Kenneth J. Shea

picture of Kenneth J. Shea

Professor, Chemistry
School of Physical Sciences

Ph.D., Pennsylvania State University, 1972
B.S., University of Toledo, 1966
M.S., University of Toledo, 1968

Phone: (949) 824-5844
Fax: (949) 824-2210

University of California, Irvine
5042B Frederick Reines Hall
Mail Code: 2025
Irvine, CA 92697
Research Interests
Synthetic Organic, Polymer and Materials Chemistry
Academic Distinctions
Regents Faculty Fellow
School of Physical Sciences Distinguished Teaching Award
NIH Senior International Fellow
Winston Churchill College Overseas Fellow, Cambridge University
Fellow of the American Association for the Advancement of Science
Arthur C. Cope Scholar Award
Postdoctoral Fellow, California Institute of Technology
Available Technologies
Selected publications from our synthetic antibody program.

“Peptide Imprinted Polymer Nanoparticles: A Plastic Antibody.” Yu Hoshino, Takashi Kodama, Yoshio Okahata, and Kenneth J. Shea, J. Amer. Chem. Soc. 2008, 130, 15242-15243.

“Synthetic Polymer Nanoparticles with Antibody-like Affinity for a Hydrophilic Peptide.” Zhiyang Zeng, Yu Hoshino, Andy Rodriguez, Hoseong Yoo, and Kenneth J. Shea, ACS Nano, 2010, 4, 199-204.

“Recognition, Neutralization and Clearance of Target Peptides in the Bloodstream of Living Mice by Molecularly Imprinted Polymer Nanoparticles: A Plastic Antibody.” Yu Hoshino, Hiroyuki Koide, Takeo Urakami, Hiroaki Kanazawa, Takashi Kodama, Naoto Oku, and Kenneth J. Shea, J. Am. Chem. Soc. 2010, 132, 6644-6645.

“The Evolution of Plastic Antibodies.” Yu Hoshino and Kenneth J. Shea, Journal of Materials Chemistry, 2011, 20, 3517-3521.

“The Rational Design of a Plastic Antidote: Synthetic Polymer Nanoparticles that Neutralize Toxic Peptides in Vivo” Yu Hoshino, Hiroyuki Koide, Keiichi Furuya, Walter W. III Haberaecker, Shih-Hui Lee, Takashi Kodama, Hiroaki Kanawaza, Naoto Oku, and Kenneth J. Shea, Proceedings of the National Academy of Science (PNAS), 2012, 109, 33-38.

“Temperature-Responsive "Catch-and-Release" of Proteins using Multifunctional Polymer Nanoparticles”, Keiichi Yoshimatsu, Benjamin K. Lesel, Yusuke Yonamine, John M. Beierle, Yu Hoshino and Kenneth J. Shea, Angewandte Chemie Int. Ed. , 2012, 51, 2405–2408.

“Synthetic Polymer Nanoparticle-Polysaccharide Interactions: A Systematic Study” Zhiyang Zeng, Jiten Patel, Shih-Hui Le1, Monica McCallum, Anu Tyagi, Mingdi Yan, Kenneth J. Shea, Journal of the American Chemical Society, 2012, 134, 2681 - 2690.

“An ELISA-mimic screen for synthetic polymer nanoparticles with high affinity to target proteins” Yusuke Yonamine, Yu Hoshino and Kenneth J. Shea. Biomacromolecules, 2012, 13, 2952–2957.

“Engineered Synthetic Polymer Nanoparticles as IgG Affinity Ligands”. Shih-Hui Lee, Yu Hoshino, Arlo Randall, Zhiyang Zeng, Piere Baldi, Ruey-an Doong and Kenneth. J. Shea, Journal of the American Chemical Society, 2012, 134, 15765-15772.

“The Polymer Nanoparticle-Protein Interface. Evaluation of the Contribution of Positively Charged Functional Groups to Protein Affinity” Yusuke Yonamine, Keiichi Yoshimatsu, Shih-Hui Lee, Yu Hoshino, Yoshio Okahata and Kenneth J. Shea, ACS Applied Materials & Interfaces, 2013, 5, 374–379.

“Epitope Discovery for a Synthetic Polymer Nanoparticle: A New Strategy for Developing a Peptide Tag” Keiichi Yoshimatsu, Tomohiko Yamazaki, Yu Hoshino, Paul E. Rose, Linda F. Epstein, Les P. Miranda, Philip Tagari, John M. Beierle, Yusuke Yonamine, and Kenneth J. Shea, Journal of the American Chemical Society, 2014, 136, 1194 - 1197.

“Polymer Nanoparticle Hydrogels with Autonomous Affinity Switching for Protection of Proteins from Thermal Stress” John M. Beierle, Keiichi Yoshimatsu, Beverly Chou, Benjamin K. Lesel, Kenneth J. Shea, Angewandte Chemie Int. Ed., 2014, 53, 9275-9279.

"Engineering Nanoparticle Anti-toxins Utilizing Aromatic Interactions" Adam Weisman, Yingyao Allie Chen, Yu Hoshino and Kenneth Shea, Biomacromolecules, 2014, 15, 3290-3295.

"Preparation and evaluation protocol for abiotic polymer nanoparticles for sequestration and
neutralization of a target peptide toxin" Keiichi Yoshimatsu, Hiroyuki Koide , Yu Hoshino & Kenneth J. Shea, Nature Protocols, 2015, 10, 595–604. doi:10.1038/nprot.2015.032

"Monitoring Peptide Uptake in Single Hydrogel Nanoparticles with Near Infrared Surface Plasmon Resonance Microscopy," Kyunghee Cho, Jennifer B. Wood, Keiichi Yoshimatsu, Kenneth J. Shea and Robert M. Corn*, Analytical Chemistry, 2015, 87, 4973–4979.

"Tuning Hydrophobicity in an Abiotic Affinity Reagent. Polymer Hydrogel Affinity Reagents for Molecules with Lipid-like Domains.” Beverly Chou, Peter Mirau, Tian Jian, Szu-Wen Wang, and Kenneth J. Shea, Biomacromolecules, 2016, 17, 1860–1868.

“Tuning the Protein Corona of Hydrogel Nanoparticles. The Synthesis of Abiotic Biomacromolecule Affinity Reagents.” Jeffrey O’Brien, Kenneth J. Shea, Accounts of Chemical Research, 2016, 49, 1200-1210.

“Engineering the Protein Corona of a synthetic polymer nanoparticle for Broad-Spectrum Sequestration and Neutralization of Venomous Biomacromolecules” Jeffrey O’Brien, Shih-Hui Lee, Shunsuke Onogi, Kenneth J. Shea, Journal of the American Chemical Society, 2016, 138, 16604 - 16607.

“Synthetic Polymer Protein Affinity Reagents. A Polymer Nanoparticle with Engineered Affinity for a Vascular Endothelial Growth Factor (VEGF165), Hiroyuki Koide, Keiichi Yoshimatsu, Yu Hoshino, Shih-Hui Lee, Ai Okajima, Saki Ariizumi, Yudai Narita, Yusuke Yonamine, Adam C. Weisman, Yuri Nishimura, Naoto Oku1, Yoshiko Miura, and Kenneth J. Shea, Nature Chemistry, 2017, 9, 715-722.

“A synthetic polymer affinity ligand for Bacillus thuringiensis (Bt) Cry1Ab/Ac protein. The use of biomimicry based on Bt protein-insect receptor binding mechanism.” Mingming Liu*, Rong Huang, Adam Weisman, Xiaoyang Yu, Shih-Hui Lee, Yalu Chen, Chao Huang, Senhua Hu, Xiuhua Chen, Wenfeng Tan, Fan Liu. Hao Chen, Kenneth J. Shea,, Journal of the American Chemical Society, 2018, 140, 6853-6864.

“Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle” Hiroyuki Koide†, Keiichi Yoshimatsu, Yu Hoshino, Saki Ariizumi, Anna Okishima, Takafumi Ide, Hiromichi Egami, Yoshitaka Hamashima, Yuri Nishimura, Yoshiko Miura, Tomohiro Asai, Naoto Oku, and Kenneth J. Shea, Journal of Controlled Release, 2019, 295, 13-20.

“A Metabolite Responsive Nanoparticle-Protein Complex.” Krista Fruehauf, Tae Il Kim, Edward Nelson, Joseph P. Patterson, Szu-Wen Wang and Kenneth J. Shea, Biomacromolecules, 2019, 20, 2703-2712.

“An abiotic mimic of endogenous tissue inhibitors of metalloproteinases. Engineering Synthetic Polymer Nanoparticles for use as a Broad-Spectrum Metalloproteinase Inhibitor. Masahiko Nakamoto, Di Zhao, Olivia Rose Benice, Shih-Hui Lee, Kenneth J. Shea, Journal of the American Chemical Society, 2020, 142, 2338–2345.

“Synthesis of a high affinity complementary peptide-polymer nanoparticle (NP) pair using phage display.” Shih-Hui Lee, Issa Moody, Zhiyang Zeng, Everly B. Fleischer, Gregory A. Weiss and Kenneth. J. Shea, ACS Applied Bio Materials, 2021, 4, in press.

“Metal-free Polymer-based Affinity Medium for Selective Purification of His6-tagged
Proteins” Keiichi Yoshimatsu, Krista R. Fruehauf, Quanhong Zhu, Adam Weisman, Jun Fan, Min Xue, John M. Beierle, Les P. Miranda, Paul E. Rose, Linda F. Epstein, Philip Tagari, Kenneth J. Shea, Biomacromolecules, 2021,22, XXXX.
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