Professor in Residence, Pathology
School of Medicine
M.D., University of Belgrade Medical School (Yugoslavia)
Ph.D., University of Montreal (Canada), 1973
Phone: (562) 494-5513
Fax: (562) 494-5623
University of California, Irvine
Veterans Affairs Medical Center of Long Beach
5901 E. 7th Street (113)
Mail Code: 8900
Long Beach, CA 90822-8900
-Pathology and pharmacology of the gastrointestinal (GI) and neuroendocrine systems. -Mechanisms and molecular biology of GI ulceration and inflammation. -Special interests in growth factors, steroids, angiogenesis, gene expression and transcription factors
Dr. Szabo's laboratory is concerned with the field of the pathogenesis of gastrointestinal (GI) ulceration, especially of duodenal ulcer. Most of the seminal contributions which evolved from his laboratory relate to the experimental models that he developed and mechanisms related to duodenal ulcers. For the past decade Dr. Szabo systematically investigated the underlying mechanisms involved in experimental ulcers using an array of morphological, functional, biochemical, molecular biologic and pharmacologic methods of approach. More recently, he applied his knowledge of angiogenesis, growth factors and gene expression to the field of experimental ulcers. This provided new venues to explain the mechanisms of GI ulceration and the action of drugs such as sucralfate and potential new therapeutic strategies for healing ulcers.
Szabo, S., A. Vincze, Z. Sandor, M. Jadus, Z. Gombos, A.
Pedram, E. Levin, J. Hagar, G. Iaquinto. Vascular
approach to gastroduodenal ulceration: new studies
with endothelins and VEGF. Dig. Dis. Sci. 43:40S-45S,
Nagy, L., B.R. Johnson, P. Hauschka, S. Szabo.
Characterization of proteases and protease inhibitors
in the rat stomach. Am J. Physiol. 272:G1151-1158,
Nagy, L., S. Kusstatscher, P.V. Hauschka, S. Szabo.
Role of cysteine proteases and protease inhibitors in
gastric mucosal damage induced by ethanol or
ammonia in the rat. J. Clin. Invest. 98:1047-1054, 1996.
Clin. Invest. 98:1047-10
Glavin, G.B., S. Szabo, B.R. Johnson, P.L. Xing, R.E.
Morales, M. Plebani, L. Nagy. Isolated rat gastric
mucosal cells: optimal conditions for cell harvesting,
measures of viability and direct cytoprotection. J.
Pharmacol Exper. Ther. 276:1174-1179, 1996.
Szabo, S., J. Folkman, P. Vattay, R.E. Morales, G.S.
Pinkus, K. Kato. Accelerated healing of duodenal ulcers
by oral administration of a mutein of basic fibroblast
growth factor in rats. Gastroenterology. 106:1106-111,