Professor in Residence, Radiological Sciences
School of Medicine

Medicine
School of Medicine

Principle Investigator, Medical Center
School of Medicine

Thyroid and Endocrine Imaging, Thyroid Hormone Metabolism, Marker For Fetal Thyroid Function

Dr. Wu is interested in an alternate sulfation pathway of thyroid hormone metabolism in the fetus and the fetal-to-maternal transfer of sulfated metabolites. High levels of sulfated thyroid hormone metabolites are found in fetuses. A new passage for fetal-to-maternal transfer of iodothyronines has been identified. Furthermore, a diiodothyronine sulfate (T2S)-like material, “Compound W,” is found in the serum of pregnant women and appears to be a thyroid hormone metabolite of fetal origin. Our goal is to establish “Compound W” as a serum marker for fetal thyroid function in pregnant women. He is interested in applying the RIA of Compound W” to identify congenital hypothyroidism and other fetal dysfunctions in utero. Various therapeutic approaches will be tried before birth to prevent serious complications (mainly mental retardations and neuromuscular abnormalities) in the fetuses whom are detected to have thyroid dysfunctions by “Compound W” assay on maternal sera. Collaborations are continuing both in the United States and abroad.

Wu, S.Y., Thyroid Hormone Metabolism: Regulation and Clinical Implications, in Contemporary Endocrine Series, Blackwell Scientific Publication, Cambridge, MA, 1991.

Wu, S.Y., Visser, T.J., Thyroid Hormone Metabolism: Molecular Biology and Alternate Pathways, CRC Press, Boca Raton, FL 1994.

Wu, S.Y., D.H. Polk, W.S. Huang, D.A. Fisher, Fetal-to-maternal transfer of 3,3’,5-triiodothyronine sulfate and its metabolite in sheep, Am J Physiol 277 (Endocrinol Metab 40): E915-E919, 1999.

Wu, S.Y. W.S. Huang, Ho E., Wu, E. S. C., Fisher, D. A., A 3,3’-diiodothyronine sulfate cross-reactive substance,compound W, in serum from pregnant women – a potential marker for fetal thyroid function, Pediatr Res 61: 307-312, 2007

Wu, S. Y. , D. H. Polk, E. Ho, D. A. Fisher, 3’-Monoiodothyronine sulfate and triac sulfate are thyroid hormone metabolites in developing sheep, Pediat Res 63: 149-153. 2008.

Vanmiddlesworth, L, N. R. Vanmiddlesworth, R. S. Egerman, A. J. Bush, R. D. Ramsey, L.P. Delmar, E. C. Ho, S. Y. Wu, thyroid function and 3,3’-diiodothyronine sulfate cross-reactive substance (compound w) in maternal hyperthyroidism with antithyroid treatment, Endocrine Pract 17: 00-00, 2011

VA Merit Review Grants, SCIRE Research Fund

Am Thyroid Assoc, Soc Nuc Med, Endocrine Society

Chemical Biology

VAMC Thyroid Research Lab, Long Beach, California

Link to this profile
https://faculty.uci.edu/profile/?facultyId=3046

Last updated
11/23/2010