Anthony J. Durkin

picture of Anthony J. Durkin

Associate Professor, Beckman Laser Institute and Medical Clinic
School of Medicine

Ph.D., University of Texas, Austin, 1995, Biomedical Engineering
M.S., University of North Texas, Denton, 1987, Physics
B.S., Lamar University, Beaumont, TX, 1985, Physics

Phone: (949) 824-3284

University of California, Irvine
Beckman Laser Institute
1002 Health Sciences Road E
Mail Code: 1475
Irvine, CA 92612
Research Interests
quantitative tissue spectroscopy, tissue imaging, fluorescence, Raman, tissue optics, chemometrics, medical lasers
Academic Distinctions
2010 - present Co-Editor (in Chief), Virtual Journal of Biomedical Optics (Optical Society of America)

2008- present Advisor, SPIE Newsroom;

2003–present Member, Editorial Board; SPIE Journal of Biomedical Optics. Scope: Assign reviewers, evaluate manuscripts and reviews, conduct author correspondence.

2003-2006 Member, Editorial Board; SPIE Journal of Biomedical Optics.

1999–2006 Topical Editor; Applied Optics: Optical Technology and Biomedical Optics.

2002-2003 Co-Editor, Biomedical Optics Feature Issue; Applied Optics: published June 2003.

2003-2005 Chair: Division of Optics in Biology and Medicine, Optical Society of America.

2003-2005 Member: Executive Committee of the Science and Engineering Council (ECSEC), Optical Society of America

2004 Program Committee member, Frontiers in Optics 2004, Optical Society of America Annual Meeting, Rochester, NY. Division of Biology and Medicine Conference program design and organization. Peer review and scoring of submitted abstracts.

2004 Conference General Chair, Biomedical Optics Topical Meeting, Optical Society of America. April 14-17 2004, Miami, FL. Overall conference organization and fundraising.

2003 Program Committee member, Frontiers in Optics 2003, Optical Society of America Annual Meeting, Tucson, AZ. Division of Biology and Medicine Conference program design and organization. Peer review and scoring of submitted abstracts.

2002-2003 Chair-Elect: Division of Optics in Biology and Medicine. Optical Society of America. Training for term as Chair of Division of Optics in Biology and Medicine.

2002 Organizer and Moderator, Industry Forum, Gordon Research Conference, Lasers in Biology and Medicine, July 14-19, 2002 Meriden NH. Participants; Infraredx, Lucid Technologies, Mauna Kea Technologies, Alcon Labs.

2002 Program Chair; Biomedical Optical Spectroscopy and Diagnostics (BOSD), OSA topical meeting on Biomedical Optical Spectroscopy and Diagnostics (BOSD) and Advances in Optical Imaging and Photon Migration (AOIPM) April 7-10, Miami. Responsible for BOSD scientific program organization and content. Chair of BOSD committee (20 members); lead peer review and scoring of submitted abstracts and sessioning of conference talks in collaboration with AOIPM program chair.

2002 Co-Chair; Biomedical Optics Industry Roll-Out. Optical Society of America Topical Meetings on Biomedical Optical Spectroscopy and Diagnostics (BOSD) and Advances in Optical Imaging and Photon Migration (AOIPM) April 7-10, Miami. Participants; Infraredx, Xillix, SpectRx, NIRx, Xenogen.

2001-present Member, Biomedical Optics Ad Hoc Advisory Committee, Optical Society of America

2000 Organizer and Moderator; Biomedical Optics Industry Roll-Out; Optical Society of America Topical Meetings on Biomedical Optical Spectroscopy and Diagnostics (BOSD) and Advances in Optical Imaging and Photon Migration (AOIPM) April 2-5, Miami. Participants; SpectRx, Imaging Diagnostic Systems, RioGrande Medical Technologies, Xenogen.

2000 Program Committee member; Biomedical Optical Spectroscopy and Diagnostics (BOSD) Committee, Optical Society of America Topical Meetings on Biomedical Optics, April 2-5, 2000. Miami.

1999-present Member; SPIE International Technical Working Group on Biomedical Optics.

1998-Present Co-Founder, Moderator, Principal Contributor, Opt-dx, email list-serve, implemented through Yahoo Groups for disseminating Biomedical Optics oriented news, journal abstracts, and intellectual property announcements.

1998 Program Committee Member; Therapeutic Laser Applications in Biomedicine, Optical Society of America Topical Meetings on Biomedical Optics, Orlando, FL.

1997 Session Moderator, Clinical and Research Applications of Raman Spectroscopy I and II. Advances in Fluorescence Sensing Technology III. SPIE: Photonics West:Bios'97, San Jose, CA.
National Academy of Sciences/National Research Council (NRC) Research Fellow: Electro-Optics Branch, Center for Devices and Radiological Health/Food and Drug Administration, Rockville MD. 1995—1997
Research Abstract
Dr. Durkin’s broad research interests center on quantitative, in vivo optical spectroscopy and imaging of tissue function. He is developing new methods both as a means for detecting disease and providing feedback for optimizing therapeutic applications of medical laser technology. His specific focus is on understanding processes such as dysplasia, malignancy, and wound healing in epithelial tissues such as skin, oral cavity, and cervix. Epithelial tissue structure imposes unique technical demands on optical diagnostic methods because it is too thick for visualizing details with high resolution techniques (e.g. microscopy) and too thin for characterizing function using diffuse optics approaches (e.g. photon migration). Consequently, despite its accessibility to non-invasive optical probes, real-time quantitative epithelial tissue imaging remains one of the most difficult and challenging problems in Biomedical Optics.

Recently, Dr. Durkin’s group has developed a novel probe design to quantitatively characterize superficial tissues volumes using diffuse optical spectroscopy (DOS). While DOS has been used for determination of in-vivo optical properties of deep tissues such as breast, a number of technical limitations must be overcome in order to effectively target in changes in superficial tissues at depths less than 1mm. In this regime, the model that is used to quantify light transport in scattering media is no longer valid. Preliminary results confirm that optical properties can be accurately recovered for tissue simulating media at depths of 250 microns using this novel probe design. Future work will include Monte-Carlo simulation to fully characterize the limitations of this system.

Finally, in concert with his involvement in the Laser Microbeam and Medical Program (LAMMP) Dr. Durkin has recently submitted an independent NIH R21 award:” Expanded Range quantitative in-vivo spectroscopy system” to National Institute for Biomedical Imaging and Biomedical Engineering (NIBIB). His proposed project involves the design and construction of a quantitative spectroscopic instrument to record changes in epithelial tissue function in the 1000 to 2400 nm spectral range. The instrument will be sensitive to a number of physiologically critical chromophores that cannot be assessed with current BLI technology. Relevant analytes in this range include glucose, urea, lactate and a range of lipids. The instrumentation development process will yield a reliable system with extended spectral range that can be subsequently adapted to a variety of compelling applications. Examples include: non-invasive assessment of glucose concentration, determination of tissue urea levels for optimization of hemodialysis, and identification and quantitation of intravascular vulnerable plaque.
Available Technologies
“Spatially-modulated structured illumination with a Computed-Tomography Imaging Spectrometer (CTIS) for multispectral absorption and scattering mapping in tissue,” J.R. Weber, D.J. Cuccia, A.J. Durkin, W.R. Johnson, G.H. Bearman, and B.J. Tromberg. Accepted for Publication, SPIE Journal of Biomedical Optics.
Noninvasive Assessment of Burn Wound Severity Using Optical Technology: A Review of Current and Future Modalities, Meghann Kaiser, Amr Yafi, Marianne Cinat, Anthony J Durkin, Epub ahead of Print(accepted Nov. 2010), Burns.
“Wavelength Optimization for Rapid Chromophore Mapping using Spatial Frequency Domain Imaging (SFDI)”, Amaan Mazhar , Steven Dell , David Cuccia , Sylvain Gioux , Anthony Durkin , John Frangioni , Bruce Tromberg, J Biomed Opt. 2010 Nov-Dec;15(6):061716.
“Postoperative Quantitative Assessment of Reconstructive Tissue Status in Cutaneous Flap Model using Spatial Frequency Domain Imaging.” Amr Yafi, Thomas S Vetter, Michael R Pharaon, Thomas Scholz, Sarin Patel, Rolf B Saager, David J Cuccia, Gregory R Evans, Anthony J Durkin, Plastic & Reconstructive Surgery. 127(1):117-130, January 2011. doi: 10.1097/PRS.0b013e3181f959cc
“Early Detection of Complete Vascular Occlusion in a Pedicle Flap Model using Quantitative Spectral Imaging”. Michael R. Pharaon, MD, Thomas Scholz, MD, Scott Bogdanoff, David Cuccia, PhD, Anthony J. Durkin, PhD, David D Hoyt, MD, FACS, Gregory R.D. Evans, MD, FACS, Plastic & Reconstructive Surgery. 126(6):1924-1935, December 2010. doi: 10.1097/PRS.0b013e3181f447ac
“A Lookup-Table Method for Imaging Optical Properties with Structured Illumination Beyond the Diffusion Theory Regime”, Tim A. Erickson, Amaan Mazhar, David Cuccia, Anthony Durkin, James W. Tunnell, J. Biomed. Opt., Vol. 15, 036013 (2010); doi:10.1117/1.3431728
“Structured Illumination Enhances Resolution and Contrast in Thick Tissue Fluorescence Imaging”. J A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, B. J. Tromberg, J. Biomed. Opt. 15(01), 010506 (Jan. 2010)
“Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light.” Konecky SD, Mazhar A, Cuccia D, Durkin AJ, Schotland JC, Tromberg BJ. Opt Express. 2009 17;17(17):14780-90.
“Determination of optical properties of turbid media spanning visible and near infrared regimes via Spatially Modulated Quantitative Spectroscopy (SMoQS)”, Rolf B Saager, David J Cuccia, Anthony J Durkin, J. Biomed. Opt., Vol. 15, 017012 (2010); doi:10.1117/1.3299322
Chromophore Concentrations, Absorption and Scattering Properties of Human Skin In-vivo Sheng-Hao Tseng, Paulo Bargo, Anthony Durkin, Nikiforos Kollias, Optics Express, Vol. 17, Issue 17, pp. 14599-14617 doi:10.1364/OE.17.014599, August 2009.
Three-dimensional surface profile intensity correction for spatially modulated imaging, Sylvain Gioux, Amaan Mazhar, David J. Cuccia, Anthony J. Durkin, Bruce J. Tromberg, John V. Frangioni, J. Biomed. Opt., Vol. 14, 034045 (2009); doi:10.1117/1.3156840, Published 24 June 2009.
Non-contact imaging of absorption and scattering in layered tissue using spatially-modulated structured light, Jessie R. Weber, David J. Cuccia, Anthony J. Durkin, Bruce J. Tromberg, J. Appl. Phys. 105, 102028 (2009); DOI:10.1063/1.3116135
Wide-field Spatial Mapping of in-vivo Tattoo Skin Optical Properties using Modulated Imaging, Frederick Ayers, David J. Cuccia, Kristen Kelly, Anthony J. Durkin, Journal of Lasers in Surgery and Medicine. 2009;41(6):442-53.
“Quantitative Mapping of Turbid Media Optical Properties using Modulated Imaging.” D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. Ayers, B. J. Tromberg, Journal of Biomedical Optics, Vol. 14, 024012 (2009); DOI:10.1117/1.3088140 Published 3 April 2009
“Spatial shift of spatially modulated light projected on turbid media”, Andrea Bassi, David J. Cuccia, Anthony J. Durkin, Bruce J. Tromberg, JOSA A, Vol. 25, Issue 11, pp. 2833-2839. 2008.
“In-vivo Determination of Skin Optical Properties using Diffuse Optical Spectroscopy”, Sheng-Hao Tseng, Alexander Grant, Anthony J. Durkin, J. Biomed. Opt. Vol. 13, 014016 (Jan. 14, 2008)
“Determination of Optical Properties of Superficial Volumes of Layered Tissue Phantoms,” Sheng-Hao Tseng, Carole Hayakawa, Jerome Spanier, Anthony J. Durkin, IEEE Trans Biomed Eng. 2008 Jan;55(1):335-9.
“Quantitative Spectroscopy of Superficial Turbid Media,” Sheng-Hao Tseng, Carole Hayakawa, Bruce J. Tromberg, Jerome Spanier, Anthony J. Durkin, Opt. Lett. 30, 3165-3167 (2005).
“Modulated Imaging: Quantitative Analysis and Tomography of Turbid Media in the Spatial Frequency Domain.” D. J. Cuccia, F. Bevilacqua, A. J. Durkin, B. J. Tromberg, Opt. Lett. 2005 Jun;30 (11).
“DETERMINATION OF OPTIMAL VIEW ANGLES FOR QUANTITATIVE FACIAL IMAGE ANALYSIS”, Byungjo Jung,* Bernard Choi,* Yongjin Shin,*Anthony J. Durkin,* J. Stuart Nelson*, Journal of Biomedical Optics, March/April 2005, Volume 10, Issue 2.
“Characterization of Port Wine Stain Skin Color Using Cross-Polarized Diffuse Reflectance Imaging” Byungjo Jung, Bernard Choi, Anthony J. Durkin, Kristen M. Kelly, J. Stuart Nelson, Lasers Surg Med. March 2004;34(2):174-81.
“Comparison of Water and Lipid Content Measurements Using Diffuse Optical Spectroscopy and MRI in Emulsion Phantoms”. Sean Merritt, Gultekin Gulsen, George Chiou, Yong Chu,Chengwu Deng, Albert E. Cerussi, Anthony J Durkin, Bruce J. Tromberg, Orhan Nalcioglu, Technol Cancer Res Treat. 2003 Dec; 2(6): 563-9.
"Topics in biomedical optics: introduction," J. C. Hebden, D. A. Boas, J. S. George, and A. J. Durkin, Applied Optics, 42, 2869-2870. June 2003.
“In-vivo quantification of optical contrast agent kinetics in tumors using a combined frequency-domain and steady state technique”, David J. Cuccia, Frederic Bevilacqua, Anthony J. Durkin, Sean Merritt, Gultekin Gulsen, Hon Yu, Jun Wang, Orhan Nalcioglu, Bruce J. Tromberg, Appl Opt. 2003 Jun 1;42(16):2940-50.
“Monitoring tumor physiology using Near-infrared spectroscopy and MRI co-registration”, Sean Merritt, Frederic Bevilacqua, Anthony J. Durkin, David J. Cuccia, Ryan Lanning, Gultekin Gulsen, Hon Yu, Jun Wang, Orhan Nalcioglu, Bruce J. Tromberg, Appl Opt. 2003 Jun 1;42(16):2951-9.
“Reflectance-based Determination of Optical Properties in Highly Attenuating Tissue”, T. Joshua Pfefer, L. Stephanie Matchette, Carrie L. Bennett, Jessica A. Gall, Joy N. Wilke, Anthony J. Durkin, Marwood N. Ediger, 206-215, Vol 8, No. 2, April 2003, Journal of Biomedical Optics
“Congruent MRI and Near-infrared spectroscopy for Functional and Structural Imaging of Tumors”, Gultekin Gulsen,Hon Yu, Jun Wang, Orhan Nalcioglu, Sean Merritt, Frederic Bevilacqua, Anthony J. Durkin, David J. Cuccia, Ryan Lanning, Bruce J. Tromberg, J. Technology in Cancer Research & Treatment 1: 497-505, Dec. 2002.
“In-vivo fluorescence spectroscopy of Non-Melanoma Skin Cancer”, Lorenzo Brancaleon, Anthony J. Durkin, John H. Tu, Gregg Menaker, Jerome D. Fallon, Nikiforos Kollias, Photochemistry and Photobiology 2001 73(2): 178-183.
“Quantifying the optical properties and chromophore concentrations of turbid media by chemometric analysis of hyperspectral, diffuse reflectance data collected using a Fourier interferometric imaging system,” Tuan H. Pham, Charlotta Eker, Anthony Durkin, Bruce J. Tromberg, Stefan Andersson-Engels , Applied Spectroscopy 55, no. 8 (2001): 1035-1045.
“Chemometric Analysis of Frequency-Domain Photon Migration Data: Quantitative Measurements of Optical Properties and Chromophore Concentrations in Multicomponent Turbid Media”, Andrew J. Berger, Vasan Venugopalan, Anthony J. Durkin, Tuan Pham, and Bruce J. Tromberg, Applied Optics; Optical Technology and Biomedical Optics, Vol. 39 No. 10 pp. 1659 - 1667 (April 2000)
"Fluorescence Excitation-Emission Matrices of Human Tissue: A system for in-vivo measurement and method of data analysis”, A.F. Zuluaga, Urs Utzinger, A.J. Durkin, Holger Fuchs, J. J. Fan, Ann Gillenwater, R. Richards-Kortum, Applied Spectroscopy, Vol. 53, No. 3 pp 302-311 (March 1999).
"Quantification of Polydimethylsiloxane Concentration in Turbid Samples Using Raman Spectroscopy and Method of Partial Least Squares,", A.J. Durkin, M.N. Ediger, G.H.Pettit, Lasers Med. Sci. 1998, 13:32-42.
"A Comparison of Methods to Determine Chromophore Concentrations from Fluorescence Spectra of Turbid Samples”, A.J. Durkin, Rebecca Richards-Kortum, Lasers in Surgery and Medicine, Vol 19, No.1, 1996 pp 75-89.
"A Fiber Optic Based Confocal Spectrofluorimeter", R. Richards-Kortum, A.J. Durkin, J. Zeng, Applied Spectroscopy Vol. 48 No. 3 (March 1994) pp. 350-355.
"Relation Between Fluorescence Spectra of Dilute and Turbid Samples", A.J. Durkin, S. Jaikumar, N. Ramanujam, R. Richards-Kortum, Applied Optics Vol.33, No.3 (January 1994) pp. 414-423.
"Optically Dilute, Absorbing and Turbid Phantoms for Fluorescence Spectroscopy of Homogeneous and Inhomogeneous Samples", A.J. Durkin, S. Jaikumar, R. Richards-Kortum, Applied Spectroscopy Vol.47, No. 12 (December 1993) pp.2114-2121.
Investigation of a probe design for facilitating the uses of the standard photon diffusion equation at short source-detector separations: Monte Carlo simulations. Tseng SH, Hayakawa C, Spanier J, Durkin AJ. J Biomed Opt. 2009 Sep-Oct;14(5):054043.
Professional Societies
Optical Society of America
Society for Applied Spectroscopy
American Physical Society
Other Experience
Beckman Fellow
Beckman Laser Institute, University of California, Irvine, CA 2001—2003

Director of Bioscience
Candela Corporation, Wayland MA 1998—2001

Visiting Scientist
Center for Devices and Radiological Health/FDA, Rockville, MD 1997—1998

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