Mark J. Fisher

Professor, Neurology
School of Medicine

M.D., University of Cincinnati, 1975

Phone: (714) 456-6856
Fax: (714) 456-6573

University of California, Irvine
UC Irvine Medical Center
101 The City Drive South
Shanbrom Hall (Building 55), Room 121
Mail Code: 4280
Orange, CA 92868
Research Interests
Mechanisms of stroke, vascular neurobiology, blood-brain barrier
Academic Distinctions
Dr. Fisher's primary academic appointment is in the Department of Neurology, with joint appointments in the Departments of Anatomy & Neurobiology, Political Science, Pathology & Laboratory Medicine, and Psychiatry & Human Behavior. Dr. Fisher was Chair of the UCI Department of Neurology from 1998-2006, during which time the Department of Neurology entered the Top 10 in NIH Research Funding for neurology departments nationwide. Dr. Fisher established the stroke program at UCI, was Founding Director of the UCI Stroke Center (forerunner of the current UC Irvine Health Comprehensive Stroke and Cerebrovascular Center), and spearheaded the effort that made the stroke program at UCI the first academic stroke program in the country to be certified as a Primary Stroke Center by the Joint Commission (JCAHO).
Research Abstract
Dr. Fisher's Stroke Research Program investigates mechanisms of stroke from both a basic science and clinical perspective.
Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages. Sumbria RK, Vasilevko V, Grigoryan MM, Paganini-Hill A, Kim R, Cribbs DH, Fisher MJ. Journal of neuroinflammation. 2017; 14(1):114.
The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms. Lau WL, Huisa BN, Fisher M.
Translational stroke research. 2017; 8(1):67-76.
Cerebral Microbleeds, Hypertension, and Intracerebral Hemorrhage in Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.
Lee JS, Ko K, Oh JH, Park JH, Lee HK, Floriolli D, Paganini-Hill A, Fisher M.
Frontiers in neurology. 2017; 8:203.
A murine model of inflammation-induced cerebral microbleeds.
Sumbria RK, Grigoryan MM, Vasilevko V, Krasieva TB, Scadeng M, Dvornikova AK, Paganini-Hill A, Kim R, Cribbs DH, Fisher MJ.
Journal of neuroinflammation. 2016; 13(1):218.
Cerebral Microbleeds and Thrombolysis: Clinical Consequences and Mechanistic Implications.
Fisher M.
JAMA neurology. 2016; 73(6):632-5.
Definition and Implications of the Preventable Stroke.
Fisher M, Moores L, Alsharif MN, Paganini-Hill A.
JAMA neurology. 2016; 73(2):186-9.
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