Ray Luo

picture of Ray  Luo

Professor, Molecular Biology and Biochemistry
School of Biological Sciences

Professor, Biomedical Engineering
The Henry Samueli School of Engineering

Professor, Chemical Engineering & Materials Science
The Henry Samueli School of Engineering

B.S., Beijing University, 1990, Biophysics
Ph.D., University of Maryland at College Park, 1998, Chemistry

Phone: (949) 824-9528
Fax: (949) 824-8551
Email: ray.luo@uci.edu

University of California, Irvine
3206 Natural Sciences I
Mail Code: 3900
Irvine, CA 92697
Research Interests
Computational analysis of biomolecular sequence, structure, dynamics, and function.
Research Abstract
We use computational approaches to study biomolecular structures and functions. Our goal is to interpret the structural and functional information encoded in genomes and to understand life at the most fundamental level based on physical and chemical principles. Our current research effort focuses on developing reliable and efficient computational methods to study and predict structures, functions, and intermolecular interactions at atomic detail.
PyRESP: A Program for Electrostatic Parameterizations of Additive and Induced Dipole Polarizable Force Fields, S. Zhao, H. Wei, P. Cieplak, Y. Duan, and R. Luo, J. Chem. Theory Comput. 18, 3654, 2022
Heparin-assisted amyloidogenesis uncovered through molecular dynamics simulations, B. Khurshid, A.U. Rehman, R. Luo, A. Khan, A. Wadood, J. Anwar, ACS Omega, 7, 15132, 2022
Stress tensor and constant pressure simulation for polarizable Gaussian multipole model, H. Wei, P. Cieplak, Y. Duan, and R. Luo, J. Chem. Phys. 156, 114114, 2022
Motif-dependent immune co-receptor interactome profiling by photoaffinity chemical proteomics, X. Chen, S. Ji, Z. Liu, X. Yuan, C. Xu, R. Qi, A. He, H. Zhao, H. Song, C. Xiao, W. Gao, P. R. Chen, R. Luo, P. Li, F. Wang, X. Yang, R. Tian, Cell Chem. Biol. 29, 1024, 2022
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1, H. Han, H.J. Nakaoka, L. Hofmann, J.J. Zhou, C. Yu, L. Zeng, J. Nan, G. Seo, R.E. Vargas, B. Yang, R. Qi, L. Bardwell, D.A. Fishman, K.W.Y. Cho, L. Huang, R. Luo, R. Warrior, W. Wang, Nature Cell Biol. 24, 74, 2022
Machine-learned molecular surface and its application to implicit solvent simulation, H. Wei, Z. Zhao, R. Luo, J. Chem. Theory Comput. 17, 6214, 2021
Professional Societies
American Chemical Society
Biophysical Society
Graduate Programs
Structural Biology and Molecular Biophysics

Biomedical Engineering

Mathematical and Computational Biology

Chemical Engineering

Research Centers
Chemical and Structural Biology
Biomedical Engineering
Center for Complex Biological Systems
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