Tumor and prognostic markers; clinicopathologic correlation studies
Anatomic Pathology as a specialty not only has definite commitments to teaching and service, it is also engaged in developing interpretation of various diagnostic and prognostic tumor markers. These markers are used to categorize tumors such that their clinical behavior and response to therapy might be predicted prior to the application of therapy. In this context, the laboratory is equipped with the applications of principles of molecular biology, immunohistochemistry and cytometry. In addition, a well catalogued human tumor tissue bank has been developed in the department. Therefore, various frozen
tumor tissues are available for molecular and biologic studies.
Last Five Years of Publications
You, J., Nguyen, A.V. Albers, C.G., Lin, F., Holcombe, R.F.: Wnt pathway-related gene expression in inflammatory bowel disease. Digestive Diseases and Sciences (in press)
Tongson-Ignacio, J.E., Lin, F., Ramzy, I.: Cytomorphologic characterization of metastatic osteosarcoma in pleural fluid. Acta Cytol. 51:676-678, 2007.
Momeni, M.G., Anavim, A., Lin, F., Tehranzadeh, J.: Giant epidermal inclusion cyst of buttock. Skeletal Radiol. 35: 864-866, 2006.
Brewster, W.R., Hubbell, F.A., Largent, J., Ziogas, A., Lin, F., Howe, S., Ganiats, T.G., Anton-Culver, H., Manetta, A.: Feasibility of management of high-grade cervical lesions in a single visit – a randomized control trial. JAMA 294:2182-2187, 2005.
Gu, M., Ghafari, S., Lin, F.: Pap smears of patients with extramammary Paget’s disease. Diagn. Cytopath. 32: 353-357, 2005.
Gu, M., Ghafari, S., Lin, F., Ramzy, I.: Cytologic diagnosis of endocrine tumor of the pancreas by endoscopic ultrasound-guided fine needle aspiration biopsy. Diagn. Cytopath. 32:204-210, 2005.
Chan, J.K., Magistris, A., Loizzi, V., Lin, F., Rutgers, J., Osann, K., DiSaia, P.J., Berman, M.L., Samoszuk, M.: Mast cell density, angiogenesis, blood clotting and prognosis in women with advanced ovarian cancer. Gynecologic Oncology 99: 20 –25, 2005.
Nguyen, A., Rosner, A., Milovanovic, T., Hope, C., Planutis, K., Saha, B., Chaiwun, B., Lin, F., Imam, A., Marsh, J.L., Holcombe, R.F.: Wnt pathway component LEF1 mediates tumor cell invasion and is expressed in human and murine breast cancers lacking erbB2 (her-2/neu) over expression. International Journal of Oncology. 27:949-956, 2005.
Byun, T., Karimi, M., Marsh, J.L., Milovanovic, T., Lin, F., Holcombe, R.F.: Expression of secreted Wnt antagonists in gastrointestinal tissues: Potential role in stem cell homeostasis. J. Clin Pathology 58:515-519, 2005
Cancer Center of UCI