Professor, Medicine
School of Medicine

Director, Graduate Program in Environmental Toxicology
School of Medicine

Molecular mechanisms in DNA damage by chemical carcinogens, and biochemical activation of environmental carcinogens

Graduate Programs in Environmental Toxicology

Gold Medal, Chulabhorn Research Institute, Bangkok, Thailand

Dr. Shank studies chemical carcinogenesis and biochemical toxicology. His research focuses on the toxicokinetics of DNA adduct formation and on molecular mechanisms in the competition for binding sites in DNA by small and bulky chemical carcinogens. These studies are highly relevant to the current problem in toxicology of extrapolating from results of in vitro and animal experiments to assess risks in human populations exposed to low environmental levels of carcinogenic chemicals.

Dr. Shank is also extensively involved in organizing and participating in training courses in environmental toxicology and technology in Southeast Asia, sponsored by the UN Development Programme. The courses are well-established (12 years) in Thailand and were offered in Vietnam in 1998.

Dr. Shank also directs the Graduate Program in Environmental Toxicology, leading to the Master of Science and Doctor of Philosophy degrees in Environmental Toxicology. Detailed information on the program can be obtained from http://www.com.uci.edu/envtox.

1. Amended safety assessment of tall oil acid, sodium tallate, potassium tallate, and ammonium tallate. Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Int J Toxicol. 2009 Nov-Dec;28(6 Suppl 2):252S-8S.PMID: 20086195

2. Final report on the safety assessment of amino nitrophenols as used in hair dyes. Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Int J Toxicol. 2009 Nov-Dec;28(6 Suppl 2):217S-51S.PMID: 20086194

3. Amended safety assessment of sodium picramate and picramic acid. Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Int J Toxicol. 2009 Nov-Dec;28(6 Suppl 2):205S-16S.PMID: 20086193

4. Final report on the safety assessment of Basic Violet 1, Basic Violet 3, and Basic Violet 4. Diamante C, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Int J Toxicol. 2009 Nov-Dec;28(6 Suppl 2):193S-204S.PMID: 20086192

5. Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract. Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW; Cosmetic Ingredient Review Expert Panel, Andersen FA. Int J Toxicol. 2009 Nov-Dec;28(6 Suppl):175S-88S.PMID: 19966149

6. Final report on the safety assessment of PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate. Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW; Cosmetic Ingredient Review Expert Panel, Andersen FA. Int J Toxicol. 2009 Nov-Dec;28(6 Suppl):162S-74S.PMID: 19966148

7. Final amended report on safety assessment on aminomethyl propanol and aminomethyl propanediol. Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW; Cosmetic Ingredient Review Expert Panel, Andersen FA. Int J Toxicol. 2009 Nov-Dec;28(6 Suppl):141S-61S.PMID: 19966147

8. Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid. Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW; Cosmetic Ingredient Review Expert Panel, Andersen FA. Int J Toxicol. 2009 Jul-Aug;28(4 Suppl):68-133.PMID: 19636068

9. Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate. Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW; Cosmetic Ingredient Review Expert Panel, Andersen FA. Int J Toxicol. 2009 Jul-Aug;28(4 Suppl):5-67.PMID: 19636067

Habib, S.L., Said, B., Awad, A.T., Mostafa, M.H., and Shank, R.C., Novel adenine adducts, N7-guanine-AFB1 adducts, and p53 mutations in patients with schistosomiasis and aflatoxin exposure. Cancer Detection and Prevention 30, 491-498, 2006.

Ross, M.K., Said, B. and Shank, R.C., DNA-damaging effects of genotoxins in mixture: 2. Modulation of covalent binding to DNA. Toxicol. Sci., 53: 224-236 (2000).

Ross, M.K., Mathison, B.H., Said, B. and Shank, R.C., 5-Methylcytosine in CpG sites and the reactivity of nearest neighboring guanines tpward the carcinogen aflatoxin B1-8,9-epoxide. Biochem. Biophys. Res. Comm., 254: 114-119, 1999.

Said, B., Matsumoto, D.C., Hamade, A.K., and Shank, R.C. Mutagenic activity and DNA adduct formation by 1,2-epoxy-3-(p-nitrophenoxy)propane, an HIV-1 Protease Inhibitor and GST Substrate. Biochem. Biophys. Res. Comm., 261: 844-847, 1999.

Said, B., Ross, M.K., Hamade, A.K., Matsumoto, D.C., and Shank, R.C., DNA-damaging effects of genotoxins in mixture: Non-additive effects of aflatoxin B1 and N-acetylamino-fluorene on their mutagenicity in Salmonella typhimurium. Toxicol. Sci., 52: 226-231 (1999)

Society of Toxicology

American Chemical Society

Environmental Toxicology

Link to this profile
https://faculty.uci.edu/profile/?facultyId=2329

Last updated
06/16/2010