Christopher C.W. Hughes

picture of Christopher C.W. Hughes

Professor, Molecular Biology and Biochemistry
School of Biological Sciences
Professor, Biomedical Engineering
The Henry Samueli School of Engineering

B.Sc (Hon)., University of London, 1981, Biochemistry
Ph.D., University of London, 1988

Phone: (949)824-8771
Fax: (949) 824-8551
Email: cchughes@uci.edu

University of California, Irvine
Dept. Mol. Biol. & Biochem.
3219 McGaugh Hall
Mail Code: 3900
Irvine, CA 92697
Research Interests
Blood vessel development, angiogenesis in cancer, bioengineering of blood vessels and tissues
URL
Research Abstract
Growth of new blood vessels (angiogenesis) is an important process both in the healthy individual and in disease. Angiogenesis is becoming a hot area of research for cancer biologists as recent data suggest that blocking new blood vessel growth can slow tumor growth by cutting off the supply of oxygen and nutrients.

We have identified several genes involved in regulating the multiple steps of angiogenesis and are developing reagents to specifically interfere with these processes.

In collaboration with Dr. Steven George we are developing multi-cellular 3D tissues for high-throughput drug screening (HTS). In addition we are using tissue engineering to create pre-vascularized thick tissues suitable for transplantation and tissue repair.

For more information see our website: http://darwin.bio.uci.edu/~cchughes/

Patents:
Doubly chimeric human T cell-microvessel SCID mice: a small animal model of human allograft rejection

Keywords: Endothelial, vascular, angiogenesis, tissue engineering, high-throughput drug screening (HTS), 3D-tissues, tumor microenvironment
Available Technologies
Publications
Selected from > 100 (h-index = 60)
 
Faughnan ME, Gossage JR, Chakinala MM, Oh SP, Kasthuri R, Hughes CCW, McWilliams JP, Parambil JG, Vozoris N, Donaldson J, Paul G, Berry P, and Sprecher D. 2019. Pazopanib may reduce bleeding in Hereditary Hemorrhagic Telangiectasia. Angiogenesis 22: 145-155
 
Phan DT, Wang X, Craver BM, Sobrino A, Zhao D, Chen JC, Lee LY, George SC, Lee AP, and Hughes CCW. 2017. A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications. Lab. Chip. 17: 511-520
 
Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, and Hughes CCW. 2017. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 116: 118-129
 
Sobrino A, Phan DTT Datta R, Wang X, Hachey SJ, Romero-López M, Gratton E, Lee AP, George SC and Hughes CCW. 2016. 3D Microtumors in vitro supported by perfused vascular networks. Sci. Rep. 6: 31589
 
Fong AH, Romero-Lopez M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, and Hughes CCW. 2016. Three-dimensional adult cardiac extracellular matrix promotes maturation of human induced pluripotent stem cell-derived cardiomyocytes. Tissue Eng Part A 22(15-16): 1016-25
 
Ziegler ME, Hatch MMS, Wu N, Muawad S, and Hughes CCW. 2016. mTORC2 mediates SDF1?/CXCL12-induced angiogenesis. Angiogenesis 19(3): 359-71
 
Wang X, Phan DT, Sobrino A, George SC, Hughes CCW, Lee AP. 2016. Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels. Lab on a Chip 16 (2): 282-290
 
Popson SA, Ziegler ME, Chen X, Holderfield MT, Shaaban CI, Fong AH, Welch-Reardon KM, Papkoff J, and Hughes CCW. 2013. Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arterio. Thromb. Vasc. Biol. 34: 1011-19
 
Welch-Reardon KM, Ehsan SM, Wang K, Newman AC, Romero-Lopez M, Fong AH, George SC, Edwards RA, Hughes CCW. 2013 Angiogenic sprouting is regulated by endothelial cell expression of Slug (Snai2). J. Cell. Sci 127: 2017-2028
 
Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CCW, and George SC. 2013. A three-dimensional in vitro model of tumor angiogenesis and intravasation. Integrative Biology (in revision)
 
Heylman C, Sobrino A, Shirure VS, Hughes CCW, and George SC 2013. A strategy for integrating essential 3D microphysiological systems of human organs for realistic anti-cancer drug screening. Exp. Biol. Med. (in revision)
 
Hsu YH, Moya ML, Hughes CCW, George SC and Lee AP. 2013 microfluidic platform for generating large-scale nearly identical human microphysiological system arrays. Lab on a Chip 13: 2990-2998
 
Moya ML, Hsu, YH, Lee AP, Hughes CCW, and George SC. 2013. In vitro perfused human capillaries. Tissue Engineering 19: 730-737
 
Gong J, Archer R, Brown M, Fisher S, Chang C, Peacock MR, Hughes CCW, Freimark B. 2013 Measuring response to therapy by near-infrared imaging of tumors using a phosphatidylserine-targeting antibody fragment. Mol. Imaging 12: 244-56
 
Newman AC and Hughes CCW. 2012. Macrophages and angiogenesis: A role for wnt signaling. Vasc. Cell 4: 13-27
 
Newman AC, Chou W, Welch-Reardon KM, Fong AH, Popson SA, Phan DT, Sandoval DR, Gershon PD, and Hughes CCW. 2012. Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived HGF and fibronectin in angiogenesis. Arterioscler. Thromb. Vasc. Biol. 33: 513-22.
 
Hsu YH, Moya ML, Abiri P, Hughes CCW, George SC, and Lee AP. 2012. Full range physiological mass transport control in 3D tissue cultures. Lab on a Chip 13: 81-89
 
White SM, Hingorania R, Aroraa R, Hughes CCW, George SC, and Choi B. 2012. Longitudinal in vivo imaging to assess vascularization of implantable engineered tissues. Tissue Eng. 18: 697-709
 
Kim J-H, George SC, and Hughes CCW. 2012. BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II. Angiogenesis 15: 497-509
 
Newman AC, Nakatsu MN, Chou W, Gershon PD, and Hughes CCW. 2011 The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation. Molecular Biology of the Cell. 22: 3791-800
 
Mestas J, and Hughes CCW. 2004. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172: 2731-2738
Grant
PI on UH3. PI on T32. MPI on UG3. Co-I on RO1. Co-I on UC4. Co-I on U54.
Professional Societies
North American Vascular Biology Organization
American Society for Investigative Pathology
Graduate Programs
Cancer Biology

Biotechnology

Biomedical Engineering

Research Centers
Cancer Research Institute
Edwards Lifesciences Center for Advanced Cardiovascular Technology
Last updated
01/10/2020