Pamela L. Flodman

picture of Pamela L. Flodman

Associate Adjunct Professor, Pediatrics
School of Medicine

Director, Graduate Program in Genetic Counseling

M.S., Oxford University, 1987, Applied Statistics
M.S., University of California, Irvine, 1990, Genetic Counseling

Phone: (714) 456-7570
Fax: (714) 456-5330

University of California, Irvine
Department of Pediatrics
101 The City Drive
Mail Code: 4482
Orange, CA 92868
Research Interests
Genetic Risk Assessment; Quantitative Human Genetics; Genetic Counseling
Newman ZL, Printz MP, Liu S, Crown D, Breen L, Miller-Randolph S, Flodman P, Leppla SH, Moayeri M.
Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.
PLoS Pathog. 2010 May 20;6(5):e1000906.
Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL; WHO/ISBRA Study on State and Trait Markers of Alcoholism.
Genetical genomic determinants of alcohol consumption in rats and humans.
BMC Biol. 2009 Oct 27;7:70.
Gage NM, Juranek J, Filipek PA, Osann K, Flodman P, Isenberg AL, Spence MA.
Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation.
J Neurodev Disord. 2009 Sep;1(3):205-214.
Smith M, Spence MA, Flodman P.
Nuclear and mitochondrial genome defects in autisms.
Ann N Y Acad Sci. 2009 Jan;1151:102-32.
Neuhausen SL, Steele L, Ryan S, Mousavi M, Pinto M, Osann KE, Flodman P, Zone JJ.
Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives.
J Autoimmun. 2008 Sep;31(2):160-5.
Richter L, Flodman P, Barria von-Bischhoffshausen F, Burch D, Brown S, Nguyen L, Turner J, Spence MA, Bateman JB.
Clinical variability of autosomal dominant cataract, microcornea and corneal opacity and novel mutation in the alpha A crystallin gene (CRYAA).
Am J Med Genet A. 2008 Apr 1;146(7):833-42.
Autism Genome Project Consortium
Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
Nat Genet. 2007 Mar;39(3):319-28.
Ogino S, Wilson RB, Gold B, Flodman P.
Bayesian risk assessment in genetic testing for autosomal dominant disorders with age-dependent penetrance.
J Genet Couns. 2007 Feb;16(1):29-39.
Bateman JB, von-Bischhoffshaunsen FR, Richter L, Flodman P, Burch D, Spence MA.
Gene conversion mutation in crystallin, beta-B2 (CRYBB2) in a Chilean family with autosomal dominant cataract.
Ophthalmology. 2007 Mar;114(3):425-32.
Schellenberg GD, Dawson G, Sung YJ, Estes A, Munson J, Rosenthal E, Rothstein J, Flodman P, Smith M, Coon H, Leong L, Yu CE, Stodgell C, Rodier PM, Spence MA, Minshew N, McMahon WM, Wijsman EM.
Evidence for multiple loci from a genome scan of autism kindreds.
Mol Psychiatry. 2006 Nov;11(11):1049-60, 979.
Bateman JB, Richter L, Flodman P, Burch D, Brown S, Penrose P, Paul O, Geyer DD, Brooks DG, Spence MA.
A new locus for autosomal dominant cataract on chromosome 19: linkage analyses and screening of candidate genes.
Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3441-9.
Geyer DD, Spence MA, Johannes M, Flodman P, Clancy KP, Berry R, Sparkes RS, Jonsen MD, Isenberg SJ, Bateman JB.
Novel single-base deletional mutation in major intrinsic protein (MIP) in autosomal dominant cataract.
Am J Ophthalmol. 2006 Apr;141(4):761-3.
Ogino S, Flodman P, Wilson RB, Gold B, Grody WW.
Risk calculations for cystic fibrosis in neonatal screening by immunoreactive trypsinogen and CFTR mutation tests.
Genet Med. 2005 May-Jun;7(5):317-27.
Grady DL, Harxhi A, Smith M, Flodman P, Spence MA, Swanson JM, Moyzis RK.
Sequence variants of the DRD4 gene in autism: further evidence that rare DRD4 7R haplotypes are ADHD specific.
Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):33-5.
Leung PW, Lee CC, Hung SF, Ho TP, Tang CP, Kwong SL, Leung SY, Yuen ST, Lieh-Mak F, Oosterlaan J, Grady D, Harxhi A, Ding YC, Chi HC, Flodman P, Schuck S, Spence MA, Moyzis R, Swanson J.
Dopamine receptor D4 (DRD4) gene in Han Chinese children with attention-deficit/hyperactivity disorder (ADHD): increased prevalence of the 2-repeat allele.
Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):54-6.
Hodge SE, Flodman PL.
Risk calculations: still essential in the molecular age.
Am J Med Genet A. 2004 Sep 1;129A(3):215-7.
Ramanathan S, Woodroffe A, Flodman PL, Mays LZ, Hanouni M, Modahl CB, Steinberg-Epstein R, Bocian ME, Spence MA, Smith M.
A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R.
BMC Med Genet. 2004 Apr 16;5:10.
Wang E, Ding YC, Flodman P, Kidd JR, Kidd KK, Grady DL, Ryder OA, Spence MA, Swanson JM, Moyzis RK.
The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.
Am J Hum Genet. 2004 May;74(5):931-44.
Goldberg WA, Osann K, Filipek PA, Laulhere T, Jarvis K, Modahl C, Flodman P, Spence MA.
Language and other regression: assessment and timing.
J Autism Dev Disord. 2003 Dec;33(6):607-16.
Flodman P, Hodge SE.
Sex-specific mutation rates for x-linked disorders: estimation and application.
Hum Hered. 2003;55(1):51-5.
Smith M, Woodroffe A, Smith R, Holguin S, Martinez J, Filipek PA, Modahl C, Moore B, Bocian ME, Mays L, Laulhere T, Flodman P, Spence MA.
Molecular genetic delineation of a deletion of chromosome 13q12-->q13 in a patient with autism and auditory processing deficits.
Cytogenet Genome Res. 2002;98(4):233-9.
Grady DL, Chi HC, Ding YC, Smith M, Wang E, Schuck S, Flodman P, Spence MA, Swanson JM, Moyzis RK.
High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder.
Mol Psychiatry. 2003 May;8(5):536-45.
Palmer AA, Breen LL, Flodman P, Conti LH, Spence MA, Printz MP.
Identification of quantitative trait loci for prepulse inhibition in rats.
Psychopharmacology (Berl). 2003 Jan;165(3):270-9.
Neiswanger K, Cooper ME, Weinberg SM, Flodman P, Keglovits AB, Liu Y, Hu DN, Melnick M, Spence MA, Marazita ML.
Cleft lip with or without cleft palate and dermatoglyphic asymmetry: evaluation of a Chinese population.
Orthod Craniofac Res. 2002 Aug;5(3):140-6.
Yu CE, Dawson G, Munson J, D'Souza I, Osterling J, Estes A, Leutenegger AL, Flodman P, Smith M, Raskind WH, Spence MA, McMahon W, Wijsman EM, Schellenberg GD.
Presence of large deletions in kindreds with autism.
Am J Hum Genet. 2002 Jul;71(1):100-15.
Jaworski RL, Jirout M, Closson S, Breen L, Flodman PL, Spence MA, Kren V, Krenova D, Pravenec M, Printz MP.
Heart rate and blood pressure quantitative trait loci for the airpuff startle reaction.
Hypertension. 2002 Feb;39(2 Pt 2):348-52.
Kelsoe, JR; Spence, MA; Loetscher, E; Foguet, M; Sadovnick, AD; Remick, RA; Flodman, P;
Khristich, J; Mroczkowski-Parker, Z; Brown, JL; Masser, D; Ungerleider, S; Rapaport, MH;
and Luebbert, H. A genome survey indicates a possible susceptibility locus for bipolar
disorder on chromosome 22. PNAS, 98(2):585-90, 2001.
Martin, RA; Hunter, V; Neufeld-Kaiser, W; Flodman, P; Spence, MA; Furnas, D; Martin, KA.
Ultrasonographic detection of orbicularis oris defects in first degree relatives of isolated
CL patients. American Journal of Medical Genetics 90(2):155-61, 2000.
Swanson, JM; Oosterlaan, J; Murias, M; Schuck, S; Flodman, P; Spence, MA; Wasdell, M;
Ding, Y; Chi, H-C; Smith, M; Mann, M; Carlson, C; Kennedy, MJ; Sergeant, J; Leung, P;
Zhang, Y-P; Sadeh A; Chen, C; Moyzis, R; and Posner, MI. ADHD Children with a 7-Repeat
Allele of the DRD4 Gene Have Extreme Behavior but Normal Performance on Critical
Neuropsychological Tests of Attention. Proceedings of the National Academy of Sciences,
97(9): 4754-4759, 2000.
Swanson, JM; Flodman, P; Kennedy, J; Spence, MA; Moyzis, R; Schuck, S; Murias, M;
Moriarity, J; Barr, C; Smith, M; Posner, M. Dopamine Genes and ADHD. Neuroscience
and Biobehavioral Reviews, 24, 21-5, 2000.
Bateman, BJ; Geyer, D; Flodman, P; Johannes, M; Sikela,J; Walter, N; Moreira, AT;
Clancy, K; Spence, MA. A New A1-crystallin Splice Junction Mutation for Autosomal
Dominant Congenital Cataract. IOVS, 41(11):3278-85, 2000.
Bateman, BJ; Johannes, M; Flodman, P; Geyer, D; Clancy, K; Heinzmann, C; Kojis, T;
and Spence, MA. A New Locus for Autosomal Dominant Cataract on Chromosome 12q13.
IOVS, 41(9):2665-70, 2000.
Professional Societies
National Society of Genetic Counselors
American Society of Human Genetics
Association of Genetic Counseling Program Directors
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