Distinguished Professor, Pathology
School of Medicine
M.D., Facultad de Medicina (Spain), 1966
Ph.D., University of Minnesota, 1974
Phone: (949) 824-7450
Fax: (949) 824-2160
University of California, Irvine
D440 Medical Sciences I
Mail Code: 4800
Irvine, CA 92697-4800
Chlamydia trachomatis. Vaccines. Sexually transmitted diseases. Diagnostic Medical Microbiology
Currently attempts are being made to vaccinate experimental animals with the purified major outer membrane protein (MOMP) of the C. trachomatis mouse pneumonitis biovar. Antibodies to this protein have been shown to occur in a majority of chlamydial infections and furthermore polyclonal and monoclonal antibodies to the MOMP are known to neutralize chlamydial infectivity in vitro. In the animal model mice will be inoculated with the purified MOMP and then they will be challenged with infectious Chlamydiae in the genital tract. The ability of the vaccine to prevent infection and/or to preserve fertility will be determined.
188. Pal, S., D. F. Tifrea, F. Follmann, P. Andersen and L. M. de la Maza. The cationic liposomal adjuvants CAF01 and CAF09 formulated with the major outer membrane protein elicit robust protection in mice against a Chlamydia muridarum respiratory challenge. Vaccine: 35: 1705-1711, 2017. PMID: 28238632.
189. Pal, S., A. Favaroni, D. F. Tifrea, P. T. Hanisch, Soren E. T. Luczak, J. H. Hegemann and L. M. de la Maza. Comparison of the nine polymorphic membrane proteins of Chlamydia trachomatis for their ability to induce protective immune responses in mice against a C. muridarum challenge. Vaccine: 35: 2543-2549, 2017. PMID: 28385608; PMCID: PMC5464790.
190. Pickering, H., A. Teng, N. Faal, H. Joof, P. Makalo, E. Cassama, M. Nabicassa, A. Last, S. Burr, S. Rowland-Jones, N. R. Thomson, C. H. Roberts, D. C. W. Mabey, R. L. Bailey, R. D. Hayward, L. M. de la Maza and M. J. Holland. Genome-wide profiling of humoral immunity and pathogen genes under selection identifies immune evasion tactics of Chlamydia trachomatis during ocular infection. Scientific Reports. 7: 9634 | DOI:10.1038/s41598-017-09193-2; 2017. PMID: 28851925; PMCID: PMC5575166.
191. Pal, S., D. F. Tifrea, G. Zhong and L. M. de la Maza. Transcervical inoculation with Chlamydia trachomatis induces infertility in HLA-DR4 transgenic and wild type mice. Infect Immun. 86:e00722-17. https://doi.org/10.1128/IAI.00722-17; 2018. PMID:29038126; PMCID: PMC5736824
192. Tifrea, D. F., S. Pal, C. Le Bon, F. Giusti, J-L Popot, M. J. Cocco, M. Zoonens and L. M. de la Maza. Co-delivery of amphipol-conjugated adjuvant with antigen, and adjuvant combinations, enhance immune protection elicited by a membrane protein-based vaccine against a mucosal challenge with Chlamydia. Vaccine 36: 6640-6649, 2018. PMID: 30293763.
193. Pal, S., D. F. Tifrea, and L. M. de la Maza. Characterization of the horizontal and vertical sexual transmission of Chlamydia genital infections in a new mouse model. Infect Immun. 87: e00834-18, 2019. PMID: 30833332. PMCID: PMC6589058. DOI: 10.1128/IAI.00834-18.
194. Tifrea, D. F., S. Pal, and L. M. de la Maza A recombinant Chlamydia trachomatis MOMP vaccine elicits cross-serogroup protection in mice against vaginal shedding and infertility. J Infect Dis. 221-191-200, 2020 doi: 10.1093/infdis/jiz438. PMID: 31504647.
195. Pal S., Ausar, S. F., Tifrea, D. F., Cheng, C., Gallichan, S., Sanchez, V., de la Maza, L.M. and L. Visan. Protection of outbreed mice against a vaginal challenge by a Chlamydia trachomatis serovar E recombinant major outer membrane protein vaccine is dependent on phosphate substitution in the adjuvant
st Recent Publications
American Society for Advancement of Science
American Society of Clinical Pathologists
American Society for Microbiology
American Association for Investigative Pathology