Qing Nie

Chancellor's Professor, Mathematics
School of Physical Sciences

Chancellor's Professor, Developmental & Cell Biology
School of Biological Sciences

Chancellor's Professor, Biomedical Engineering
The Henry Samueli School of Engineering

Ph.D., The Ohio State University, 1995

Phone: (949) 824-5530
Fax: (949) 824-7993
Email: qnie@uci.edu

University of California, Irvine
Department of Mathematics
University of California, Irvine
Mail Code: 3875
Irvine, CA 92697
Research Interests
Computational Biology; Systems Biology; Stem Cells; Regulatory Networks; Stochastic Dynamics; Scientific Computing and Numerical Analysis
Academic Distinctions
Chancellor's Professor, UC Irvine, 2017-
Chancellor's Fellow, UC Irvine (2005-2008)
Fellow, American Association for the Advancement of Science (AAAS), elected 2013
Fellow, American Physical Society (APS), elected 2014
Professor (05-present); Associate Professor (02-05);Assistant Professor (99-02); Department of Mathematics, UC Irvine. 1997-1999: L.E. Dickson Instructor, Department of Mathematics, University of Chicago.
W. R. Holmes, Nabora Soledad Reyes de Mochel, Qixian Wang, Huijing Du, Michael Chiang, Olivier Cinquin, Ken W.Y. Cho, Qing Nie, Gene expression noise enhances robust
organization of the early mammalian balstocyst., 13(1): e1005320, PLoS Computational Biology, 2017. PMID 28114387
Q. Wang, W. R. Holmes, J. Julian, T. Schilling, Q. Nie. Cell sorting and noise-induced cell plasticity coordinate to sharpen boundaries between gene expression domains, 13(1): e1005307, PLoS Computational Biology, 2017, PMID: 28135279
Qixuan, Wang, Ji Won Oh, Anukriti Dhar, Jonathan Le, Shelby C. Jocoy, Antoni R. Rossi, Hoang T. Ha, Melisa A. Fuentes, Manda P. Nguyen, Julien Legrand, Eve Kandyba, Jung Chul Kim, Moonkyu Kim, Krzysztof Kobielak, Kiarash Khosrotehrani, Qing Nie*, Maksim V. Plikus*. A multi-scale model for the hair follicle reveals a pacemaker mechanism driving rapid hair growth patterning, *co-corresponding author, eLife 2017;6:e22772
C. Li**, T. Hong**, Y. Tung, Y. Yen, H. Hsu2, Y. Lu, M. Chang, Q. Nie3,*, J. Chen*. MicroRNA Filters Hox Temporal Transcription Noise to Confer Boundary Formation in the Spinal Cord
**: equal-contribution, *:co-corresponding authors. Nature Communication, 8:14685, 2017
J. Xie, C. Xiang, J. Ma, J. Tan, T. Wen, J. Lei, and Q. Nie. An Adaptive Hybrid Algorithm for Global Network Alignment, IEEE/ACM Transactions on Computational Biology and
Bioinformatics, 3(3) P483-493,. doi:10.1109/TCBB.2015.2465957, 2016.
J. Julian, L. Zheng, C. Rackaukas, M. Digman, E. Gratton. Q. Nie, T. Schilling. Noise Modulation in Retinoic acid Signaling Sharpens Segmental Boundaries of Gene Expression in the Zebrafish Hindbrain, eLife, e14034, 2016.
J. Lei, S. Levin and Q. Nie. A Mathematical Model of Adult Stem Cells Regeneration
with Crosstalk between Genetic and Epigenetic Regulation. Proceeding of National
Academy of Sciences, USA, E880-E887, doi: 10.1073/pnas.1324267111, 2014
J. Ovadia and Q. Nie. Stem Cell Niche As an Inherent Cause of Undulating Epithelial Morphologies. Biophysical Journal, 104 (1): 237-46, 2013
M. Chen, L. Wang, C. Liu, and Q. Nie. Noise Attenuation in the ON and OFF States of Biological Switches. Featured and cover page article, ACS Synthetic Biology, 2, pp587-593,2013.
L. Zhang, K. Radtke, L. Zheng, T. Schilling, Q. Nie. Noise Drives Sharpening of Gene Expression Boundaries in Zebrafish Hindbrain. Nature Molecular Systems Biology, 8:613, 2012.
L. Wang, J. Xin, and Q. Nie. A Critical Quantity for Noise Attenuation in Feedback Systems. PLoS Computational Biology, 6(4): e1000764, 2010.
Q. Nie, Y. Zhang and R. Zhao. Efficient Semi-implicit Schemes for Stiff Systems. Journal of Computational Physics, 214, pp 521-537, 2006.
Professional Societies
Society for Applied and Industrial Mathematics (SIAM)
American Physical Society
Graduate Programs
Biomedical Engineering

Mathematical and Computational Biology

Research Centers
Center for Mathematical and Computational Biology
Center for Complex Biological Systems
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