Breast cancer, cellular motility, prognostic indicators
Our laboratory is interested in the role of normal tissue in promoting metastasis, the spread of tumor tissue throughout the body. Metastasis is a multistep process in which tumor cells invade into surrounding tissue, induce the formation of blood vessels (angiogenesis), invade into those vessels (intravasation), flow with the blood or lymph to a distant site, and invade the tissue of the new site. Many of these steps are characterized by movement of tumor cells from one compartment to another. Our studies focus on how this tumor cell movement may be induced by secretion of factors from the nearby normal tissue. We have learned that in the initial invasion step, normal mammary duct cells secrete a factor that increases the migratory ability of MCF-7 breast cancer cells. We are currently investigating the nature of this mammary motility factor. When these tumor cells are exposed to lymphocytes, as they might if they were to metastasize to a lymph node, secretion of tumor necrosis factor also increases the motility of these cells. We have recently developed an assay to study tumor cell movement into vascular-like structures, and we will be developing it as an in vitro assay of tumor intravasation and the role of endothelial cells in influencing this behavior in cancer cells.
Last Five Years of Publications
Min-Ying Su, M-Y, Yu, HJ, Carpenter, PM, McLaren, CE, and Nalcioglu O, Ph.D.Pharmacokinetic Parameters Analyzed from MR Contrast Enhancement Kinetics of Multiple Malignant and Benign Breast Lesions Detected in the Same Patients. Technology in Cancer Research and Treatment, 2005, 4:255-63.
Hardison, J.L., R.A. Wrightsman, P.M. Carpenter, W.A. Kuziel, T.E. Lane, and J.E. Manning. The CC chemokine receptor 5 (CCR5) is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi. Infect. Immun. 2006, 74:135-43
Hardison, J.L., R.A. Wrightsman, P.M. Carpenter, T.E. Lane, and J.E. Manning. The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi. Infect. Immun. 2006;74:125-34.
Theuer CP, Al-Kuran R, Akiyama Y, Okumura M, Ziogas A, Carpenter PM,. Increased E-Cadherin Expression Among Japanese Intestinal-type Gastric Cancers Compared to Specimens from American Patients of European Descent Am. Surgeon . 2006;72:332-8 (2006).
Wirth, GA, Sundine, MJ, Kong, AP, Carpenter, PM. Auricular Angioleiomyoma: A Case Report and Review of the Literature. Ear, Nose & Throat J. 86(5):281-3. (2007).
Chen JH, Agrawal G, Feig B, Baek HM, Carpenter PM, Mehta RS, Nalcioglu O, Su MY. Triple-negative breast cancer: MRI features in 29 patients. Ann Oncol. 2007 Dec;18(12):2042-3.
Chen JH, Mehta RS, Carpenter PM, Nalcioglu O, Su MY. Magnetic resonance imaging in predicting pathological response of triple negative breast cancer following neoadjuvant chemotherapy. J Clin Oncol. 2007 Dec 10;25(35):5667-9.
47. Chen JH, Agrawal G, Carpenter P, Mehta RS, Nalcioglu O, Su MY. Pathological Axillary Lymph Node Status in HER-2 Receptor Positive and Negative Breast Cancers. Ann Surg Oncol. 2008 Mar;15(3):941-2.
Chen JH, Feig B, Agrawal G, Yu H, Carpenter PM, Mehta RS, Nalcioglu O, Su MY. MRI evaluation of pathologically complete response and residual tumors in breast cancer after neoadjuvant chemotherapy. Cancer. 112:17-26 2008
Carpenter PM, Wang-Rodriguez J, Chan O T.M.. Wilczynski SP Laminin 5 Expression in Metaplastic Breast Carcinomas. Am J Surg Pathol 32:345-53, 2008
FL. Meyskens, Jr., CE. McLaren, D Pelot, S Fujikawa-Brooks, PM. Carpenter, E Hawk, G Kelloff, MJ. Lawson, J Kidao, J McCracken, CG Albers, DJ. Ahnen, DK Turgeon, S Goldschmid, P Lance, CH. Hagedorn, DL. Gillen and EW. Gerner. Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial. Cancer Prevention Res 1: (2008)
Yarosh W, Barrientos T, Esmailpour T, Lin L, Carpenter PM, Osann K,Anton-Culver H, Huang T. TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases. Cancer Res. 2008 Feb 1;68(3):693-9.
Kwon, SW,. Carpenter WB and. Carpenter, PM A Potent Metastatic Factor in Squamous Cell Carcinoma?Laminin 332. Korean J Otorhinolaryngol-Head Neck Surg 2008;51:956-9
Mehta RS, Schubbert T, Marshall J and Carpenter PM. Successful and rational use of carboplatin and albumin-bound paclitaxel in recurrent metaplastic breast cancer presenting as multiple organ tumor emboli. Clinical Breast Cancer 2009 Feb;9(1):56-9
Philip M. Carpenter, Anh V. Dao, Zahida S. Arain, Michelle K. Chang, Hoa P. Nguyen, Shehla Arain, Jessica Wang-Rodriguez, Soon-Young Kwon, and Sharon P. Wilczynski Motility Induction in Breast Carcinoma by Mammary Epithelial Laminin 332 (Laminin 5) Mol Cancer Res 2009;7 462-475
Carpenter PM, Chen WP, Mendez A, McLaren CE, Su MY. Angiogenesis in theProgression of Breast Ductal Proliferations. Int J Surg Pathol. 2009 Apr 29
Bahri S, Chen JH, Mehta RS, Carpenter PM, Nie K, Kwon SY, Yu HJ, Nalcioglu O, Su MY. Residual breast cancer diagnosed by MRI in patients receiving neoadjuvant chemotherapy with and without bevacizumab. Ann Surg Oncol. 2009;16:1619-28
Siwa Chan, MD1, Jeon-Hor Chen, MD2, 3, Garima Agrawal, MD2, Muqing Lin, MS2Rita S. Mehta, MD4, Philip M. Carpenter, MD5, Orhan Nalcioglu, PhD2, Min-Ying Su, PhD2 Characterization of Pure Ductal Carcinoma in Situ on Dynamic Contrast-Enhanced MR Imaging: Do Non-High Grade and High Grade Show Different Imaging Features? Journal of Oncology In Press 2010
American Association for the Advancement of Science
American Society of Investigative Pathologists
Metastasis Research Society
American Association for Cancer Research