Autism, ADHD, Family Genetics Studies
Grinnell College Distinguished Alumnae Award, 1990
Grinnell College Honorary Degree, 2001
Vice Chancellor-Academic Programs 1992-1994
Our research focus is identifying the genes responsible for human disease with a particular emphasis on birth defects and behavior disorders in children. We work with the patients and their families to collect data, including DNA for genetic analysis. Current funding includes studies on autism, ADHD, and congenital cataract among others. The analyses are statistical in nature for human data and the laboratory is primarily computer based.
Genes and attention-deficit hyperactivity disorder, Swanson, J; Deutsch, C; Cantwell, D; Posner, M; Kennedy, J; Barr, C; Moyzis, R; Schuck, S; Flodman, P; Spence, MA. , Clinical Neuroscience Research, 2001, 1:207-16,
Flodman, P; Macula, AJ; Spence, MA; and Torney, DC. Preliminary implementation of new data mining techniques for the analysis of simulation data from GAW12: Problem 2. Genetic Epidemiology, 21(Suppl 1):p.S390-5, 2001.
Spence, MA; and Hodge, SE. The "Circular" Problems of Calculating Risk: Dealing with Consanguinity. Journal of Genetic Counseling, 9(3):179 - 201, 2000.
Swanson, JM; Flodman, P; Kennedy, J; Spence, MA; Moyzis, R; Schuck, S; Murias, M; Moriarity, J; Barr, C; Smith, M; Posner, M. Dopamine Genes and ADHD. Neuroscience and Biobehavioral Reviews, 24, 21-5, 2000.
Swanson, JM; Oosterlaan, J; Murias, M; Schuck, S; Flodman, P; Spence, MA; Wasdell, M; Ding, Y; Chi, H-C; Smith, M; Mann, M; Carlson, C; Kennedy, MJ; Sergeant, J; Leung, P; Zhang, Y-P; Sadeh A; Chen, C; Moyzis, R; and Posner, MI. ADHD Children with a 7-Repeat Allele of the DRD4 Gene Have Extreme Behavior but Normal Performance on Critical Neuropsychological Tests of Attention. Proceedings of the National Academy of Sciences, 97(9):4754-4759, 2000.
Martin, RA; Hunter, V; Neufeld-Kaiser, W; Flodman, P; Spence, MA; Furnas, D; Martin, KA. Ultrasonographic detection of orbicularis oris defects in first degree relatives of isolated CL patients. American Journal of Medical Genetics 90(2):155-61, 2000.
Smith, M; Filipek, PA; Wu, C; Bocian, M; Hakim, S; Modahl, C; Spence, MA. Analysis of 1Mb deletion in 15q22-q23 in an autistic patient: identification of candidate genes for autism and of homologous DNA segments in 15q22-q23 and 15q11-q13. American Journal of Medical Genetics, 96(6):765-70, 2000.
Slager, SL; Foroud, T; Haghighi, Spence, MA; Hodge, SE. Stoppage: An Issue for Segregation Analysis. Genetic Epidemiology, 20:328-39, 2001.
Kelsoe, JR; Spence, MA; Loetscher, E; Foguet, M; Sadovnick, AD; Remick, RA; Flodman, P; Khristich, J; Mroczkowski-Parker, Z; Brown, JL; Masser, D; Ungerleider, S; Rapaport, MH; Wishart, WL; Luebbert, H. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. PNAS, 98(2):585-90, 2001.
American Society of Human Genetics
The American Genetics Association