Irina F. Sevrioukova

Researcher, Molecular Biology and Biochemistry
School of Biological Sciences

M.D., School of Medicine, Moscow, Russia
PH.D., Institute of Biomedical Chemistry, Moscow, Russia

Phone: (949) 824-1953
Fax: (949) 824-3280

University of California, Irvine
3205 McGaugh Hall
Mail Code: 3900
Irvine, CA 92697
Research Interests
Structure/function of flavo- and metalloenzymes, protein-protein interactions and molecular recognition, electron transport, protein crystallography
Academic Distinctions
1993-1995 - Postdoctoral Fellowship, Robert Welch Foundation;

1997-2000 - Institutional and Individual Postdoctoral National Research Service Awards, NIH.
Postdoctoral fellow, University of Texas Southwestern Medical Center, Dallas TX
Postdoctoral fellow, University of California, Irvine CA
I. Sevrioukova and T.L. Poulos "Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4" (2017) PNAS 114, 486-491.
I. Sevrioukova “Structure/function relations in AIFM1 variants associated with neurodegenerative disorders” (2016) J. Mol. Biol. 428, 3650-3665.
I. F. Sevrioukova and T. L. Poulos “Anion-dependent stimulation of CYP3A4 monooxygenase” (2015) Biochemsitry 54, 4083-4096.
P. Kaur, R. Chamberlin, T. L. Poulos and I. F. Sevrioukova “Structure-based inhibitor design for evaluation of a CYP3A4 pharmacophore model” (2015) J. Med. Chem. 59, 4210-4220.
I. F. Sevrioukova and T. L. Poulos “Current approaches for investigating and predicting cytochrome P450 3A4-ligand interactions” (2015) Adv. Exp. Med. Biol.851, 83-105.
I. F. Sevrioukova and T. L. Poulos “Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism” (2014) Curr. Top. Med. Chem. 14, 1348-1355.
NIH ES025767
Professional Society
American Society for Biochemistry and Molecular Biology
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