Science policy; stem cell policy, research ethics, NK lymphocytes, cancer immunotherapy
Chair, UCI Human Stem Cell Research Oversight Committee
Unit Coordinator for Clinical Research Ethics, UCI Institute for Clinical & Translational Science
Member Board of Trustees Smith College, Northampton MA, 2003-2013.
Damon Runyon Memorial Fund Postdoctoral Fellow, Dept. of Tumor Biology, Karolinska Institute, Stockholm, Sweden 1969-1971
Assistant Professor of Surgery/Oncology and Microbiology & Immunology, UCLA School of Medicine 1971-1977.
Associate Professor, UCLA School of Medicine 1977-1983.
Professor, UCLA School of Medicine 1983-1994.
Associate Dean, UCLA School of Medicine 1984-1992.
Interim Dean and Provost for Medical Sciences, UCLA School of Medicine 1992-1994.
UCI Executive Vice-Chancellor, 1994-1998.
Executive Director FASEB (Federation of Societies for Experimental Biology), 1999-2003.
My current interests focus on research ethics and science policy issues. I am particularly concerned with how we make and implement policy on human stem cells including embryonic and other pluripotent stem cells. One aspect of this interest is exploring the differences between California and the other states on stem cell policy. A related interest focuses on how to promote ethical principles within basic and translational research. My laboratory research program is not currently active. It followed two closely related themes: the in vitro regulation of cytotoxic cells by cell interactions, cytokines, and other regulatory factors and the in vivo expression of cytotoxic cell function in cancer patients. The major focus of these studies was on the regulation and expression of cytotoxicity by human Natural Killer (NK) lymphocytes including the function of lymphocytes at the tumor site (tumor infiltrating lymphocytes, or TILs) as these cells represent the immune response at the interface with the malignant cells.
Golub, S.H. The New Federalism: State Policies Regarding Embryonic Stem Cell Research. IN:The Stem Cell Controversy: Biology, Ethics and Policy. R. Dorit (ed.) In press.
Golub, S.H. Stem Cell Politics: The Perfect is the Enemy of the Good. IN: Fundamentals of the Stem Cell Debate. The Scientific, Religious, Ethical & Political Issues, K.R. Monroe, R.B. Miller and J. Tobis (eds.), University of California Press, pp. 134-145, 2008.
Korn, D., Rich, R.R., Garrison, H.H., Golub, S.H., Hendrix, M.J.C., Heinig, S.J., Masters,
B.S., Turman, R.S. The NIH Budget in the "Postdoubling" Era. Science 296:1401-1402, 2002.
Butterfield, L.H., Merino, A., Golub, S.H., and Shau, H. From cytoprotection to tumor suppression: the mutifactorial role of peroxiredoxins. Antiox Redox Sig: 1, 385-402, 1999.
Rhoades, Kristina L., Cai, Sanjun, Golub, Sidney H., and Economou, James S. Granulocyte-macrophage colony-stimulating factor and interleukin-4 differentially regulate the human tumor necrosis factor-alpha promoter region. Cell. Immunol. 161:125-131 1995.
Sarna, G., Machleder, H., Collins, J., Bonavida, B., Jacobs, E., Hawkins, R., Golub, S.H., Shau, H., Fahey, J.L., Popow, J., Robertson, P., Ahn, S., and Quinones, W. A comparative study of intravenous versus intralymphatic interleukin-2 upon both peripheral blood and thoracic duct lymph. J. Immunothera. 15:140-146, 1994.
Federation of American Societies for Experimental Biology 1999—2003
Stem Cell Research Center