Brian S. Andrews

Picture of Brian S. Andrews
Professor and Chief, Division of Rheumatology and Professor of Biological Chemistry, Medicine
School of Medicine
M.B., B.S.(Honors), University of Sydney, 1969
M.D., University of New South Wales, 1978
B.Sc (Med) (Honors), University of Sydney, 1967
Phone: (714) 456-6602
Fax: (714) 456-6164
Email: bsandrew@uci.edu
University of California, Irvine
UCI Medical Center, Bldg 53-Rm 219D - Rt 81
101 City Drive South
Mail Code: 4072
Orange, CA 92868
Research Interests
Tissue Factor, Scleroderma, Rheumatoid Arthritis
Appointments
7/1977 - 6/1980
Assistant Professor
Department of Medicine
University of Virginia School of Medicine

7/1980 - 6/1986
Associate Professor
Department of Medicine
UCI College of Medicine

7/1986 - present
Professor
Department of Medicine
UCI College of Medicine

9/1994 - present
Chief, Division of Rheumatology and Clinical
Immunology
Department of Medicine
UCI College of Medicine

1/1990 - present
Professor
Department of Biological Chemistry
UCI College of Medicine
Publications
Beeton C, Wulff H, Standifer N, Mullen KM, Counts DR, Wang PH, LeeHealey CJ, Andrews, BS, Pennington MW, Knaus H-G, Gutman GA, Nepom GT, Calabresi, PA and Chandy GK. Kv1.3 chanels: therapeutic target for type-1 diabetes mellitus, rheumatoid arthritis and multiple sclerosis. Proc. Natl. Acad. Sci 103:17414-17419, 2006
Khanna D, Furst DE, Hays RD, Park GS, Wong Wk, Seibold JR, Mayes MD, White B, Wigley FF, Weisman M, Barr W, Moreland L, Medsger Jr TA, Steen VD, Martin RW, Collier D, Weinstein A, Lally EV, Weiner SR, Andrews B, Abeles M, Clements PF: Minimally important difference in diffuse systemic sclerosis: results from the D-penicillamine study. Ann. Rheum. Dis., 65:1325-1329, 2006.
Watrous, D.A. and Andrews, B.S. The Metabolism and Immunology of Bone. Sem. Arthritis. Rheum., 19:45-65, 1989.
Schatten, G., Simerly, C., Palmer, D.K., Margolis, R.L., Maul, G., Andrews, B.S. and Schatten, H. Kinetochore appearance during meiosis, fertilization and mitosis in mouse oocytes and zygotes. Chromosoma, 96:341-352, 1988.
Shiel, W.C., Jr., Prete, P.E., Jason, M. and Adnrews, B.S. Palmar fasciitis and arthritis associated with ovarian and non-ovarian corcinomas: A new syndrome. Amer. J. Med., 79:640-644, 1985
Allen, B.J. and Andrews, B.S. Bilateral aseptic necrosis of calcanei in an adult male with sickle cell disease treated by a surgical coring procedure. J. Rheumatol. 10:294-296, 1983
Cesario, T.C., Jason, M., Andrews, B.S., Shanbron, E., Juranas, D., Katz, L. and Friou, G.J. Limulus assay for bacterial endotoxin in synovial fluid. Ann. Rheum. Dis., 42:571-574, 1983
Boyd, R.E. and Andrews, B.S. Sarcoidosis presenting as cutaneous ulceration, subcutaneous nodules and chronic arthritis. J. Rheumatol., 8:311-316, 1981.
Beacham, B.E., Greep, K.E., Andrews, B.S. and Cooper, P.H. Bullous amyloidosis. J. Amer. Acad. Dermatol., 3:506-510, 1980.
Cunningham, P.H., Andrews, B.S. and Davis, J.S., IV. Sclerderma. Developments from Osler to the present. South Med. J., 73: 770-774, 1980.
Eisenberg, R.A., Theofilopoulos, A.N., Andrews, B.S., Peters, C.J., Thor, L. and Dixon, F.J. Natural thymocytotoxic antibodies in autoimmune and normal mice. J. Immunol., 122:2272-2278, 1979
Zager, R.A., Couser, W.G., Andrews, B.S., Bolton, W.K. and Pohl, M.A. Membranous nephropathy:A radioimmunologic search for anti-renal tubular epithelial antibodies and circulating immune complexes. Nephron, 24:1016, 1979.
Andrews, B.S., Petts, V., McIntosh, J. and Penny, R. Circulating immune complexes in acute uveitis. Int. Arch. All. Appl. Immunol., 58:313-321, 1979
Andrews, B.S. and Penny, R. Immune complexes and human disease. Clinical expression and methods of detection. Illinois Med. J., 154:146-153, 1978
Andrews, B.S. and Penny, R. Immune complexes and human disease. Historical aspects. Illinois Med. J., 154:85-89, 1978.
Andres, B.S. and Penny, R. The role of immune complexes in the pathogenesis of disease. Aust. N.Z.J. Med., 6:591-602, 1976.
Stokes, G.S., Andrews, B.S., Hagon, E., Thronell, I.R., Palmer, A. and Posen, S. Barter's syndrome presenting during pregnency. Results of amiloride therapy. Med. J. Aust., 2:360-365, 1974
Andrews, B.S., Podolsky, S. and Posen, S. Thyrotrophin in Albright's syndrome with Hyperthyroidism. Ann. Intern. Med., 81:561. 1974
Clements, PJ, Seibold, JR, Furst DE, Wong, WK, Mayes, M, White, B, Wigley, F, Weisman, MD, Barr, W, Moreland, L, Medsger, TA, Jr, Steen, V, Martin, RW, Collier, D, Weinstein, A, lally, E, Varga, J, weiner, SR, Andrews, B, Abeles,M.: High-dose vs Low-dose Penicillamine in Early Diffuse Systemic Sclerosis Trial: Lessons Learned. Sem. Arthritis Rheum. 33:249-623, 2004
DeMarco PJ, Weisman MH, Seibold JR, Furst DE, Wong WK, Hurwitz EL, Mayes M, White B, Wigley F, Barr W, Moreland L, Medsger TA Jr, Steen V, Martin RW, Collier D, Weinstein A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Clements PJ. Predictors and outcomes of scleroderma renal crisis: the high-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis trial. Arthritis Rheum. Nov;46 :2983-9, 2002
Clements PJ, Hurwitz EL, Wong WK, Seibold JR, Mayes M, White B, Wigley F,
Weisman M, Barr W, Moreland L, Medsger TA Jr, Steen VD, Martin RW, Collier D,Weinstein A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Furst DE.: Skin score as a predictor and correlate of outcome: High-dose vs Low-dose penicillamine in systemic sclerosis trial. Arthritis Rheum., 43: 2445-2454, 2000
Cunningham, P.H., Andrews, B.S. and Davis, J.S., IV. Immune complexes in progressive systemic sclerosis and mixed connective tissue disease. J. Rheumatol., 7:301-308, 1980
Andrews, B.S., Theofilopoulos, A.N., Brandt, W.E., Loskutoff, D., Peters, C.J. and Dixon, F.J. Replication of dengue and Junin virus in endothelial cells. Infect. Immun., 20:776-781, 1978
Andrews, B.S. and Theofilopoulos, A.N. A microassay for the determination of hemolytic complement activity in mouse serum. J. Immunol. Methods, 22:273-281, 1978
Andrews, B.S., Petts, V., McIntosh, J. and Penny, R. Circulating immune complexes in acute uveitis. Int. Arch. All. Appl. Immunol., 58:313-321, 1979
Andrews, B.S., Cains, G., McIntosh, J., Petts, V. and Penny, R. Circulating immune complexes in human neutrophilic and lymphocytic vasculitis. J. Clin. Lab. Immunol. 1:311-320, 1979
Andrews, B.S., McIntosh, J., Petts, V. and Penny, R. Immune complexes in retinal vasculitis. Clin. Exp. Immunol., 29:23-29, 1977
Theofilopoulos, A.N., Andrews, B.S., Urist, M.M., Morton, D.S. and Dixon, F.J. The nature of immune complexes in human cancer sera. J. Immunol., 119:657-663, 1977
Andrews, B.S., Eisenberg, R.A., Theofilopoulos, A.N., Izui, S., Wilson, C.B., McConahey, P.J., Murphy, D.E., Roths, J.B. and Dixon, F.J. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med., 148:1198-1215, 1978
Dixon, F.J., Andrews, B.S., Eisenberg, R.A., et al. The etiology and pathogenesis of a spontaneous lupus-like syndrome of mice. Arthritis Rheum., 21:S64-S67, 1978
Waller, S.J., Taylor, R.P. and Andrews, B.S. A polyethylene glycol radioimmunoprecipitation assay for human immunoglobulin G. J. Immunol. Methods, 30:171-177, 1979
Abel, T., Andrews, B.S., Cunningham, P.H., Brunner, C., Horwitz, D.A. and Davis J.S., IV. Rheumatoid vasculitis: The effect of cyclophosphamide on the clinical course and levels of circulating immune complexes. Ann. Intern. Med., 93:407-413, 1980
Taylor, R.P., Andrews, B.S., Morles, K.W. and Conlon, T. Quantitative studies of the interaction of 3H-ds DNA/anti-DNA immune complexes with complement. Comparison and evaluation of the Raji cell, the solution phase C1q, and the red blood cell linked complement fixation radioimmunoassays. Int. J. Rheumatol., 1:29-34, 1981
Andrews, B.S., Arora, N., Shadforth, M.F., Goldberg, S.K. and Davis, J.S., IV. The role of immune complexes in the pathogenesis of pleural effusions. Amer. Rev. Resp. Dis., 124:115-120, 1981
Barada, F.A., Jr., Andrews, B.S., Davis, J.S., IV and Taylor, R.P. Antibodies to Sm in patients with systemic lupus Erythematosus: Correlation of Sm antibody titers with disease activity and other laboratory parameters. Arthritis Rheum., 24:1236-1244, 1981
Andrews, B.S., Cunningham, P.H., Shadforth, M.F. and Davis, J.S., IV. Demonstration of a C1q receptor on the surface of human endothelial cells. J. Immunol., 127:1075-1244, 1981
Carvalho, E.M., Andrews, B.S., Martinelli, R., Dutra, M. and Rocha, H. Circulating immune complexes and rheumatoid factor in schistosomiasis and visceral leishmaniasis. Amer. J. Trop. Med. Hyg., 32:61-68, 1983
Wilson, H.A., Askari, A.D., Neiderhiser, D.H., Johnson, A.M., Andrews, B.S. and Hoskins, L.C. The syndrome of pancreatitis with arthropathy and subcutaneous fat necrosis: Evidence fo the pathogenicity of lipolytic enzymes. Arthritis Rheum., 26:121-126, 1983
Cesario, T.C., Andrews, B.S., Martin, D.A., Jason, M. Treadwell, T., Friou, G.J. and Tilles, J.G. Interferon in synovial fluid and serum of patients with rheumatic diseases. J. Rheumatol., 10:647-650, 1983
Jason, M., Andrews, B.S., Colvin, M. and Friou, G.J. The in-vitro effects of 4-hydroperoxycyclophosphamide (4-HPCY) on the morphology and function of human peripheral blood mononuclear phagocytic cells (macrophages). Cancer Res., 44:3936-3941, 1984
Sandborg, C.I., Berman, M.A., Andrews, B.S. and Friou, G.J. Interleukin-1 production by mononuclear cells from patients with scleroderma syndromes. Clin. Exp. Immunol., 60:294-302, 1985
Zilberfarb, J.L., Andrews, B.S., Young, A.C. and Davis, J.S., IV. Enhancement of C1q binding activity by IgM-rheumatoid factor (IgM-RF). J. Rheumatol., 12:444-448, 1985
Andrews, B.S., Ascher, M.S., Barada, F.A., Jr. and Davis, J.S., IV. The Raji cell radioimmunoassay (Raji RIA) in patients with systemic lupus erythematosus (SLE): Clinical significance and relationship to other serologic parameters assessed by discriminant analysis. J. Rheumatol., 12:718-723, 1985
. Andrews, B.S., Friou, G.J., Barr, R.J., Mirick, G.R., Ross, P.A., Sandborg, C.I. and Berman, M.A. Loss of epidermal Langerhans cells and endothelial cell HLA-DR antigens in the skin in progressive systemic sclerosis (PSS). J. Rheumatol., 13:341-348, 1986
Berman, M.A., Sandborg, C.I., Calabia, B.S., Andrews, B.S. and Friou, G.J. Studies of an interleukin-1 inhibitor: Characterization and clinical significance. Clin. Exp. Immunol., 64:136-145, 1986
Andrews, B.S., Schenk, A.R., Mirick, G.R., Ross, P.A., Barr, R.J. and Friou, G.J. Immunopathology of cutaneous lupus erythematosus (LE) defined by murine monoclonal antibodies. J. Amer. Acad. Dermatol., 16:474-481, 1986
Shiel, W.C., Andrews, B.S., Friou, G.J., Martin, D.A., Scopelitis, E. and Barada, F.A. Immune complexes in synovial fluid and serum from patients with disseminated gonococcal infections: Evidence for local immune complex formation within the joint space. Ann. Rheum. Dis., 4:816-820, 1986
. Sandborg, C.I., Berman, M.A., Andrews, B.S., Mirick, G.R. and Friou, G.J. Increased production of an interleukin-1 (IL-1) inhibitor with fibroblast stimulating activity by mononuclear cells from patients with scleroderma. Clin. Exp. Immunol., 66:312-319, 1986
Berman, M.A., Sandborg, C.I., Andrews, B.S. and Friou, G.J. Interleukin 1 inhibitor masks high interleukin-1 production in AIDS. Clin. Immunol. Immunopathol., 42:133-140, 1987
. Palmer, K.D., O'Day, K., Wener, M.H., Andrews, B.S. and Margolis, R.L. A 17-kDa centromere protein (CENP-A) co-purifies with nucleosome core particles and with histones. J. Cell Biol., 104:805-815, 1987
Andrews, B.S., Mirick, G.R., Friou, G.J., Berman, M.A., Sandborg, C.I. and Cesario, T.C. Changes in circulating monocytes in patients with progressive systemic sclerosis. J. Rheumatol., 14:930-935, 1987
Marks, R.M., Czerniecki, M., Andrews, B.S. and Penny, R. The effects of scleroderma serum on human microvascular endothelial cells. Induction of antibody dependent cellular cytotoxicity. Arthritis Rheum., 31:1524-1534, 1988
. Watrous, D., Andrews, B.S., Levonian, P. and Friou, G.J. Effects of 17 kDa human interleukin-1 (IL-1), 25-31 kDa thymocyte stimulating activity and the 6-9 kDa IL-1 inhibitor on calcium release in the newborn murine calvarial assay. J. Rheumatol., 17:1142-1147, 1990
. Andrews, B.S., Mackman, N., Rehemtulla, A., Fowler, B.J. and Edgington, T.S. Conservation of tissue factor primary sequence among three mammalian species. Gene, 98:265-269, 1991
Andrews, B.S. Is the tryptophan-lysine-serine (WKS) motif the time factor binding site for coagulation factor VII? TIBS, 16:31-36, 1991
. Lehmer, R.R., Andrews, B.S., Robertson, J.A., Stanbridge, E.J., delaMaza, L. and Friou, G.J. Clinical and biological characteristics of Ureaplasma urealyticum-induced polyarthritis in a patient with common variable immunodeficiency (CVID). Ann. Rheum. Dis., 50:574-576, 1991
Clements, P.J. et al. Skin thickness score in systemic sclerosis: An assessment of interobserver variability in 3 independent studies. J. Rheumatol., 20:1892-1896, 1993
53. Clements, P.J., Furst, D.E., Wong, W-K., et al.: High-Dose (HI-DPA) vs Low-Dose (LO-DPA) Penicillamine in Early Diffuse Systemic Sclerosis (SSc) Trial: Analysis of Trial. Arthritis Rheum. 42:1194-1203, 1999
Clements PJ, Wong WK, Hurwitz EL, Furst DE, Mayes M, White B, Wigley F,
Weisman M, Barr W, Moreland L, Medsger TA Jr, Steen V, Martin R, Collier D,
Weinstein A, Lally E, Varga J, Weiner S, Andrews B, Abeles M, Seibold J. Correlates of the disability index of the health assessment questionnaire. A measure of functional impairment in systemic sclerosis (SSC). Arthritis Rheum. 42:2372-2380, 1999
Clements PJ, Wong WK, Hurwitz EL, Furst DE, Mayes M, White B, Wigley F,
Weisman M, Barr W, Moreland L, Medsger TA Jr, Steen V, Martin RW, Collier D,
Weinstein A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Seibold JR. The Disability Index of the Health Assessment Questionnaire is a predictor and correlate of outcome in the high-dose versus low-dose penicillamine in systemic sclerosis trial. Arthritis Rheum. 44: 653-661, 2001
Furst DE, Clements PJ, Wong WK, Mayes MD, Wigley F, White B, Weisman M, Barr
W, Moreland L, Martin R, Medsger TA Jr, Steen V, Collier D, Weinstein A, Lally
E, Varga J, Weiner SR, Andrews B, Abeles M, Peter JB, Seibold JR. Effects of the American College of Rheumatology systemic sclerosis trial guidelines on the nature of systemic sclerosis patients entering a clinical trial. Rheumatology (Oxford). Jun;40 :615-22, 2001
Mouradi, B. and Andrews, B.S. Usefulness of Online Mendelian Inheritance in Man in Clinical Practice. Ann. Intern. Med.135:70, 2001
Professional Societies
Fellow, Royal Australasian College of Physicians 1975
Fellow, American College of Physicians 1980
Fellow, American College of Rheumatology 1990
American Association of Immunology 1979
Society for Leukocyte Biology 1979
Other Experience
Member, Royal Australasian College of Physicians 1972

Diplomate, American Board of Internal Medicine 1978

Subspecialty certification in Rheumatology 1980

Subspecialty certification in Allergy and Immunology 1983

Subspecialty certification in Geriatrics 1992

Graduate Programs
Allergy and Immunology
Rheumatology (IM)
Last updated
08/26/2008