Larry Stein

picture of Larry  Stein

Professor Emeritus, Pharmacology
School of Medicine

PH.D., University of Iowa, 1955

Fax: (949) 824-4855

University of California, Irvine
Department of Pharmacology
Mail Code: 4625
Irvine, CA 92697
Research Interests
reinforcement, reward, dopamine, opioid, hippocampal
Research Abstract
Dr. Stein is a neuropharmacologist. His research focused on biochemistry, brain, and behavior. Specific interests included reward, punishment, and memory mechanisms as they pertain to psychiatric disease and drug abuse. Dr. Stein has used brain self-stimulation and drug self-administration methods to identify dopamine and opioid brain systems important in reward.
Selected Publications:

Self, D.W. and Stein, L.: Pertussis toxin attenuates intracranial morphine self-administration. Pharmacol. Biochem. Behav. 46:689-695, 1993.

Stein, L., Xue, B.G. and Belluzzi, J.D.: In vitro reinforcement of hippocampal bursting: A search for Skinner's atoms of behavior. J. Exp. Anal. Behav. 61:155-168, 1994.

Self, D.W., Terwilliger, R.Z., Nestler, E.J. and Stein, L.: Inactivation of Gi and Go proteins in nucleus accumbens reduces both cocaine and heroin self-administration. J. Neuroscience 14:6239-6247, 1994.

Stein, L.: In vitro reinforcement of hippocampal bursting: Possible cellular and molecular mechanism of drug reward. Reg. Peptides 54:285-286, 1994.

Self, D.W., Belluzzi, J.D., Kossuth, S. and Stein, L. Self-administration of the D1 agonist SKF82958 is mediated by D1, not D2, receptors. Psychopharmacol. 123:303-306, 1996.

Stein, L. Biological substrates of operant conditioning and the operant-respondent distinction. J. Exp. Anal. Behav. 67:246-253, 1997.

Stein, L. and Belluzzi, D. Reinforcement, neurochemical substrates. Elsevier’s Encyclopedia of Neuroscience 1774-1776, 1999.

Manzardo, A., Stein, L. and Belluzzi, J.D. Rats prefer cocaine over nicotine in a two-lever self-administration choice test. Brain Research, 924:10-19, 2002.
Other Experience
Chair, Department of Pharmacology
UC Irvine 1979—2000

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