Neuroscience, neurobiology, psychiatric disoreders, epigenetics, epilepsy, epileptogenesis, learning and memory, stress, corticotropin releasing hormone, hippocampus, development, programming.
2020 Elected Fellow, ACNP
2019 Elected Fellow, AAAS
2018: Cotzias Award and Lecture, American Academy of Neurology
2018 Distinguished Professor UCI
2015: Elected member, American College of Neuropsychopharmacology
2013: Bernard Sachs Distinguished Award for Research, Child Neurology Society.
2011: Soriano Lectureship Award of the American Neurological Association.
2010: Mentorship Award; UCI Alumni Association.
2009: Distinguished Award for Research in Epilepsy, American Society of Pharmacology and Experimental Therapeutics.
2008: Distinguished Scholar Lectureship, Office of the President, University of California.
2006: National Institute of Health NINDS, Javits Merit award.
2005: Research Recognition Award in Basic Science, the premier Epilepsy Research honor.
2005-2010: Epilepsy Foundation, Research Council and Professional Advisory Board.
2004-2006: Elected, AES Executive Board
2003: American Epilepsy Society (AES) Research Initiative Award.
1999: Athalie Clarke Excellence in Research Award, University of California-Irvine.
1995-current: Danette D. Shepard Endowed Chair in Neurological Sciences, University of California-Irvine.
1991: American Epilepsy Society Young Investigator Research Award
1988-1993: NINDS: Career Development Research Award (KO8)
1978-1980: Kennedy Postdoctoral Award (highest Weizmann Institute Graduate Award)
1977: EMBO: Short-term International Research Award; In J. Axelrod’s lab, NIH, Bethesda
1976-1977: Bloom Fellowship for doctoral studies, life sciences, Weizmann Institute of Science
Tallie Z. Baram, MD, PhD is a Professor of Pediatrics, Anatomy/Neurobiology, Neurology and Physiology/Biophysics at the University of California-Irvine, and the Danette Shepard Professor of Neurological Sciences. Baram is a child neurologist and developmental neuroscientist and who has been focusing her efforts on programming the developing brain as a result of early-life experiences. Baram’s group has studied this broad topic in two contexts: a. how early-life experiences including stress and maternal care influence resilience and vulnerability to cognitive and emotional disorders; b. how early life seizures, especially those associated with fever, can convert a normal brain into an epileptic one. Using rodent models and cutting-edge molecular, cellular epigenetic and imaging methods, Baram’s group has made enormous contributions to our understanding of the effects of early-life experience on normal brain function and the contributions of early-life adversity and seizures to neuropsychiatric disorders. Baram’s discoveries have been translational, providing the foundation of an FDA-approved therapy and of novel clinical imaging approaches.
Baram’s research contributions have been recognized by prestigious awards including the NIH NINDS Javits Merit Award, AES Basic Science Research Award, and the CNS Sachs Award, and she has chaired the NIH Developmental Brain Disorders study section. Baram has had a long commitment to mentoring. She is PI of one of two NIH funded T32s focused on epilepsy, and is mentor of several currently funded K awards. Baram’s numerous students from diverse backgrounds are now contributing independently to Neuroscience research.
Research Description and Approach
We are interested in how early-life experience (specifically stress or seizures) influence the function of brain cells persistently ('re-program' them), to promote or protect from in human disease. We aim to understand the mechanisms of this neuroplasticity and employ the information to design therapies for prevention/treatment of stress-related disorders and epilepsy, respectively.
Lab members use molecular biology, transgenic, epigenetic and in vitro and in vivo imaging methods. We use both in animal models where genes are controlled in time and space and in vitro systems including slice cultures and dissociated neurons. We study:
(a) how seizures induce large-scale, epigenetic changes in gene transcription programs in neurons, and the mechanisms of this coordinate transformation of normal neurons into 'epileptic' ones.
(b) how early life stress or enriched experience modify gene expression and synaptic function in the hippocampus and in specific hypothalamic neurons, predisposing to- or protecting from-cognitive and emotional stress related disorders including depression. Students use genetically modified mice where hippocampal neurons are visible to examine in real time how stress and hormones influence dendritic spine dynamics and neuronal structure. They test how these changes influence learning and memory. Mechanisms of experience- induced changes in neuronal gene expression (programming) are studied using neuroanatomical, molecular biology and physiological approaches.
Lab members collaborate extensively, and publish in outstanding journals.
2021 Bren Endowed Professor, UC-Irvine
2020 Elected Fellow, American College of Neuropsychopharmacology
2019 Elected Fellow, American Association for the Advancement of Science
2018 Fritz Dreifus Lecture, American Epilepsy Society
2018 George C. Cotzias Lectureship, American Academy of Neurology (the highest research award of the American Academy of Neurology)
2017 CURE Lectureship, University of Maryland, Baltimore
2017 Einstein Translational Medicine Lecture, Albert Einstein Sch. Med., NY
2015 Elected Member, American College of Neuropsychopharmacology
2014 Phil Dodge lectureship, Washington University St Louis
2013 Bernard Sachs Distinguished Research Award Child Neurology Society
2013 Lothman Memorial Lecturer, University of Virginia School of Medicine.
2012 Soriano Lectureship Award, American Neurological Association
2010 Outstanding Mentor Award, University of California Emeriti Association
2010-6 Chair, Board of Trustees, Lennox & Lombroso Research Trust of the American Epilepsy Society
2009 International Award for Epilepsy Research; American Society of Pharmacology and Experimental Therapeutics/ International League Against Epilepsy (ASPET-ILAE)
2006 National Institute of Health, Javits Neuroscience Merit Award
2005 American Epilepsy Society Basic Research Recognition Award (premier worldwide prize in Epilepsy Research)
2004-2006 American Epilepsy Society, Executive Board member; elected.
2003 American Epilepsy Society, Research Initiative Award
1999 Athalie Clarke Outstanding Research Award, UCalifornia-Irvine
1995 Endowed Chair, Danette Shepard Professor in Neurological Sciences
1994 Innovative Clinical Research Award, University of Southern California
1991 Epilepsy Foundation of America, Young Investigator Award
1988 NIH NINDS Clinical Investigator Development Award, (Ko8) 1988-1993
1978 Kennedy Memorial Award (Highest Weizmann Institute PhD prize, provides funds for a postdoctoral fellowship).
1975 Haim Weizmann Fellowship, 1975-1980
1976 Bloom fellowship for life science doctoral studies, 1976-1977
Peer-reviewed publications 1997- 2020
(H factor = 92; > 26,000 citations, google scholar)
Papers are grouped by topic, in reverse chronology.
Neurobiology of Stress, early-life adversity and its psychiatric consequences CRH
Bonapersona V, Hoijtink H; RELACS Consortium (Abbinck, M, Baram TZ, Bolton J et al) Sarabdjitsingh RA, Joëls M. Increasing the statistical power of animal experiments with historical control data.
Nat Neurosci. 2021. doi: 10.1038/s41593-020-00792-3. Epub ahead of print.
Hokenson RE, Short AK, Chen Y, Pham AL, Adams ET, Bolton JL, Swarup V, Gall CM, Baram TZ. Unexpected Role of Physiological Estrogen in Acute Stress-Induced Memory Deficits. J Neurosci. 2021 ;41; 648-662
Glynn LM, Davis EP, Luby JL, Baram TZ, Sandman CA. A predictable home environment may protect child mental health during the COVID-19 pandemic. Neurobiol Stress. 2021 PMC7823041.
Granger SJ, Glynn LM, Sandman CA, Small SL, Obenaus A, Keator DB, Baram TZ, Stern H, Yassa MA, Davis EP. Aberrant Maturation of the Uncinate Fasciculus Follows Exposure to Unpredictable Patterns of Maternal Signals. J Neurosci. 2021 41:1242-1250
Bolton JL, Schulmann A, Garcia-Curran MM, Regev L, Chen Y, Kamei N, Shao M, Singh-Taylor A, Jiang S, Noam Y, Molet J, Mortazavi A, Baram TZ. Unexpected Transcriptional Programs Contribute to Hippocampal Memory Deficits and Neuronal Stunting after Early-Life Adversity. Cell Rep. 2020 33: 108511.
Birnie MT, Kooiker CL, Short AK, Bolton JL, Chen Y, Baram TZ. Plasticity of the reward circuitry after early life adversity: mechanisms and significance. Biol Psychiatry. 2020 87:875-884
Luby JL, Baram TZ, Rogers CE, Barch DM. Neurodevelopmental Optimization after Early-Life Adversity: Cross-Species Studies to Elucidate Sensitive Periods and Brain Mechanisms to Inform Early Intervention. Trends Neurosci. 2020 43:744-751. doi: 10.1016/j.tins.2020.08.001: PMC7530018.
Short AK and Baram TZ. Adverse early-life experiences and neurologic disease: Age-old questions and novel answers. Nature Rev Neur 2019; 15:657-669
Levis SC, Bentzley BS, Molet J, Bolton JL, Perrone CR, Baram TZ, Mahler SV. On the early life origins of vulnerability to opioid addiction. Mol Psychiatry. 2019 Dec
Howland MA, Sandman CA, Davis EP, Stern HS, Phelan M, Baram TZ, Glynn LM. Prenatal maternal mood entropy is associated with child neurodevelopment. Emotion. 2020 Mar doi: 10.1037/emo0000726
Norona-Zhou AN, Morgan A, Glynn LM, Sandman CA, Baram TZ, Stern HS, Davis EP. Unpredictable maternal behavior is associated with a blunted infant cortisol response. Dev Psychobiol. 2020 Mar doi: 10.1002/dev.21964
Short AK, Bolton JL, Baram TZ. Mechanisms by which early-life experiences promote enduring stress resilience or vulnerability. Stress Resilience. 2020; 165-180
Short AK, Maras PM, Pham AL, Ivy AS, Baram TZ. Blocking CRH receptors in adults mitigates age-related memory impairments provoked by early-life adversity. Neuropsychopharmacology. 2020 Feb. 45:515-523
Mortazavi A, Baram TZ. Intra-individual changes in methylome profiles: an epigenetic 'scar' of early-life adversity? Neuropsychopharmacology. 2020 Jan;45(1):218. doi: 10.1038/s41386-019-0496-3.
Davis EP, Korja R, Karlsson L, Glynn LM, Sandman CA, Vegetabile B, Kataja EL, Nolvi S, Sinervä E, Pelto J, Karlsson H, Stern HS, Baram TZ. Across continents and demographics, unpredictable maternal signals are associated with children's cognitive function. EBioMedicine. 2019 doi:
Glynn LM and Baram TZ. The influence of unpredictable, fragmented parental signals on the developing brain. Front Neuroendocrinol (IF = 10) 2019. 53:100736
Jiang S, Kamei N, Bolton JL, Ma X, Stern HS, Baram TZ, Mortazavi A. Intra-individual methylomics detects the impact of early-life adversity. Life Sci Alliance. 2019. doi: 10.26508/lsa.201800204.
Baram TZ, Donato F., and Holmes GL. Construction and disruption of spatial memory networks during development. Learn Mem. 2019. 26:206-218
Bolton JL, Molet J, Regev L, Chen Y, Rismanchi N, Haddad E, Yang DZ, Obenaus A, Baram TZ. Anhedonia following early-life adversity involves aberrant interaction of reward and anxiety circuits and is reversed by partial silencing of amygdala corticotropin-releasing hormone gene. Biol Psychiatry. 2018. 83:137-147
Bolton JL, Short AK, Simeone KA, Daglian J, Baram TZ. Programming of stress-sensitive neurons and circuits by early-life experiences. Front Behav Neurosci, 2019. 18;13:30
Gunn BG, Sanchez GZ, Lynch G, Chen Y. Hyper-diversity of CRH interneurons in mouse hippocampus. Brain Struct Funct. 224:583-598. 2019
Glynn LM, Stern HS, Howland MA, Risbrough VB, Baker DG, Neivergelt CM, Baram TZ, Davis EP. Measuring novel antecendents of mental illness: the Questionnaire of Unpredictability in Childhood (QUIC). Neuropsychopharmacology. 2019. 44:876-882
Itoga CA, Chen Y, Fateri C, Echeverrry PA, Lai JM, Delgado J, Badhon S, Short A, Baram TZ and Xu X. New viral-genetic mapping uncovers an enrichment of corticotropin-releasing hormone-expressing neuronal inputs to the nucleus accumbens from stress-related brain regions. J Comp Neurol. 2019. 527:2474-2478.
Vogel-Cernia A, Laufer BI, Dunaway KW, Moraunt CE, Coulson RL, Totah TS, Stolzenberg DS, Frahm JC, Singh-Taylor A, Baram TZ, LaSalle JM, Yasui DH. Experience-dependent neurop0lasticity of the developing hypothalamus: integrative epigenomic approaches. Epigenetics. 2018. 13:318-330
Vegetabile B, Molet J, Baram TZ, Stern H. Estimating the entropy rate of Finite Markov chains with Application to behavior studies. J Educ Behav Statistics; 2019,
Baram TZ and Bolton JL. Parental smartphone use and children’s mental outcomes: a neurosciences perspective. Neuropsychopharmacology. 2019. 44:239-240
Glynn LM, Howland MA, Sandman CA, Davis EP, Phelan M, Baram TZ, Stern HS. Prenatal maternal mood patterns predict child temperament and adolescent mental health. J Affect Disord. 2018. 228:83-90.
Sandman CA, Curran MM, Davis EP, Glynn LM, Head K, Baram TZ. Cortical thinning and neuropsychiatric outcomes in children exposed to prenatal adversity: A role for placental CRH?. Am J Psychiatry. 2018;175:471-479
Risbrough VB, Glynn LM, Davis EP, Sandman CA, Obenaus A, Keator DB, Yassa MA, Baram TZ, Baker DG. Adolescent anhedonia and posttraumatic disorders. Curr Top Behav Neurosci. 2018;38:249-265
Bolton JL, Ruiz CM, Rismanchi N, Sanchez GA, Castillo E, Huang J, Cross C, Baram TZ, Mahler SV. Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia. Neurobiol Stress. 2018;8:57-67
Riley JD, Chen EE, Winsell J, Davis Poggi E, Glynn LM, Baram TZ, Sandman CA, Small SL. Network specialization during adolescence: Hippocampal effective connectivity in boys and girls. Neuroimage. 2018;175:402-412.
Singh-Taylor A, Molet J, Jiang S, Korosi A, Bolton JL, Noam Y, Simeone K, Cope J, Chen Y, Mortazavi A, Baram TZ. NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience. Mol Psychiatry. 23:648-657. 2018
Obenaus A, Kinney-Lang E, Jullienne A, Haddad E, Shereen D, Solodkin A, Dunn JF, Baram TZ. Novel use of Diffusion Tensor Imaging to delineate the rate basolateral amygdala. BioRxiv. 2018
Bolton JL, Molet J, Ivy A, Baram TZ. New insights in early-life stress and behavioral outcomes. Curr Opin Behavioral Sciences. 2017;14:133-139
Curran MM, Sandman C, Davis E, Glynn L, Andres A, Baram TZ. Abnormal dendritic maturation of developing cortical neurons exposed to high levels of Corticotropin Releasing Hormone (CRH): insight into effects of prenatal adversity? PLoS ONE, 2017;12:e0180311.
Gunn BG, Cox CD, Chen Y, Frotscher M, Gall CM, Baram TZ, Lynch G. The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus. Cereb Cortex, 2017;27:4182-4198
Davis EP, Stout SA, Molet J, Vegetabile B, Glynn LM, Sandman CA, Heins K, Stern H, Baram TZ. Exposure to unpredictable maternal sensory signals influences cognitive development across-species.
Proc Natl Acad Sci U S A, 2017; 114:10390-10395.
Gunn BG and Baram TZ. Stress and seizures: space, time and hippocampal circuits. Trends Neurosci. 2017;40:667-679.
Keator DB, Chen H, Nichols BN, Fana F, Stern H, Baram TZ, Small SL. A Semantic Cross-Species Derived Data Management Application. Data Science 2017
Walker CD, Bath KG, Joels M, Korosi A, Larauche M, Lucassen PJ, Morris MJ, Raineki C, Roth TL, Sullivan RM, Tache Y, Baram TZ. Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress 2017;20:421-448
Chen Y, Molet J, Lauterborn JC, Trieu BH, Bolton JL, Patterson KP, Gall CM, Lynch G, Baram TZ. Converging, synergistic actions of multiple stress hormones mediate enduring memory impairments after acute simultaneous stresses. J Neurosci, 2016;36:11295-11307. *subject of J Neurosci Journal Club
Molet J, Maras PM, Kinney-Lang E, Harris NG, Rashid F, Ivy AS, Solodkin A, Obenaus A, Baram TZ. MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early-life adversity. Hippocampus, 2016;16:1618-1632.
Molet J, Heins K, Zhuo X, Mei YT, Regev L, Baram TZ, Stern H. Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome. Transl Psychiatry, 2016;6:e702, 2016.
Chen Y, Baram TZ*. Towards understanding how early-life stress re-programs cognitive and emotional brain networks. Neuropsychopharmacology, 41:197-206, 2016.
*Highly cited article per Web of Science
Chen Y, Molet J, Gunn BG, Ressler K, Baram TZ. *Diversity of reporter expression patterns in transgenic mouse lines targeting corticotropin releasing hormone-expressing neurons. Endocrinology, 156:4769-80, 2015.
Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM. Short-term modern life-like stress exacerbates Aß-pathology and synapse loss in 3xTg-AD mice. J Neurochem, 134:915-26, 2015.
Dubé CM, Molet J, Singh-Taylor A, Ivy A, Maras PM, Baram TZ. Hyper-excitability and epilepsy generated by chronic early-life stress. Neurobiol Stress, 2:10-19, 2015.
Singh-Taylor A, Korosi A, Molet J, Gunn BG, Baram TZ. Synaptic rewiring of stress-sensitive neurons by early-life experience: a mechanism for resilience? Neurobiol Stress, 1:109-115, 2015.
Molet J, Maras, PM, Avishai-Eliner S, Baram TZ. Naturalistic models of Chronic Early-Life Stress. Develop Psychobiol, 56:1675-88, 2014.
Maras PM, Chen Y, Molet J, Rice C, Ji SG, Solodkin A, Baram TZ. Preferential loss of dorsal-hippocampus synapses underlies memory process impairment provoked by short, multi-modal stress. Mol Psychiatry, 19:811-22, 2014.
Andres AL, Regev L, Phi L, Seese RR, Chen Y, Gall CM, Baram TZ. NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci, 33:16945-60, 2013.
Karsten CA, Baram TZ. How does a neuron “know” to modulate its epigenetic machinery in response to early-life environment/experience? Front Psychiatry, 4:89, 2013.
Vogel-Ciernia A, Barrett RM, Matheos DP, Kramár E, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan A, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci, 16:552-61, 2013.
Cope JL, Regev L, Chen Y, Korosi A, Rice CJ, Ji S, Rogge GA, Wood MA, Baram TZ. Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus. Stress, 17:39-50, 2014.
Chen Y, Kramár EA, Chen LY, Babayan AH, Andres AL, Gall CM, Lynch G, Baram TZ. Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol Psychiatry, 18:485-96, 2013.
Maras, PM, Baram TZ. Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci, 35:315-24, 2012.
Baram TZ, Davis EP, Obenaus A, Sandman CA, Small SL, Solodkin A, Stern H. Fragmentation and unpredictability of early-life experience in mental disorders. Am J Psychiatry, 169:907-915, 2012.
Chen Y, Andres A, Frotscher M, Baram TZ. Tuning synaptic transmission in the hippocampus by stress: The CRH system. Front Cellular Neurosci, 6:13, 2012.
Wang XD, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV. Forebrain CRF1 modulates early-life stress-programmed cognitive deficits. J Neurosci, 31:13625-13634, 2011.
McClelland S, Korosi A, Cope J, Ivy A, Baram TZ. Emerging roles of epigenetic mechanisms in the enduring effects of neonatal stress and experience on learning and memory. Neurobiol Learn Mem, 96:79-88, 2011.
Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV. Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiol Dis, 42:300-310, 2011.
Ivy A, Rex C, Chen Y, Dubé C, Maras P, Grigoriadis D, Gall C, Lynch G, Baram TZ. Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci 30:13005-13015, 2010.
Korosi A, Baram TZ. Plasticity of the stress response early-in life: mechanisms and significance. Dev Psychobiol, 52:661-670, 2010.
Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler, EJ. *Early life programming and neurodevelopmental disorders. Biol Psychiatry, 68:314-319, 2010.
*Highly cited article per Web of Science
Chen Y, Rex CS, Rice CJ, Dubé CM, Gall CM, Lynch G, Baram TZ. Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc National Acad Sci, 29:13123-13128, 2010.
Pellock JM, Hrachovy R, Shinnar S, Baram TZ, Bettis D, Dlugos DJ, Gaillard WD, Gibson PA, Holmes GL, Nordli DR, O'Dell C, Shields WD, Trevathan E, Wheless JW. Infantile spasms: A U.S. consensus report. Epilepsia, 51:2175-2189, 2010.
Korosi A, Shanabrough M, McClelland S, Liu ZW, Borak E, Gao XB, Horvath TL, Baram TZ. Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone. J Neurosci, 30:703-713, 2010.
Joëls, M, Baram TZ. *The neuro-symphony of stress. Nature Reviews Neuroscience, 6:459-466, 2009.
*Highly cited article per Web of Science; cited > 1300 times
Korosi A, Baram TZ. The pathways from mother’s love to baby’s future. Front Behav Neurosci, 3:27, 2009.
Chen Y, Dubé C, Rice CJ, Baram TZ. Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci, 28:2903-2911, 2008.
Ivy AS, Brunson KL, Sandman C, Baram TZ. Dysfunctional nurturing behavior in rat dams with limited access to nesting material: A clinically relevant model for early-life stress. Neuroscience, 154:1132-42, 2008.
Rice CJ, Sandman CA, Lenjavi MR, Baram TZ. A novel mouse model for acute and long-lasting consequences of early life stress. Endocrinology, 149:4892-900, 2008.
Korosi A, Baram TZ. The central corticotropin releasing factor system during development and adulthood. Eur J Pharmacol, 583:204-14, 2008.
Fenoglio KA, Chen Y, Baram TZ. Neuroplasticity of the hypothalamic-pituitary-adrenal (HPA) axis early in life requires recurrent recruitment of stress-regulating brain regions. J Neurosci, 26:2434-2442, 2006.
Chen Y, Fenoglio KA, Dube CM, Grigoriadis DE, Baram TZ. Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent. Mol Psychiatry, 11:992-1002, 2006.
Fenoglio KA, Brunson KL, Baram TZ. Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects. Front Neuroendocrinol, 27:180-192, 2006.
Brunson KL, Kramár E, Lin B, Chen Y, Colgin LL, Yanagihara TL, Lynch G, Baram TZ. Mechanisms of late-onset cognitive decline after early life stress. J Neurosci, 25:9328-9338, 2005.
Fenoglio KA, Brunson KL, Avishai-Eliner S, Stone BA, Kapadia BJ, Baram TZ. Enduring, handling-evoked enhancement of hippocampal memory function and GR expression involves activation of the CRF type-1 receptor. Endocrinology, 146:4090-4096, 2005.
Brunson KL, Baram TZ, Bender RA. Hippocampal neurogenesis is not enhanced by lifelong reduction of glucocorticoid levels. Hippocampus, 15:491-501, 2005.
Chen Y, Bender RA, Brunson KL, Pomper J, Grigoriadis DE, Wurst W, Baram TZ. Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus. Proc Nat Acad Sci, 101:15782-15787, 2004.
Chen Y, Brunson KL, Adelmann G, Bender RA, Frotscher M, Baram TZ. Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress. Neuroscience, 126:533-540, 2004.
Mackay MT, Weiss SK, Adams-Webber T, Ashwal S, Stephens D, Ballaban-Gill K, Baram TZ, Duchowny M, Hirtz D, Pellock JM, Shields WD, Shinnar S, Wyllie E, Snead OC 3rd; American Academy of Neurology; Child Neurology Society. Practice parameter: medical treatment of infantile spasms: report of the AAN and Child Neurology Society. Neurology, 62:1668-1681, 2004.
Fenoglio KA, Brunson KL, Avishai-Eliner S, Chen Y, Baram TZ. Region-specific onset of handling-induced changes in corticotropin-releasing factor and glucocorticoid receptor expression. Endocrinology, 145:2702-6, 2004.
Brunson KL, Chen Y, Avishai-Eliner S, Baram TZ. Stress and the developing hippocampus: a double-edged sword? Mol Neurobiol, 27:121-136, 2003.
Avishai-Eliner S, Brunson KL, Sandman CA, Baram TZ. ‘Stressed out?’ Or in (utero). Trends Neurosci, 25:518-524, 2002.
Brunson KL, Grigoriadis DE, Lorang MT, Baram TZ. Corticotropin-releasing hormone (CRH) down-regulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain. Exp Neurol, 176:75-86, 2002.
Roozendaal B, Brunson KL, Holloway B, McGaugh JL, Baram TZ. Involvement of stress-released Corticotropin-Releasing Hormone in the basolateral amygdala in regulating memory consolidation. Proc Nat Acad Sci, 99:13908-13913, 2002.
Brunson KL, Eghbal-Ahmadi M, Roland R, Chen Y, Baram TZ. Long-term progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin releasing hormone reproduce the effects of early-life stress. Proc Nat Acad Sci, 98:8856-8861, 2001.
Avishai-Eliner S, Eghbal-Ahmadi M, Tabatchnik E, Brunson KL, Baram TZ. Down-regulation of hypothalamic corticotropin-releasing hormone messenger ribonucleic acid (mRNA) precedes early-life experience-induced changes in hippocampal glucocorticoid receptor mRNA. Endocrinology, 142:89-97, 2001.
Avishai-Eliner S, Gilles EE, Eghbal-Ahmadi M, Bar-El Y, Baram TZ. Altered regulation of Gene and Protein Expression of Hypothalamic-Pituitary-Adrenal Axis Components in an immature Rat Model of Chronic Stress. J Neuroendocrinol, 13:799-807, 2001.
Bender R, Lauterborn J, Gall CM, Cariaga W, Baram TZ. Enhanced CREB phosphorylation in immature dentate gyrus granule cells indicates a specific role for CREB in granule cell differentiation. Eur J Neurosci, 13:679-86, 2001.
Brunson KL, Avishai-Eliner S, Hatalski CG, Baram TZ. Neurobiology of the stress response early in life: evolution of a concept and the role of corticotropin releasing hormone. Mol Psychiatry, 6:647-656, 2001.
Brunson KL, Khan N, Eghbal-Ahmadi, Baram TZ. Corticotropin (ACTH) acts directly on amygdala neurons to down-regulate corticotropin releasing hormone gene expression. Ann Neurol, 49:304-312, 2001.
Chen Y, Bender R, Frotscher M, Baram TZ. Novel and transient populations of corticotropin-releasing hormone-expressing neurons in developing hippocampus suggest unique functional roles: a quantitative spatiotemporal analysis. J Neurosci, 21:7171-7181, 2001.
Chen Y, Hatalski CG, Brunson KL, Baram TZ. Rapid phosphorylation of the CRE binding protein precedes stress-induced activation of the corticotropin releasing hormone gene in medial parvocellular hypothalamic neurons of the immature rat. Mol Brain Res, 96:39-49, 2001.
Chen Y, Brunson K, Müller MB, Cariaga W, Baram TZ. Immunocytochemical distribution of corticotropin-releasing hormone receptor type-1 (CRF1)-like immunoreactivity in the mouse brain: Light microscopy analysis using an antibody directed against the C-terminus. J Comp Neurol, 420:305-23, 2000.
Dubé C, Brunson K, Nehlig A, Baram TZ. Activation of specific neuronal circuits by corticotropin releasing hormone, as indicated by c-fos expression and glucose metabolism. J Cerebral Blood Flow & Metabolism, 20:1414-24, 2000.
Hatalski CG, Brunson K, Tantayanubutr B, Chen Y, Baram TZ. Neuronal activity and stress differentially regulate hippocampal and hypothalamic corticotropin releasing hormone expression in the immature rat. Neuroscience, 101:571-80, 2000.
Eghbal-Ahmadi M, Avishai-Eliner S, Hatalski CG, Baram TZ. Differential regulation of the expression of corticotropin releasing factor receptor type 2 (CRF2) in hypothalamus and amygdala of the immature rat by sensory input and food intake. J Neurosci, 19:3982-3991, 1999.
Tran V, Hatalski CG, Yan XX and Baram TZ. Effects of blocking GABA degradation on corticotropin-releasing hormone gene expression in selected brain regions. Epilepsia, 40:1190-7, 1999.
Hatalski CG, Guirguis C, Baram TZ. Corticotropin releasing factor mRNA expression in the hypothalamic paraventricular nucleus and the central nucleus of the amygdala is modulated by repeated acute stress in the immature rat. J Neuroendocrinol, 10:663-9, 1998.
Hatalski CG, Baram TZ. Stress-induced transcriptional regulation in the developing rat brain involves increased cyclic adenosine 3',5'-monophosphate-regulatory element binding activity. Mol Endocrinol, 11:2016-2024, 1997.
Hollrigel G, Baram, TZ, Soltesz I. Corticotropin releasing hormone increases excitatory synaptic transmission in the hippocampus of infant rats. Neuroscience, 8:71-9, 1998.
Yan XX, Toth Z, Schultz L, Ribak CE, Baram TZ. Corticotropin releasing hormone (CRH)-containing neurons in the hippocampal formation. Light and electron microscopic features and co-localization with glutamate decarboxylase and parvalbumin. Hippocampus, 8:231-43, 1998.
Eghbal-Ahmadi M, Avishai-Eliner S, Hatalski CG, Baram TZ. Corticotropin releasing factor receptor type II (CRF2) mRNA levels in the hypothalamic ventromedial nucleus of the infant rat are reduced by maternal deprivation. Endocrinology, 138:5048-51, 1997.
Baram TZ, Mitchell WG, Tournay A, Snead OC, Hanson RA, Horton EJ. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics, 97:375-9, 1996.
Baram TZ, Koch Y, Hazum E, Fridkin M. Gonadotropin-releasing hormone in milk. Science, 198:300-302, 1977.
Febrile seizures, Developmental Epilepsy and underlying mechanisms
Chen KD, Hall AM, Garcia-Curran MM, Sanchez GA, Daglian J, Luo R, Baram TZ. Augmented seizure susceptibility and hippocampal epileptogenesis in a translational mouse model of febrile status epilepticus. Epilepsia. 2021. doi: 10.1111/epi.16814. Epub ahead of print. PMID: 33475157
Brennan GP, Garcia-Curran MM, Patterson KP, Luo R, Baram TZ. Multiple Disruptions of Glial-Neuronal Networks in Epileptogenesis That Follows Prolonged Febrile Seizures. Frontiers in Neurology, 2021; 12; 151-160
Garcia-Curran MM, Hall AM, Patterson KP, Shao M, Eltom N. Chen K, Dube CM, Baram TZ. Dexamethasone attenuates hyperexcitability provoked by experimental febrile status epilepticus. eNeuro. 2019. . eNeuro. 2019 pii: ENEURO.0430-19.2019. doi: 10.1523/ENEURO.0430-19.2019
Curran MM, Haddad E, Patterson KP, Choy M, Dubé CM, Baram TZ, Obenaus A. Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic? Epilepsia. 2018 59:2005-2018.
Hall AM, Short AK, Sing-taylor A, Daglian J, Mishina T, Schmidt WK, Kouji H, Baram TZ. NRSF-mediated repression of neuronal genes in developing brain persists in the absence of NRSF-Sin3 interaction. 2018.bioRxiv 245993;
Patterson KP, Barry JM, Curran MM, Singh-Taylor A, Brennan G, Rismanchi N, Page M, Noam Y Holmes GL, Baram TZ. Enduring memory impairments provoked by febrile seizures are mediated by functional and structural effects of neuronal restrictive silencing factor. J Neurosci 2017;3799-3812
Hall AM, Brennan GP, Nguyen TM, Sing-Taylor A, Mun H-S, Sargious MJ, Baram TZ. The Role of Sirt1 in Epileptogenesis. eNeuro. 2017. 10;4
Koepp MJ, Årstad E, Bankstahl JP, Dedeurwaerdere S, Friedman A, Potschka H, Ravizza T, Theodore WH and Baram TZ. (2017), Neuroinflammation imaging markers for epileptogenesis. Epilepsia. 2017;58: 11–19.
Brennan GP, Dey D, Chen Y, Patterson KP, Magnetta E, Hall AM, Dube CM, Mei Y-T, Baram TZ. Dual and opposing roles of microRNA-124 in the generation of epilepsy are mediated through inflammatory and NRSF-dependent gene networks. Cell Reports, 14:2402-12, 2016.
Barry JM Sakkaki S, Barriere SJ, Patterson KP, Lenck-Santini P, Scott RC, Baram TZ, Holmes GL. Temporal Coordination of hippocampal neurons reflects cognitive outcome post-febrile status epilepticus. EBioMedicine, 7:175-190, 2016.
Patterson KP, Brennan GP, Curran M, Kinney-Lang E, Dubé C, Rashid F, Ly C, Obenaus A, Baram TZ. Rapid, coordinate inflammatory responses after experimental febrile status epilepticus: implications for epileptogenesis. eNeuro, 2:e0034-15.2015, 2015.
Choy M, Dubé CM, Patterson K, Barnes SRS, Maras P, Blood AB, Hasso AN, Obenaus A, Baram TZ. A novel, noninvasive, predictive epilepsy biomarker with clinical potential. J Neurosci, 34:8672-84, 2014.
McClelland S, Brennan GP, Dubé C, Rajpara S, Iyer S, Richichi C, Bernard C, Baram TZ. The transcription factor NRSF: contributes to epileptogenesis by selective repression of a subset of target genes. eLife, 3:e01267, 2014.
Patterson KP, Baram TZ, Shinnar S. Origins of temporal lobe epilepsy: febrile seizures and febrile status epilepticus. Neurotherapeutics, 11:242-50, 2014.
Barry JM, Choy M, Dube C, Robbins A, Obenaus A, Lenck-Santini PP, Scott RC, Baram TZ, Holmes GL. T2 relaxation time post febrile status epilepticus predicts cognitive outcome. Exp Neurol, 269:242-252, 2015.
Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem, 289:5889-903, 2014.
Nakamura Y, Shi X, Numata T, Mori Y, Inoue R, Lossin C, Baram TZ, Hirose S. Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner. PLoS One, 8:e80376, 2013.
Marcelin B, Liu Z, Chen Y, Lewis AS, Becker A, McClelland S, Chetkovich DM, Migliore M, Baram TZ, Esclapez M, Bernard C. Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells. J Neurosci, 32:3736-3747, 2012.
McClelland S, Flynn C, Dubé C, Richichi C, Zha QQ, Ghestem A, Esclapez M, Bernard C Baram TZ Neuron-restrictive silencer factor-mediated hyperpolarization activated, cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol, 70:454-465, 2011.
Vezzani A, French J, Bartfai T, Baram TZ. *The role of inflammation in epilepsy. Nat Rev Neurol, 7:31-40, 2011.
*Highly cited article per Web of Science. Cited > 1300 times, google scholar.
Noam Y, Bernard C, Baram TZ. Towards an integrated view of HCN channel role in epilepsy. Curr Opin Neurobiol, 21:873-879, 2011.
Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are regulated by interaction with tetratricopeptide repeat-containing RAB8B-interacting protein (TRIP8B) and cyclic AMP at distinct sites. J Biol Chem, 286:20823-20834, 2011.
Hill EL, Hosie S, Mulligan RS, Richards KL, Davies PJ, Dubé CM, Baram TZ, Reid CA, Jones MV, Petrou S. Temperature elevation increases GABA(A) –mediated cortical inhibition in a mouse model of genetic epilepsy. Epilepsia, 52:179-184, 2011.
McClelland S, Dubé CM, Yang J, Baram TZ. Epileptogenesis after prolonged febrile seizures: mechanisms, biomarkers and therapeutic opportunities. Neurosci Lett, 497:155-162, 2011.
Dubé CM, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, Andres AL, Nalcioglu O, Obenaus A, Vezzani A, Baram TZ. Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci, 30:7484-7494, 2010.
Noam Y, Zha Q, Phan L, Wu RL, Chetkovich DM, Wadman WJ, Baram, TZ. Trafficking and surface expression of the hyperpolarization-activated nucleotide-gated (HCN) channels in hippocampal neurons. J Biol Chem, 285:14724-14736, 2010.
Dibbens LM, Reid CA, Hodgson B, Thomas EA, Phillips AM, Gazina E, Cromer BA, Clarke AL, Baram TZ, Scheffer IE, Berkovic SF, Petrou S. Augmented currents of an HCN2 variant in patients with febrile seizure syndromes. Ann Neurol, 67:542-546, 2010.
Martin MS, Dutt K, Papale LA, Dube CM, Dutton SB, de Haan G, Ghankar A, Tufik S, Meisler MH, Baram TZ, Golden AL, Escayg A. Altered function of the SCN1A voltage-gated sodium channel leads to GABAergic interneuron abnormalities. J Biol Chem, 285:9823-9834, 2010.
Kanyshkova T, Pawlowski M, Meuth P, Dube C, Bender RA, Brewster Al, Baumann A, Baram, TZ, Pape, HC, Budde T. Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamortical oscillations. J Neurosci, 27:8847-8857, 2009.
Lewis A, Schwartz E, Chan S, Noam Y, Shin M, Wadman W, Surmeier D, Baram TZ, Macdonald R, Chetkovich D. Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. J Neurosci, 29:6250-6265, 2009.
Dube C, Zhou J, Hamamura M, Zhao Q, Ring A, Abrahams J, McIntyre K, Nalcioglu O, Shatskih T, Baram TZ. Cognitive Dysfunction after Experimental Febrile Seizures. Exp Neurol, 251:167-177, 2009.
Kerjan G, Koizumi H, Han EB, Dubé CM, Djakovic SN, Patrick GN, Baram TZ, Heinemann SF, Gleeson JG. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal maturation and spontaneous seizures. Proc Nat Acad Sci, 106:6766-6771, 2009.
Richichi C, Brewster AL, Bender RA, Simeone TA, Zha Q, Yin HZ, Weiss JH, Baram TZ. Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiol Dis, 29:297-305, 2008.
Zha QQ, Brewster AL, Richichi C, Bender RA, Baram TZ. Activity-dependent heteromerization of the Hyperpolarization-activated, cyclic nucleotide gated (HCN) channels: role of N-linked glycosylation J Neurochem, 105:68-77, 2008.
Bender RA, Baram TZ. Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks. Prog Neurobiol, 86:129-40, 2008.
Dube C, Brewster AL, Richichi, C, Zha QQ, Baram TZ. Fever, febrile seizures and epilepsy. Trends Neurosci, 30:490-496, 2007.
Bender RA, Kirschstein T, Kretz O, Brewster AL, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram TZ. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci, 27:4697-4706, 2007.
Brewster AL, Chen Y, Bender RA, Yeh A, Shigemoto R, Baram TZ. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development hippocampus. Cereb Cortex, 17:702-712, 2007.
Dubé C, Richichi C, Bender RA, Chung G, Litt B, Baram TZ. Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain, 129:911-22, 2006.
Kuisle M, Wanaverbecq N, Brewster AL, Frere SG, Pinault D, Baram TZ, Luthi A. Functional stabilization of weakened thalamic pacemaker channel regulation in absence epilepsy. J Physiol, 575:83-100, 2006.
Surges R, Brewster AL, Bender RA, Beck H, Feuerstein TJ, Baram TZ. Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. Eur J Neurosci, 24: 94-104, 2006.
Bender RA, Galindo R, Mameli M, Gonzalez-Vega R, Valenzuela F, Baram TZ. Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide gated (HCN) channel function. Eur J Neurosci, 22:2669-2674, 2005.
Brewster AL, Bernard JA, Gall CM, Baram TZ. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis, 19:200-207, 2005.
Dubé C, Vezzani A, Behrens M, Bartfai T, Baram TZ. Interleukin 1beta contributes to the generation of experimental febrile seizures. Ann Neurol, 57:152-155, 2005.
Simeone TA, Rho JM, Baram TZ. Single channel properties of hyperpolarization activated cation currents in acutely dissociated rat hippocampal neurons. J Physiol, 568:371-380, 2005.
Dubé C, Yu H, Nalcioglu O, Baram TZ. Serial magnetic resonance imaging (MRI) after experimental febrile seizures: altered T2 signal does not signify neuronal death. Ann Neurol, 56:709-714, 2004.
Baram TZ. Long-term neuroplasticity and functional consequences of single versus recurrent early-life seizures. Ann Neurol, 54; 701-705, 2003.
Bender RA, Dubé C, Gonzalez-Vega R, Mina EW, Baram TZ. Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus, 13:399-412, 2003.
Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci, 23:6826-6836, 2003.
Santoro B, Baram TZ. The multiple personalities of h-channels. Trends Neurosci, 26:550-554, 2003.
Sullivan PG, Dubé C, Dorenbos K, Steward O, Baram TZ. Mitochondrial uncoupling protein-2 contributes crucially to the resistance of immature brain to excitotoxic neuronal death. Ann Neurol, 53:711-717, 2003.
Brewster A, Bender RA, Chen Y, Eghbal-Ahmadi M, Dubé C, Baram TZ. Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform and cell-specific manner. J Neurosci, 22:4591-4599, 2002.
Bender RA, Brewster A, Santoro B, Ludwig A, Hofmann F, Biel M, Baram TZ. Differential and age-dependent expression of Hyperpolarization-activated, Cyclic Nucleotide-gated cation channel isoforms 1-4 suggest evolving roles in the developing rat hippocampus. Neuroscience, 106:689-98, 2001.
Chen K, Aradi I, Eghbal-Ahmadi M, Baram TZ, Soltesz I. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition into hyperexcitability. Nature Medicine, 7:331-337, 2001.
Dubé C, Chen K, Eghbal-Ahmadi M, Brunson K, Soltesz I, Baram TZ. Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long-term. Ann Neurol, 47:336-344, 2000.
Chen K, Baram TZ, Soltesz I. Febrile Seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nature Medicine, 5:888-894, 1999.
Baram TZ, Hatalski CG. Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain. Trends Neurosci, 21:471-476, 1998.
Toth Z, Yan XX, Heftoglu S, Ribak CE, Baram TZ. Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model. J Neurosci, 18:4285-4294, 1998.
NIH NIMH MH 96889 (P50, PI: Baram), 06/17/2013-04/30/2024, Fragmented early life environment and emotional/cognitive vulnerabilities.
NIH NINDS NS 35439 (R01, PI: Baram), 4/01/1997-07/31/2019,
Epileptogenesis following FSE: mechanisms, biomarkers, prevention. (Senator Javits Career Merit award, R37; 2006-2014)
NIH NINDS NS 45540 (T32, PI: Baram), 7/01/2003 - 6/30/2024,
Training grant for post-doctoral fellows focused on Epilepsy Research. (One of only two such grants in the U.S.)
NIH NIMH MH 73136 (R01, PI: Baram), 12/01/1999-05/31/2022, Effects of early life experience: Role of CRH.
NIH NINDS NS 108296 (R01, Multiple PIs: Gregory Holmes & Baram), 07/01/2018-6/30/2023, Cognitive deficits after experimental febrile seizures: neurobiology & biomarkers.
Hewitt fellowship, Jessica Bolton, PhD (Sponsor: Baram), 10/01/2015-09/30/2018
Hewitt Fellowship, Matt Birnie 10/2018-10/2021
American College of Neuropsychopharmacology (elected)
American Neurological Association (elected)
American Epilepsy Society
Society for Neuroscience
American Association for Advancement of Science
American Academy of Neurology
Child Neurology Society
Chair Developmental Brain Disorders study section
Chair Lennox/Lombroso research trust,
American Epilepsy Society 2010—2016
Chair and member NIH NIMH P50 Conte Center Study Section
NIH CSR study sections and SEPs
Interdepartmental Neuroscience Program
Cellular and Molecular Biosciences
Epilepsy Research Center
Conte Center @ UCI
Center for the Neurobiology of Learning and Memory