Michael T. Alkire
Associate Professor, Anesthesiology
School of Medicine
B.S., University of Oregon
M.D., University of California, Los Angeles
Phone: (714) 456-5501, 8308
Fax: (714) 456-7702
University of California, Irvine
Rm 104B - Bldg 53 - Rt 81A
Irvine, CA 92868
Functional brain imaging; Mechanisms of anesthetic action on consciousness, memory and pain processing; Investigation and development of new clinical monitoring technology
Alkire MT, Asher CD, Franciscus AM, Hahn EL: Thalamic microinfusion of antibody to a voltage-gated potassium channel restores consciousness during anesthesia. Anesthesiology 2009; 110: 766-73
"Anesthesiology Editor's pick for Best-of-Meeting abstract award 2008"
Alkire MT, Hudetz AG, Tononi G: Consciousness and anesthesia. Science 2008; 322: 876-80
Alkire MT, Gruver R, Miller J, McReynolds JR, Hahn EL, Cahill L: Neuroimaging analysis of an anesthetic gas that blocks human emotional memory. Proc Natl Acad Sci U S A 2008; 105: 1722-7
Alkire MT, Nathan SV: Does the amygdala mediate anesthetic-induced amnesia? Basolateral amygdala lesions block sevoflurane-induced amnesia. Anesthesiology 2005; 102: 754-760
Alkire MT, Haier RJ, Fallon JH: Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness. Conscious Cogn 2000; 9: 370-86
MT Alkire, M.D., RJ Haier, Ph.D., SJ Barker, Ph.D., M.D., NK Shah, M.D., JC Wu, M.D., and YJ Kao, Ph.D.: Cerebral metabolism during propofol anesthesia in humans studied with positron emission tomography. Anesthesiology, 1995 February, 82(2):393-403;discussion 27A.
The editorial HIGHLIGHT by Michael M. Todd, M.D.: p. 27A, acclaimed the manuscript as a "major achievement" in anesthesia research.
American Society of Anesthesiologists