Claudia H. Kawas

picture of Claudia H. Kawas

Professor, Neurology
School of Medicine
Professor, Neurobiology and Behavior
School of Biological Sciences

M.D., University of Louisville, Kentucky

Phone: (949) 824-2323
Fax: (949) 824-4165

University of California, Irvine
1121 Gillespie
Mail Code: 4540
Irvine, CA 92697
Research Interests
Dementia and Memory Disorders, Geriatric Neurology, Epidemiology
Research Abstract
Claudia Kawas, M.D., Al and Trish Nichols Chair in Clinical Neuroscience and Professor of Neurobiology & Behavior and Neurology, at the University of California, Irvine, is a geriatric neurologist and researcher in the areas of aging and dementia. Her work is concentrated on the epidemiology of aging and Alzheimer's disease, in the determinants of successful aging, longitudinal and clinical pathological investigations, clinical trials, and most recently, studies in cognitive and functional abilities of the Oldest Old (over 90 years of age). Dr. Kawas is a graduate of Swarthmore College (Pennsylvania), and completed her medical studies at the University of Louisville (Kentucky) and neurology residency training and a fellowship in dementia and aging at Albert Einstein College of Medicine, Bronx, New York. After 15 years on the faculty at Johns Hopkins School of Medicine, Dr. Kawas moved to the University of California, Irvine in 2000, where she is Principle Investigator of The 90+ Study and Associate Director of the UCI Institute for Memory Impairments and Neurological Disorders. Dr. Kawas serves on committees for the National Institutes of Health and the Scientific Advisory Board of several organizations, including the Medical and Scientific Advisory Council of the National Alzheimer’s Association, The Dana Foundation, and the United States Food & Drug Administration. Over the past 25 years, Dr. Kawas has published more than 100 peer-reviewed manuscripts, and has worked on numerous longitudinal studies of aging and dementia, including the Bronx Aging Study, the Baltimore Longitudinal Study of Aging (NIA), and most recently, The 90+ Study, a population based sample of more than 1,800 people aged 90 years and older.
1. Kawas CH, Corrada MM, Brookmeyer R, Morrison A, Resnick SM, Zonderman AB, Arenberg D. Visual Memory Predicts Alzheimer's Disease More Than a Decade Before Diagnosis. Neurology, 2003 Apr, 60(7):1089-1093. PMID 12682311

2. Kawas, CH, Early Alzheimer's Disease, New England Journal of Medicine, 2003;349:1056-63. PMID 12968090

3. Kawas, C. Diet and the Risk of Alzheimer’s Disease. Editorial. Annals of Neurology, June 2006, Vol. 59, No. 6, 877-879. PMID 16718710

4. Kawas CH, Corrada MM. Alzheimer’s and Dementia in the Oldest-Old: A Century of Challenges. Current Alzheimer Research, 2006, 3, 411-419. PMID 17168640

5. Kahle-Wrobleski K, Corrada MM, Li B, Kawas CH. Sensitivity and Specificity of the Mini-Mental State Examination for Identifying Dementia in the Oldest-Old: The 90+ Study. JAGS, 2007, 55:284-289. PMID 17302668

6. Kawas, C, The Oldest Old and the 90+ Study. Alzheimer’s & Dementia, January 2008, Vol. 4, Issue 1, Suppl 1, S56-S59. PMID 18632002

7. Corrada M, Brookmeyer R, Berlau D, Paganini-Hill A, Kawas C. Prevalence of dementia after age 90: results from The 90+ Study. Neurology 71;337-343, 2008. PMID 18596243

8. Head E, Corrada M, Kahle-Wrobleski K, Kim R, Sarsoza F, Goodus M, Kawas C. Synaptic Proteins, Neuropathology and Cognitive Status in the Oldest-Old. Neurobiology of Aging. 2009, 30, 1125-1134. PMID 18006193

9. Brumback-Peltz C, Balasubramanian AB, Corrada MM, Kawas CH. Diagnosing Dementia in the Oldest-Old. Maturitas. 2011. 70;164-168.

10. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carillo MC, Thies B, Weintraub S, Phelps CH. The Diagnosis of Dementia Due to Alzheimer’s Disease: Recommendations from the National Institute on Aging and the Alzheimer’s Association Workgroup. Alzheimer’s & Dementia. 2011. May 7(3):263-9.

11. Peltz CB, Corrada MM, Berlau DJ, Kawas CH. Incidence of Dementia in Oldest-old with Amnestic MCI and Other Cognitive Impairments. Neurology. 2011. Nov 22;77(21):1906-12.

12. Robinson JL, Geser F, Corrada M, Berlau D. Neocortical and Hippocampal Amyloid-? and Tau Measures Associate with Dementia in the Oldest-Old. Brain. 2011. Dec;134(Pt 12):3708-15.

13. Berlau DJ, Corrada MM, Peltz CB, Kawas CH. Disability in the Oldest-old: Incidence and Risk Factors in The 90+ Study. American Journal of Geriatric Psychiatry. 2012. Feb;20(2):159-68.
14. Kawas CH, Greenia DE, Bullain SS, Clark CM, Pontecorvo MJ, Joshi A, Corrada MM. Amyloid Imaging and Cognitive Decline in Non-demented Oldest-Old: The 90+ Study. Alzheimer’s and Dementia. 2013. Mar; 9(2):199-203. PMID 23164550.
15. Kawas CH, Kim RC, Sonnen JA, Bullain SS, Trieu T, Corrada MM. Multiple Pathologies are Common and Related to Dementia in the Oldest-Old: The 90+ Study. Neurology 2015 Aug 11; 85(6): 535-42. PMID: 26180144.
16. Brookmeyer R, Kawas CH, Abdallah N, Paganini-Hill A, Kim RC, Corrada M, Impact of interventions to reduce Alzheimer’s disease pathology on the prevalence of dementia in the oldest-old. Alzheimer’s & Dementia 12(3):225-32, 2016. [Epub Feb 17, 2016]. PMID: 26900132. PMCID: PMC4808364.
17. Lee DR, Kawas CH, Gibbs L, Corrada MM. Prevalence and associated factors of frailty in the oldest-old: The 90+ Study. J Am Geriatr Soc. [Epub Sep 2, 2016]. PMID: 27590837. Volume 64, Issue 11
November 2016 Pages 2257–2262.
18. Paganini-Hill A, Corrada MM, Kawas CH, Greenia, D, Sajjadi S.A. Lower likelihood of falling at age 90+ is associated with daily exercise a quarter of a century earlier: The 90+ Study. Age and Ageing, Volume 46, Issue 6, 1 November 2017, Pages 951–957,
19. Pierce A, Bullain S, Kawas CH. Late-Onset Alzheimer Disease. Neurol Clin May 2017 Vol 35, Issue 2, Pages 283–293,
20. Brookmeyer R, Abdalla N, Kawas CH, Corrada MM. Forecasting the Prevalence of Preclinical and Clinical Alzheimer’s disease in the United States. Alzheimer’s & Dementia 14 (2018) 121-129.
Clinical and Pathological Studies in the Oldest Old, National Institute on Aging 09/01/02 - 06/30/23. This project will examine biological, psychological, and social factors associated with functional, cognitive and behavioral capacities of individuals aged 90 years and older living independently.
Alzheimer's Disease Research Center of the University of California, Irvine (Clinical Core), National Institute on Aging, 04/01/2000 - 03/31/2020. The effort on this project is focused on clinical evaluation and characterization of research subjects in the ADRC.
Alzheimer's Disease Risks and Projections Using Multi-State Models with Biomarkers 4/1/2017 - 3/31/2019. The overarching goal of this project is to apply stochastic multistate models that incorporate biomarkers to determine lifetime risks and population projections of Alzheimer’s disease (AD).
Epidemiology of Age-related Dementia Mild Cognitive Impairment and Brain Pathology in a Multiethnic Cohort of Oldest-old 09/01/2017 – 08/30/2022.The overall objectives of this application are to estimate incidence of dementia/MCI in a multiracial cohort of oldest-old, identify midlife and late-life risk and protective factors, and understand the pattern of cerebral and brain pathologies in this diverse oldest-old population.
Neuropathologic substrates for motor and cognitive impairment in three existing cohort studies of Alzheimer’s disease and related dementias 09/01/2017 – 08/30/2022.The overall objectives of the application are to identify common patterns for the singular, concurrent, or sequential development of cognitive and motor impairments in persons with and without dementia These different conjoint patterns will be linked with neuropathologic features, thereby defining specific disease processes and implicating molecular mechanisms, thereby informing future development of effective strategies for prevention and management of cognitive and motor decline with advancing age.
Apolipoprotein E2 and Brain Aging 09/30/2017 – 06/30/2021.The Apolipoprotein E gene (ApoE) is a major inherited determinate of the common form of late onset Alzheimer's disease (LOAD). The “4” version of the gene increases risk, the “2” version is protective, and the “3” version is neutral. The aim of this project is to search for suspected but as yet unrecognized genetic abnormalities neighboring the ApoE gene that might be responsible for these apparent differences in the influences of the ApoE variants.
Professional Societies
American Neurological Association
Society of Neurosciences
American Academy of Neurology
American Geriatric Society
American Medical Association
National Arab American Medical Association
Research Centers
Institute for Memory Impairments & Neurological Disorders (IMIND)
Clinic for Aging Research and Education (CARE) - The 90+ Study
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