvant in Clinically-staged, Resectable Pancreatic Adenocarcinoma. AARC Annual Meeting, San Diego, CA 2008

15. Naemi, K, Billings, T, Zhao, X. A Case Report of Bone marrow Intravascular large B-cell Lymphoma as a rare form of Post-transplant Lymphoproliferative Disorders in “Bone Marrow Workshop”. XIV. Meeting of the European Association for Haematopathology. Bordeaux, France, Sept. 2008

16. Billings, T., Tongson-Ignacio, J, Zhao, X.. Clinicopathological Heterogeneity in Plasmablastic Lymphoma in “Lymphoma Symposium”. J Hematopathol 2008;1:186 #L23 (XIV. Meeting of the European Association for Haematopathology. Bordeaux, France, Sept. 2008)

17. Wang, MX, Zhao, X, Srilatha, N, Wang, HY, Taylor, KH, Shi, HD, Caldwell CW. A Sensitive Molecular Method for Detection of Disseminating Hematopoietic Tumor Cells by Using Specific Epigenetic DNA Methylation Biomarkers. Blood, 2008, 112 (American Society of Hematology Annual Meeting, San Francisco, CA ) 2008

18. K Naemi, RK Brynes, R Dhillon, X Zhao, & S Rezk. Benign Lymphoid aggregates in the Bone Marrow. United States and Canadian Academy of Pathology Annual Meeting, Washington, DC, March, 2010

19. V Walavalkar, CJ Yue, J Radomski, X Zhao. Diffuse Large B-cell Lymphoma with Lack of Surface Immunoglobulin Light Chain Expression by Flow Cytometry: Morphology, Flow Cytometry, and Immunohistochemistry. American Society for Clinical pathology Annual Meeting, San Francisco, CA, March, 2010

20. W Wu, V Walavalkar, X Zhao. NK Cell lymphoma, Nasal type. XVI. Meeting of the European Association for Haematopathology. Lisbon, Portugal, October. 2012

21. Pasch W, Wu W, Zhao X, and Rezk S. “Solitary plasmacytoma of the bone involving young individuals, does trauma play the role of a triggering stimulus?” The American Society of Clinical Pathology (ASCP) meeting, Boston, Massachusetts, October 2012

22. Johnston A, Brynes RK, Naemi K, Reisian N, Bhansali D, Zhao X, and Rezk S. "Differentiating benign from malignant bone marrow lymphoid aggregates" The US and Canadian Academy of Pathology (USCAP) meeting, Baltimore, Maryland, March 2013

23. Johnston A, Zhao X & Rezk S. Differentiating Benign from Malignant Bone Marrow Lymphoid Aggregates: A statistical Analysis of Distinguishing Features College of American Pathologists Annual Meeting. Orlando, FL October 13, 2013. Published abstract in Arch Pathol Med 137(9):1344.

24. Saharti S, Zhao X, Wu, ML. “Pelvic Splenosis Mimicking Metastatic Carcinoma” The American Society of Clinical Pathology (ASCP) meeting, Chicago, Illinois, September 2013

25. Nael A, Wu ML, Zhao X. “Extra Nodal Marginal Zone Lymphoma Presenting within the Meckel's Diverticulum as Diverticulitis” The American Society of Clinical Pathology (ASCP) meeting, Chicago, Illinois, September 2013

26. Nael A, Whitney P, Wu W, Dacosta-Iyer M, Zhao X, Rezk S. Epstein-Barr virus Expression May Have a Role in Plasma Cell Neoplasm Pathogenesis and Have an Association with Plasmablastic Morphologic Features, Especially in Younger Age Groups: Report of Two Cases. ASCP annual meeting, Chicago, IL, USA, September 20, 2013.

27. Lyou Y, Zhao X, Nangia CS. Pancytopenia in a patient with cystinosis secondary to myelosuppression from cystine crystal deposition. 2014 ACP (American College of Physicians) Southern California Region, October 2014 Orange, CA

28. Ali Nael, Vignesh Walavalkar, William Wu, Kambiz Nael, Sherif Rezk, Sheila Zhao. A Case of CD4-positive T-cell Primary Central Nervous System lymphoma in HIV infected patient. 2015 Workshop of the Society for hematopathologist/European Association for Hematopathology, Long Beach, CA, USA, September, 2015

29. Ali Nael, John Paul Graff, Geoffrey Sempa, Sheila Zhao. The important role of autopsy to finalize the cause of death. 2015 CAP annual meeting, Nashville, TN, USA, October 15

30. Ibe Ifegwu, Xiaohui Zhao, & Beverly Wang “Sinonasal extranodal sinus histocytosis with massive lymphadenopathy mimicking malignant sarcomas” ASCP 2016 Annual Meeting, September 14-16, 2016, in Las Vegas, NV

31. Ali Nael, Anna Shestakova, Virgilita Nora, Sherif Rezk and Xiaohui Zhao. "Automated Neutrophil Parameters are Useful in Assessing Myelodysplastic Syndrome" USCAP 2017 Annual Meeting, March 4-10, 2017, San Antonio, TX

32. Behdokht Nowroozizadeh, Nicolas Gallegos, Sherif Rezk MD, Sheila X. Zhao, Beverly Y. Wang "Molecular detection of Ebstein Barr Virus in Extranodal NK/T-cell Lymphoma" 2018 UC Irvine Research Day

33. Kuixing Zhang, MD, Deepa Jeyakumar, MD, Xiaohui Zhao, MD PhD, and Sherif A. Rezk, MD "Lymphoplasmacytic lymphoma transformation to B-cell Prolymphocytic leukemias; an extremely unusual event" ASCP 2018

34. Mark Evans and Xiaohui Zhao, An aggressive case of primary bone marrow B-cell non-Hodgkin lymphoma. EAHP Workshop September 29-October 4, 2018, Edinburgh, Scotland, UK

35. Mark Evans, Jayne Healey, and Xiaohui Zhao, Eosinophilic Granulomatosis with Polyangiitis Mimicking Chronic Eosinophilic Leukemia, NOS SH/EAHP Workshop September 12-14, 2019, Phoenix, AZ

36. Anna Shestakova MD. PhD, Jane Healey MD, Sheila Zhao MD PhD, and Sherif Rezk MD Three cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) involving cerebrospinal fluid (CSF), ASCP 2019 September 11–13 Phoenix, AZ

37. Anna Shestakova MD. PhD, Jefferson Chan, MD, PhD, Xiaohui Zhao MD PhD, and Sherif Rezk MD.
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Involving Cerebrospinal Fluid (CSF) Shows Pathogenic TP53 Mutations, USCAP 2020 Feb 29 - March 5, Annual Meeting, Los Angeles, CA

38. Sami Souccar, MD, Xiaohui Zhao MD PhD, and Beverly Wang, MD. What We Can Learn from Usual presentation of Lymphoproliferative Disorders, USCAP 2020 Feb 29 - March 5, Annual Meeting, Los Angeles, CA
Publications
1. Zhao, Xiaohui. Pelvic Mass and Infection of Pelvis. In Endocrinology in Obstetrics/Gynecology. Huang, Liangjuan (Ed), Shanghai Translation and Publication Company, Shanghai, China. 1989, p 230-300

2. NCJ Sun, J Wang, SX Zhao, EF Glassy. 12. Bone Marrow. In Silverberg's Principles and Practice of Surgical Pathology and Cytopathology. 5th Edition. Mark R. Wick, Virginia LiVolsi, John Pfeifer, Edward Stelow, Paul Wakely (Eds), Cambridge University Press, May 2015

1. Zhao, Xiaohui & Huang, Liangjuan. The relationship between serum lipids & lipoproteins and vascular lesions of placental bed in pregnancy-induced hypertension. Journal of Chinese Obstetrics & Gynecology. 1989,24:357-359

2. Zhao, X, Unterman, TG & Donovan, SM. Human GH but not Human IGF-I enhances recovery from neonatal malnutrition in rats. J Nutr 1995,125:1316-1327

3. Zhao, X & Donovan, SM. Combined GH and IGF-I treatment is more effective than GH or IGF-I alone at enhancing recovery from neonatal malnutrition in rats. J Nutr 1995,125:2773-2786

4. Zhao, X, Nijland, MJM, Ervin, G & Ross, M. Regulation of hypothalamic arginine vasopressin mRNA and pituitary arginine vasopressin content in fetal sheep: Effects of acute tonicity alterations and fetal maturation. Am J Obstet Gynecol 1998,179:899-905

5. Zhao, X, Mo, J, Wang, J & French, S. Nesidioblastosis Co-existing with Islet Cell Tumor and Intraductal Papillary Mucinous Hyperplasia: a case report. Arch Pathol Lab Med 2001,125:1344-1347

6. Zhao, X, Mcphaul, L & Sun, NCJ. Pathologic Quiz Case: A 23-year old woman with left ovarian mass. Arch Pathol Lab Med 2003,Vol 127, March:e169-e170 (web only issue at www.cap.org)

7. Zhao, X, & Sun, N. Changing Pattern of AIDS: A bone marrow study. Am J Clin Pathol 2004,121:393-401

8. Zhao, X, Huang, Q, Slovak, ML, Weiss LM. Comparison of Ancillary Studies in Residual Disease of Plasma Cell Myeloma on Bone Marrow. Am J Clin Pathol 2006,125:895-904

9. Adhikari, M. WU, MLC, & Zhao, X.. Gastrointestinal Stromal Tumor Colliding With Angiosarcoma: A case report. Int J Surg Pathol 2006,14:252-256

10. Wu, ML, Zhao, X. Multinucleated Stromal Giant Cells in Colonic Lamina Propria. Histopathology 2007,50:584-590

11. Moore, JC, Zhao, X, Nelson, EL. Concomitant Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) and Diffuse large B-cell Lymphoma: a case report. J Med Case Rep 2008;2:70

12. MX Wang, HY Wang, XH Zhao, N Srilatha, DL Zheng, HD Shi, J Ning, DJ Duff, KH Taylor, BA Gruner, W Caldwell. Molecular detection of B-cell neoplasms by specific DNA methylation biomarkers. Int J Clin Exp Pathol 2010;3:265-279.

13. Lu Y, Zhao X, Wang E, Chen W, Huang Q. ALK-negative anaplastic large cell lymphoma with extensive peripheral blood and bone marrow involvements manifested as "leukemic phase". Leuk Res. 2010 Apr;34(4):475-82.

14. Pasch W, Zhao X, and Rezk S. “Solitary plasmacytoma of the bone involving young individuals, is there a role for a preceding trauma?” Int J Clin Exp Pathol. 2012;5(5):463-7.

15. Zhao, X and Yue, C. Gastrointestinal Stromal Tumor. J Gastrointest Oncol 2012;3(3):189-208 (invited review article)

16. Naemi K, Brynes RK, Reisian N, Johnston A, Dhillon R, Walavalkar V, Zhao X, and Rezk S. "Benign lymphoid aggregates in the bone marrow, distribution patterns of B and T lymphocytes". Hum Pathol 2013;44:512-520

17. Rezk S, Nathwani B, Zhao X, and Weiss LM. "Follicular dendritic cells: origin, function, and disease-associated patterns" Hum Pathol 2013;44:937-950
18. Wu W, Pasch W, Zhao X, Rezk SA. “Extraosseous plasmacytoma with an aggressive course occurring solely in the CNS. Neuropathology. 2013;33:320-323.

19. Wu W, Youm W, Rezk S, and Zhao X. “HHV-8 Unrelated Primary Effusion Lymphoma-Like Lymphoma, a rare case and review of 54 cases in the literature” Am J Clin Pathol 2013;140;258-273

20. Nael A, Wu ML, Rao PN, Rezk S, Zhao X. Extranodal Marginal Zone Lymphoma Presenting within the Meckel Diverticulum as Diverticulitis: A Case Report. Case Rep Pathol. 2014;2014:374814. PubMed PMID: 24868477

21. Johnston A, Brynes RK, Naemi K, Reisian N, Bhansali D, Zhao X, Rezk SA. Differentiating benign from malignant bone marrow B-cell lymphoid aggregates: a statistical analysis of distinguishing features. Arch Pathol Lab Med. 2015;139(2):233-40

22. Yung Lyou, Xiaohui Zhao and Chaitali S. Nangia. Pancytopenia in a patient with cystinosis secondary to myelosuppression from cystine crystal deposition: a case report. J Med Case Rep 2015; 9:205 PMID: 26377065

23. Ali Nael, Vighnesh Walavalkar, William Wu, Kambiz Nael, Ronald Kim, Sherif Rezk, Xiaohui Zhao. CD4-positive T-cell Primary Central Nervous System Lymphoma in an HIV Positive Patient. Am J Clin Pathol 2016;145:258-265 PMID: 27124906

24. Ifegwu Ibe, Behdokht Nowroozizadeh, Xiaohui S Zhao, Wamda Goreal and Naveen Bhandarkar, Beverly Wang. Sinonasal Extranodal Sinus Histocytosis Mimicking Malignant Sarcomas. J Med Onco1:3, 2018

25. Behdokht Nowroozizadeh, Beverly Y. Wang, Neshat Nilforoushan, Sherif Rezk, Sheila X. Zhao, Nicolas Gallegos. Laryngeal NK/T-cell Lymphoma: A Report of a Rare Case with Unusual Location. J Pathology and Infectious Disease, 2018

26. Sherif A. Rezk, Xiaohui Zhao, and Lawrence M. Weiss. Epstein - Barr virus - associated lymphoid proliferations, a 2018 update. Human Pathology (2018) 79, 18–41

27. Nael A, Wu WW, Siddiqi I, Zhao X, Kahlon KS, Rezk SA. Epstein - Barr virus association with plasma cell neoplasms. Histol Histopathol. 2018 Nov 19:18066. [Epub ahead of print] PMID: 30452079

28. Zhang K, Farrell D, Jeyakumar D, O'Brien S, Zhao X, Rezk SA. Prolymphocytic transformation of Lymphoplasmacytic lymphoma; an extremely unusual event. Hum Pathol. 2018 Oct 17. [Epub ahead of print] PMID: 30342054

29. Farrell D, Nael A, Law T, Zhao X, Weiss LM, Rezk SA. Epstein-Barr virus incidental expression in bone marrow cells: a study of 230 consecutive bone marrow biopsy samples. Hum Pathol. 2019 88:60-65. PMID: 30946931

30. Farzaneh T, Wang B, Clark N, Eade-Viele C, Kelner J, Rodgers J, Sempa G, Detweiler N, Kasmarek T, Lee T, Zhao X, Monuki ES, Rezk SA. Crucial role for pathology residents in laboratory self-inspection, a single Institute's experience. Pract Lab Med. 2019 eCollection 2019.PMID: 31193900

31. Joshua Mo , Donald Tan , Xiaohui Zhao , Tjoson Tjoa , Beverly Wang. Anaplastic Transformation of Papillary Thyroid Carcinoma Mimicking Plasmacytoma. Diagnostics 2020, 10, 29 PMID: 31936233

32. Anna Shestakova, Sherif Rezk, Dara Ghasemizadeh, Ali Nael and Xiaohui Zhao. High-grade B-cell Lymphoma with MYC and BCL2 Rearrangement Arising from Follicular Lymphoma: Presentation as a Large Peripancreatic Mass. Diagnostics 2020, 10, 157 PMID: 32183313
Professional Societies
College of American Pathologists
Society for Hematopathology
American Society for Clinical Pathology
Other Experience
Graduate Programs
Pathology-Anatomic and Clinical

Last updated
04/07/2020