Hartmut Luecke

picture of Hartmut  Luecke

Professor, Molecular Biology and Biochemistry
School of Biological Sciences
Professor, Physiology & Biophysics
School of Medicine
Professor, Computer Science
Donald Bren School of Information and Computer Sciences
Director, Center for Biomembrane Systems

B.S., Heidelberg College, OH

Ph.D., Rice University

Email: hudel@uci.edu

University of California, Irvine

Mail Code: 3900
Irvine, CA 92697-3900
Research Interests
Protein crystallography Structure function studies Membrane proteins Bacteriorhodopsin Annexin G protein-coupled receptors (GPCR) Structure-based drug design
Research Abstract
See web page
Available Technologies
A transporter converted into a sensor, a phototaxis signaling mutant of bacteriorhodopsin at 3.0 Å.
Spudich EN, Ozorowski G, Schow EV, Tobias DJ, Spudich JL, Luecke H.
J Mol Biol. 2012 Jan 20;415(3):455-63. Epub 2011 Nov 22.
Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein.
Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH.
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9449-54. Epub 2011 May 23.
Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization.
Stagno J, Aphasizheva I, Bruystens J, Luecke H, Aphasizhev R.
J Mol Biol. 2010 Jun 11;399(3):464-75. Epub 2010 Apr 18.
Apo and calcium-bound crystal structures of cytoskeletal protein alpha-14 giardin (annexin E1) from the intestinal protozoan parasite Giardia lamblia.
Pathuri P, Nguyen ET, Ozorowski G, Svärd SG, Luecke H.
J Mol Biol. 2009 Jan 30;385(4):1098-112. Epub 2008 Nov 20.
Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore.
Luecke H, Schobert B, Stagno J, Imasheva ES, Wang JM, Balashov SP, Lanyi JK.
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16561-5. Epub 2008 Oct 15.
Crystal structure of metastasis-associated protein S100A4 in the active calcium-bound form.
Pathuri P, Vogeley L, Luecke H.
J Mol Biol. 2008 Oct 31;383(1):62-77. Epub 2008 May 7.
Professional Societies
Alexander von Humboldt Foundation
Graduate Programs
Structural Biology and Molecular Biophysics


Research Centers
Cancer Research Institute
Center for Biomembrane Systems
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