Researcher, Molecular Biology and Biochemistry
School of Biological Sciences

Structure/function of drug metabolizing enzymes, protein crystallography, rational drug design

1993-1995 - Postdoctoral Fellowship, Robert Welch Foundation;

1997-2000 - Institutional and Individual Postdoctoral National Research Service Awards, NIH.

Postdoctoral fellow, University of Texas Southwestern Medical Center, Dallas TX
Postdoctoral fellow, University of California, Irvine CA

Sevrioukova IF. Structural basis for the diminished ligand binding and catalytic ability of fetal-specific CYP3A7. Int. J. Mol. Sci. 2021, 22(11), 5831.

Toupin N, Steinke SJ, Nadella S, Li A, Rohrabaugh TN Jr, Samuels ER, Turro C, Sevrioukova IF, Kodanko JJ. Photosensitive Ru(II) complexes as inhibitors of the major human drug metabolizing enzyme CYP3A4. J. Am. Chem. Soc. 2021, 143(24), 9191-9205

Samuels ER, Sevrioukova IF. Rational design of CYP3A4 inhibitors: A one-atom linker elongation in ritonavir-like compounds leads to a marked improvement in the binding strength. Int. J. Mol. Sci. 2021, 22(2) E852

Samuels ER, Sevrioukova IF. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg & Med Chem 2020, 28(6) 115349.

Sevrioukova IF. Structural insights into the interaction of cytochrome P450 3A4 with suicide substrates: Mibefradil, azamulin and 6',7'-dihydroxybergamottin. Int. J. Mol. Sci. 2019, 20(17), pii: E4245.

Samuels ER, Sevrioukova I. Structure-activity relationships of rationally designed ritonavir analogs: Impact of side-group stereochemistry, headgroup spacing, and backbone composition on the Interaction with CYP3A4. Biochemistry. 2019, 58(15), 2077-2087.

Sevrioukova I. Interaction of human drug-metabolizing CYP3A4 with small inhibitory molecules. Biochemistry. 2019, 58(7), 930-939.

Samuels ER, Sevrioukova IF Inhibition of human CYP3A4 by rationally designed ritonavir-like compounds: Impact and interplay of the side group functionalities. Mol. Pharm. 2018, 15(1), 279-288.

I. Sevrioukova and T.L. Poulos "Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4" (2017) PNAS 114, 486-491.

Complete List of Published Work at
https://www.ncbi.nlm.nih.gov/myncbi/1tutXnF23pnQn/bibliography/public/

NIH ES025767

American Society for Biochemistry and Molecular Biology

Link to this profile
https://faculty.uci.edu/profile/?facultyId=4606

Last updated
04/06/2022