Skeletal Muscle Hypertrophy Atrophy Growth Factors Cytokines.
Since becoming an independent investigator my primary focus has been on the cellular and molecular mechanisms that mediate the adaptation of tissues to changes in functional demands. A major theme in this work has been the modulation of the adaptation of skeletal muscle in the presence of alterations in loading state as well as changing signals received via endocrine, autocrine / paracrine agents (e.g. hormones, growth factors & cytokines). In this process my work has been focused on the effects of various loading states such as spinal cord injury, experimental unloading or resistance exercise. In parallel, my work has investigated the interactions of manifestations of disease states (e.g., renal failure, chronic inflammation) with cellular and molecular mechanisms that regulate skeletal muscle homeostasis in humans, mature and developing animals. A relevant, over-arching, theme of my work has been the application of programmed increases in functional demand (e.g., exercise) in the presence of unloading, various diseases or disease related components. The work from my laboratory has demonstrated, both in humans and animals, that programmed exercise can modulate and ameliorate some manifestations of disease states. I have worked to identify and develop opportunities for the translation of research findings pioneered in animals to human studies.
I have had a long standing interest in the area of space biology and, in particular, the effects of space flight on functional capacity and skeletal muscle homeostasis. I conducted a number of studies directly related to space research.
Adams GR, Zaldivar FP, Nance DM, Kodesh E, Radom-Aizik S, Cooper DM.
Exercise and leukocyte interchange among central circulation, lung, spleen, and muscle. Brain Behav Immun. 2011 May;25(4):658-66.
Adams GR, Bamman MM. Characterization and regulation of mechanical loading-induced compensatory muscle hypertrophy. Compr Physiol. 2012 Oct;2(4):2829-70.
Radom-Aizik S, Zaldivar FP, Nance DM, Haddad F, Cooper DM, Adams GR.
Growth inhibition and compensation in response to neonatal hypoxia in rats. Pediatr Res. 2013 Aug;74(2):111-20
Cotter JA, Yu A, Kreitenberg A, Haddad FH, Baker MJ, Fox JC, Adams GR.
Suction-modified needle biopsy technique for the human soleus muscle. Aviat Space Environ Med. 2013 Oct;84(10):1066-73.
Cotter JA, Yu A, Haddad F, Kreitenberg A, Baker MJ, Tesch PA, Baldwin KM, Caiozzo VJ, Adams GR. Concurrent exercise on a gravity-independent device during simulated microgravity.
Med Sci Sports Exerc. 2015 May;47(5):990-1000
Owerkowicz T, Cotter JA, Haddad F, Yu AM, Camilon ML, Hoang TN, Jimenez DJ, Kreitenberg A, Tesch PA, Caiozzo VJ, Adams GR. Exercise Responses to Gravity-Independent Flywheel Aerobic and Resistance Training. Aerosp Med Hum Perform. 2016 Feb;87(2):93-101
Cotter JA, Yu A, Kreitenberg A, Haddad F, Baker MJ, Fox JC, and GR Adams Suction-modified needle biopsy technique for the human soleus muscle Aviation, Space and Environmental Medicine 84: 1066-1073, 2013
Radom-Aizik S, Zaldivar FP., Nance DM., Haddad F, Cooper DM and GR Adams. Growth Inhibition and Compensation in Response to Neonatal Hypoxia in Rats. Ped. Res. 74(2):111-20, 2013.
Adams G.R., D. Nance, S. Radom-Aizik, F. Zaldivar, D. Cooper Exercise and Leukocyte Interchange Among Central Circulation, Lung, Spleen, and Muscle. Brain, Behavior Immunity 25:658-666, 2011
Kodesh E., C. Schwindt, P. Tran, A. Yu, M. Camilon, D. Nance, F. Zaldivar, D. Cooper and G.R. Adams. A rat model of exercise induced asthma: a non-specific response to a specific immunogen. Am. J. Physiol 300:R917-R924, 2011
Buchowicz B, Yu T, Nance DM, Zaldivar FP, Cooper DM and GR Adams. Increased rat neonatal activity influences adult cytokine levels and relative muscle mass. Pediatr Res. 68(5):399-404, 2010.
Adams, Gregory R. IGF-I Signaling in Skeletal Muscle and the Potential for Cytokine Interactions. Med. Sci. Sport Exerc. 42(1):50-7, 2010.
Adams, Gregory R. The molecular response of skeletal muscle to resistance training. Deutsche Zeit. Sportmedizin 61(3):61-67, 2010.
Adams, Gregory R and Bamman, M.. Characterization and Regulation of Mechanical Loading-Induced Compensatory Muscle Hypertrophy Comprehensive Physiol 2: 2829-2870, 2012
Adams, Gregory R. and Nosratola D. Vaziri Skeletal Muscle Dysfunction in Chronic Renal Failure: Effects of Exercise. Am. J. Physiol. 290:F753-F761, 2006.
Haddad, F., and G.R. Adams Aging Sensitive Cellular and Molecular Mechanisms Associated with Skeletal Muscle Hypertrophy J. Appl. Physiol. 100(4):1188-203, 2006
American Physiological Society