Madeleine V. Pahl

picture of Madeleine V. Pahl

Professor of Medicine, Medicine
School of Medicine

M.D., University of California, Irvine

Phone: (714) 456-5142, 6670
Fax: (714) 456-6034
Email: mpahl@uci.edu

University of California, Irvine
City Tower, Ste 400
101 The City Drive
Mail Code: 4088
Orange, CA 92868
Research Interests
Chronic inflammation and oxidative stress in CKD, immunodeficiency in CKD, genetics of diabetic nephropathy
Academic Distinctions
Golden Apple Award (College of Medicine excellence in teaching) 1999, 1984
Dean’s Award for Compassion in Medicine, 2002
The Best Doctors in America, Pacific region, 1996-1997, 1997-1998, 2009-2010
Academic Senate Award for Distinguished Service, Promotions & Honors Committee, 2000-2003
The Best Doctors in America, 2005-2006
Western Association of Physicians, elected member 2007
Fellow of the American College of Physicians: 1989-present
Member of American College of Physicians Governor’s Council: 2003-2004
Guide to America's Top Physicians, Consumers' Reserach Council of America, 2008
Physicians of Excellence Award, Orange County Medical Association, 2010
Appointments
Director of Renal Clinics, Division of Nephrology and Hypertension, Department of Medicine
Chair of Faculty, UCI College of Medicine, 2005-2006 and
Member, Committee on Committees, 2004-2006
Chair of Scientific Advisory Board, GCRC School of Medicine, 2000-2004
Research Subject Advocate UCI General Clinical Research Center 2004-current
Director of Regulatory Knowledge and Support Unit; UCI Institute Clinical Translational Science 2005-present
Research Abstract
Dr. Pahl’s research is focused on determining the role of a variety of pathogenetic mechanisms that result in chronic inflammation and oxidative stress in patients with CKD and to determine their relationship to the immunodeficiency of uremia.

She is also the principal investigator at UC Irvine in an NIDDK-funded, national study named: The Family Investigation of Nephropathy and Diabetes. FIND is a multicenter study designed to identify genetic determinants of diabetic nephropathy in different ethnic groups using a variety of strategies to localize susceptibility genes.
Publications
Moradi H., Ganji S., Kamanna V., Pahl M.V., Vaziri N.D.: Increased monocyte adhesion-promoting capacity of plasma in end-stage renal disease-response to antioxidant therapy. Clin Neph. 2010
 
Kim, S., Abboud, H., Pahl, M., Tayek, J., Snyder, S., Tamkin, J., Alcorn, H. Ipp, E. Nast, C., Elston, R., Iyengar, S. Adler, S.: Examination of association with candidate genes for diabetic nephropathy in a Mexican-American population. Clin J Am Soc Nephrol. 5: 1072-1078, 2010.
 
Adler S, Pahl M, Abboud H, Nicholas S, Ipp E, Seldin M.: Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus. Semin Nephrol. 2010 Mar;30(2):141-9.
 
Pahl M.V., Vaziri ND, Yuen J, Adler SG. Upregulation of monocyte/macrophage HGFIN (Gpnmb/Osteoactivin) expression in end-stage renal disease. Clin J Am Soc Nephrol 2010 Jan;5(1):56-61.
 
Pahl M.V. , Gollapudi S., Sepassi L., Gollapudi P., Elahimehr R., Vaziri N.D.: Effect of End-Stage Renal Disease on B Lymphocytes Subpopulations, IL-7, BAFF and BAFF receptor expression. Nephrol Dial Transplant 2010 Jan; 25(1):205-12
 
Gollapudi P, Yoon, JW, Gollapudi, S, Pahl, MV, Vaziri, ND.: Leukocyte Toll-Like Receptor Expression in End-Stage Kidney Disease Am J Nephrol. 2010 Jan 15;31(3):247-254.
 
Aminzadeh, A., Pahl, M.V., Barton, C.H., Dotor, NS, Vaziri, N.D.: Human uremic plasma stimulates release of leptin and uptake of tumor necrosis factor-o in visceral adipocytes. Nephrol Dial Transplant. 2009 Dec;24(12):3626-31
 
Agrawal S, Gollapudi P, Elahimehr R, Pahl MV, Vaziri ND.: Effects of end-stage renal disease and haemodialysis on dendritic cell subsets and basal and LPS-stimulated cytokine production. Nephrol Dial Transplant 2009 Nov 9
 
Vaziri N.D., Moradi H., Pahl M.V., Fogelman A.M., Navab M. In vitro stimulation of HDL anti-inflammatory activity and inhibition of LDL pro-inflammatory activity in the plasma of patients with end-stage renal disease by an apoA-1 mimetic peptide. Kidney Int. 76(4):437-44, 2009 Aug.
 
Pahl M.V., Ni Z., Sepassi L., Moradi H., Vaziri N.D.: Plasma phospholipid transfer protein, cholesteryl ester transfer protein and lecithin: cholesterol acyltransferase in end-stage renal disease (ESRD). Nephrol Dial Transplant 24(8):2541-6, 2009 Aug. Epub 2009 Mar 18
 
Kamgar, M., Zaldivar, F., Vaziri, N.D., Pahl, M.V.: Antioxidant therapy does not ameliorate oxidative stress and inflammation in patients with end-stage renal disease. J Natl Med Assoc. Apr 101(4):336-344, 2009
 
Moradi H., Pahl M.V., Elahimehr R., Vaziri N.D.: Impaired antioxidant activity of HDL in chronic kidney disease. Transl Res. 153(2):77-85, 2009 Feb.
 
Kao W H L, Klag M J., Meoni L A., Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Tandon A , Powe N R., Fink N E., Sadler J, Weir M R., Adler S, Divers J, Iyengar S K, Freedman B I., Kimmel P L., Kamp K, Kohn O F., Leehey D J., Nicholas S, Pahl M, Schelling J R., Sedor J R., Thornley-Brown D, Winkler CA., Smith M W., and Parekh, R S., on behalf of the Family Investigation of Nephropathy and Diabetes (FIND) Research Group: MYH9 is associated with non-diabetic end stage renal disease in African Americans. Nature-Genetics, 2008 Oct;40(10):1185-1192
 
Arar NH, Freedman BI, Adler SG, Iyengar SK, Chew EY, Davis MD, Satko SG, Bowden DW, Duggirala R, Elston RC, Guo X, Hanson RL., Igo Jr. RP., Ipp E, Kimmel PL, Knowler WC, Monlineros J, Nelson R, Pahl MV., et al on behalf of the Family Investigation of Nephropathy and Diabetes Research Group: Heritability of the Severity of Diabetic Retinopathy: The FIND-Eye Study. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3839-45.
 
Schelling, J R, Abboud, Hanna E, Nicholas, Susanne B., Pahl, Madeleine V., et al: Genome-Wide scans for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes. Diabetes, 2008 Jan;57(1):235-43.
 
Parekh RS, Kao WH, Meoni LA, Ipp E, Kimmel PL, La Page J, Fondran C, Knowler WC, Klag MJ; Family Investigation of Nephropathy and Diabetes Research Group: Reliability of urinary albumin, total protein, and creatinine assays after prolonged storage: the family investigation of nephropathy and diabetes. Clin J Am Soc Neph, 2007 Nov;2(6):1156-62.
 
Tian C, Hinds DA, Shigeta R, Adler SG, Lee A, Pahl MV, Silva G, Belmont JW, Hanson RL, Knowler WC, Gregersen PK, Ballinger DG, Seldin MF. A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping. Am J Hum Genet. 2007 Jun;80(6):1014-23.
 
Iyengar S K., Abboud H E., Goddard K A. B., Saad M F., Adler S G., Arar N H, Bowden Donald W., Duggirala R , Elston R C., Hanson R L., Ipp E, Kao, W.H L, Kimmel Paul L., Klag Michael J., Knowler W C., Meoni, L A., Nelson Robert G., Nicholas Susanne B., Pahl, MV., Parekh Rulan S.,. Rasooly Rebekah S, Rich Stephen S., Scavini M, Schelling Jeffrey R., Sedor John R., Sehgal Ashwini R., Shah Vallabh O., Smith, M W., Winkler Cheryl A., Zager Philip G., and Freedman B I. on behalf of the Family Investigation of Nephropathy and Diabetes Research Group: Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes. Diabetes, 2007 Jun;56(6):1577-85. Epub 2007 Mar 15.
 
Chao, C., Hinds, D.A., Shigeta, R., Adler, S.G., Lee, A., Pahl, M.V., et al: A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping. Am J Hum Genet. 2007 Jun;80(6):1014-23.
 
Yoon, J., Pahl, M., Vaziri, N.: Spontaneous leukocyte activation and oxygen-free radical generation in end stage renal disease. Kidney Int 2007 Jan;71(2):167-72. Epub 2006 Nov 15.
 
Yoon, J.W., Gollapudi S., Pahl, M.V., Vaziri, N.D.: Naïve and central memory T-cell Lymphopenia in end-stage renal disease. Kidney Int 70: 371-376, 2006.
 
Pahl, M.V., Vaziri, N.D., Connall, T., Morrison, D., Kim, C., Kaupke, C.J., Wilson, S.E.: Systemic Upregulation of leukocyte integrins in response to lower body ischemia-reperfusion during abdominal aortic aneurysm repair. J National Medical Association 97 (2):1-8, 2005.
 
Knowler, W.C., Plaetke, R., Iyengar S., Sedor, J., Coresh, J., Kimmel, P.L., Olson, J., Seldin, M.F., Elston, R.C., Freedman, B. I. on behalf of the Family Investigation of Nephropathy and Diabetes Research Group: The Family Investigation of Nephropathy and Diabetes (FIND): Design and Methods. J Diabetes Complications 19(1):1-9, 2005.
 
The Family Investigation of Nephropathy and Diabetes Research Group: Genetic Determinants of Diabetic Nephropathy: The Family Investigation of Nephropathy and Diabetes (FIND). JASN 14 (7 Suppl 2):S202-204, 2003 Jul.
 
Williams Jr., J. H., Pahl, M.V., Kwong, D., Zhang, J., Hatakeyama, D., Ahmad, K., Naderi, M., Kim, M., Vaziri, N.: Modulation of neutrophil complement receptor-3 expression by pneumococci and pneumococcal vaccine. Clin Science 104:615-625, 2003.
 
Barth J.D., Pahl, M., Zhang L., Zonjee M. Vaziri N.: Sonographic reproducibility of a novel approach in the assessment of centralized access in end-stage renal disease. Int J Clin Pract 57(5):360-362, 2003.
 
Mehta, R.L., McDonald, B., Gabbai, F, Pahl, M.V., Farkas, A, Pascual, M.T.A., Zhuang, S., Kaplan R., Chertow, G.M.: Nephrology consultation in acute renal failure: Does timing matter? Am J Med 113(6):456-461, 2002.
 
Pahl, M.V., Nast, C.C., Adler, S.G: Proteinuria in patients with arterial/arteriolar nephrolsclerosis Clinical Nephrology 58(4):260-266, 2002.
 
Vaziri, N.D., Oveisi, F., Culver, B.D., Pahl, M.V. Andersen, M.E., Strong, P.L., Murray, J.: The effect of pregnancy on boron renal clearance in Sprague-Dawley rats given boric acid orally. Toxicological Sciences 60:257-263, 2001
 
Pahl, M.V., Culver, B.D., Strong, P.L., Murray, J., Vaziri, N.D.: The effect of pregnancy on renal clearance of boron in humans: A study based on normal dietary intake of boron. Toxicological Sciences 60:252-256, 2001.
 
Mehta, R.L., McDonald, B., Gabbai, F.B., Pahl, M., Pascual, M.T., Farkas, A., Kaplan, R.M.: A randomized clinical trial of continuous vs. intermittent dialysis for acute renal failure. Kidney International 60(3) 1154-63, 2001.
 
Adler, S.G., Pahl, M., Seldin, M.F.: Deciphering diabetic nephropathy: progress using genetic strategies. Current Opinions in Nephrology and Hypertension, 9(2):99-106, 2000.
 
Rajpoot, D., Pahl, M., Clark, J.: Nephrotic syndrome associated with Kimura Disease. Pediatr Nephrol 14(6):486-88, 2000.
 
Holgado, R, Haire, H., Ross, D, Sprague, S, Pahl, M., Jara, A, Martin-Malo, A, Rodriguez, M, Almaden, Y, Felsenfeld, AJ. Effect of a low calcium dialysate on PTH secretion in diabetic patients on maintenance hemodialysis. J. Bone Mineral Research 15(5):927-35, 2000.
 
Cyrlak, D, Pahl, M., Carpenter, S.E.: Breast imaging case of the day: multiple giant fibroadenomas associated with cyclosporin A therapy in a renal transplant patient. Radiographics 19(2):549-51, 1998.
 
Wang, Z.Q., Liang, K.H., Pahl, M.V., Vaziri, N.D.: Effect of heparin on growth and gene expression of matrix proteins. Nephrol, Dialysis, Transplantation 13(12):3052-3057, 1998.
 
Pahl, M.V., Oveisi, F., Khamiseh, G., Vaziri, N.D.: Intestinal absorption and biliary secretion of cholesterol in rats with nephrotic syndrome. Nephrol, Dialysis, Transplantation 13(6):1446-14451, 1998.
 
Pahl, M.V., Wang, J., Zhou, X.J., Wang, X.Q., Tehranzadeh, A., Vaziri, N.D.: Effects of LDL on cytosolic [Ca++] in cultured rat mesangial cells. J. Investigative Med. 44:556-560, 1997.
 
Pahl, M.V., Vaziri, N.D., Oveisi, F., Wang, J., Ding, Y.: Antithrombin III inhibits mesangial cell proliferation. J. Am. Soc. Nephrol. 7:2249-2253, 1996.
 
Pahl, M.V., Jara, A., Bover, J., Rodriquez, M., Felsenfeld, A. J.: The set point of calcium and the reduction of parathyroid hormone in hemodialysis patients. Kidney Int. 49:226-231, 1996.
 
Pahl M, Jara A, Bover J, Felsenfeld AJ: Studies in a hemodialysis patient indicating that calcitriol may have a direct suppresive effect on bone. Nephron 71(2):218-23, 1995.
 
Felsenfeld AJ, Jara A, Pahl M, Boever J, Rodriguez M: Differences in the dynamics of parathyroid hormone secretion in hemodialysis patients with marked secondary hyperparathyroidism. J Am Soc Nephrol 6(5):1371-1378, 1995.
 
Pahl, M.V., Vaziri, N.D., Gonzales, E.: Coagulation profile in persons with long-standing spinal cord injury. J. Am. Paraplegia Soc. 17(3) 133-135, 1994.
 
Novey H, Pahl MV, Haydik IB, Vaziri ND: Immunological studies of anaphylaxis to iron dextran in patients on renal dialysis. Ann Allergy 72(3):224-228, March 1994.
 
Tominaga, G.T., Ingegno, M.D., Scannell, G., Pahl, M.V., Waxman, K.: Continuous arteriovenous hemodiafiltration in post-operative and traumatic renal failure. Amer. J. Surgery 166(6):612-616, Dec. 1993.
 
Pahl, M.V., Vaziri, N.D., Kaufman, D., Martin D.C.: Childbirth after renal transplantation. Transplantation Proc. 25(4):2727-2731, Aug. 1993.
 
Hou, S., Orlowski, J., Pahl, M.V., Ambrose, S., Hussey, M., Wong, D.: Pregnancy in women with end stage renal disease: Treatment of anemia and premature labor. Amer. J. Kidney Disease 21(1):16-22, 1993
Grants
NephroGenex, Inc.: Pahl (PI), 2/01/09-6/30/11, -‘A Randomized, Double-blind, Placebo-controlled, Multi-center, Phase 2b Study to Evaluate the Safety and Efficacy of Pyridorin (Pyridoxamine Dihydrocholride) in Patients with Nephropathy Due to Type 2 Diabetes’
Mitsubishi Tanabe Pharma Corp.: Pahl (PI), 3/09-3/11 - ‘A Phase III, Open-label, Multi-center Flexible Dose, Long-term Safety Study of MCI-196 Chronic Kidney Disease Stage 5 Subjects on Dialysis with Hyperphosphatemia’
F. Hoffman la-Roche Ltd.: Pahl (PI), 7/16/07-6/30/11, -Prospective , Open-label, Randomized, Multi-center Study to Demonstrate the Efficacy and Safety of IV RO 0503821 for Hemoglobin Control in Patients Transitioning from Chronic Kidney Disease Stage 4 through Dialysis’
Amgen Inc.: Pahl (PI), 11/01/06-11/28/10, ‘Evolve Trial - Evaluation of Cinacalcet Therapy to Lower Cardiovascular Events
1-R01-DK069844-01, NIH/NIDDK, Adler (PI) Pahl (co-PI), 9/01/05-06/30/10, ‘SNPS Haplotyping to Detect Diabetic Nephropathy Genes’
F. Hoffman la-Roche Ltd. Pahl (PI), 5/20/05-12/31/09,‘An Open-label Multi-Center Study to Document the Efficacy, Safety and Tolerability of Long-term Administration of RO 0503821 in Patients with Chronic Renal Anemia’ This is an open-label clinical trial designed to study the safety, efficacy and tolerability of a new long acting erythropoetic stimulating agent on dialysis patients. Subjects who participated in HLR-BH16739 will be asked to continue in this open-label study.
Watson Laboratories, Inc. Pahl (PI), 3/01/05-3/31/08, ‘A Multi-Center, Open Label, Randomized, Parallel Group Study of the Efficacy and Safety of Ferrlecit in the Maintenance of Iron Stores and Serum Hemoglobin Concentration in Hemodialysis Patients Receiving Erythropoietin’ This is an open-label clinical trial designed to study the safety and efficacy of a ferric gluconate complex (Ferrlecit) given intravenously to the maintain iron stores and hemoglobin levels in hemodialysis patients treaded with erythropoetic stimulating agents.
F. Hoffman la-Roche Ltd. Pahl (PI), 5/01/04-1/30/06, ‘A Randomized Controlled Open-label Multi-center Parallel Group to Study the Efficacy and Safety of RO 0503821 When Administered Intravenously for the Maintenance Treatment of Anemia in Patients with Chronic Kidney Disease Who Are on Dialysis’ This is a randomized clinical trial designed to study the safety, efficacy and pharmacokinetics of a new long acting erythropoetic stimulating agent on dialysis patients.
1-U01-DK57249-01(05) NIH/NIDDK Adler (PI) Pahl (co-PI), 9/30/99-9/29/04, ‘The Family Investigation of Nephropathy and Diabetes (FIND)’ FIND is a multi-center consortium established by the NIDDK to identify the gene(s) responsible for diabetic nephropathy. Two independent strategies to detect causative genes will be performed. These include family-based linkage analyses in African American, American Indian, Hispanic American and European American families (predominantly affected and discordant relative pair analyses) and mapping by admixture linkage disequilibrium (MALD) in African- and Hispanic Americans. Cell lines are being created from participants, and a repository containing stored urine and serum samples has been developed.
PRO MED DX LLC- Pahl PI, 8/4/09 – 8/4/10, Clinical Specimen Collection Study: Renal Failure Population
NCRR-Award: Pahl, Director of Knowledge & Regulatory Support Unit, 2010-2015, UCI Institute for Clinical and Translational Science (ICTS) CTSA Grant
Professional Societies
Fellow of the American College of Physicans
American Society of Nephrology
International Society of Nephrology
Last updated
02/02/2012