Marquis Philip Vawter

Director, Functional Genomics Laboratory, Psychiatry & Human Behavior
School of Medicine

Research Professor of Psychiatry, Psychiatry & Human Behavior
School of Medicine

Senior Associate Director, UC Irvine-Davis Brain Bank, Psychiatry & Human Behavior
School of Medicine

Ph.D., 1992, Psychology


M.S., 1985, Counseling Psychology


M.A., 1978, Physiological Psychology

Phone: Office (949) 824-9014, Laboratory (949)-824-8220
Fax: (949) 824-7012
Email: mvawter@uci.edu

University of California, Irvine
Gillespie Neuroscience, Room 2119 (office)
Functional Genomics Laboratory
Third Floor, Room 3226
Mail Code: 4260
Irvine, CA 92697

picture of Marquis Philip Vawter

Research
Interests
Gene Expression, Neuropsychiatric Disorders; Schizophrenia; Bipolar Disorder; Genetic Association Studies Of NCAM
   
URL Homepage of the Functional Genomics Laboratory
   
Academic
Distinctions
· Predoctoral Fellowship Research Award, 1985 - 1986 (Medical Faculty, Rudolf Magnus Institute for Pharmacology, Utrecht, Netherlands).

· Gladys Byram Graduate Scholarship, 1985 (University of Southern California, Los Angeles CA).

· California State Scholar, 1969 - 1973 (University of California, Santa Cruz, CA).
   
Appointments October, 1997 – October, 1999. Postdoctoral Fellow.
NATIONAL INSTITUTE ON DRUG ABUSE, ADDICTION RESEARCH CENTER, JOHNS HOPKINS BAYVIEW MEDICAL CENTER, BALTIMORE, MD. October, Work with research protocols approved by the NIH for drug use, drug abuse, and substance dependence disorders. Perform neuropsychological and clinical assessments of in-patient and out-patient substance abuse populations focusing on methadone and polysubstance abuse patients. Performed research with schizophrenia population focusing upon cell adhesion molecules and progressive brain enlargement and symptom change. Utilize neuroscience research methods such as confocal microscopy, in situ hybridization with oligonucleotide probes, transcription factor electrophoretic mobility shift assays, immunohistochemistry, and two dimensional electrophoresis, and MALDI-TOF. Key accomplishments include neuropsychological assessment of methadone patients to determine effects of methadone treatment following a period of heroin and cocaine abstinence.

October, 1994 – October, 1997. Postdoctoral Fellow.
NATIONAL INSTITUTE OF MENTAL HEALTH, SAINT ELIZABETHS HOSPITAL, WASHINGTON, DC. Work with research protocols approved by the NIH for severe mental illness. Enrolled patients with schizophrenia in olfactory receptor neuron study and isolated human cell cultures involving neuronal and glial populations. Perform neuropsychological assessment of patients with schizophrenia. Research focus on cell adhesion molecules and cytokines in neurodegenerative and neuropsychiatric disorders: schizophrenia, bipolar disorder, suicide, Parkinson’s, multiple sclerosis, and Alzheimers. Utilize neuroscience research methods such as cell culture models, flow cytometry, in situ hybridization, Western immunoblot, immunocytochemistry, and molecular biology. Key accomplishments include determining elevated neural cell adhesion molecule isoforms in the brain and CSF of patients with schizophrenia and identification of abnormalities in CSF of the multifunctional cytokines transforming growth factor beta 1 and 2 in Parkinson’s and other neurodegenerative disorders.
   
Research
Abstract
Projects
1. Mitochondrial Abnormalities in Schizophrenia and Bipolar Disorder

Abstract
Mitochondria are organelles that provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ) and bipolar disorder (BD). The overarching hypothesis for this grant is that mitochondrial dysfunction is one of the risk factors for SZ and BD based upon evidence of mitochondrial dysfunction in transcriptomic, proteomic, and metabolomic studies, genetic studies of families, in vivo neuroimaging studies, and mitochondrial DNA (mtDNA) sequence variations. Several mildly deleterious mutations in mtDNA have been reported in SZ and BD patients. The investigators found deletion of a large portion of mtDNA was increased in the brain, dorsolateral prefrontal cortex (DLPFC), of BD subjects relative to age-matched controls. The substitution of synonymous base pairs in the entire mtDNA genome was elevated in DLPFC of individuals with SZ compared to controls and subjects with SZ had a significantly decreased expression of 10 mtDNA transcripts. The decreased expression of mtDNA transcripts in SZ might be related to increased mtDNA substitution in the control or coding regions which will be tested. The causes for increased base pair substitutions in SZ might be inherited or accumulated substitutions in brain. Two of the aims for this grant are to study mtDNA substitutions in brain and to compare the substitution rate in the same subjects' germ line tissue. This grant proposes to examine mtDNA common deletion, copy number, and transcript abundances in brain from individuals with SZ and BD and compare to controls. The accumulation of novel mtDNA substitutions and deletions in brain might be a risk factor for BD and SZ, and has a great potential significance in determining future targets for therapy of chronic mood and psychotic disorders. This study fills a void as there has not been an integrative brain study of the entire mitochondrial genome and transcriptome conducted in the same subjects with psychiatric disorders. A comprehensive integration of data from the genome and transcriptome of brain mitochondria can show whether moderate dysfunction in one or both systems leads to disease threshold. Focusing on the mitochondria, as a target organelle of functional brain deficits, may lead to improvements in integrative treatments that improve mitochondrial health and brain function.

Relevance
The causes of schizophrenia and bipolar disorder have not been discovered. This grant proposes to analyze mitochondrial DNA, contained in brain cells, which might harbor abnormal structure and sequence. By understanding the accumulation of mitochondrial DNA defects in brain, it will advance mitochondrial medicine for earlier diagnosis and treatment of brain related disorders.

2. A collaboration with the Allen Institute of Brain Science, and the Functional Genomics Laboratory has been granted IRB approval November 25, 2008 titled ‘Postmortem Specimen Collection for An Atlas of Gene Expression in Whole Human Brain’. The purpose of the project is the collection of high-quality clinically characterized postmortem whole brain specimens from normal controls. These brains will be used by the Allen Institute in the creation a comprehensive multimodal human brain atlas that surveys the entire human genome throughout the brain and shows which genes are turned on, or expressed, in which brain structures. Specifically, the goal of the project is to create a detailed three-dimensional human brain atlas that includes quantitative data for all genes for all brain structures at the anatomic structure level. As part of this effort, the Institute will (1) create a series of high-resolution annotated atlases from whole human brains; (2) generate quantitative readouts of structure-specific gene expression data by isolating genetic material (RNA) from carefully dissected anatomic regions and analyzing it on microarrays; and (3) develop a series of Web-based tools for visualizing, accessing and mining the data. In addition to microarray gene expression data, 3D MRI data, detailed histological data, and in situ hybridization-based gene expression data will be integrated into the Allen Human Brain Atlas dataset so that users may assess gene expression in its anatomic and cytoarchitectural context, possibly helping researchers to better connect anatomic and functional information with underlying genetic information. While various human brain atlases exist in print or online form, none of the currently available atlases combine all of the data modalities into a single resource with 3D representation of the data. All data and tools will be made freely available to the scientific community on the Web in order to encourage widespread use and scientific collaboration.

3. An active and nascent biomarker program was started in the laboratory. Current biomarker projects involve studying healthy controls for circadian fluctuations in lymphocyte gene expression. A clinical project in collaboration with Dr. John Kelsoe, Dr. Joseph Wu, Dr. Blynn Bunney, and Dr. William Bunney is focused on sleep deprivation as an adjunct rapid antidepressant and using lymphocyte gene expression to predict responders. Comparisons of blood and brain gene expression have been conducted.

4. An active genetics study focused on an isolated population in the Central Valley of Costa Rica in collaboration with Dr. Lynn DeLisi, Dr. William Bunney, and Dr. William Byerley is underway. The laboratory is genotyping NRG1 (neuregulin 1) as a candidate gene for schizophrenia in Costa Rica samples. Sample ascertainment is directed by Andrea Fainardi-Mesén, M.D.

5. A recent project comparing schizophrenia and bipolar disorder found 78 genes that were dysregulated in both disorders in the DLPFC (PDF). This project demonstrated that both mental disorders share common gene expression alterations in pathways involving cellular apoptosis and immune dysregulation in brain.
   
Publications 122. Limon A., Mamdani F., Hjelm B.E., Vawter M.P., Sequeira A. Targets of polyamine dysregulation in major depression and suicide: Activity-dependent feedback, excitability, and neurotransmission. Neurosci Biobehav Rev. 2016 Apr 21. pii: S0149-7634(16)30100-2. doi: 10.1016/j.neubiorev.2016.04.010.

121. Morgan LZ, Rollins B, Sequeira A, Byerley W, DeLisi LE, Schatzberg AF, Barchas JD, Myers RM, Watson SJ, Akil H, Bunney WE Jr,Vawter MP. Quantitative Trait Locus and Brain Expression of HLA-DPA1 Offers Evidence of Shared Immune Alterations in Psychiatric Disorders. Microarrays (Basel). 2016 Mar;5(1). pii: 6. Epub 2016 Mar 7.

120. Schneider K, Valdez J, Nguyen J, Vawter M, Galke B, Kurtz TW, Chan JY. Increased energy expenditure, UCP1 expression and resistance to diet-induced obesity in mice lacking nuclear factor-erythroid-2 related transcription factor-2 (Nrf2). J Biol Chem. 2016 Feb 3. pii: jbc.M115.673756.

119. Sellgren CM, Kegel ME, Bergen SE, Ekman CJ, Olsson S, Larsson M, Vawter MP, Backlund L, Sullivan PF, Sklar P, Smoller JW, Magnusson PK, Hultman CM, Walther-Jallow L, Svensson CI, Lichtenstein P, Schalling M, Engberg G, Erhardt S, Landén M. A genome-wide association study of kynurenic acid in cerebrospinal fluid:implications for psychosis and cognitive impairment in bipolar disorder. Mol Psychiatry. 2015 Dec 15. doi: 10.1038/mp.2015.186. [Epub ahead of print]

118. Hjelm B.E., Rollins B., Mamdani F., Lauterborn J.C., Kirov G., Lynch G., Gall C.M., Sequeira A., Vawter M.P. (2015). Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia. Mol Neuropsychiatry;1:201-219, DOI:10.1159/000441252.

117. Guella I, Sequeira A, Rollins B, Morgan L, Torri F, van Erp TG, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Bunney WE, Potkin SG, Macciardi F, Vawter MP. (2013). Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex. J Psychiatr Res. Sep;47(9):1215-21. doi: 10.1016/j.jpsychires.2013.05.021. Epub 2013 Jun 17.

116. Martin M, Nisenbaum, L., Mirnics, K. Vawter MP. Olanzapine Reversed Brain Gene Expression Changes Induced by Phencyclidine Treatment in Non-Human Primates. (2015). Mol Neuropsychiatry; 1:82-93.

115. Leonpacher AK, Liebers D, Pirooznia M, Jancic D, MacKinnon DF,Mondimore FM, Schweizer B, Potash JB, Zandi PP; NIMH Genetics Initiative Bipolar Disorder Consortium, Goes FS. (2015). Distinguishing bipolar from unipolar depression: the importance of clinical symptoms and illness features. Psychol Med. Apr 8:1-10.

114. Sequeira A, Rollins B, Magnan C, van Oven M, Baldi P, Myers RM,Barchas JD, Schatzberg AF, Watson SJ, Akil H, Bunney WE, Vawter MP. (2015). Mitochondrial mutations in subjects with psychiatric disorders. PLoS One. May 26;10(5):e0127280. doi: 10.1371/journal.pone.0127280.

113. Bunney BG, Li JZ, Walsh DM, Stein R, Vawter MP, Cartagena P,Barchas JD, Schatzberg AF, Myers RM, Watson SJ, Akil H, Bunney WE. (2014). Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder. Mol Psychiatry. 2014 Nov 4. doi: 10.1038/mp.2014.138.

112. Esmailpour T, Riazifar H, Liu L, Donkervoort S, Huang VH, Madaan S, Shoucri BM, Busch A, Wu J, Towbin A, Chadwick RB, Sequeira A, Vawter MP, Sun G, Johnston JJ, Biesecker LG, Kawaguchi R, Sun H, Kimonis V, Huang T. (2014). A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome. J Med Genet. Mar;51(3):185-96. doi: 10.1136/jmedgenet-2013-101660.

111. Mamdani F, Rollins B, Morgan L, Sequeira PA, Vawter MP. The somatic common deletion in mitochondrial DNA is decreased in schizophrenia. (2014). Schizophr Res. Sep 27. pii: S0920-9964(14)00468-X. doi: 10.1016/j.schres.2014.08.026.

110. Nurnberger JI Jr, Koller DL, Jung J, Edenberg HJ, Foroud T, Guella I, Vawter MP, Kelsoe JR; for the Psychiatric Genomics Consortium Bipolar Group. (2014). Identification of Pathways for Bipolar Disorder: A Meta-analysis. JAMA Psychiatry. Apr 9. doi:10.1001/jamapsychiatry.2014.176.

109. Guella, I., Vawter, M.P.., Allelic imbalance associated with the schizophrenia risk SNP rs1344706 indicates a cis-acting variant in ZNF804A. (2014). Schizophr Res. http://dx.doi.org/10.1016/j.schres.2014.01.005.

108. Guella I, Sequeira A, Rollins B, Morgan L, Myers RM, Watson SJ,Akil H, Bunney WE, Delisi LE, Byerley W, Vawter MP. (2014). Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex. Schizophr Res. Jan;152(1):111-6. doi: 10.1016/j.schres.2013.11.021.

107. Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Del Carpio JC, Nesburn AB, Boyer DS, Kuppermann BD, Vawter MP, Jazwinski SM, Miceli MV, Wallace DC, Udar N. (2014). Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases. Biochim Biophys Acta. Feb;1842(2):208-19. doi: 10.1016/j.bbadis.2013.10.016.

106. Tomita H, Ziegler ME, Kim HB, Evans SJ, Choudary PV, Li JZ, Meng F, Dai M, Myers RM, Neal CR, Speed TP, Barchas JD,Schatzberg AF, Watson SJ, Akil H, Jones EG, Bunney WE, Vawter MP. (2013). G protein-linked signaling pathways in bipolar and major depressive disorders. Front Genet. 2013 Dec 23;4:297. doi: 10.3389/fgene.2013.00297.

105. Hayashi-Takagi A, Vawter MP, Iwamoto K. (2013). Peripheral Biomarkers Revisited: Integrative Profiling of Peripheral Samples for Psychiatric Research. (2013). Biol Psychiatry. Oct 18. pii: S0006-3223(13)00944-X. doi:10.1016/j.biopsych.2013.09.035.

104. van Erp TG, Guella I, Vawter MP, Turner J, Brown GG, McCarthy G, Greve DN, Glover GH, Calhoun VD, Lim KO, Bustillo JR, Belger A, Ford JM, Mathalon DH, Diaz M,Preda A, Nguyen D, Macciardi F, Potkin SG. (2013). Schizophrenia miR-137 Locus Risk Genotype is Associated with Dorsolateral Prefrontal Cortex Hyperactivation. Biol Psychiatry. Aug 1. pii: S0006-3223(13)00595-7. doi: 10.1016/j.biopsych.2013.06.016.

103. Firoza Mamdani, Maureen V. Martin, Todd Lencz, Brandi Rollins, Delbert G. Robinson, Emily A.Moon, Anil K. Malhotra, Marquis P. Vawter. (2013). Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia. Disease Markers, Volume 35 (2013), Issue 1, Pages 11–21, http://dx.doi.org/10.1155/2013/748095.

102. Bharadwaj R, Jiang Y, Mao W, Jakovcevski M, Dincer A, Krueger W, Garbett K, Whittle C, Tushir JS, Liu J, Sequeira A, Vawter MP, Gardner PD, Casaccia P, Rasmussen T, Bunney WE Jr, Mirnics K, Futai K, Akbarian S. (2013). Conserved Chromosome 2q31 Conformations Are Associated with Transcriptional Regulation of GAD1 GABA Synthesis Enzyme and Altered in Prefrontal Cortex of Subjects with Schizophrenia. J Neurosci. Jul 17;33(29):11839-11851.

101. Li JZ, Bunney BG, Meng F, Hagenauer MH, Walsh DM, Vawter MP, Evans SJ, Choudary, PV, Cartagena P, Barchas JD, Schatzberg AF, Jones EG, Myers RM, Watson SJ Jr,Akil H, Bunney WE. (2013). Proc Natl Acad Sci U S A. May 13. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder.

100. Guia Guffanti, Federica Torri, Jerod Rasmussen, Andrew P.Clark, Anita Lakatos, Jessica A. Turner, James H. Fallon, Andrew J. Saykin, Michael Weiner, ADNI the Alzheimer’s Disease Neuroimaging Initiative, Marquis P. Vawter, James A. Knowles, Steven G. Potkin, Fabio Macciardi. Increased CNV-Region Deletions in Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD) Subjects in the ADNI Sample. (2013). Genomics doi: 10.1016/j.ygeno.2013.04.004.

99. Lavebratt C, Olsson S, Backlund L, Frisén L, Sellgren C, Priebe L, Nikamo P, Träskman-Bendz L, Cichon S, Vawter MP, Osby U, Engberg G, Landén M, Erhardt S, Schalling M. (2013). The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression. Mol Psychiatry. 2013 Mar 5. doi: 10.1038/mp.2013.11.

98. Greenwood TA; Bipolar Genome Study (BiGS) Consortium, Kelsoe JR. Collaborators: Nurnberger J, Miller M, Bowman E, Reich T, Goate A, Rice J, DePaulo J Jr, Simpson S, Stine C, Gershon E, Kazuba D, Maxwell E, Nurnberger J, Miller MJ, Bowman ES, Rau N, Moe P, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg HJ, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo J Jr, MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, Byerley W, Vawter M, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, McMahon FJ, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL, Gejman PV, Gejman PV, Sanders AR, Amin F, Byerley WF, Black DW, Crowe RR, Cloninger C, Freedman R, Olincy A, Levinson DF, Buccola NG, Mowry BJ, Silverman JM, Kelsoe JR, Greenwood TA, Nievergelt CM, McKinney R, Shilling PD, Smith EN, Schork NJ, Bloss CS, Nurnberger JI Jr, Edenberg HJ, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Potash JB, Rice J, Byerley W, McMahon FJ, Schulze TG, Berrettini WH, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB (2013). Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder. PLoS One. 2013;8(1):e53804. doi: 10.1371/journal.pone.0053804. Epub 2013 Jan 10.

97. Nissen S, Liang S, Shehktman T, Kelsoe JR; Bipolar Genome Study (BiGS), Greenwood TA, Nievergelt CM, McKinney R, Shilling PD, Smith EN, Schork NJ, Bloss CS, Nurnberger JI Jr, Edenberg HJ, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon FJ, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Schulze TG. Collaborators: Keck P, McElroy S, Remick R, Sadovnick A, Nurnberger J, Miller M, Bowman E, Reich T, Goate A, Rice J, DePaulo J Jr, Simpson S, Stine C, Gershon E, Kazuba D, Maxwell E, Nurnberger J, Miller MJ, Bowman ES, Rau N, Moe P, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo J Jr,MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J,Berrettini W, Byerley W, Vawter M, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L,McMahon FJ, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL. (2012). Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, IFT27 and parvalbumin. Am J Med Genet B Neuropsychiatr Genet. Dec;159B(8):941-50.

96. M. J. Hawrylycz, E. S. Lein, A. L. Guillozet-Bongaarts, E. H. Shen, L. Ng, J. A. Miller, L. N. van de Lagemaat, K. A. Smith, A. Ebbert, Z. L. Riley, C. Abajian, C. F. Beckmann, A. Bernard, D. Bertagnolli, A. F. Boe, P. M. Cartagena, M. M. Chakravarty, M. Chapin, J. Chong, R. A. Dalley, B. D. Daly, C. Dang, S. Datta, N. Dee, T. A. Dolbeare, V. Faber, D. Feng, D. R. Fowler, J. Goldy, B. W. Gregor, Z. Haradon, D. R. Haynor, J. G. Hohmann, S. Horvath, R. E. Howard, A. Jeromin, J. M. Jochim, M. Kinnunen, C. Lau, E. T. Lazarz, C. Lee, T. A. Lemon, L. Li, Y. Li, J. A. Morris, C. C. Overly, P. D. Parker, S. E. Parry, M. Reding, J. J. Royall, J. Schulkin, P. A. Sequeira, C. R. Slaughterbeck, S. C. Smith, A. J. Sodt, S. M. Sunkin, B. E. Swanson, M. P. Vawter, D. Williams, P. Wohnoutka, H. R. Zielke, D. H. Geschwind, P. R. Hof, S. M. Smith, C. Koch, S. G. N. Grant and A. R. Jones. (2012). An anatomically comprehensive atlas of the adult human brain transcriptome. Nature, 489 (7416); 391-399.

95. HD iPSC Consortium (Alvin R. King, Malcolm Casale, Sara T. Winokur, Gayani Batugedara, Marquis Vawter, Peter J. Donovan, Leslie F. Lock and Leslie M. Thompson). Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell. 2012 Aug 3;11(2):264-78. Epub 2012 Jun 28.

94. Torri F, Dinov ID, Zamanyan A, Hobel S, Genco A, Petrosyan P, Clark AP, Liu Z,Eggert P, Pierce J, Knowles JA, Ames J, Kesselman C, Toga AW, Potkin SG, Vawter MP, Macciardi F. (2012). Next generation sequence analysis and computational genomics using graphical pipeline workflows. Genes (Basel); 3(3): 545-575. Aug 30.

93. Backlund L, Lavebratt C, Frisén L, Nikamo P, Hukic Sudic D, Träskman-Bendz L,Landén M, Edman G, Vawter MP, Osby U, Schalling M. (2012). P2RX7: Expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1. PLoS One;7(8):e43057. Epub 2012 Aug 28.

92. Sequeira A, Martin MV, Rollins B, Moon EA, Bunney WE, Macciardi F, Lupoli S, Smith EN, Kelsoe J, Magnan CN, van Oven M, Baldi P, Wallace DC, Vawter MP. (2012). Mitochondrial mutations and polymorphisms in psychiatric disorders. Front Genet.;3:103. Epub 2012 Jun 20.

91. Sequeira A, Morgan L, Walsh DM, Cartagena PM, Choudary P, Li, J., Schatzberg, A.F., Watson, S.J., Akil, H., Myers, R.M., Jones, E.G., Bunney, W.E., Vawter, M.P. (2012). Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide. PLoS ONE 7(4): e35367. doi:10.1371/journal.pone.0035367.

90. Goes FS, McCusker MG, Bienvenu OJ, Mackinnon DF, Mondimore FM, Schweizer B; National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium, Depaulo JR, Potash JB. Collaborators: Weissman MM, Knowles JK, Zubenko GS, Zubenko WN, DePaulo J,McInnis MG, MacKinnon D, Levinson DF, Gladis MM, Murphy-Eberenz K, Holmans P,Crowe RR, H W, Scheftner WA, Nurnberger J, Miller M, Bowman E, Reich T, Goate A, Rice J, DePaulo J Jr, Simpson S, Stine C, Gershon E, Kazuba D, Maxwell E, Nurnberger J, Miller MJ, Bowman ES, Rau N, Moe P, Samavedy N, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo J Jr, MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, Byerley W, Vawter M, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, McMahon FJ, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL, Kogod R, Kogod A, El-Mallakh R. Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. Psychol Med. 2012 Jul;42(7):1449-59. Epub 2011 Nov 21.

89. Karlsson R, Graae L, Lekman M, Wang D, Favis R, Axelsson T, Galter D, Carmine, Belin A, Paddock S. MAGI1 Copy Number Variation in Bipolar Affective Disorder and Schizophrenia. Biol Psychiatry. 2012 May;71(10):922-30. Epub 2012 Feb 28.

88. Sequeira PA, Martin MV, Vawter MP. (2012). The first decade and beyond of transcriptional profiling in schizophrenia. Neurobiol Dis. 45(1):23-36.

87. Willour VL, Seifuddin F, Mahon PB, Jancic D, Pirooznia M, Steele J, Schweizer B, Goes FS, Mondimore FM, Mackinnon DF; Bipolar Genome Study Consortium, Perlis RH, Lee PH, Huang J, Kelsoe JR, Shilling PD, Rietschel M, Nöthen M, Cichon S, GurlingH, Purcell S, Smoller JW, Craddock N, DePaulo JR Jr, Schulze TG, McMahon FJ,Zandi PP, Potash JB. Collaborators: Kelsoe JR, Greenwood TA, McKinney R, Shilling D, Schork N, SmithEN, Nurnberger JI Jr, Edenberg HJ, Foroud T, Koller DM, Gershon E, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W,Berrettini W, Potash JB, Zandi PP, McInnis MG, Zollner S, Craig D, Szelinger S,Nurnberger J, Miller M, Bowman E, Rice J, DePaulo R Jr, Simpson S, Stine C,Gershon E, Kazuba D, Maxwell E, Nurnberger J, Miller MJ, Bowman ES, Rau NL, MoePR, Samavedy N, El-Mallakh R, Manji H, Glitz A, Meyer ET, Flury L, Dick DM,Edenberg H, Rice J, Reich T, Goate A, Bierut L, DePaulo R Jr, MacKinnon DF,Potash JB, Zandi PP, Payne J, Berrettini W, Byerley W, Vawter M, Coryell W,Badner J, McMahon F, Liu C, Sanders A, Caserta M, Harakal D, Scheftner W, KravitzHM, Marta D, Vaughn-Brown A, McMahon FJ, Kassem L, Murphy DL, Nurnberger J,Miller MJ, Bowman ES, Rau NL, Moe PR, Samavedy N, Glitz A, Meyer ET, Smiley C,Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Bierut L, MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, ByerleyW, Vinogradov S, Coryell W, Crowe R, Gershon E, Liu C, Sanders A, Caserta M,Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftner W, Kravitz HM, Marta D, Bederow L, McMahon FJ, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL,Lawson WB, Nwulia E, Hipolito M. A genome-wide association study of attempted suicide. Mol Psychiatry. 2012 Apr;17(4):433-44. doi: 10.1038/mp.2011.4. Epub 2011 Mar 22.

86. Vawter MP, Mamdani F, Macciardi F. An integrative functional genomics approach for discovering biomarkers in schizophrenia. Brief Funct Genomics. 2011 Nov;10(6):387-99. doi: 10.1093/bfgp/elr036. Epub 2011 Dec 8.

85. Goes FS, Rongione M, Chen YC, Karchin R, Elhaik E; Bipolar Genome Study, Potash JB. Collaborators: Kelsoe JR, Greenwood TA, Nievergelt CM, McKinney R, Shilling PD, Schork N, Smith EN, Bloss C, Nurnberger J, Edenberg HJ, Foroud T, Koller DL, Gershon E, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Schulze TG, Berrettini W, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Nurnberger J, Miller M, Bowman E, Reich T, Goate A, Rice J, DePaulo JR Jr, Simpson S, Stine C, Gershon E, Kazuba D, Maxwell E, Nurnberger J, Miller MJ, Bowman ES, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz A, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo JR Jr, MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, Byerley W, Vawter M, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe JR, McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL, Gejman PV, Sanders AR, Amin F, Buccola N, Byerley W, Cloninger CR, Crowe R, Black D, Freedman R, Levinson D, Mowry B, Silverman J. Exonic DNA sequencing of ERBB4 in bipolar disorder. PLoS One. 2011;6(5):e20242. Epub 2011 May 26.

84. Bellet MM, Vawter MP, Bunney BG, Bunney WE, Sassone-Corsi P. Ketamine influences CLOCK:BMAL1 function leading to altered circadian gene expression (2011). PLoS One. 6(8):e23982.

83. Moon E, Rollins B, Mes´en A, Sequeira A, Myers RM, Akil H, Watson SJ, Barchas J, Jones EG, Schatzberg A, Bunney WE, DeLisi LE, Byerley W, Vawter MP. (2011). Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population, Schizophrenia Research, doi:10.1016/j.schres.2011.06.024.

82. Hartz, S.M., P. Lin, H.J. Edenberg, X. Xuei, N. Rochberg, S. Saccone, W. Berrettini, E. Nelson, J. Nurnberger, L.J. Bierut, and J.P. Rice, NIMH Genetics Initiative Bipolar Disorder Consortium. Genetic association of bipolar disorder with the beta(3) nicotinic receptor subunit gene. Psychiatric genetics, 2011 Apr;21(2):77-84.

81. Belmonte Mahon P, Pirooznia M, Goes FS, Seifuddin F, Steele J, Lee PH, Huang J, Hamshere ML; Bipolar Genome Study (BiGS) Consortium, The Wellcome Trust Case Control Consortium Bipolar Disorder Group, Depaulo JR Jr, Kelsoe JR, Rietschel M, Nöthen M, Cichon S, Gurling H, Purcell S, Smoller JW, Craddock N, Schulze TG, McMahon FJ, Potash JB, Zandi PP. Collaborators: Nurnberger J, Miller M, Bowman E, Reich T, Goate A, Rice J, DePaulo JR Jr, Simpson S, Stine C, Gershon E, Kazuba D, Maxwell E, Nurnberger J, Miller MJ, Bowman ES, Rau L, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo JR Jr, MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, Byerley W, Vawter M, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftnerv W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, McMahon FJ, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL, Nurnberger J, Miller MJ, Bowman ES, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo JR Jr, MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, Byerley W, Vinogradov S, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, McMahon FJ, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL, Lawson WB, Nwulia E, Hipolito M, Gejman PV, Sanders AR, Amin F, Buccola N, Byerley W, Cloninger CR, Crowe R, Black D, Freedman R, Levinson D, Mowry B, Silverman J, Kelsoe JR, Greenwood TA, Shilling PD, Nievergelt C, Schork N, Smith EN, Nurnberger J, Edenberg HJ, Foroud T, Gershon E, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Schulze TG, Berrettini W, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Craig D, Szelinger S, Breen G, Clair DS, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskvina V, Nikolov I, O'Donovan MC, Owen MJ, Craddock N, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN. (2011). Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):370-8.

80. Lee CS, Lee C, Hu T, Nguyen JM, Zhang J, Martin MV, Vawter MP, Huang EJ, Chan JY. (2011). Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. Proc Natl Acad Sci U S A. 108(20): 8408-13.

79. Potkin SG, Macciardi F, Guffanti G, Fallon JH, Wang Q, Turner JA, Lakatos A, Miles MF, Lander A, Vawter MP, Xie X. (2010). Identifying gene regulatory networks in schizophrenia. Neuroimage 53: 839-47.

78. Knight, J., N.S. Rochberg, S.F. Saccone, J.I. Nurnberger, Jr., NIMH Genetics Initiative Bipolar Disorder Consortium and J.P. Rice, An investigation of candidate regions for association with bipolar disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010 Oct 5;153B(7):1292-7.

77. Oedegaard, K.J., T.A. Greenwood, A. Lunde, O.B. Fasmer, H.S. Akiskal, and J.R. Kelsoe, NIMH Genetics Initiative Bipolar Disorder Consortium. A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11. Journal of affective disorders, 2010 Apr;122(1-2):14-26.

76. Goes, F.S., V.L. Willour, P.P. Zandi, P.L. Belmonte, D.F. MacKinnon, F.M. Mondimore, B. Schweizer, NIMH Genetics Initiative Bipolar Disorder Consortium, J.R. DePaulo, Jr., E.S. Gershon, F.J. McMahon, and J.B. Potash, Sex-specific association of the Reelin gene with bipolar disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010 Mar 5;153B(2):549-53.

75. Lavebratt C, Sjöholm LK, Soronen P, Paunio T, Vawter MP, Bunney WE, Adolfsson R, Forsell Y, Wu JC, Kelsoe JR, Partonen T, Schalling M. (2010). CRY2 is associated with depression. PLoS One. 2010 Feb 24;5(2):e9407.

74. Rollins, B., M. V. Martin, Morgan, L., Vawter, M.P. (2010). Analysis of whole genome biomarker expression in blood and brain. Am J Med Genet B Neuropsychiatr Genet. Feb 2.

73. Genetics Initiative Bipolar Disorder Collaborative, Bipolar Disorder Phenome Group, Gershon ES, McMahon FJ, Potash JB. Collaborators: McMahon FJ, Steele J, Pearl J, Kassem L, Lopez V, Schulze T,Potash JB, MacKinnon D, Miller E, Toolan J, Zandi P, Simpson S, Nurnberger J, Miller M, Bowman E, Reich T, Goate A, Rice J, DePaulo JR Jr, Simpson S, Stine C, Gershon E, Kazuba D, Maxwell E, Nurnberger J, Miller MJ, Bowman ES, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo JR Jr, MacKinnon DF, Mondimore FM, Mondimore JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, Byerley W, Vawter M, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, McMahon F, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL. Family-based association of YWHAH in psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):977-83.

72. Martin MV, Rollins B, Sequeira PA, Mesen A, Byerley W, Stein R, Moon EA, Akil H, Jones EG, Watson SJ, Barchas J, Delisi LE, Myers RM, Schatzberg A, Bunney WE, Vawter MP. Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation. BMC Med Genomics. 2009 Sep 22;2(1):62.

71. Sequeira A, Mamdani F, Ernst C, Vawter MP, Bunney WE, Lebel V, Rehal S,Klempan T, Gratton A, Benkelfat C, Rouleau GA, Mechawar N, Turecki G. Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS One. 2009 Aug 11;4(8):e6585.

70. Rollins B, Martin MV, Sequeira PA, Moon EA, Morgan LZ, Watson SJ, Schatzberg A, Akil H, Myers RM, Jones EG, Wallace DC, Bunney WE, Vawter MP. Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder. PLoS One. 2009;4(3):e4913.

69. Mahon PB, Payne JL, MacKinnon DF, Mondimore FM, Goes FS, Schweizer B, Jancic D; NIMH Genetics Initiative Bipolar Disorder Consortium; BiGS Consortium, Coryell WH, Holmans PA, Shi J, Knowles JA, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR Jr, Zandi PP, Potash JB. Collaborators: Weissman MM, Knowles JK, Zubenko GS, Zubenko WN, DePaulo JR, McInnis MG, MacKinnon D, Levinson DF, Gladis MM, Murphy-Eberenz K, Holmans P, Crowe RR, Coryell WH, Scheftner WA, Nurnberger J, Miller M, Bowman E, Reich T, Goate A, Rice J, DePaulo JR Jr, Simpson S, Stine C, Gershon E, Kazuba D, Maxwell E, Nurnberger J, Miller MJ, Bowman ES, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo JR Jr, MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, Byerley W, Vawter M, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, McMahon FJ, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL, Gejman PV, Sanders AR, Amin F, Buccola N, Byerley W, Cloninger CR, Crowe R, Black D, Freedman R, Levinson D, Mowry B, Silverman J, Kelsoe JR, Greenwood TA, Nievergelt C, Schork N, Smith EN, Bloss C, Nurnberger J, Edenberg HJ, Foroud T, Gershon E, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Schulze TG, Berrettini W, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Craig D, Szelinger S. Genome-wide linkage and follow-up association study of postpartum mood symptoms. Am J Psychiatry. 2009 Nov;166(11):1229-37. Epub 2009 Sep 15. Comment in Am J Psychiatry. 2009 Nov;166(11):1201-4.

68. Goes, F.S., V.L. Willour, P.P. Zandi, P.L. Belmonte, D.F. MacKinnon, F.M. Mondimore, B. Schweizer, E.S. Gershon, F.J. McMahon, and J.B. Potash, Bipolar Disorder Phenome Group; NIMH Genetics Initiative Bipolar Disorder Consortium. Family-based association study of Neuregulin 1 with psychotic bipolar disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009 Jul 5;150B(5):693-702.

67. Schulze, T.G., S.D. Detera-Wadleigh, N. Akula, A. Gupta, L. Kassem, J. Steele, J. Pearl, J. Strohmaier, R. Breuer, M. Schwarz, P. Propping, M.M. Nothen, S. Cichon, J. Schumacher, NIMH Genetics Initiative Bipolar Disorder Consortium, M. Rietschel, and F.J. McMahon, Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Molecular Psychiatry, 2009 May;14(5):487-91.

66. Willour VL, Chen H, Toolan J, Belmonte P, Cutler DJ, Goes FS, Zandi PP, Lee RS, MacKinnon DF, Mondimore FM, Schweizer B; Bipolar Disorder Phenome Group; NIMH Genetics Initiative Bipolar Disorder Consortium, DePaulo JR Jr, Gershon ES, McMahon FJ, Potash JB. Collaborators: McMahon F, Steele J, Pearl J, Kassem L, Lopez V, Potash J, MacKinnon D, Miller E, Toolan J, Zandi P, Schulze T, Nwulia E, Simpson S, Nurnberger J, Miller M, Bowman E, Reich T, Goate A, Rice J, DePaulo JR Jr, Simpson S, Stine C, Gershon E, Kazuba D, Maxwell E, Nurnberger J, Miller MJ, Bowman ES, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo JR Jr, MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, Byerley W, Vawter M, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, McMahon FJ, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL. Family-based association of FKBP5 in bipolar disorder. Mol Psychiatry. 2009 Mar;14(3):261-8.

65. Bertisch H, Mesen-Fainardi A, Martin MV, Pérez-Vargas V, Vargas-Rodríguez T, Delgado G, Delgado C, Llach M, LaPrade B, Byerley W, Bunney WE, Vawter MP, DeLisi LE; Pritzker Neuropsychiatric Research Consortium. Neuropsychological performance as endophenotypes in extended schizophrenia families from the Central Valley of Costa Rica. Psychiatr Genet. 2009 Feb;19(1):45-52.

64. Payne JL, Klein SR, Zamoiski RB, Zandi PP, Bienvenu OJ, Mackinnon DF, Mondimore FM, Schweizer B, Swartz KL; NIMH Genetics Initiative Bipolar Disorder Consortium, Crowe RP, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR Jr, Potash JB. Collaborators: Nurnberger J, Miller MJ, Bowman ES, Rau NL, Moe PR Jr, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice J, Reich T, Goate A, Bierut L, McInnis M, DePaulo JR Jr, MacKinnon DF, Mondimore FM, Potash JB, Zandi PP, Avramopoulos D, Payne J, Berrettini W, Byerley W, Vawter M, Coryell W, Crowe R, Gershon E, Badner J, McMahon F, Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe J, McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, McMahon FJ, Kassem L, Detera-Wadleigh S, Austin L, Murphy DL. Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees. Arch Womens Ment Health. 2009 Feb;12(1):27-34. Epub 2009 Jan 10.

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60. Zandi PP, Belmonte PL, Willour VL, Goes FS, Badner JA, Simpson SG, Gershon ES, McMahon FJ, DePaulo JR Jr, Potash JB; Bipolar Disorder Phenome Group; National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. Collaborators: Nurnberger , Miller MJ, Bowman ES, Reich T, Goate , Rice , DePaulo , Simpson , Stine C, Gershon , Kazuba D, Maxwell E, Miller , Bowman , Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Foroud T, Flury L, Dick DM, Edenberg H, Rice , Reich , Goate , Bierut L, McInnis M, DePaulo , MacKinnon DF, Mondimore FM, Potash , Zandi , Avramopoulos D, Payne J, Berrettini W, Byerley , Vawter M, Coryell , Crowe R, Gershon , Badner , McMahon , Liu C, Sanders A, Caserta M, Dinwiddie S, Nguyen T, Harakal D, Kelsoe , McKinney R, Scheftner W, Kravitz HM, Marta D, Vaughn-Brown A, Bederow L, McMahon , Kassem L, Detera-Wadleigh S, Austin S, Murphy DL. Association study of Wnt signaling pathway genes in bipolar disorder. Arch Gen Psychiatry, 2008 Jul;65(7):785-93.

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57. Li JZ, Meng F, Tsavaler L, Evans SJ, Choudary PV, Tomita H, Vawter MP, Walsh D, Shokoohi V, Chung T, Bunney WE Jr, Jones EG, Akil H, Watson SJ, Myers RM. (2007). Sample matching by inferred agonal stress in gene expression analyses of the brain. BMC Genomics. 8(1):336.

56. Atz, M.E., Walsh, D., Cartagena, P., Li, J., Evans, S., Choudary, P., Overman, K., Stein, R., Tomita, H., Potkin, S.G., Myers, R.M., Watson, S.J. Jones, E.G., Akil, H., Bunney, Jr., W.E., Vawter, M.P (2007). Methodological considerations for gene expression profiling of human brain. J Neurosci Methods. 163(2):295-309.

55. Vawter, M.P,. Harvey, P.D., DeLisi, L.E. (2007). Dysregulation of X-linked gene expression in Klinefelter’s Syndrome and association with verbal cognition. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 144B(6):728-34.

54. Detera-Wadleigh, S.D., C.Y. Liu, M. Maheshwari, I. Cardona, W. Corona, N. Akula, C.J. Steele, J.A. Badner, M. Kundu, L. Kassem, J.B. Potash, R. Gibbs, E.S. Gershon, and F.J. McMahon, NIMH Genetics Initiative Bipolar Disorder Consortium. Sequence variation in DOCK9 and heterogeneity in bipolar disorder. Psychiatric genetics, 2007 Oct;17(5):274-86.

53. Potash, J.B., J. Toolan, J. Steele, E.B. Miller, J. Pearl, P.P. Zandi, T.G. Schulze, L. Kassem, S.G. Simpson, V. Lopez, NIMH Genetics Initiative Bipolar Disorder Consortium, D.F. MacKinnon, and F.J. McMahon, The bipolar disorder phenome database: a resource for genetic studies. The American journal of psychiatry, 2007 Aug;164(8):1229-37.

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45. Vawter, M.P , Ferran, E., Galke, B., Cooper, K.C., Bunney, W.E., Byerley, W. (2004). Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree. Schizophrenia Research 67(1):41-52.

44. Evans S.J., Choudary P.V., Neal C.R., Li J.Z., Vawter M.P., Tomita H., Lopez J.F., Thompson R.C., Meng F., Stead J.D., Walsh D.M., Myers R.M., Bunney W.E., Watson S.J., Jones E.G., Akil H. (2004). Dysregulation of the fibroblast growth factor system in major depression. Proceedings National Academy Science, 101(43):15506 - 11.

43. Li, J.Z., Vawter, M.P, Walsh, D.M., Tomita, H., Evans, S.J., Choudary, P.V., Lopez, J.F., Avelar,A., Shokoohi, V., Chung, T., Mesarwi, O., Jones, E.G., Watson, S.J., Akil, H., Bunney, W.E., Myers, R.M. (2004). Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Human Molecular Genetics, 13(6):609-16.

42. *Tomita ,H., *Vawter ,M.P., *Walsh, D.M., Evans, S.J., Choudary, P.V., Li, J., Overman, K.M., Atz , M. E. , Myers, R.M., Jones E. G., Watson, S.J., Akil, H., Bunney, W.E. Jr. (2004). Postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biological Psychiatry 55(4), 346 - 352. *Authors contributed equally to the work.

41. *Vawter, M.P, *Evans, S.J., *Choudary, P.V., *Tomita, H., Meador-Woodruff, J.H., Molnar, M., Lopez J.F., Li J., Myers R.M., Akil H., Watson S.J., Jones E.G., Bunney W.E. (2004). Gender specific gene expression in postmortem human brain: localization to sex chromosomes. Neuropsychopharmacology,29(2):373-84.*Authors contributed equally to the work.

40. Vawter, M.P, Shannon Weickert, C., Ferran, E., Matsumoto, M.,Overman, K., Hyde, T.M., Weinberger, D.R., Bunney, W.E., Kleinman, J.E. (2004). Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia. Neurochem Res. 29 (6): 1245-1255.

39. Cheadle, C., Cho-Chung, Y.S., Becker, K.G., Vawter, M.P (2003). Application of z-score transformation to Affymetrix® data. Applied Bioinformatics, 2(4) 209-217

38. Blaabjerg, M., Baskys, M., Zimmer, J., Vawter, M.P (2003). Changes in hippocampal gene expression after neuroprotective activation of group I metabotropic glutamate receptors. Brain Res Mol Brain Res. 117(2), 196 - 205.

37. *Evans S.J., *Choudary P.V., *Vawter M.P., Li J., Meador-Woodruff J.H., Lopez J.F., Burke S.M., Thompson R.C., Myers R.M., Jones E.G., Bunney W.E., Watson S.J., and Akil H. (2002). DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles. Neurobiology of Disease 14, 240 - 250. *Authors contributed equally to the work.

36. Lehrmann, E., Hyde, T.M., Vawter, M.P Becker, K.G., Freed, W.J. (2003). Neuropsychiatric disorders studied by microarrays: postmortem studies in drug abuse and schizophrenia. Current Molecular Medicine 3(5), 437 - 46.

35. Cheadle, C.*, Vawter, M.P*, Freed, W.J., Becker, K.G. (2003). Analysis of microarray data using z-score transformation. Mol Diagn 5 (2), 73 - 81. *Authors contributed equally to the work.

34. Bunney, W.E., Bunney, B.G., Vawter, M.P, Tomita, H., Li, J., Evans, S.J., Choudray, P., Myers, R.M., Jones, E.G., Watson, S.J., Akil, H. (2003). Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders. American Journal of Psychiatry, 160 (4), 657 - 666.

33. Thompson, P.M., Egbufoama, S., Vawter, M.P (2003). Selective presynaptic pathology in hippocampus of patients with schizophrenia. Progress in Neuropsychopharmacology and Biological Psychiatry, 27 (3). 411 - 417.

32. Comi, A.M., Hunt, P., Vawter, M.P, Pardo, C., Becker, K., Pevsner, J. (2003). Increased fibronectin expression in Sturge-Weber syndrome fibroblasts and brain tissue. Pediatric Research, 53 (5).

31. Lehrmann, E. Oyler, J., Vawter, M.P, Hyde, T.M., Kolachana, B, Kleinman, J.E., Huestis, M.A., Becker, K.G., Freed, W.J. (2003). Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. The Pharmacogenomics Journal (3), 27-40.

30. Vawter, M.P, Crook, J.M., Hyde, T.M., Kleinman, J.E., Weinberger, D.R., Becker, K.G., Freed, W.J. (2002). Microarray analysis of gene expression in the prefrontal cortex in schizophrenia. Schizophrenia Research 58 (1) 11 - 20.

29. Truckenmiller, M. E., Vawter, M.P, Zhang, P., Conejero-Goldberg, C., Torres, A., Bouvier, M., Dillon-Carter, O., Cheadle, C., Becker, K.G., Freed, W.J. (2002). AF5, a CNS cell line with an N-Terminal fragment of SV-40 Large T: growth, differentiation, genetic stability, and gene expression. Experimental Neurology, 175(2):318-37.

28. Vawter, M.P, Thatcher, L., Usen, N., Hyde, T.M., Kleinman, J.E., and Freed. W.J. (2002). Alterations in synapsin in the hippocampus of patients with bipolar disorder and schizophrenia. Molecular Psychiatry, 7(6):571-8.

27. Freed, W.J., Hyde, T., Kleinman, J. E., Becker, K. G., Vawter, M.P Analysis of gene expression in schizophrenia using DNA microarrays (2002). Trends in Evidence-Based Neuropsychiatry, 4(1): 48-57.

26. Barrett, T. Xie, T., Piao, Y., Dillon-Carter, O.,Kargul, G.J., Lim, M.K., Chrest, F.J., Wersto, R.,Rowley, D.L., Juhaszova1, M., Zhou, L., Vawter, M.P, Becker,K.G., Cheadle, C.,Wood, W., McCann, U.D.,Freed, W.J.,Ko, M.S., Ricaurte, G.S., Donovan, D.M. (2001). A murine dopamine neuron-specific cDNA library and microarray: increased COX I expression during methamphetamine neurotoxicity. Neurobiology of Disease, 8(5):822-33.

25. Vawter, M.P, Usen, N., Thatcher, L., Ladenheim, B., Zhang, P., VanderPutten, D., Conant, C., Herman, M.,van Kammen, D.P., Garver, D., Freed, W.J. (2001). Characterization and role of cytosolic human N-CAM in schizophrenia. Experimental Neurology, Nov;172(1), 29-46.

24. Vawter, M.P, Barrett, T., Cheadle, C., Sokolov, B.P., Wood, W.H., Donovan, D., Webster, M., Freed, W.J., Becker, K.G. (2001). Application of cDNA microarrays to examine gene expression differences in schizophrenia. Brain Research Bulletin, 55 (5), 641-650.

23. Truckenmiller, E., Vawter, M.P, Cheadle, C., Coggiano, M., Donovan, D.M., Freed, W.J., Becker, K.G. (2001). Gene expression profile in early stage of retinoic acid-induced differentiation of human SH-SY5Y neuroblastoma cells. Restorative Neurology and Neuroscience, 18(2,3), 67 – 80.

22. Barrett, T., Cheadle, C., Wood, W.H., Donovan, D., Freed, W.J., Becker, K.G. and Vawter, M.P Assembly and use of a broadly applicable neural cDNA microarray. (2001) Restorative Neurology and Neuroscience, 18(2,3), 127 – 135.

21. Konu O., Kane J.K., Barrett T., Vawter M.P., Chang R., Ma J.Z., Donovan D.M., Sharp B., Becker K.G., Li M.D. (2001). Region-specific transcriptional response to chronic nicotine in rat brain. Brain Research 909(1-2):194-203.

20. Cadet, J.L., Jayanthi, S., McCoy, M., Vawter, M., Ladenheim, B. (2001). Temporal profiling of methamphetamine-induced changes in gene expression in the mouse brain: evidence from cDNA array. Synapse, 41, 40-48.

19. Vawter, M.P, Freed. W.J, Kleinman, J.E. (2000). The neuropathology of bipolar disorder. Biological Psychiatry, 405 (1-3), 385-395.

18. Vawter, M.P (2000). Neuropsychiatric disorders and cell adhesion molecules. European Journal of Pharmacology 48(6):486-504.

17. Conejero-Goldberg, C., Tornatore, C., Abi-Saab, W., Monaco, M., Dillon-Carter, O., Vawter, M., Elsworth, J., and Freed, W. (2000). Transduction of human GAD67 cDNA into immortalized striatal cell lines using an Epstein Barr virus-based plasmid vector increases GABA content. Experimental Neurology, 161(2), 453 – 461.

16. Vawter, M.P, VanderPutten, D.M., Hemperly, J.J., Doherty, P., Saffell, J., Issa, F., Wyatt, R. J., and Freed, W. J. (2000). Elevated concentration of N-CAM VASE isoforms in CSF of patients with schizophrenia. J Psychiatric Research, 34,(1) 25 - 34.

15. Vawter, M.P, Howard, A.L., Hyde, T.M., Kleinman, J.E., and Freed, W.J. (1999). Alteration of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia. Molecular Psychiatry, 4(5), 467 – 475.

14. Webster, M., Vawter, M. P., and Freed, W. J. (1999). Immunohistochemical localization of the cell adhesion molecules Thy-1 and L1 in the human prefrontal cortex: patients with schizophrenia, bipolar disorder, and depression. Molecular Psychiatry, 4, 42 – 46.

13. Vawter M. P., Hemperly, J. J., Hyde, T. M. Bachus, S. E., VanderPutten, D. M., Webster, M. J., Howard , A. L., Cannon-Spoor H. E., McCoy M. M., Kleinman, J. E., and Freed, W. J. (1998). VASE-containing N-CAM isoforms are increased in the hippocampus in bipolar disorder but not schizophrenia. Experimental Neurology, 1, 1 – 11.

12. Vawter, M.P, Hemperly, J.J., Freed, W.J., and Garver, D.L. (1998). CSF N-CAM in neuroleptic-naïve first-episode patients with schizophrenia. Schizophrenia Research, 34, 123 – 131.

11. Vawter, M.P, Cannon-Spoor, H., Hemperly, J., Vander Putten, D., Hyde, T., Kleinman, J. and Freed, W.J. (1998). Abnormal expression of cell recognition molecules in schizophrenia. Experimental Neurology, 149, 424-432.

10. Bachus, S. E., Hyde, T. M., Akil, M., Shannon Weickert, C., Vawter, M. P., and Kleinman, J. E. (1997). Neuropathology of suicide: a review and approach. Annals of New York Academy of Sciences,836, 201 – 219.

9. Vawter, M. P., Dillon-Carter, O., Issa, F., Wyatt, R. J. and Freed, W. J. (1997). TGF-*1 and TGF*2 in the cerebrospinal fluid of schizophrenics. Neuropsychopharmacology, 16 (1), 83 - 87.

8. Vawter, M.P, De Wied, D. and Van Ree, J. M. (1997). The effects of AVP -(4-8) on long term and short term memory. Neuropeptides, 31 (5) 489 - 494.

7. Vawter, M. P., Dillon–Carter, O., Tourtellotte, W.W., Carvey, P. M., and Freed, W. J. (1996). TGF*1 and TGF*2 concentrations are elevated in Parkinson’s disease in ventricular cerebrospinal fluid. Experimental Neurology, 142, 313 - 322.

6. Vawter, M. P., Basic-Keys, J., Lie, Y., Lester, D. S., Lebovics, R. S., Lesch, K. P., Freed, W. J., Sunderland, T., and Wolozin, B. (1996). Tyrosine phosphorylation and process extension in human olfactory neuroepithelial cells are increased by a combination of neurotrophic factors: IL-1*, IL-6, NGF, AND bFGF. Experimental Neurology, 142, 179 - 194.

5. Vawter, M. P. and Van Ree, J. M. (1995). The effects of des-glycinamide-lysine-vasopressin on the hole board search task. Psychobiology, 23 (1), 45 - 51.

4. Vawter, M. P. (1994). Can short term rehabilitation counseling services increase employment of SSDI beneficiaries? NARPPS Journal, 9(4), 139 - 150.

3. Vawter, M. P. (1992). Value of household services: a comparison of methods, NARPPS Journal, 8 (4), 237 -242.

2. Vawter, M. P. and Van Ree, J. M. (1989). Hole board search test. Physiology & Behavior, 45 (5), 891-895.

1. Vawter, M. P. & Green, K. F. (1980). Effects of desglycinamide-lysine vasopressin on a conditioned taste aversion. Physiology & Behavior, 25, 851-854.
   
Grants Stanley Foundation No. SF-29693 or the project entitled "Functional Genomic Expression Using Focused Neuropsychiatric Arrays"
   
· Principal Investigator for “Computer Assisted Vocational Assessment and Intensive Job Placement” Grant, 1989 - 1991. Department of Health and Human Services, Research and Demonstration Grant No. 13-P-10035-9-01 to C.A.R.E., Inc., Orange CA, grantee. Total grant award - $168,769 in direct costs.
   
· Principal Investigator for “Re-employment Assistance Program, 1989 –1992 (REAP) at CDR Stage” Grant. Department of Health and Human Services, Research and Demonstration Grant No. 13-P-10058-9-01 to C.A.R.E., Inc., Orange CA, grantee. Total grant award - $186,342 in direct costs.
   
· Research Grant Award “Biomarker Genes in Mood Disorder: Lymphocyte and Brain”. 2005 – 2007. Grant No. R21MH074307-01, National Institute of Mental Health. Total grant award $275,000 in direct costs.
   
· Clinical Research Feasibility Funds Award, “Effects of Sleep Deprivation on Circadian Fluctuation of 54,000 Biomarkers”. Academic year 2004-05 to support a clinical research project through University of California Irvine General Clinical Research Center Sponsoring Agency the National Center for Research Resources M01 RR00827. $10,000 direct cost.
   
• Allen Institute for Brain Science, Human Brain Transcriptome Project. This is a sponsored research project award for $200,000, 2008 - 2012. Dr. Vawter is the PI at UCI.
   
• NIMH Grant 1R01MH085801" Mitochondrial Variants in Schizophrenia and Bipolar Disorder". 2009 - 2014. This grant studies mtDNA from postmortem brain in subjects with psychiatric disorders. Total grant award in direct costs, $1,250,000. Dr. Vawter is the PI.
   
Professional
Society
Member elected to American College of Neuropsychophamacology
   
Other Experience Postdoctoral Fellow and Staff Scientist
National Institutes of Health 1994—2000

Staff Scientist, NIDA
National Institutes of Health 1997—2001

Research Center Pritzker Neuropsychiatric Disease Research Foundation
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=4935
   
Last updated 04/17/2017