Frederic Y.M. Wan

picture of Frederic Y.M. Wan

Professor, Mathematics
School of Physical Sciences

Professor, Mechanical & Aerospace Engineering
The Henry Samueli School of Engineering

S.B., Massachusetts Institute of Technology, 1959, Mathematics
S.M. and Ph.D. Mathematics, June, 1963 and September, 1965, MIT

Phone: (949) 824-5529
Fax: (949) 824-7993

University of California, Irvine
510B Rowland Hall
Mail Code: 3875
Irvine, CA 92697
Research Interests
Applied Mathematics, Solid Mechanics, Resource Economics, Biomathematics
Academic Distinctions
Honors and Awards:
**Arthur Beaumont Distinguished Service Award, Canadian Applied Mathematics Society, 1991
**Foreign Member, Russian Academy of Natural Sciences, 1999 -
**Fellow: American Academy of Mechanics (AAM), 1981, American Society of Mechanical Engineers (ASME), 1987; American Association for the Advancement of Science (AAAS), 1995; Society for Industrial and Applied Mathematics (SIAM), 2010.

**University of British Columbia: Director, Institute of Applied Mathematics and Statistics (1974-83)
**University of Washington: Chair, Department of Applied Mathematics (1983-88); Divsional Dean of Natural and Mathematical Sciences, College of Arts & Sciences (1988-92)
**Natural Science and Engineering Council of Canada: Member (1980-83) and Chairman (1982-83), Committee of Pure and Applied Mathematics
**National Science Foundation: Program Officer, Appl. Math. Program, DMS (1986-87); Division Director, DMS (January, 1993 - December, 1994)
**MIT: MIT Educational Council (1974-79) MIT Visiting Committee for Mathematics (1991-93)
**University of California, Irvine: Vice Chancellor for Research and Dean of Graduate Studies (1995-2000)
Chair of Board of Trustees, IPAM, UCLA (1999-2002)
Member of Scientific Committee, ZCAM, Tsinghua University, 2002 -
Member of Advisory Committee, Center for the Mathematical Sciences, Renmin University of China, 2015 -.

Editorial Board Membership: 1) Studies in Appl. Math. 84- ; 2) Canadian Appl. Math. Quarterly, 93- ; 3) International J. Solids & Strucutres 96- ; 4) World Sci. Publ. 95- ; 5) J. Mech. Materials & Structures (JoMMS), 05 - ; 6) International J. Num. Anal. & Modeling, Series B, 10 -16.

Professional Societies: Canadian Applied Mathematics Society (CAMS/SCMA): Council Member 1980-82, President 1983-85, Past President 1985-87. American Mathematical Society (AMS): Committee of Committees (1995-97), Science Policy Committee (1995-97). Society for Industrial and Applied Mathematics (SIAM): Educational Committee (1983-87), Representative on the U.S. National Committee on Theoretical and Applied Mechanics (1991-93, 2001-), Science Policy Committee (1990-92,1995-) Mathematical Association of America (MAA)
Department of Mathematics, MIT, 1965-67
Research Abstract
**Copyrights on Books: 1) Mathematical Models and Their Analysis, Harper and Row, February, 1989. 2) Introduction to the Calculus of Variations and Its Applications, Chapman & Hall, January, 1995.
**Recent Presentations: 2004-05 - SIAM Conferences on the Life Sciences (7/11-16/04, Portland, OR), AIM's 5th Int'l Conf. on Dyn. Syst. & Diff. Eq'ns (6/16-19/04, Pomona, CA); 2003-04 - Int'l Conf. Math. & Its Applications (5/28-31/04, City Univ. of Hong Kong), Math. Seminar (5/21/04, Peking Univ.), Mechanics Seminar (5/14/04, Peking Univ.), Comp. Math. Seminar (4/23/04, Xian Jaotong Univ.), Mechanics Seminar (4/9/04, Tsinghua Univ.), 5th ICIAM (7/7-11/03, Sydney, Australia); 2002-03 - W.M. Keck Seminars in Comp. Biology (5/21/03, UCLA), 3rd So.Calif. Appl. Math. Symp. (5/3/2003, UC Irvine), Annual SIAM Meeting (7/8-12/2002, Philadelphia, PA).
Progressive decrease in Chlamydia cell size precedes differentiation, Nature Communications, Vol. 9, 2018, Article # 45, doi:10.1038/s41467-017-02432-0. ( J.K. Lee, G.A. Enciso, D. Boassa, C.N. Chander, T.H. Lou, S.S. Pairawan. M.C. Guo, F.Y.M.Wan, M.J. Ellisman, C. Suetterlin and Ming Tan)
Optimal Proliferation and Differentiation of Chlamydia Trachomatis, Studies in Applied. Math. 139 (1), 2017, 129-178 (DOI: 10.1111/sapm.12175). (F.Y.M. Wan and G.A. Enciso).
Dynamical System Models in the Life Sciences and their scientific issues, World Scientific, Singapore, New Jersey, etc. , 2017
Timing of CD8 T cell effector responses in viral infections, Royal Society Open Science (2016) 3.2: 150661: 140. (with S.R. Stipp, A. Iniguez, and D. Wodarz)
Transient Feedback and Robust Signaling Gradients, Int. J. Num. Anal. & Modeling, Series B, 13 (2), 2016, Pgs.175-200. (with A. Simonyan)
Robust and precise morphogen-mediated patterning: trade-offs, constraints and mechanisms, Interface, J. Royal Soc. 12 . 2014, Pgs. 1014-26. (with W.-C. Lo, S. Zhou, A.D. Lander and Q. Nie)
A new approach to feedback for robust signaling gradients, Studies in Appl. Math. 133, 2014, 18-51. (with T. Kushner abd A. Simonyan)
Fastest time to cancer by loss of tumor suppressor genes, Bull. Math Bio.. 76. 2014, 2737-2784. (with C. Sanchez-Tapia)
Robustness of signaling gradient in Drosophila wing imaginal disc, J. DCDS-B (Discrete and Continuous Dynamical Systems, Series B) Vol. 16 (3) 2011, Pgs. 835-866. (with J. Lei, A.D. Lander, and Q. Nie)
Size-normalized robustness of Dpp gradient in Drosophila wing imaginal disc, JoMMS Vol. 6 (1-4), 2011, Pgs. 321-350. (with A.D. Lander, Q, Nie, and B. Vargas)
Timing of CD8 T cell effector responses in viral infections, Royal Society Open Science (2016) 3.2: 150661: 140. (with S.R. Stipp, A. Iniguez, and D. Wodarz)
Genetic instability in cancer: an optimal control problem, Studies in Appl. Math., Vol. 125(1), 2010, Pgs. 1 - 10. (with A. Sadovsky and N. L. Komarova)

Spatial dynamics of multi-state cell lineages in tissue stratification, Biophysical J. Vol. 99 (10), 2010, Pgs. 3145-3154. (with C.-S. Chiou, W. Lo, K. Gokoffski,Y.-T.Zhang, A.D. Lander, A.L. Calof, and Q. Nie)
Feedback regulation in multistage cell lineages, Math. Biosci. & Eng., 6(1), 2009, Pgs. 59-82. (W.-C. Lo, C.-S. Chou, K. Gokoffski, A.D. Lander, A.L. Calof and Q. Nie)
Compact integration factor methods in high spatial dimension, J. Comp. Phys., 227, 2008, Pgs. 5238-5525. (with Q. Nie, F.Y.M. Wan, Y.-T. Zhang and X.-F. Liu)
Selective pressures for and against genetic instability in cancer: a time-dependent problem, J. Royal Society, Interface, 2007, Online, June 19, 2007, doi: 10.1098/rsif.2007.1054. (with N. Komarova and A. Sadovsky)
Elastodynamics of embryonic epidermal wound closure, Studies in Appl. Math., 118, 2007, Pgs. 365-395. (with A. Sadovsky)
Time to first spike in Hodgkin-Huxley stochastic systems, Physica A - Stat. Mech. Applic., 351 (2-4), 2005, Pgs. 427-438. (with H.C. Tuckwell)
Effects of Sog on Dpp-receptor binding, SIAM J. Appl. Math., 65, 2005, Pgs. 1748 - 1771. (with Y. Lou and Q. Nie)
Formation of the BMP activity gradient in the Drosophila embryo, Dev. Cell, 8, 2005, Pgs. 519-5?? [plus supplement]. (with C.M. Mizutani, Q. Nie, Y.-T. Zhang, P. Vilmos, E. Bier, J.L. Marsh and A.D. Lander)
Spatially distributed morphogen synthesis and morphogen gradient formation, Math. Biosci. & Eng. (MBE), 2 , 2005, Pgs. 239 – 262. (with A.D. Lander and Q. Nie)
Stress boundary conditions for plate bending, Int. J. Solids Structure Vol. 40, 2003, 4107-4123. (A Special Issue in honour of Arthur. W. Leissa on his 70th Birthday)
Determination of Firing Times for the Stochastic Fitzhugh-Nagumo Neuronal Model, Neural Comp., vol. 15, 2003, 143-159. (with H.C. Tuckwell and Rodriguez)
Do morphogen gradients arise by diffusion? Dev. Cell, vol. 2, 2002, 785-796. (with A.D. Lander and Q. Nie)
Nature of equilibria and effects of drug treatments in some viral population dynamical models, IMA J. Math. Appl. Med. & Biol. vol. 17, 2000, Pgs. 311-327. (with H.C. Tuckwell)
Locational equilibrium models for publicly owned residential land, Natural Resource Modeling vol. 13(2), 2000, 219-246.
A thick hollow sphere compressed by equal and opposite concentrated axial loads, an asymptotic solution, SIAM J. Appl. Math., vol. 59, 1999, 1080-1097. (with R. D. Gregory & T. I. Milac)
NIH grant R01GM67247 (PI), 2002-2006, 2006-2010; 2010-2014; NIH grant R25GM-096989 (PI), 2011 - 2016; NIH grant P50GM-066051 (Co-PI), 2007-2012, 2013-2018; NSF DMS (SCREMS) grant DMS-0112416 (PI), 2001-2003, DMS (UBM) grant DMS-1129008 (PI), 2011 - 2016
Professional Societies
American Academy of Mechanics
American Society for Mechanical Engineers (ASME)
Canadian Applied Mathematical Society (CAMS/SCMA)
Society for Industrial and Applied Mathematics (SIAM)
American Mathematical Society (AMS)
Mathematical Association of America (MAA)
Other Experience
Research Center
Center for Research on Complex Biological Systems
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