Tahseen Mozaffar

picture of Tahseen  Mozaffar

Professor and Interim Chair, Neurology
School of Medicine

Professor, Orthopaedic Surgery
School of Medicine

Chair, Institutional Review Board A, Research Administration

Director, Neuromuscular Program, Neurology
School of Medicine

Director, UC Irvine-MDA ALS and Neuromuscular Center, Neurology
School of Medicine

Affiliate Faculty, Institute for Memory Impairments and Neurological Disorders (UCI MIND)

Professor, Pathology
School of Medicine

M.B.B.S., The Aga Khan University, 1989
Neurology Residency, Barnes Hospital, St. Louis, 1995
Fellowship in Neuromuscular Diseases, Washington University in St. Louis, 1997

Phone: (714) 456-2332
Fax: (714) 456-5997
Email: mozaffar@uci.edu

University of California, Irvine
UC Irvine-MDA ALS and Neuromuscular Center
200 South Manchester Avenue, #110
Mail Code: 4280
Orange, CA 92868
Research Interests
Mechanisms underlying muscle atrophy in various neuromuscular disorders; ALS; Compression neuropathy; Clinical Trials
Academic Distinctions
Board Certification in Neurology, 1996-2016
Sven Elliason Faculty Award for Teaching Excellence, Department of Neurology, Washington University in St. Louis, 1997
Faculty Teaching Award, Department of Neurology University of California, Irvine, 2001, 2002, 2003, 2007
National Teaching Recognition, American Academy of Neurology, 2003
Elected Fellow, American Academy of Neurology, 2007
Elected member American Neurological Association, 2007
President, Orange County Neurological Society, 2006-2008
Elected, Physician of Excellence, Orange County Medical Association, 2008
Board Certification in Neuromuscular Medicine, 2008-2018
1. Bannwarth S, Procaccio V, Rouzier C, Fragaki K, Poole J, Chabrol B, Desnuelle C, Pouget J, Azulay JP, Attarian S, Pellissier JF, Gargus JJ, Abdenur JE, Mozaffar T, Calvas P, Labauge P, Pages M, Wallace DC, Lambert JC, and Paquis-Flucklinger V. Rapid identification of mitochondrial DNA (mtDNA) mutations in neuromuscular disorders by using surveyor strategy. Mitochondrion 8: 136-145, 2008.

2. Donaldson MR, Jensen JL, Tristani-Firouzi M, Tawil R, Bendahhou S, Suarez WA, Cobo AM, Poza JJ, Behr E, Wagstaff J, Szepetowski P, Pereira S, Mozaffar T, Escolar DM, Fu YH, and Ptacek LJ. PIP2 binding residues of Kir2.1 are common targets of mutations causing Andersen syndrome. Neurology 60: 1811-1816, 2003.

3. Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, Mozaffar T, Jackson CE, Bosch P, McVey A, Dick A, Barohn R, Lomen-Hoerth C, Rosenfeld J, O'Connor D T, Zhang K, Crook R, Ryberg H, Hutton M, Katz J, Simpson EP, Mitsumoto H, Bowser R, Miller RG, Appel SH, and Stephan DA. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. N Engl J Med 357: 775-788, 2007.

4. Gordon PH, Cheung YK, Levin B, Andrews H, Doorish C, Macarthur RB, Montes J, Bednarz K, Florence J, Rowin J, Boylan K, Mozaffar T, Tandan R, Mitsumoto H, Kelvin EA, Chapin J, Bedlack R, Rivner M, McCluskey LF, Pestronk A, Graves M, Sorenson EJ, Barohn RJ, Belsh JM, Lou JS, Levine T, Saperstein D, Miller RG, and Scelsa SN. A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS. Amyotroph Lateral Scler 9: 212-222, 2008.

5. Gordon PH, Moore DH, Miller RG, Florence JM, Verheijde JL, Doorish C, Hilton JF, Spitalny GM, MacArthur RB, Mitsumoto H, Neville HE, Boylan K, Mozaffar T, Belsh JM, Ravits J, Bedlack RS, Graves MC, McCluskey LF, Barohn RJ, and Tandan R. Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial. Lancet Neurol 6: 1045-1053, 2007.

6. Gupta R, Gray M, Chao T, Bear D, Modafferi E, and Mozaffar T. Schwann cells upregulate vascular endothelial growth factor secondary to chronic nerve compression injury. Muscle Nerve 31: 452-460, 2005.

7. Gupta R, Lin YM, Bui P, Chao T, Preston C, and Mozaffar T. Macrophage recruitment follows the pattern of inducible nitric oxide synthase expression in a model for carpal tunnel syndrome. J Neurotrauma 20: 671-680, 2003.

8. Gupta R, Rowshan K, Chao T, Mozaffar T, and Steward O. Chronic nerve compression induces local demyelination and remyelination in a rat model of carpal tunnel syndrome. Exp Neurol 187: 500-508, 2004.

9. Gupta R, Rummler LS, Palispis W, Truong L, Chao T, Rowshan K, Mozaffar T, and Steward O. Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury. Exp Neurol 200: 418-429, 2006.

10. Habib AA, and Mozaffar T. The neuropathology of leprosy. Arch Neurol 59: 138-140, 2002.

11. Lee SU, Grigorian A, Pawling J, Chen IJ, Gao G, Mozaffar T, McKerlie C, and Demetriou M. N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration. J Biol Chem 282: 33725-33734, 2007.

12. Levin MI, Mozaffar T, Al-Lozi MT, and Pestronk A. Paraneoplastic necrotizing myopathy: clinical and pathological features. Neurology 50: 764-767, 1998.

13. Mozaffar T. Case 21-1997: Paraneoplastic cerebellar degeneration and Hodgkin's disease. N Engl J Med 338: 66, 1998.

14. Mozaffar T. Critical illness myopathy. Muscle Nerve 24: 973-974, 2001.

15. Mozaffar T, and Gordon PH. Minocycline-induced skin and dental pigmentations. Neurology 67: 2185, 2006.

16. Mozaffar T, Haddad F, Zeng M, Zhang LY, Adams GR, and Baldwin KM. Molecular and cellular defects of skeletal muscle in an animal model of acute quadriplegic myopathy. Muscle Nerve 35: 55-65, 2007.

17. Mozaffar T, Lopate G, and Pestronk A. Clinical correlates of granulomas in muscle. J Neurol 245: 519-524, 1998.

18. Mozaffar T, and Mozaffar FH. Critical care myopathy: an emerging medical catastrophe. J Pak Med Assoc 53: 608-611, 2003.

19. Mozaffar T, and Pestronk A. Myopathy with anti-Jo-1 antibodies: pathology in perimysium and neighbouring muscle fibres. J Neurol Neurosurg Psychiatry 68: 472-478, 2000.

20. Mozaffar T, Strandberg E, Abe K, Hilgenberg LG, Smith MA, and Gupta R. Neuromuscular junction integrity after chronic nerve compression injury. J Orthop Res 2008.

21. Ringman JM, and Mozaffar T. Myopathy associated with chronic orlistat consumption: a case report. Neuromuscul Disord 18: 410-412, 2008.

22. Strandberg EJ, Mozaffar T, and Gupta R. The role of neurodiagnostic studies in nerve injuries and other orthopedic disorders. J Hand Surg [Am] 32: 1280-1290, 2007.

23. Karayan R and Mozaffar T. Emery-Dreifuss muscular dystrophy. In: Lisak RP, Truong DD, Carroll W, Bhidayasiri R (eds). International Neurology: a clinical approach. Blackwell Publishing, Oxford, United Kingdom (in press 2008).

24. Chui LA, Mozaffar T. Oculopharyngeal muscular dystrophy. In: Lisak RP, Truong DD, Carroll W, Bhidayasiri R (eds). International Neurology: a clinical approach. Blackwell Publishing, Oxford, United Kingdom (in press 2008).

25. Gupta R, Mozaffar T. Form and Function of the Spinal Cord and Peripheral Nerves. In: Buckwalter JA, Einhorn TA, O’Keefe RJ (eds). Orthopedic Basic Science: Biology and Biomechanics of the Musculoskeletal System. 3rd Ed (Chapter 13), pp 245-258. American Academy of Orthopedic Surgeons, Rosemont, Illinois, 2007.

26. Gupta R, Mozaffar T. Peripheral Nerve Physiology, Anatomy, and Pathology. In: Buckwalter JA, Einhorn TA, O’Keefe RJ (eds). Orthopedic Basic Science: Biology and Biomechanics of the Musculoskeletal System. 3rd Ed (chapter 23), pp 427-443. American Academy of Orthopedic Surgeons, Rosemont, Illinois, 2007.

27. Solbrig MV, Mozaffar T, Kim RC. Pediatric Leprosy. In: Jones HR, Darras BT, De Vivo DC (eds.). Neuromuscular disease of infancy, childhood and adolescence: A clinician’s approach. Butterworth-Heineman, Boston 2003, pp 505-518.

28. Mozaffar T, Pestronk A. Cancer-related muscle diseases. In: Karpati G: Structural and Molecular Basis of Skeletal Muscle Diseases. ISN Neuropath Press, Basel 2002, pp 266-269.

29. Yamada K, Mozaffar T, Awadalla S. Neurologic emergencies. In: Carey CF, Lee HH, Woeltje KF, eds. The Washington Manual of Medical Therapeutics (29th edition). Philadelphia: Lippincott Raven 1998: 475-493.
Professional Societies
American Academy of Neurology
World Muscle Society
American Neurological Association
Research Centers
UC Irvine-MDA ALS and Neuromuscular Center
Peripheral Nerve Research Laboratory
Institute for Memory Impairments and Neurological Disorders (UCI MIND)
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